BMRB Entry 53405
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR53405
NMR-STAR file interactive viewer.
NMR-STAR v3 text file.
All files associated with the entry
Citation: Tjero-Ojeda, Maria; Bernaus Vives, Ada; Wojciechowski, Michal; Pham, Dinh Quoc Huy; Chwastyk, Mateusz; Vallejo, mario; Novials, Anna; Laurents, Douglas; Carrion Vazquez, Mariano Sixto. "QBP1 Peptide as a Potential Anti-Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study" Sci. Adv. ., e08344-e08344 (2026).
PubMed: 42017387
Assembly members:
entity_1, polymer, 37 residues, Formula weight is not available
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: chemical synthesis
Entity Sequences (FASTA):
entity_1: TCNTATCATQRLANFLVHSS
NNFGAILSSTNVGSNTY
- assigned_chemical_shifts
| Data type | Count |
| 1H chemical shifts | 212 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | hIAPP | 1 |
Entities:
Entity 1, hIAPP 37 residues - Formula weight is not available
| 1 | THR | CYS | ASN | THR | ALA | THR | CYS | ALA | THR | GLN | ||||
| 2 | ARG | LEU | ALA | ASN | PHE | LEU | VAL | HIS | SER | SER | ||||
| 3 | ASN | ASN | PHE | GLY | ALA | ILE | LEU | SER | SER | THR | ||||
| 4 | ASN | VAL | GLY | SER | ASN | THR | TYR |
Samples:
sample_1: hIAPP 100 ± 10 uM; DSS 100 ± 10 uM; KH2PO4 1000 ± 50 uM; sodium acetate 400 ± 40 uM
sample_conditions_1: ionic strength: 0.01 M; pH: 5.58; pressure: 0.90 atm; temperature: 283.2 K
Experiments:
| Name | Sample | Sample state | Sample conditions |
|---|---|---|---|
| 1D 1H | sample_1 | isotropic | sample_conditions_1 |
| 2D 1H-1H TOCSY | sample_1 | isotropic | sample_conditions_1 |
| 2D 1H-1H NOESY | sample_1 | isotropic | sample_conditions_1 |
Software:
TOPSPIN v4.4 - collection
POKY - chemical shift assignment
NMR spectrometers:
- Bruker AVANCE NEO 800 MHz