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PDB ID: 1ih0
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR4994
MolProbity Validation Chart
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NMR-STAR v3 text file.
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Citation: Wang, Xu; Li, Monica; Spyracopoulos, Leo; Beier, Norbert; Chandra, Murali; Solaro, R.; Sykes, Brian. "Structure of the C-domain of Human Cardiac Troponin C in Complex with the Ca2+
Sensitizing drug EMD 57033" J. Biol. Chem. 276, 25456-25466 (2001).
PubMed: 11320096
Assembly members:
C-domain of human Cardiac Troponin C, polymer, 71 residues, 8230.28 Da.
EMD 57033, non-polymer, 425.501 Da.
CALCIUM ION, non-polymer, 40.078 Da.
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: recombinant technology
Entity Sequences (FASTA):
C-domain of human Cardiac Troponin C: GKSEEELSDLFRMFDKNADG
YIDLEELKIMLQATGETITE
DDIEELMKDGDKNNDGRIDY
DEFLEFMKGVE
Data type | Count |
13C chemical shifts | 217 |
15N chemical shifts | 74 |
1H chemical shifts | 515 |
coupling constants | 48 |
Entity Assembly ID | Entity Name | Entity ID |
---|---|---|
1 | C domain of cardiac troponin C | 1 |
2 | EMD 57033 | 2 |
3 | Ca2+ I | 3 |
4 | Ca2+ II | 3 |
Entity 1, C domain of cardiac troponin C 71 residues - 8230.28 Da.
1 | GLY | LYS | SER | GLU | GLU | GLU | LEU | SER | ASP | LEU | ||||
2 | PHE | ARG | MET | PHE | ASP | LYS | ASN | ALA | ASP | GLY | ||||
3 | TYR | ILE | ASP | LEU | GLU | GLU | LEU | LYS | ILE | MET | ||||
4 | LEU | GLN | ALA | THR | GLY | GLU | THR | ILE | THR | GLU | ||||
5 | ASP | ASP | ILE | GLU | GLU | LEU | MET | LYS | ASP | GLY | ||||
6 | ASP | LYS | ASN | ASN | ASP | GLY | ARG | ILE | ASP | TYR | ||||
7 | ASP | GLU | PHE | LEU | GLU | PHE | MET | LYS | GLY | VAL | ||||
8 | GLU |
Entity 2, EMD 57033 1 residues - C22 H23 N3 O4 S - 425.501 Da.
1 | EMD |
Entity 3, Ca2+ I - Ca - 40.078 Da.
1 | CA |
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