BMRB Entry 18995

Click here to enlarge.

PDB ID: 2m49
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS, SPARTA
BMRB Entry DOI: doi:10.13018/BMR18995
MolProbity Validation Chart

NMR-STAR file interactive viewer.
NMR-STAR v3 text file.
XML gzip file.
RDF gzip file.
All files associated with the entry

Title:
Structural Insights into Human S100B and Basic Fibroblast Growth Factor (FGF2) Interaction
Deposition date:
2013-02-03
Original release date:
2013-12-16
Authors:
Gupta, Arun; Yu, Chin
Citation:

Citation: Gupta, Arun; Chou, Ruey-Hwang; Li, Hongchun; Yang, Lee-Wei; Yu, Chin. "Structural insights into the interaction of human S100B and basic fibroblast growth factor (FGF2): Effects on FGFR1 receptor signaling"  Biochim. Biophys. Acta. 2013, 2606-2619 (2013).
PubMed: 24063890

Assembly members:

Assembly members:
FGF2, polymer, 126 residues, 14422.641 Da.
S100B, polymer, 182 residues, 21173.836 Da.

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: pET(20b)+

Entity Sequences (FASTA):

Entity Sequences (FASTA):
FGF2: DPKRLYCKNGGFFLRIHPDG RVDGVREKSDPHIKLQLQAE ERGVVSIKGVSANRYLAMKE DGRLLASKSVTDECFFFERL ESNNYNTYRSRKYTSWYVAL KRTGQYKLGSKTGPGQKAIL FLPMSA
S100B: SELEKAMVALIDVFHQYSGR EGDKHKLKKSELKELINNEL SHFLEEIKEQEVVDKVMETL DNDGDGECDFQEFMAFVAMV TTACHEFFEHESELEKAMVA LIDVFHQYSGREGDKHKLKK SELKELINNELSHFLEEIKE QEVVDKVMETLDNDGDGECD FQEFMAFVAMVTTACHEFFE HE

Data sets:
Data typeCount
13C chemical shifts250
15N chemical shifts81
1H chemical shifts81

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
  • Hide all

Assembly:

Entity Assembly IDEntity NameEntity ID
1FGF2_11
2S100B2
3FGF2_21

Entities:

Entity 1, FGF2_1 126 residues - 14422.641 Da.

1   ASPPROLYSARGLEUTYRCYSLYSASNGLY
2   GLYPHEPHELEUARGILEHISPROASPGLY
3   ARGVALASPGLYVALARGGLULYSSERASP
4   PROHISILELYSLEUGLNLEUGLNALAGLU
5   GLUARGGLYVALVALSERILELYSGLYVAL
6   SERALAASNARGTYRLEUALAMETLYSGLU
7   ASPGLYARGLEULEUALASERLYSSERVAL
8   THRASPGLUCYSPHEPHEPHEGLUARGLEU
9   GLUSERASNASNTYRASNTHRTYRARGSER
10   ARGLYSTYRTHRSERTRPTYRVALALALEU
11   LYSARGTHRGLYGLNTYRLYSLEUGLYSER
12   LYSTHRGLYPROGLYGLNLYSALAILELEU
13   PHELEUPROMETSERALA

Entity 2, S100B 182 residues - 21173.836 Da.

1   SERGLULEUGLULYSALAMETVALALALEU
2   ILEASPVALPHEHISGLNTYRSERGLYARG
3   GLUGLYASPLYSHISLYSLEULYSLYSSER
4   GLULEULYSGLULEUILEASNASNGLULEU
5   SERHISPHELEUGLUGLUILELYSGLUGLN
6   GLUVALVALASPLYSVALMETGLUTHRLEU
7   ASPASNASPGLYASPGLYGLUCYSASPPHE
8   GLNGLUPHEMETALAPHEVALALAMETVAL
9   THRTHRALACYSHISGLUPHEPHEGLUHIS
10   GLUSERGLULEUGLULYSALAMETVALALA
11   LEUILEASPVALPHEHISGLNTYRSERGLY
12   ARGGLUGLYASPLYSHISLYSLEULYSLYS
13   SERGLULEULYSGLULEUILEASNASNGLU
14   LEUSERHISPHELEUGLUGLUILELYSGLU
15   GLNGLUVALVALASPLYSVALMETGLUTHR
16   LEUASPASNASPGLYASPGLYGLUCYSASP
17   PHEGLNGLUPHEMETALAPHEVALALAMET
18   VALTHRTHRALACYSHISGLUPHEPHEGLU
19   HISGLU

Related Database Links:

BMRB 4091 15923 4001 4105 5206 5895
PDB 1BAS 1BFB 1BFC 1BFF 1BFG 1BLA 1BLD 1CVS 1EV2 1FGA 1FQ9 1II4 1IIL 2BFH 2FGF 2M49 4FGF 4OEE 4OEF 4OEG 1B4C 1DT7 1MQ1 1MWN 1QLK 1SYM 1UWO 1XYD 2H61 2K7O 2PRU 3CZT 3D0Y 3D10 3HCM 4N6I
DBJ BAG70135 BAG70264 BAE22214 BAE22413 BAE36647 BAE88979 BAG74213
EMBL CCO13911 CCO13913 CAA25567 CAG46920
GB AAA31248 AAA52448 AAA52531 AAA52532 AAA52533 AAA03075 AAA42096 AAA60367 AAH01766 AAH61178
REF NP_001103711 NP_001997 XP_001099284 XP_002717284 XP_002815172 NP_001076199 NP_001247455 NP_001270589 NP_006263 NP_033141
SP P09038 P48799 Q5IS69 P04271 P04631 P50114 Q6YNR6
PRF 2003367B
AlphaFold P09038 P48799 Q5IS69 P04271 P04631 P50114 Q6YNR6

Download HSQC peak lists in one of the following formats:
CSV: Backbone or all simulated peaks
SPARKY: Backbone or all simulated peaks