BMRB Entry 18755

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PDB ID: 2lzg
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS, SPARTA
BMRB Entry DOI: doi:10.13018/BMR18755
MolProbity Validation Chart

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Title:
NMR Structure of Mdm2 (6-125) with Pip-1
Deposition date:
2012-10-02
Original release date:
2012-11-02
Authors:
Michelsen, Klaus; Jordan, John; Lewis, Jeffrey; Long, Alexander; Yang, Evelyn; Rew, Yosup; Zhou, Jing; Yakowec, Peter; Schnier, Paul; Huang, Xin; Poppe, Leszek
Citation:

Citation: Michelsen, Klaus; Jordan, John; Lewis, Jeffrey; Long, Alexander; Yang, Evelyn; Rew, Yosup; Zhou, Jing; Yakowec, Peter; Schnier, Paul; Huang, Xin; Poppe, Leszek. "Ordering of the N-terminus of human MDM2 by small molecule inhibitors."  J. Am. Chem. Soc. 134, 17059-17067 (2012).
PubMed: 22991965

Assembly members:

Assembly members:
entity_1, polymer, 124 residues, 13882.983 Da.
{(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(2S,3S)-2-hydroxypentan-3-yl]-3-methyl-2-oxopiperidin-3-yl}acetic acid, non-polymer, 478.408 Da.

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: Proprietary

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: MCNTNMSVPTDGAVTTSQIP ASEQETLVRPKPLLLKLLKS VGAQKDTYTMKEVLFYLGQY IMTKRLYDEKQQIVYCSNDL LGDLFGVPSFSVKEHRKIYT MIYRNLVVVNQQESSDSGTS VSEN

Data sets:
Data typeCount
13C chemical shifts405
15N chemical shifts113
1H chemical shifts609

Additional metadata:

  • Assembly
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Assembly:

Entity Assembly IDEntity NameEntity ID
1entity_11
2(5-HYDROXY-1H-INDOL-3-YL)ACETIC ACID_12
3(5-HYDROXY-1H-INDOL-3-YL)ACETIC ACID_22

Entities:

Entity 1, entity_1 124 residues - 13882.983 Da.

1   METCYSASNTHRASNMETSERVALPROTHR
2   ASPGLYALAVALTHRTHRSERGLNILEPRO
3   ALASERGLUGLNGLUTHRLEUVALARGPRO
4   LYSPROLEULEULEULYSLEULEULYSSER
5   VALGLYALAGLNLYSASPTHRTYRTHRMET
6   LYSGLUVALLEUPHETYRLEUGLYGLNTYR
7   ILEMETTHRLYSARGLEUTYRASPGLULYS
8   GLNGLNILEVALTYRCYSSERASNASPLEU
9   LEUGLYASPLEUPHEGLYVALPROSERPHE
10   SERVALLYSGLUHISARGLYSILETYRTHR
11   METILETYRARGASNLEUVALVALVALASN
12   GLNGLNGLUSERSERASPSERGLYTHRSER
13   VALSERGLUASN

Entity 2, (5-HYDROXY-1H-INDOL-3-YL)ACETIC ACID_1 - C25 H29 Cl2 N O4 - 478.408 Da.

1   0R3

Related Database Links:

BMRB 11569 18876 2410
PDB 1RV1 1T4E 1T4F 1YCR 1Z1M 2AXI 2GV2 2LZG 2M86 2MPS 2RUH 3EQS 3G03 3IUX 3IWY 3JZK 3JZR 3JZS 3LBK 3LBL 3LNJ 3LNZ 3TJ2 3TPX 3TU1 3V3B 3VBG 3VZV 3W69 4DIJ 4ERE 4ERF 4HBM 4HFZ 4JV7 4JV9 4JVE 4JVR 4JWR 4MDN 4MDQ 4OAS 4OBA 4OCC 4ODE 4ODF 4OGN 4OGT 4OGV 4OQ3 4QO4 4QOC 4UMN 4WT2 4ZYC 4ZYF 4ZYI
DBJ BAF83030 BAJ17752
EMBL CAA78055 CAD23251 CAD36959 CAH89564 CAP16708
GB AAA60568 AAI48523 AAI52385 AAI52391 AAI53118
PRF 1814460A
REF NP_001124685 NP_001138809 NP_001138811 NP_001253331 NP_002383
SP Q00987
AlphaFold Q00987

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