BMRB Entry 17186

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR17186

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Title:
NMR Reveals Anomalous Copper(II) Binding to the Amyloid ABeta Peptide of Alzheimer's Disease
Deposition date:
2010-09-10
Original release date:
2010-11-10
Authors:
Hou, Liming; Zagorski, Michael
Citation:

Citation: Hou, Liming; Zagorski, Lauren. "NMR Reveals Anamalous Copper(II) Binding to the Amyloid ABeta Peptide of Alzheimer's Disease"  J. Am. Chem. Soc. 128, 9260-9261 (2006).
PubMed: 16848423

Assembly members:

Assembly members:
Abeta, polymer, 40 residues, Formula weight is not available
CU, non-polymer, 63.546 Da.

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: purified from the natural source

Entity Sequences (FASTA):

Entity Sequences (FASTA):
Abeta: DAEFRHDSGYEVHHQKLVFF AEDVGSNKGAIIGLMVGGVV

Data sets:
  • binding_constants
Data typeCount
binding constants3

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
  • Hide all

Assembly:

Entity Assembly IDEntity NameEntity ID
1Abeta1
2CU2

Entities:

Entity 1, Abeta 40 residues - Formula weight is not available

1   ASPALAGLUPHEARGHISASPSERGLYTYR
2   GLUVALHISHISGLNLYSLEUVALPHEPHE
3   ALAGLUASPVALGLYSERASNLYSGLYALA
4   ILEILEGLYLEUMETVALGLYGLYVALVAL

Entity 2, CU - Cu - 63.546 Da.

1   CU

Samples:

sample_1: potassium phosphate buffer 5 mM; Abeta 130 uM; copper chloride0 – 130 uM

sample_conditions_1: pH: 7.3; pressure: ambient atm; temperature: 278 K

Experiments:

NameSampleSample stateSample conditions
2D 1H-15N HSQCsample_1isotropicsample_conditions_1

Software:

software, na - na

NMR spectrometers:

  • ns ns ns MHz

Related Database Links:

BMRB 11435 15775 17159 17764 17793 17794 17795 17796 18052 18127 18128 18129 18131 19009 19309 19393 25218 25289 25429 26508 26516
PDB
DBJ BAA22264 BAA84580 BAB71958 BAD51938 BAE01907
EMBL CAA30050 CAA31830 CAA39589 CAA39590 CAA39591
GB AAA35540 AAA36829 AAA51564 AAA51722 AAA51726
PIR A60045 D60045 E60045 G60045 PQ0438
PRF 1303338A 1403400A 1405204A 1507304A 1507304B
REF NP_000475 NP_001006601 NP_001013036 NP_001070264 NP_001127014
SP P05067 P53601 P79307 P86906 Q28053
TPG DAA33655
AlphaFold P05067 P53601 P79307 P86906 Q28053