BMRB Entry 30726

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PDB ID: 6vxg
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR30726
MolProbity Validation Chart

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Title:
Structure of the C-terminal Domain of RAGE and Its Inhibitor
Deposition date:
2020-02-21
Original release date:
2021-02-20
Authors:
Ramirez, L.; Shekhtman, A.
Citation:

Citation: Manigrasso, Michaele; Rabbani, Piul; Egana-Gorrono, Lander; Quadri, Nosirudeen; Frye, Laura; Zhou, Boyan; Reverdatto, Sergey; Ramirez, Lisa; Dansereau, Stephen; Pan, Jinhong; Li, Huilin; D'Agati, Vivette; Ramasamy, Ravichandran; DeVita, Robert; Shekhtman, Alexander; Schmidt, Ann. "Small-molecule antagonism of the interaction of the RAGE cytoplasmic domain with DIAPH1 reduces diabetic complications in mice"  Sci. Transl. Med. 13, eabf7084-eabf7084 (2021).
PubMed: 34818060

Assembly members:

Assembly members:
entity_1, polymer, 43 residues, 5035.241 Da.
entity_RQV, non-polymer, 388.462 Da.

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli BL21(DE3)

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: MWQRRQRRGEERKAPENQEE EEERAELNQSEEPEAGESST GGP

Data sets:
Data typeCount
13C chemical shifts112
15N chemical shifts40
1H chemical shifts231

Additional metadata:

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Assembly:

Entity Assembly IDEntity NameEntity ID
1unit_11
2unit_22

Entities:

Entity 1, unit_1 43 residues - 5035.241 Da.

1   METTRPGLNARGARGGLNARGARGGLYGLU
2   GLUARGLYSALAPROGLUASNGLNGLUGLU
3   GLUGLUGLUARGALAGLULEUASNGLNSER
4   GLUGLUPROGLUALAGLYGLUSERSERTHR
5   GLYGLYPRO

Entity 2, unit_2 - C23 H24 N4 O2 - 388.462 Da.

1   RQV

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