BMRB Entry 19966

Name: Structure and function of the JAK interaction region in the intrinsically disordered N-terminus of SOCS5
Published: 2015-05-18

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PDB ID: 2n34
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS, SPARTA
BMRB Entry DOI: doi:10.13018/BMR19966
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Nicholas Rego and David Koes
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Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

Structure and function of the JAK interaction region in the intrinsically disordered N-terminus of SOCS5

Deposition date:

2014-05-12

Original release date:

2015-05-18

Authors:

Chandrashekaran, Indu; Mohanty, Biswaranjan; Linossi, Edmond; Dagley, Laura; Murphy, James; Nicholson, Sandra; Babon, Jeffrey; Norton, Raymond

Citation:

Citation: Chandrashekaran, Indu; Mohanty, Biswaranjan; Linossi, Edmond; Dagley, Laura; Murphy, James; Nicholson, Sandra; Babon, Jeffrey; Norton, Raymond. "Structure and function of the JAK interaction region in the intrinsically disordered N-terminus of SOCS5" J. Mol. Biol. ., .-..

Assembly members:

Assembly members:
entity, polymer, 70 residues, 8116.588 Da.

Natural source:

Natural source: Common Name: house mouse Taxonomy ID: 10090 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Mus musculus

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pGEX2T

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity: RSLRQRLQDTVGLCFPMRTY SKQSKPLFSNKRKIHLSELM LEKCPFPAGSDLAQKWHLIK QHTAPVSPHS

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list_1

Data type	Count
13C chemical shifts	232
15N chemical shifts	63
1H chemical shifts	452

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	N-terminus of SOCS5	1

Entities:

Entity 1, N-terminus of SOCS5 70 residues - 8116.588 Da.

1	ARG	SER	LEU	ARG	GLN	ARG	LEU	GLN	ASP	THR
2	VAL	GLY	LEU	CYS	PHE	PRO	MET	ARG	THR	TYR
3	SER	LYS	GLN	SER	LYS	PRO	LEU	PHE	SER	ASN
4	LYS	ARG	LYS	ILE	HIS	LEU	SER	GLU	LEU	MET
5	LEU	GLU	LYS	CYS	PRO	PHE	PRO	ALA	GLY	SER
6	ASP	LEU	ALA	GLN	LYS	TRP	HIS	LEU	ILE	LYS
7	GLN	HIS	THR	ALA	PRO	VAL	SER	PRO	HIS	SER

Name	Sample	Sample state	Sample conditions
2D 1H-15N HSQC	sample_1	isotropic	sample_conditions_1
2D 1H-13C HSQC aliphatic	sample_1	isotropic	sample_conditions_1
3D HNCO	sample_1	isotropic	sample_conditions_1
3D HNCA	sample_1	isotropic	sample_conditions_1
3D HN(CO)CA	sample_1	isotropic	sample_conditions_1
3D HNCACB	sample_1	isotropic	sample_conditions_1
3D CBCA(CO)NH	sample_1	isotropic	sample_conditions_1
3D HBHA(CO)NH	sample_1	isotropic	sample_conditions_1
3D 1H-15N NOESY	sample_1	isotropic	sample_conditions_1
3D 1H-13C NOESY aliphatic	sample_1	isotropic	sample_conditions_1
3D 1H-13C NOESY aromatic	sample_1	isotropic	sample_conditions_1
2D 1H-15N HSQC	sample_1	isotropic	sample_conditions_1

PDB	2N34
DBJ	BAA31646 BAF82883 BAG11225 BAG59372
EMBL	CAB66830
GB	AAB96648 AAD40484 AAH32862 AAH53015 AAI14097
REF	NP_001039647 NP_001102744 NP_001120786 NP_001156362 NP_001253857
SP	O54928 O75159 Q29RN6
TPG	DAA24700
AlphaFold	O54928 O75159 Q29RN6

BMRB Entry 19966

Additional metadata:

Assembly:

Entities:

Samples:

Experiments:

Software:

NMR spectrometers:

Related Database Links:

1	ARG	SER	LEU	ARG	GLN	ARG	LEU	GLN	ASP	THR
2	VAL	GLY	LEU	CYS	PHE	PRO	MET	ARG	THR	TYR
3	SER	LYS	GLN	SER	LYS	PRO	LEU	PHE	SER	ASN
4	LYS	ARG	LYS	ILE	HIS	LEU	SER	GLU	LEU	MET
5	LEU	GLU	LYS	CYS	PRO	PHE	PRO	ALA	GLY	SER
6	ASP	LEU	ALA	GLN	LYS	TRP	HIS	LEU	ILE	LYS
7	GLN	HIS	THR	ALA	PRO	VAL	SER	PRO	HIS	SER

1	ARG	SER	LEU	ARG	GLN	ARG	LEU	GLN	ASP	THR
2	VAL	GLY	LEU	CYS	PHE	PRO	MET	ARG	THR	TYR
3	SER	LYS	GLN	SER	LYS	PRO	LEU	PHE	SER	ASN
4	LYS	ARG	LYS	ILE	HIS	LEU	SER	GLU	LEU	MET
5	LEU	GLU	LYS	CYS	PRO	PHE	PRO	ALA	GLY	SER
6	ASP	LEU	ALA	GLN	LYS	TRP	HIS	LEU	ILE	LYS
7	GLN	HIS	THR	ALA	PRO	VAL	SER	PRO	HIS	SER

1	ARG	SER	LEU	ARG	GLN	ARG	LEU	GLN	ASP	THR
2	VAL	GLY	LEU	CYS	PHE	PRO	MET	ARG	THR	TYR
3	SER	LYS	GLN	SER	LYS	PRO	LEU	PHE	SER	ASN
4	LYS	ARG	LYS	ILE	HIS	LEU	SER	GLU	LEU	MET
5	LEU	GLU	LYS	CYS	PRO	PHE	PRO	ALA	GLY	SER
6	ASP	LEU	ALA	GLN	LYS	TRP	HIS	LEU	ILE	LYS
7	GLN	HIS	THR	ALA	PRO	VAL	SER	PRO	HIS	SER