BMRB Entry 17968

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PDB ID: 2ljy
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS, SPARTA
BMRB Entry DOI: doi:10.13018/BMR17968
MolProbity Validation Chart

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Title:
Haddock model structure of the N-terminal domain dimer of HPV16 E6
Deposition date:
2011-09-30
Original release date:
2012-04-04
Authors:
Zanier, Katia; ould M'hamed ould Sidi, Abdellahi; Boulade-Ladame, Charlotte; Rybin, Vladimir; Chappelle, Anne; Atkinson, Andrew; Kieffer, Bruno; Trave, Gilles
Citation:

Citation: Zanier, Katia; Boulade-Ladame, Abdellahi; Rybin, Charlotte; Chappelle, Vladimir; Atkinson, Anne; Kieffer, Andrew; Trave, Bruno. "Solution structure analysis of the HPV16 E6 oncoprotein reveals a self-association mechanism required for E6-mediated degradation of p53."  Structure 20, 604-617 (2012).
PubMed: 22483108

Assembly members:

Assembly members:
HPV16_E6, polymer, 82 residues, 8505.967 Da.
ZN, non-polymer, 65.409 Da.

Natural source:

Natural source:   Common Name: Human papillomavirus type 16   Taxonomy ID: 333760   Superkingdom: Viruses   Kingdom: not available   Genus/species: Alphapapillomavirus Human papillomavirus 16

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: petM41

Entity Sequences (FASTA):

Entity Sequences (FASTA):
HPV16_E6: GAMFQDPQERPRKLPQLCTE LQTTIHDIILECVYCKQQLL RREVYDFAFRDLCIVYRDGN PYAVCDKCLKFYSKISEYRH YS

Data sets:
Data typeCount
13C chemical shifts259
15N chemical shifts83
1H chemical shifts549

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
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Assembly:

Entity Assembly IDEntity NameEntity ID
1HPV_16_E6_11
2HPV_16_E6_21
3ZINC ION_12
4ZINC ION_22

Entities:

Entity 1, HPV_16_E6_1 82 residues - 8505.967 Da.

The natural E6 sequence starts at M1. Residues G-1 and A0 are introduced by colning. Residues G-1 to A0 and S71 to S80 are not displayed in the coordinate file because unstructured.

1   GLYALAMETPHEGLNASPPROGLNGLUARG
2   PROARGLYSLEUPROGLNLEUCYSTHRGLU
3   LEUGLNTHRTHRILEHISASPILEILELEU
4   GLUCYSVALTYRCYSLYSGLNGLNLEULEU
5   ARGARGGLUVALTYRASPPHEALAPHEARG
6   ASPLEUCYSILEVALTYRARGASPGLYASN
7   PROTYRALAVALCYSASPLYSCYSLEULYS
8   PHETYRSERLYSILESERGLUTYRARGHIS
9   TYRSER

Entity 2, ZINC ION_1 - Zn - 65.409 Da.

1   ZN

Related Database Links:

BMRB 17967
PDB 2LJX 2LJY 4GIZ
DBJ BAN15903 BAN15904 BAN15905 BAN15906 BAN15907
EMBL CAB45104 CAB45106 CAB45108 CAB45110 CAB45112
GB AAA46939 AAA91654 AAA91655 AAA91656 AAA91657
REF NP_041325
SP P03126
AlphaFold P03126

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