BMRB Entry 6960

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PDB ID: 2d82
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR6960
MolProbity Validation Chart

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Title:
Target Structure-Based Discovery of Small Molecules that Block Human p53 and CREB Binding Protein (CBP) Association
Deposition date:
2006-01-27
Original release date:
2006-04-26
Authors:
Sachchidanand, .; Resnick-Silverman, L.; Yan, S.; Mujtaba, S.; Liu, W.; Zeng, L.; Manfredi, J.; Zhou, M.
Citation:

Citation: Sachchidanand, .; Resnick-Silverman, L.; Yan, S.; Mujtaba, S.; Liu, W.; Zeng, L.; Manfredi, J.; Zhou, M.. "Target structure-based discovery of small molecules that block human p53 and CREB binding protein association"  Chem. Biol. 13, 81-90 (2006).
PubMed: 16426974

Assembly members:

Assembly members:
CREB-binding protein (E.C.2.3.1.48), polymer, 121 residues, Formula weight is not available

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology

Entity Sequences (FASTA):

Entity Sequences (FASTA):
CREB-binding protein (E.C.2.3.1.48): GSHMRKKIFKPEELRQALMP TLEALYRQDPESLPFRQPVD PQLLGIPDYFDIVKNPMDLS TIKRKLDTGQYQEPWQYVDD VWLMFNNAWLYNRKTSRVYK FCSKLAEVFEQEIDPVMQSL G

Data sets:
Data typeCount
13C chemical shifts441
15N chemical shifts116
1H chemical shifts845

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
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Assembly:

Entity Assembly IDEntity NameEntity ID
1CREB-binding protein1

Entities:

Entity 1, CREB-binding protein 121 residues - Formula weight is not available

1   GLYSERHISMETARGLYSLYSILEPHELYS
2   PROGLUGLULEUARGGLNALALEUMETPRO
3   THRLEUGLUALALEUTYRARGGLNASPPRO
4   GLUSERLEUPROPHEARGGLNPROVALASP
5   PROGLNLEULEUGLYILEPROASPTYRPHE
6   ASPILEVALLYSASNPROMETASPLEUSER
7   THRILELYSARGLYSLEUASPTHRGLYGLN
8   TYRGLNGLUPROTRPGLNTYRVALASPASP
9   VALTRPLEUMETPHEASNASNALATRPLEU
10   TYRASNARGLYSTHRSERARGVALTYRLYS
11   PHECYSSERLYSLEUALAGLUVALPHEGLU
12   GLNGLUILEASPPROVALMETGLNSERLEU
13   GLY

Related Database Links:

BMRB 17392 17393 7110
PDB 1JSP 2D82 2L84 2L85 2RNY 3DWY 3P1C 3P1D 3P1E 3P1F 3SVH 4A9K 4N3W 4N4F 4NR4 4NR5 4NR6 4NR7 4NYV 4NYW 4NYX 4OUF
DBJ BAE06125 BAG65526 BAI45616
GB AAB28651 AAC51331 AAC51770 AAH72594 AAI72737
PRF 1923401A
REF NP_001020603 NP_001073315 NP_001157494 NP_001247644 NP_004371
SP P45481 Q6JHU9 Q92793
TPG DAA15549
AlphaFold P45481 Q6JHU9 Q92793

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