BMRB Entry 4596
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PDB ID:
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR4596
MolProbity Validation Chart
NMR-STAR file interactive viewer.
NMR-STAR v3 text file.
XML gzip file.
RDF gzip file.
All files associated with the entry
Citation: Massiah, M.; Ko, Y.; Pedersen, P.; Mildvan, A.. "Cystic fibrosis transmembrane conductance regulator: solution structures of
peptides based on the Phe508 region, the most common site of disease-causing
DeltaF508 mutation -- P26" Biochemistry 38, 7453-7461 (1999).
PubMed: 10360942
Assembly members:
PROTEIN (CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR)), polymer, 26 residues, Formula weight is not available
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eucaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: chemical synthesis
Entity Sequences (FASTA):
PROTEIN (CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR)): MPGTIKENIIFGVSYDEYRY
RSVIKA
- assigned_chemical_shifts
| Data type | Count |
| 1H chemical shifts | 170 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | cystic fibrosis transmembrane conductance regulator | 1 |
Entities:
Entity 1, cystic fibrosis transmembrane conductance regulator 26 residues - Formula weight is not available
| 1 | MET | PRO | GLY | THR | ILE | LYS | GLU | ASN | ILE | ILE | ||||
| 2 | PHE | GLY | VAL | SER | TYR | ASP | GLU | TYR | ARG | TYR | ||||
| 3 | ARG | SER | VAL | ILE | LYS | ALA |
Samples:
sample_1: PROTEIN (CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR)) mM; Trifluroethanol, [U-2H], 43%
sample_cond_1: pH: 4.0; temperature: 298 K; pressure: 1 atm
Experiments:
| Name | Sample | Sample state | Sample conditions |
|---|---|---|---|
| NOESY | sample_1 | not available | sample_cond_1 |
| COSY | sample_1 | not available | sample_cond_1 |
| TOCSY | sample_1 | not available | sample_cond_1 |
Software:
X-PLOR v3.8 - structure refinement
NMRVIEW2.1 - Structure solution
NMR spectrometers:
- Varian UnityPlus 600 MHz