BMRB Entry 25120

Name: Human cardiac troponin C (aCys) in complex with cTnI[1-73] and cTnI[144-163]
Published: 2014-09-03

Chem Shift validation: AVS_anomalous, AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR25120

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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

Human cardiac troponin C (aCys) in complex with cTnI[1-73] and cTnI[144-163]

Deposition date:

2014-07-31

Original release date:

2014-09-03

Authors:

Hwang, Peter

Citation:

Citation: Hwang, Peter. "The intrinsically disordered cardiac-specific N-terminal region of troponin I positions the regulatory domain of troponin C" Proc. Natl. Acad. Sci. U.S.A. ., .-..

Assembly members:

Assembly members:
cTnC, polymer, 161 residues, Formula weight is not available

Natural source:

Natural source: Common Name: human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pET3

Entity Sequences (FASTA):

Entity Sequences (FASTA):
cTnC: MDDIYKAAVEQLTEEQKNEF KAAFDIFVLGAEDGSISTKE LGKVMRMLGQNPTPEELQEM IDEVDEDGSGTVDFDEFLVM MVRSMKDDSKGKSEEELSDL FRMFDKNADGYIDLDELKIM LQATGETITEDDIEELMKDG DKNNDGRIDYDEFLEFMKGV E

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list_1

Data type	Count
1H chemical shifts	908
13C chemical shifts	615
15N chemical shifts	162

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	cTnC-cTnI[1-73]-cTnI[144-163]	1

Entities:

Entity 1, cTnC-cTnI[1-73]-cTnI[144-163] 161 residues - Formula weight is not available

1

MET

ASP

ILE

TYR

LYS

ALA

VAL

GLU

2

GLN

LEU

THR

GLU

GLN

LYS

ASN

GLU

PHE

3

LYS

ALA

PHE

ASP

ILE

PHE

VAL

LEU

GLY

4

ALA

GLU

ASP

GLY

SER

ILE

SER

THR

LYS

GLU

5

LEU

GLY

LYS

VAL

MET

ARG

MET

LEU

GLY

GLN

6

ASN

PRO

THR

PRO

GLU

LEU

GLN

GLU

MET

7

ILE

ASP

GLU

VAL

ASP

GLU

ASP

GLY

SER

GLY

8

THR

VAL

ASP

PHE

ASP

GLU

PHE

LEU

VAL

MET

9

MET

VAL

ARG

SER

MET

LYS

ASP

SER

LYS

10

GLY

LYS

SER

GLU

LEU

SER

ASP

LEU

11

PHE

ARG

MET

PHE

ASP

LYS

ASN

ALA

ASP

GLY

12

TYR

ILE

ASP

LEU

ASP

GLU

LEU

LYS

ILE

MET

13

LEU

GLN

ALA

THR

GLY

GLU

THR

ILE

THR

GLU

14

ASP

ILE

GLU

LEU

MET

LYS

ASP

GLY

15

ASP

LYS

ASN

ASP

GLY

ARG

ILE

ASP

TYR

16

ASP

GLU

PHE

LEU

GLU

PHE

MET

LYS

GLY

VAL

17

GLU

Name	Sample	Sample state	Sample conditions
3D 1H-15N NOESY	sample_1	isotropic	sample_conditions_1
3D 1H-13C NOESY	sample_1	isotropic	sample_conditions_1

Related Database Links:

BMRB	15385 15388 15400 15427 16190 16752 17103 19789 25034 25035 25495 25797
PDB	1AJ4 1AP4 1DTL 1J1D 1J1E 1LA0 1LXF 1MXL 1SPY 1WRK 1WRL 2CTN 2JT0 2JT3 2JT8 2JTZ 2KFX 2KRD 2L1R 2MKP 2MZP 3SD6 3SWB 4GJE
DBJ	BAA02369 BAG36483
EMBL	CAA30736 CAG46663 CAG46683
GB	AAA36772 AAA37492 AAA37493 AAA48654 AAB91994
PIR	TPHUCC
PRF	1510257A 750650A
REF	NP_001029277 NP_001029523 NP_001123715 NP_001272501 NP_001291793
SP	P02591 P09860 P19123 P63315 P63316
TPG	DAA16908
AlphaFold	P02591 P09860 P19123 P63315 P63316

Download HSQC peak lists in one of the following formats:
CSV: Backbone or all simulated peaks
SPARKY: Backbone or all simulated peaks

BMRB Entry 25120

Additional metadata:

Assembly:

Entities:

Samples:

Experiments:

Software:

NMR spectrometers:

Related Database Links: