BMRB Entry 2208

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR2208

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Title:
1H, 13C and 15N backbone assignments of cyclophilin when bound to cyclosporin A (CsA) and preliminary structural characterization of the CsA binding site
Deposition date:
1995-07-31
Original release date:
1995-07-31
Authors:
Neri, Placido; Meadows, Robert; Gemmecker, G.; Olejniczak, E.; Nettesheim, David; Logan, Timothy; Simmer, R.; Helfrich, R.; Holzman, Thomas; Severin, Jean; Fesik, Stephen
Citation:

Citation: Neri, Placido; Meadows, Robert; Gemmecker, G.; Olejniczak, E.; Nettesheim, David; Logan, Timothy; Simmer, R.; Helfrich, R.; Holzman, Thomas; Severin, Jean; Fesik, Stephen. "1H, 13C and 15N backbone assignments of cyclophilin when bound to cyclosporin A (CsA) and preliminary structural characterization of the CsA binding site"  FEBS Lett. 294, 81-88 (1991).

Assembly members:

Assembly members:
cyclophilin, polymer, 165 residues, Formula weight is not available

Natural source:

Natural source:   Common Name: human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: not available   Host organism: Escherichia coli

Entity Sequences (FASTA):

Entity Sequences (FASTA):
cyclophilin: MVNPTVFFDIAVDGEPLGRV SFELFADKVPKTAENFRALS TGEKGFGYKGSCFHRIIPGF MCQGGDFTRHNGTGGKSIYG EKFEDENFILKHTGPGILSM ANAGPNTNGSQFFICTAKTE WLDGKHVVFGKVKEGMNIVE AMERFGSRNGKTSKKITIAD CGQLE

Data sets:
Data typeCount
13C chemical shifts318
15N chemical shifts156
1H chemical shifts323

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
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Assembly:

Entity Assembly IDEntity NameEntity ID
1cyclophilin1

Entities:

Entity 1, cyclophilin 165 residues - Formula weight is not available

1   METVALASNPROTHRVALPHEPHEASPILE
2   ALAVALASPGLYGLUPROLEUGLYARGVAL
3   SERPHEGLULEUPHEALAASPLYSVALPRO
4   LYSTHRALAGLUASNPHEARGALALEUSER
5   THRGLYGLULYSGLYPHEGLYTYRLYSGLY
6   SERCYSPHEHISARGILEILEPROGLYPHE
7   METCYSGLNGLYGLYASPPHETHRARGHIS
8   ASNGLYTHRGLYGLYLYSSERILETYRGLY
9   GLULYSPHEGLUASPGLUASNPHEILELEU
10   LYSHISTHRGLYPROGLYILELEUSERMET
11   ALAASNALAGLYPROASNTHRASNGLYSER
12   GLNPHEPHEILECYSTHRALALYSTHRGLU
13   TRPLEUASPGLYLYSHISVALVALPHEGLY
14   LYSVALLYSGLUGLYMETASNILEVALGLU
15   ALAMETGLUARGPHEGLYSERARGASNGLY
16   LYSTHRSERLYSLYSILETHRILEALAASP
17   CYSGLYGLNLEUGLU

Related Database Links:

BMRB 17218 25104 25337 25502
PDB 1AK4 1AWQ 1AWR 1AWS 1AWT 1AWU 1AWV 1BCK 1CWA 1CWB 1CWC 1CWF 1CWH 1CWI 1CWJ 1CWK 1CWL 1CWM 1CWO 1FGL 1M63 1M9C 1M9D 1M9E 1M9F 1M9X 1M9Y 1MF8 1MIK 1NMK 1OCA 1RMH 1VBS 1VBT 1W8L 1W8M 1W8V 1YND 1ZKF 2ALF 2CPL 2CYH 2MS4 2MZU 2N0T 2RMA 2RMB 2WLW 2X25 2X2A 2X2C 2X2D 2X83 2XGY 3CYH 3CYS 3K0M 3K0N 3K0O 3K0P 3K0Q 3K0R 3ODI 3ODL 3RDD 4CYH 4DGA 4DGB 4DGC 4DGD 4DGE 4IPZ 4N1M 4N1N 4N1O 4N1P 4N1Q 4N1R 4N1S 4YUG 4YUH 4YUI 4YUJ 4YUK 4YUL 4YUM 4YUN 4YUO 4YUP 5CYH
DBJ BAE01146 BAE30323 BAE87660 BAF82774 BAF83540
EMBL CAA34961 CAA37039 CAA68264 CAG32988 CAH91833
GB AAB81959 AAB81960 AAB81961 AAF69142 AAF78600
PIR CSHYAC
PRF 1503232A
REF NP_001009370 NP_001027981 NP_001126060 NP_001270275 NP_001271703
SP P14851 P62935 P62936 P62937 P62938
TPG DAA25853 DAA25854
AlphaFold P14851 P62935 P62936 P62937 P62938

Download HSQC peak lists in one of the following formats:
CSV: Backbone or all simulated peaks
SPARKY: Backbone or all simulated peaks