BMRB Entry 17330

Name: NMR solution structure of GIP in micellular media
Published: 2011-06-01

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PDB ID: 2l70
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR17330
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Nicholas Rego and David Koes
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Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

NMR solution structure of GIP in micellular media

Deposition date:

2010-12-01

Original release date:

2011-06-01

Authors:

Venneti, Kalyana; Alana, Inigo; O'Harte, Finbarr; Malthouse, Paul; Hewage, Chandralal

Citation:

Citation: Venneti, Kalyana; Malthouse, J. Paul G; Hewage, Finbarr. "Conformational, receptor interaction and alanine scan studies of glucose-dependent insulinotropic polypeptide." Biochim. Biophys. Acta 1814, 882-888 (2011).
PubMed: 21539943

Assembly members:

Assembly members:
GIP, polymer, 42 residues, 4990.634 Da.

Natural source:

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: chemical synthesis

Entity Sequences (FASTA):

Entity Sequences (FASTA):
GIP: YAEGTFISDYSIAMDKIHQQ DFVNWLLAQKGKKNDWKHNI TQ

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list_1

Data type	Count
1H chemical shifts	275

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	GIP	1

Entities:

Entity 1, GIP 42 residues - 4990.634 Da.

1

TYR

ALA

GLU

GLY

THR

PHE

ILE

SER

ASP

TYR

2

SER

ILE

ALA

MET

ASP

LYS

ILE

HIS

GLN

3

ASP

PHE

VAL

ASN

TRP

LEU

ALA

GLN

LYS

4

GLY

LYS

ASN

ASP

TRP

LYS

HIS

ASN

ILE

5

THR

GLN

Samples:

sample_1: DHPC 150 mM; H2O 90%; D2O 10%

sample_conditions_1: pH: 3.9; temperature: 273 K

Experiments:

Name	Sample	Sample state	Sample conditions
2D 1H-1H TOCSY	sample_1	isotropic	sample_conditions_1
2D 1H-1H NOESY	sample_1	isotropic	sample_conditions_1
2D DQF-COSY	sample_1	isotropic	sample_conditions_1

Software:

CYANA v2.0, Guntert, Mumenthaler and Wuthrich - structure solution

NMR spectrometers:

Bruker Avance 500 MHz
Bruker DRX 800 MHz
Bruker DRX 900 MHz

BMRB	17331
PDB	1T5Q 2B4N 2L70 2L71 2OBU 2QKH
GB	AAA53192 AAA88043 AAH69100 AAH69663 AAH69686
REF	NP_004114 XP_001091383 XP_001172671 XP_002806900 XP_003278797
SP	P09681
AlphaFold	P09681