USER MOD reduce.3.24.130724 H: found=0, std=0, add=256, rem=0, adj=12 USER MOD reduce.3.24.130724 removed 255 hydrogens (71 hets) HEADER DNA 25-OCT-02 1N37 TITLE NMR SOLUTION STRUCTURE OF THE ANTHRACYCLINE RESPINOMYCIN D TITLE 2 INTERCALATION COMPLEX WITH A DOUBLE STRANDED DNA MOLECULE TITLE 3 (AGACGTCT)2 COMPND MOL_ID: 1; COMPND 2 MOLECULE: 5'-D(*AP*GP*AP*CP*GP*TP*CP*T)-3'; COMPND 3 CHAIN: A, B; COMPND 4 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 SYNTHETIC: YES KEYWDS DRUG-DNA RECOGNITION, ANTHRACYCLINE ANTIBIOTCS, KEYWDS 2 RESPINOMYCIN D, MOLECULAR DYNAMICS SIMULATIONS, NMR KEYWDS 3 SPECTROSCOPY EXPDTA SOLUTION NMR AUTHOR A.J.MAYNARD,H.E.L.WILLIAMS,M.S.SEARLE REVDAT 2 24-FEB-09 1N37 1 VERSN REVDAT 1 28-JAN-03 1N37 0 JRNL AUTH M.S.SEARLE,A.J.MAYNARD,H.E.L.WILLIAMS JRNL TITL DNA RECOGNITION BY THE ANTHRACYCLINE ANTIBIOTIC JRNL TITL 2 RESPINOMYCIN D: NMR STRUCTURE OF THE INTERCALATION JRNL TITL 3 COMPLEX WITH D(AGACGTCT)2 JRNL REF ORG.BIOMOL.CHEM. V. 1 60 2003 JRNL REFN ISSN 1477-0520 JRNL PMID 12929391 JRNL DOI 10.1039/B208622K REMARK 1 REMARK 2 REMARK 2 RESOLUTION. NOT APPLICABLE. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 PROGRAM : SANDER(AMBER) 4.1 REMARK 3 AUTHORS : PEARLMAN,CASE,CALDWELL,ROSS,CHEATHAM,FERGUSON, REMARK 3 SEIBEL,SINGH,WEINER,KOLLMAN REMARK 3 REMARK 3 OTHER REFINEMENT REMARKS: SAMPLE WAS SUBJECTED TO 500PS OF REMARK 3 RESTRAINED MOLECULAR DYNAMICS. USING THE AMBER94 FORCE FIELD REMARK 4 REMARK 4 1N37 COMPLIES WITH FORMAT V. 3.15, 01-DEC-08 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 12-NOV-02. REMARK 100 THE RCSB ID CODE IS RCSB017461. REMARK 210 REMARK 210 EXPERIMENTAL DETAILS REMARK 210 EXPERIMENT TYPE : NMR REMARK 210 TEMPERATURE (KELVIN) : 298 REMARK 210 PH : 7 REMARK 210 IONIC STRENGTH : 100MM NACL 10MM NA2HPO4 REMARK 210 PRESSURE : 1 ATM REMARK 210 SAMPLE CONTENTS : RESPINOMYCIN D, D(AGACGTCT)2, REMARK 210 TSP, NAN3, NA-ETDA REMARK 210 REMARK 210 NMR EXPERIMENTS CONDUCTED : 2D NOESY, 2D TOCSY, DQF-COSY REMARK 210 SPECTROMETER FIELD STRENGTH : 500 MHZ REMARK 210 SPECTROMETER MODEL : AVANCE REMARK 210 SPECTROMETER MANUFACTURER : BRUKER REMARK 210 REMARK 210 STRUCTURE DETERMINATION. REMARK 210 SOFTWARE USED : SANDER(AMBER) 4.1 REMARK 210 METHOD USED : MOLECULAR DYNAMICS REMARK 210 REMARK 210 CONFORMERS, NUMBER CALCULATED : NULL REMARK 210 CONFORMERS, NUMBER SUBMITTED : 1 REMARK 210 CONFORMERS, SELECTION CRITERIA : NULL REMARK 210 REMARK 210 BEST REPRESENTATIVE CONFORMER IN THIS ENSEMBLE : 1 REMARK 210 REMARK 210 REMARK: NULL REMARK 215 REMARK 215 NMR STUDY REMARK 215 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM SOLUTION REMARK 215 NMR DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE THAT REMARK 215 CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES ON REMARK 215 THESE RECORDS ARE MEANINGLESS. REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 DA A 1 O4' - C1' - N9 ANGL. DEV. = 2.4 DEGREES REMARK 500 DA A 1 C4 - C5 - C6 ANGL. DEV. = -3.7 DEGREES REMARK 500 DA A 1 C5 - C6 - N1 ANGL. DEV. = 3.3 DEGREES REMARK 500 DA A 1 N1 - C6 - N6 ANGL. DEV. = -6.1 DEGREES REMARK 500 DA A 3 O4' - C1' - N9 ANGL. DEV. = 2.6 DEGREES REMARK 500 DA A 3 C5 - C6 - N1 ANGL. DEV. = 3.4 DEGREES REMARK 500 DA A 3 N1 - C6 - N6 ANGL. DEV. = -4.4 DEGREES REMARK 500 DC A 4 N3 - C2 - O2 ANGL. DEV. = -4.7 DEGREES REMARK 500 DG A 5 O4' - C1' - N9 ANGL. DEV. = 2.8 DEGREES REMARK 500 DT A 6 O4' - C1' - N1 ANGL. DEV. = 4.2 DEGREES REMARK 500 DT A 6 C6 - C5 - C7 ANGL. DEV. = -5.5 DEGREES REMARK 500 DC A 7 N1 - C2 - O2 ANGL. DEV. = 3.9 DEGREES REMARK 500 DC A 7 N3 - C2 - O2 ANGL. DEV. = -5.7 DEGREES REMARK 500 DT A 8 O4' - C1' - N1 ANGL. DEV. = 2.4 DEGREES REMARK 500 DT A 8 C6 - C5 - C7 ANGL. DEV. = -4.5 DEGREES REMARK 500 DA B 9 C4 - C5 - C6 ANGL. DEV. = -3.5 DEGREES REMARK 500 DA B 9 C5 - C6 - N1 ANGL. DEV. = 3.8 DEGREES REMARK 500 DA B 9 N1 - C6 - N6 ANGL. DEV. = -5.5 DEGREES REMARK 500 DG B 10 O4' - C1' - N9 ANGL. DEV. = 5.9 DEGREES REMARK 500 DA B 11 C4 - C5 - C6 ANGL. DEV. = -3.7 DEGREES REMARK 500 DA B 11 C5 - C6 - N1 ANGL. DEV. = 3.5 DEGREES REMARK 500 DA B 11 N1 - C6 - N6 ANGL. DEV. = -6.0 DEGREES REMARK 500 DC B 12 N3 - C2 - O2 ANGL. DEV. = -4.8 DEGREES REMARK 500 DG B 13 O4' - C1' - N9 ANGL. DEV. = 3.7 DEGREES REMARK 500 DT B 14 C6 - C5 - C7 ANGL. DEV. = -3.9 DEGREES REMARK 500 DC B 15 N3 - C2 - O2 ANGL. DEV. = -4.8 DEGREES REMARK 500 DT B 16 O4' - C1' - N1 ANGL. DEV. = 1.9 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: PLANAR GROUPS REMARK 500 REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS REMARK 500 AN RMSD GREATER THAN THIS VALUE REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 M RES CSSEQI RMS TYPE REMARK 500 DG B 10 0.07 SIDE_CHAIN REMARK 500 DA B 11 0.08 SIDE_CHAIN REMARK 500 REMARK 500 REMARK: NULL REMARK 800 REMARK 800 SITE REMARK 800 SITE_IDENTIFIER: AC1 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE RSD B 17 DBREF 1N37 A 1 8 PDB 1N37 1N37 1 8 DBREF 1N37 B 9 16 PDB 1N37 1N37 9 16 SEQRES 1 A 8 DA DG DA DC DG DT DC DT SEQRES 1 B 8 DA DG DA DC DG DT DC DT HET RSD B 17 146 HETNAM RSD RESPINOMYCIN D FORMUL 3 RSD C51 H75 N2 O22 1+ SITE *** AC1 6 DC A 4 DG A 5 DT A 6 DC B 12 SITE *** AC1 6 DG B 13 DT B 14 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000 USER MOD ----------------------------------------------------------------- USER MOD scores for adjustable sidechains, with "set" totals for H,N and Q USER MOD "o" means original, "f" means flipped, "180deg" is methyl default USER MOD "!" flags a clash with an overlap of 0.40A or greater USER MOD flip categories: "K"=keep, "C"=clashes, "X"=uncertain, "F"=flip USER MOD NoAdj-H: B 17 RSDH228 : B 17 RSD C28 : B 17 RSD C25 :(H bumps) USER MOD NoAdj-H: B 17 RSDH221 : B 17 RSD C21 : B 17 RSD C24 :(H bumps) USER MOD NoAdj-H: B 17 RSDH119 : B 17 RSD C19 : B 17 RSD C20 :(H bumps) USER MOD Single : A 1 DA O5' : rot 180:sc= 0 USER MOD Single : A 6 DT C7 :methyl 150:sc= 0 (180deg=0) USER MOD Single : A 8 DT C7 :methyl 150:sc= 0 (180deg=0) USER MOD Single : A 8 DT O3' : rot 180:sc= 0 USER MOD Single : B 9 DA O5' : rot 180:sc= 0 USER MOD Single : B 14 DT C7 :methyl 150:sc= 0 (180deg=0) USER MOD Single : B 16 DT C7 :methyl -30:sc= -0.0614 (180deg=-0.0727) USER MOD Single : B 16 DT O3' : rot 180:sc= 0 USER MOD Single : B 17 RSD O1 : rot -158:sc= 0.127 USER MOD Single : B 17 RSD O28 : rot 9:sc= 1.12 USER MOD Single : B 17 RSD O33 : rot 66:sc= 0.4 USER MOD Single : B 17 RSD O36 : rot 105:sc= 0.749 USER MOD Single : B 17 RSD O4 : rot -30:sc= 0 USER MOD Single : B 17 RSD O44 : rot -154:sc= 0.0792 USER MOD Single : B 17 RSD O47 : rot -29:sc= 0 USER MOD ----------------------------------------------------------------- ATOM 1 O5' DA A 1 12.657 3.373 4.265 1.00 0.00 O ATOM 2 C5' DA A 1 13.965 3.820 4.546 1.00 0.00 C ATOM 3 C4' DA A 1 14.162 5.249 4.049 1.00 0.00 C ATOM 4 O4' DA A 1 13.345 6.123 4.794 1.00 0.00 O ATOM 5 C3' DA A 1 15.592 5.739 4.265 1.00 0.00 C ATOM 6 O3' DA A 1 16.315 5.688 3.055 1.00 0.00 O ATOM 7 C2' DA A 1 15.413 7.160 4.794 1.00 0.00 C ATOM 8 C1' DA A 1 13.912 7.409 4.678 1.00 0.00 C ATOM 9 N9 DA A 1 13.385 8.307 5.723 1.00 0.00 N ATOM 10 C8 DA A 1 12.475 7.990 6.699 1.00 0.00 C ATOM 11 N7 DA A 1 12.090 8.993 7.439 1.00 0.00 N ATOM 12 C5 DA A 1 12.791 10.059 6.885 1.00 0.00 C ATOM 13 C6 DA A 1 12.821 11.445 7.108 1.00 0.00 C ATOM 14 N6 DA A 1 12.106 12.120 8.017 1.00 0.00 N ATOM 15 N1 DA A 1 13.561 12.251 6.337 1.00 0.00 N ATOM 16 C2 DA A 1 14.292 11.708 5.375 1.00 0.00 C ATOM 17 N3 DA A 1 14.348 10.431 5.029 1.00 0.00 N ATOM 18 C4 DA A 1 13.576 9.663 5.834 1.00 0.00 C ATOM 0 H5' DA A 1 14.691 3.160 4.070 1.00 0.00 H new ATOM 0 H5'' DA A 1 14.148 3.774 5.620 1.00 0.00 H new ATOM 0 H4' DA A 1 13.919 5.244 2.986 1.00 0.00 H new ATOM 0 H3' DA A 1 16.168 5.128 4.960 1.00 0.00 H new ATOM 0 H2' DA A 1 15.754 7.248 5.826 1.00 0.00 H new ATOM 0 H2'' DA A 1 15.984 7.880 4.207 1.00 0.00 H new ATOM 0 HO5' DA A 1 12.549 2.455 4.589 1.00 0.00 H new ATOM 0 H1' DA A 1 13.670 7.913 3.742 1.00 0.00 H new ATOM 0 H8 DA A 1 12.105 6.986 6.844 1.00 0.00 H new ATOM 0 H61 DA A 1 12.205 13.132 8.095 1.00 0.00 H new ATOM 0 H62 DA A 1 11.462 11.622 8.631 1.00 0.00 H new ATOM 0 H2 DA A 1 14.914 12.385 4.808 1.00 0.00 H new ATOM 31 P DG A 2 17.920 5.568 3.051 1.00 0.00 P ATOM 32 OP1 DG A 2 18.378 5.459 1.648 1.00 0.00 O ATOM 33 OP2 DG A 2 18.312 4.520 4.019 1.00 0.00 O ATOM 34 O5' DG A 2 18.417 6.980 3.642 1.00 0.00 O ATOM 35 C5' DG A 2 18.708 8.073 2.800 1.00 0.00 C ATOM 36 C4' DG A 2 19.250 9.241 3.620 1.00 0.00 C ATOM 37 O4' DG A 2 18.238 9.850 4.390 1.00 0.00 O ATOM 38 C3' DG A 2 20.373 8.824 4.566 1.00 0.00 C ATOM 39 O3' DG A 2 21.588 9.357 4.087 1.00 0.00 O ATOM 40 C2' DG A 2 19.879 9.342 5.914 1.00 0.00 C ATOM 41 C1' DG A 2 18.866 10.413 5.520 1.00 0.00 C ATOM 42 N9 DG A 2 17.859 10.693 6.561 1.00 0.00 N ATOM 43 C8 DG A 2 17.078 9.785 7.227 1.00 0.00 C ATOM 44 N7 DG A 2 16.258 10.314 8.092 1.00 0.00 N ATOM 45 C5 DG A 2 16.509 11.678 7.978 1.00 0.00 C ATOM 46 C6 DG A 2 15.900 12.785 8.623 1.00 0.00 C ATOM 47 O6 DG A 2 15.017 12.794 9.478 1.00 0.00 O ATOM 48 N1 DG A 2 16.395 14.019 8.226 1.00 0.00 N ATOM 49 C2 DG A 2 17.359 14.150 7.246 1.00 0.00 C ATOM 50 N2 DG A 2 17.698 15.398 6.898 1.00 0.00 N ATOM 51 N3 DG A 2 17.951 13.122 6.625 1.00 0.00 N ATOM 52 C4 DG A 2 17.469 11.924 7.032 1.00 0.00 C ATOM 0 H5' DG A 2 17.808 8.380 2.267 1.00 0.00 H new ATOM 0 H5'' DG A 2 19.439 7.777 2.048 1.00 0.00 H new ATOM 0 H4' DG A 2 19.642 9.947 2.888 1.00 0.00 H new ATOM 0 H3' DG A 2 20.586 7.758 4.648 1.00 0.00 H new ATOM 0 H2' DG A 2 19.420 8.551 6.507 1.00 0.00 H new ATOM 0 H2'' DG A 2 20.692 9.756 6.510 1.00 0.00 H new ATOM 0 H1' DG A 2 19.355 11.372 5.349 1.00 0.00 H new ATOM 0 H8 DG A 2 17.137 8.721 7.050 1.00 0.00 H new ATOM 0 H1 DG A 2 16.033 14.861 8.675 1.00 0.00 H new ATOM 0 H21 DG A 2 18.405 15.553 6.179 1.00 0.00 H new ATOM 0 H22 DG A 2 17.249 16.194 7.352 1.00 0.00 H new ATOM 64 P DA A 3 23.002 9.066 4.798 1.00 0.00 P ATOM 65 OP1 DA A 3 24.046 9.248 3.765 1.00 0.00 O ATOM 66 OP2 DA A 3 22.934 7.788 5.541 1.00 0.00 O ATOM 67 O5' DA A 3 23.094 10.296 5.834 1.00 0.00 O ATOM 68 C5' DA A 3 23.079 11.613 5.330 1.00 0.00 C ATOM 69 C4' DA A 3 22.803 12.696 6.369 1.00 0.00 C ATOM 70 O4' DA A 3 21.499 12.633 6.902 1.00 0.00 O ATOM 71 C3' DA A 3 23.712 12.667 7.594 1.00 0.00 C ATOM 72 O3' DA A 3 25.008 13.120 7.275 1.00 0.00 O ATOM 73 C2' DA A 3 22.908 13.564 8.531 1.00 0.00 C ATOM 74 C1' DA A 3 21.480 13.526 7.993 1.00 0.00 C ATOM 75 N9 DA A 3 20.465 13.124 8.985 1.00 0.00 N ATOM 76 C8 DA A 3 20.073 11.856 9.329 1.00 0.00 C ATOM 77 N7 DA A 3 19.099 11.807 10.196 1.00 0.00 N ATOM 78 C5 DA A 3 18.829 13.149 10.441 1.00 0.00 C ATOM 79 C6 DA A 3 17.888 13.838 11.222 1.00 0.00 C ATOM 80 N6 DA A 3 16.972 13.253 12.005 1.00 0.00 N ATOM 81 N1 DA A 3 17.826 15.176 11.210 1.00 0.00 N ATOM 82 C2 DA A 3 18.689 15.829 10.448 1.00 0.00 C ATOM 83 N3 DA A 3 19.625 15.316 9.663 1.00 0.00 N ATOM 84 C4 DA A 3 19.644 13.963 9.700 1.00 0.00 C ATOM 0 H5' DA A 3 22.322 11.679 4.548 1.00 0.00 H new ATOM 0 H5'' DA A 3 24.041 11.818 4.860 1.00 0.00 H new ATOM 0 H4' DA A 3 22.976 13.600 5.785 1.00 0.00 H new ATOM 0 H3' DA A 3 23.926 11.691 8.031 1.00 0.00 H new ATOM 0 H2' DA A 3 22.952 13.201 9.558 1.00 0.00 H new ATOM 0 H2'' DA A 3 23.300 14.581 8.536 1.00 0.00 H new ATOM 0 H1' DA A 3 21.181 14.534 7.706 1.00 0.00 H new ATOM 0 H8 DA A 3 20.533 10.970 8.916 1.00 0.00 H new ATOM 0 H61 DA A 3 16.321 13.825 12.543 1.00 0.00 H new ATOM 0 H62 DA A 3 16.925 12.236 12.063 1.00 0.00 H new ATOM 0 H2 DA A 3 18.622 16.907 10.469 1.00 0.00 H new ATOM 96 P DC A 4 26.250 12.911 8.278 1.00 0.00 P ATOM 97 OP1 DC A 4 27.485 13.310 7.567 1.00 0.00 O ATOM 98 OP2 DC A 4 26.173 11.541 8.833 1.00 0.00 O ATOM 99 O5' DC A 4 25.970 13.948 9.478 1.00 0.00 O ATOM 100 C5' DC A 4 25.901 15.337 9.244 1.00 0.00 C ATOM 101 C4' DC A 4 25.316 16.101 10.428 1.00 0.00 C ATOM 102 O4' DC A 4 23.968 15.744 10.632 1.00 0.00 O ATOM 103 C3' DC A 4 26.018 15.844 11.759 1.00 0.00 C ATOM 104 O3' DC A 4 27.177 16.644 11.803 1.00 0.00 O ATOM 105 C2' DC A 4 24.912 16.176 12.756 1.00 0.00 C ATOM 106 C1' DC A 4 23.619 16.112 11.948 1.00 0.00 C ATOM 107 N1 DC A 4 22.630 15.132 12.436 1.00 0.00 N ATOM 108 C2 DC A 4 21.381 15.579 12.827 1.00 0.00 C ATOM 109 O2 DC A 4 21.085 16.771 12.777 1.00 0.00 O ATOM 110 N3 DC A 4 20.433 14.723 13.287 1.00 0.00 N ATOM 111 C4 DC A 4 20.726 13.417 13.300 1.00 0.00 C ATOM 112 N4 DC A 4 19.782 12.601 13.789 1.00 0.00 N ATOM 113 C5 DC A 4 21.977 12.901 12.829 1.00 0.00 C ATOM 114 C6 DC A 4 22.902 13.795 12.421 1.00 0.00 C ATOM 0 H5' DC A 4 25.292 15.523 8.359 1.00 0.00 H new ATOM 0 H5'' DC A 4 26.900 15.716 9.029 1.00 0.00 H new ATOM 0 H4' DC A 4 25.445 17.148 10.155 1.00 0.00 H new ATOM 0 H3' DC A 4 26.399 14.842 11.956 1.00 0.00 H new ATOM 0 H2' DC A 4 24.897 15.464 13.581 1.00 0.00 H new ATOM 0 H2'' DC A 4 25.057 17.165 13.191 1.00 0.00 H new ATOM 0 H1' DC A 4 23.148 17.092 12.029 1.00 0.00 H new ATOM 0 H41 DC A 4 19.946 11.595 13.825 1.00 0.00 H new ATOM 0 H42 DC A 4 18.899 12.986 14.125 1.00 0.00 H new ATOM 0 H5 DC A 4 22.172 11.839 12.802 1.00 0.00 H new ATOM 0 H6 DC A 4 23.866 13.449 12.079 1.00 0.00 H new ATOM 126 P DG A 5 28.161 16.741 13.073 1.00 0.00 P ATOM 127 OP1 DG A 5 29.453 17.291 12.605 1.00 0.00 O ATOM 128 OP2 DG A 5 28.162 15.424 13.748 1.00 0.00 O ATOM 129 O5' DG A 5 27.470 17.841 14.025 1.00 0.00 O ATOM 130 C5' DG A 5 27.101 19.094 13.494 1.00 0.00 C ATOM 131 C4' DG A 5 26.236 19.929 14.434 1.00 0.00 C ATOM 132 O4' DG A 5 25.180 19.157 14.962 1.00 0.00 O ATOM 133 C3' DG A 5 26.973 20.588 15.596 1.00 0.00 C ATOM 134 O3' DG A 5 26.407 21.868 15.771 1.00 0.00 O ATOM 135 C2' DG A 5 26.666 19.642 16.753 1.00 0.00 C ATOM 136 C1' DG A 5 25.272 19.154 16.369 1.00 0.00 C ATOM 137 N9 DG A 5 24.985 17.815 16.918 1.00 0.00 N ATOM 138 C8 DG A 5 25.609 16.629 16.632 1.00 0.00 C ATOM 139 N7 DG A 5 25.197 15.628 17.360 1.00 0.00 N ATOM 140 C5 DG A 5 24.218 16.187 18.176 1.00 0.00 C ATOM 141 C6 DG A 5 23.401 15.601 19.177 1.00 0.00 C ATOM 142 O6 DG A 5 23.366 14.436 19.567 1.00 0.00 O ATOM 143 N1 DG A 5 22.539 16.499 19.791 1.00 0.00 N ATOM 144 C2 DG A 5 22.435 17.822 19.410 1.00 0.00 C ATOM 145 N2 DG A 5 21.446 18.548 19.949 1.00 0.00 N ATOM 146 N3 DG A 5 23.193 18.386 18.462 1.00 0.00 N ATOM 147 C4 DG A 5 24.067 17.520 17.897 1.00 0.00 C ATOM 0 H5' DG A 5 26.561 18.938 12.560 1.00 0.00 H new ATOM 0 H5'' DG A 5 28.003 19.655 13.250 1.00 0.00 H new ATOM 0 H4' DG A 5 25.869 20.736 13.800 1.00 0.00 H new ATOM 0 H3' DG A 5 28.047 20.731 15.477 1.00 0.00 H new ATOM 0 H2' DG A 5 27.385 18.825 16.820 1.00 0.00 H new ATOM 0 H2'' DG A 5 26.673 20.153 17.716 1.00 0.00 H new ATOM 0 H1' DG A 5 24.525 19.823 16.796 1.00 0.00 H new ATOM 0 H8 DG A 5 26.372 16.532 15.874 1.00 0.00 H new ATOM 0 H1 DG A 5 21.956 16.166 20.559 1.00 0.00 H new ATOM 0 H21 DG A 5 21.336 19.529 19.693 1.00 0.00 H new ATOM 0 H22 DG A 5 20.803 18.119 20.615 1.00 0.00 H new ATOM 159 P DT A 6 27.057 22.994 16.719 1.00 0.00 P ATOM 160 OP1 DT A 6 26.382 24.274 16.409 1.00 0.00 O ATOM 161 OP2 DT A 6 28.527 22.919 16.566 1.00 0.00 O ATOM 162 O5' DT A 6 26.668 22.556 18.219 1.00 0.00 O ATOM 163 C5' DT A 6 25.346 22.734 18.675 1.00 0.00 C ATOM 164 C4' DT A 6 25.069 22.032 20.002 1.00 0.00 C ATOM 165 O4' DT A 6 25.031 20.630 19.854 1.00 0.00 O ATOM 166 C3' DT A 6 26.080 22.291 21.116 1.00 0.00 C ATOM 167 O3' DT A 6 25.725 23.448 21.839 1.00 0.00 O ATOM 168 C2' DT A 6 26.043 20.984 21.901 1.00 0.00 C ATOM 169 C1' DT A 6 25.001 20.137 21.175 1.00 0.00 C ATOM 170 N1 DT A 6 25.315 18.698 21.248 1.00 0.00 N ATOM 171 C2 DT A 6 24.589 17.909 22.121 1.00 0.00 C ATOM 172 O2 DT A 6 23.689 18.332 22.845 1.00 0.00 O ATOM 173 N3 DT A 6 24.915 16.561 22.153 1.00 0.00 N ATOM 174 C4 DT A 6 25.915 15.961 21.401 1.00 0.00 C ATOM 175 O4 DT A 6 26.088 14.751 21.521 1.00 0.00 O ATOM 176 C5 DT A 6 26.650 16.871 20.554 1.00 0.00 C ATOM 177 C7 DT A 6 27.800 16.398 19.697 1.00 0.00 C ATOM 178 C6 DT A 6 26.331 18.182 20.496 1.00 0.00 C ATOM 0 H5' DT A 6 24.655 22.358 17.921 1.00 0.00 H new ATOM 0 H5'' DT A 6 25.147 23.800 18.787 1.00 0.00 H new ATOM 0 H4' DT A 6 24.109 22.461 20.289 1.00 0.00 H new ATOM 0 H3' DT A 6 27.097 22.514 20.793 1.00 0.00 H new ATOM 0 H2' DT A 6 27.018 20.496 21.907 1.00 0.00 H new ATOM 0 H2'' DT A 6 25.764 21.153 22.941 1.00 0.00 H new ATOM 0 H1' DT A 6 24.009 20.214 21.620 1.00 0.00 H new ATOM 0 H3 DT A 6 24.376 15.963 22.780 1.00 0.00 H new ATOM 0 H71 DT A 6 27.866 17.018 18.803 1.00 0.00 H new ATOM 0 H72 DT A 6 28.730 16.474 20.261 1.00 0.00 H new ATOM 0 H73 DT A 6 27.635 15.360 19.408 1.00 0.00 H new ATOM 0 H6 DT A 6 26.890 18.835 19.842 1.00 0.00 H new ATOM 191 P DC A 7 26.571 23.967 23.106 1.00 0.00 P ATOM 192 OP1 DC A 7 26.234 25.394 23.310 1.00 0.00 O ATOM 193 OP2 DC A 7 27.991 23.585 22.935 1.00 0.00 O ATOM 194 O5' DC A 7 25.948 23.123 24.327 1.00 0.00 O ATOM 195 C5' DC A 7 24.556 23.118 24.556 1.00 0.00 C ATOM 196 C4' DC A 7 24.155 22.156 25.671 1.00 0.00 C ATOM 197 O4' DC A 7 24.360 20.825 25.252 1.00 0.00 O ATOM 198 C3' DC A 7 24.933 22.382 26.964 1.00 0.00 C ATOM 199 O3' DC A 7 24.021 22.466 28.036 1.00 0.00 O ATOM 200 C2' DC A 7 25.824 21.145 27.020 1.00 0.00 C ATOM 201 C1' DC A 7 24.943 20.113 26.321 1.00 0.00 C ATOM 202 N1 DC A 7 25.664 18.945 25.780 1.00 0.00 N ATOM 203 C2 DC A 7 25.212 17.668 26.061 1.00 0.00 C ATOM 204 O2 DC A 7 24.218 17.450 26.750 1.00 0.00 O ATOM 205 N3 DC A 7 25.864 16.576 25.585 1.00 0.00 N ATOM 206 C4 DC A 7 26.922 16.772 24.788 1.00 0.00 C ATOM 207 N4 DC A 7 27.530 15.669 24.332 1.00 0.00 N ATOM 208 C5 DC A 7 27.398 18.075 24.432 1.00 0.00 C ATOM 209 C6 DC A 7 26.735 19.129 24.955 1.00 0.00 C ATOM 0 H5' DC A 7 24.040 22.840 23.637 1.00 0.00 H new ATOM 0 H5'' DC A 7 24.229 24.125 24.813 1.00 0.00 H new ATOM 0 H4' DC A 7 23.102 22.346 25.878 1.00 0.00 H new ATOM 0 H3' DC A 7 25.518 23.300 27.015 1.00 0.00 H new ATOM 0 H2' DC A 7 26.771 21.296 26.502 1.00 0.00 H new ATOM 0 H2'' DC A 7 26.063 20.856 28.043 1.00 0.00 H new ATOM 0 H1' DC A 7 24.239 19.693 27.040 1.00 0.00 H new ATOM 0 H41 DC A 7 28.342 15.750 23.720 1.00 0.00 H new ATOM 0 H42 DC A 7 27.181 14.748 24.597 1.00 0.00 H new ATOM 0 H5 DC A 7 28.246 18.208 23.777 1.00 0.00 H new ATOM 0 H6 DC A 7 27.057 20.132 24.717 1.00 0.00 H new ATOM 221 P DT A 8 24.480 22.865 29.526 1.00 0.00 P ATOM 222 OP1 DT A 8 23.304 23.395 30.251 1.00 0.00 O ATOM 223 OP2 DT A 8 25.688 23.713 29.422 1.00 0.00 O ATOM 224 O5' DT A 8 24.908 21.474 30.217 1.00 0.00 O ATOM 225 C5' DT A 8 23.957 20.444 30.368 1.00 0.00 C ATOM 226 C4' DT A 8 24.587 19.064 30.530 1.00 0.00 C ATOM 227 O4' DT A 8 25.316 18.674 29.388 1.00 0.00 O ATOM 228 C3' DT A 8 25.593 18.923 31.669 1.00 0.00 C ATOM 229 O3' DT A 8 24.970 18.747 32.922 1.00 0.00 O ATOM 230 C2' DT A 8 26.394 17.697 31.237 1.00 0.00 C ATOM 231 C1' DT A 8 26.041 17.524 29.762 1.00 0.00 C ATOM 232 N1 DT A 8 27.227 17.353 28.902 1.00 0.00 N ATOM 233 C2 DT A 8 27.528 16.081 28.450 1.00 0.00 C ATOM 234 O2 DT A 8 26.917 15.070 28.791 1.00 0.00 O ATOM 235 N3 DT A 8 28.591 15.964 27.565 1.00 0.00 N ATOM 236 C4 DT A 8 29.400 17.016 27.157 1.00 0.00 C ATOM 237 O4 DT A 8 30.309 16.780 26.366 1.00 0.00 O ATOM 238 C5 DT A 8 29.062 18.295 27.736 1.00 0.00 C ATOM 239 C7 DT A 8 29.868 19.528 27.404 1.00 0.00 C ATOM 240 C6 DT A 8 28.007 18.423 28.568 1.00 0.00 C ATOM 0 H5' DT A 8 23.298 20.436 29.499 1.00 0.00 H new ATOM 0 H5'' DT A 8 23.335 20.657 31.238 1.00 0.00 H new ATOM 0 H4' DT A 8 23.709 18.448 30.725 1.00 0.00 H new ATOM 0 H3' DT A 8 26.206 19.812 31.819 1.00 0.00 H new ATOM 0 H2' DT A 8 27.464 17.851 31.376 1.00 0.00 H new ATOM 0 H2'' DT A 8 26.120 16.817 31.819 1.00 0.00 H new ATOM 0 HO3' DT A 8 25.654 18.660 33.618 1.00 0.00 H new ATOM 0 H1' DT A 8 25.457 16.613 29.630 1.00 0.00 H new ATOM 0 H3 DT A 8 28.792 15.038 27.187 1.00 0.00 H new ATOM 0 H71 DT A 8 29.226 20.408 27.458 1.00 0.00 H new ATOM 0 H72 DT A 8 30.686 19.631 28.117 1.00 0.00 H new ATOM 0 H73 DT A 8 30.274 19.437 26.397 1.00 0.00 H new ATOM 0 H6 DT A 8 27.774 19.394 28.979 1.00 0.00 H new TER 254 DT A 8 ATOM 255 O5' DA B 9 28.002 4.822 30.929 1.00 0.00 O ATOM 256 C5' DA B 9 27.673 6.192 30.990 1.00 0.00 C ATOM 257 C4' DA B 9 26.160 6.383 31.065 1.00 0.00 C ATOM 258 O4' DA B 9 25.881 7.744 31.303 1.00 0.00 O ATOM 259 C3' DA B 9 25.447 5.991 29.774 1.00 0.00 C ATOM 260 O3' DA B 9 24.215 5.404 30.129 1.00 0.00 O ATOM 261 C2' DA B 9 25.308 7.344 29.083 1.00 0.00 C ATOM 262 C1' DA B 9 25.006 8.212 30.302 1.00 0.00 C ATOM 263 N9 DA B 9 25.191 9.665 30.126 1.00 0.00 N ATOM 264 C8 DA B 9 26.181 10.302 29.424 1.00 0.00 C ATOM 265 N7 DA B 9 26.156 11.603 29.511 1.00 0.00 N ATOM 266 C5 DA B 9 25.042 11.841 30.308 1.00 0.00 C ATOM 267 C6 DA B 9 24.416 12.986 30.826 1.00 0.00 C ATOM 268 N6 DA B 9 24.788 14.250 30.585 1.00 0.00 N ATOM 269 N1 DA B 9 23.385 12.895 31.675 1.00 0.00 N ATOM 270 C2 DA B 9 22.946 11.683 31.979 1.00 0.00 C ATOM 271 N3 DA B 9 23.414 10.517 31.561 1.00 0.00 N ATOM 272 C4 DA B 9 24.458 10.669 30.712 1.00 0.00 C ATOM 0 H5' DA B 9 28.066 6.704 30.112 1.00 0.00 H new ATOM 0 H5'' DA B 9 28.145 6.646 31.861 1.00 0.00 H new ATOM 0 H4' DA B 9 25.800 5.739 31.867 1.00 0.00 H new ATOM 0 H3' DA B 9 25.944 5.265 29.130 1.00 0.00 H new ATOM 0 H2' DA B 9 26.219 7.647 28.567 1.00 0.00 H new ATOM 0 H2'' DA B 9 24.504 7.359 28.347 1.00 0.00 H new ATOM 0 HO5' DA B 9 28.976 4.721 30.880 1.00 0.00 H new ATOM 0 H1' DA B 9 23.945 8.117 30.535 1.00 0.00 H new ATOM 0 H8 DA B 9 26.922 9.770 28.846 1.00 0.00 H new ATOM 0 H61 DA B 9 24.272 15.023 31.006 1.00 0.00 H new ATOM 0 H62 DA B 9 25.587 14.440 29.980 1.00 0.00 H new ATOM 0 H2 DA B 9 22.102 11.640 32.651 1.00 0.00 H new ATOM 285 P DG B 10 23.200 4.754 29.061 1.00 0.00 P ATOM 286 OP1 DG B 10 22.256 3.896 29.810 1.00 0.00 O ATOM 287 OP2 DG B 10 23.986 4.140 27.968 1.00 0.00 O ATOM 288 O5' DG B 10 22.374 5.990 28.442 1.00 0.00 O ATOM 289 C5' DG B 10 21.536 6.780 29.255 1.00 0.00 C ATOM 290 C4' DG B 10 21.185 8.118 28.610 1.00 0.00 C ATOM 291 O4' DG B 10 22.301 8.978 28.574 1.00 0.00 O ATOM 292 C3' DG B 10 20.640 7.979 27.191 1.00 0.00 C ATOM 293 O3' DG B 10 19.508 8.793 26.983 1.00 0.00 O ATOM 294 C2' DG B 10 21.793 8.564 26.381 1.00 0.00 C ATOM 295 C1' DG B 10 22.272 9.653 27.336 1.00 0.00 C ATOM 296 N9 DG B 10 23.567 10.231 26.932 1.00 0.00 N ATOM 297 C8 DG B 10 24.593 9.609 26.268 1.00 0.00 C ATOM 298 N7 DG B 10 25.517 10.417 25.826 1.00 0.00 N ATOM 299 C5 DG B 10 25.065 11.666 26.239 1.00 0.00 C ATOM 300 C6 DG B 10 25.623 12.953 26.022 1.00 0.00 C ATOM 301 O6 DG B 10 26.649 13.245 25.412 1.00 0.00 O ATOM 302 N1 DG B 10 24.885 13.990 26.575 1.00 0.00 N ATOM 303 C2 DG B 10 23.734 13.775 27.306 1.00 0.00 C ATOM 304 N2 DG B 10 23.155 14.868 27.822 1.00 0.00 N ATOM 305 N3 DG B 10 23.180 12.572 27.502 1.00 0.00 N ATOM 306 C4 DG B 10 23.895 11.565 26.944 1.00 0.00 C ATOM 0 H5' DG B 10 22.028 6.960 30.211 1.00 0.00 H new ATOM 0 H5'' DG B 10 20.618 6.231 29.467 1.00 0.00 H new ATOM 0 H4' DG B 10 20.401 8.540 29.238 1.00 0.00 H new ATOM 0 H3' DG B 10 20.340 6.960 26.948 1.00 0.00 H new ATOM 0 H2' DG B 10 22.568 7.827 26.169 1.00 0.00 H new ATOM 0 H2'' DG B 10 21.465 8.967 25.423 1.00 0.00 H new ATOM 0 H1' DG B 10 21.629 10.533 27.360 1.00 0.00 H new ATOM 0 H8 DG B 10 24.633 8.540 26.123 1.00 0.00 H new ATOM 0 H1 DG B 10 25.206 14.948 26.436 1.00 0.00 H new ATOM 0 H21 DG B 10 22.301 14.781 28.373 1.00 0.00 H new ATOM 0 H22 DG B 10 23.568 15.787 27.664 1.00 0.00 H new ATOM 318 P DA B 11 18.035 8.279 27.383 1.00 0.00 P ATOM 319 OP1 DA B 11 18.087 7.573 28.682 1.00 0.00 O ATOM 320 OP2 DA B 11 17.501 7.564 26.202 1.00 0.00 O ATOM 321 O5' DA B 11 17.196 9.636 27.599 1.00 0.00 O ATOM 322 C5' DA B 11 17.567 10.574 28.585 1.00 0.00 C ATOM 323 C4' DA B 11 17.995 11.919 28.005 1.00 0.00 C ATOM 324 O4' DA B 11 19.279 11.870 27.424 1.00 0.00 O ATOM 325 C3' DA B 11 17.071 12.473 26.924 1.00 0.00 C ATOM 326 O3' DA B 11 16.001 13.178 27.513 1.00 0.00 O ATOM 327 C2' DA B 11 17.998 13.350 26.087 1.00 0.00 C ATOM 328 C1' DA B 11 19.396 13.000 26.589 1.00 0.00 C ATOM 329 N9 DA B 11 20.320 12.702 25.479 1.00 0.00 N ATOM 330 C8 DA B 11 20.536 11.492 24.870 1.00 0.00 C ATOM 331 N7 DA B 11 21.575 11.473 24.082 1.00 0.00 N ATOM 332 C5 DA B 11 22.019 12.791 24.108 1.00 0.00 C ATOM 333 C6 DA B 11 23.070 13.505 23.509 1.00 0.00 C ATOM 334 N6 DA B 11 24.008 12.998 22.697 1.00 0.00 N ATOM 335 N1 DA B 11 23.240 14.813 23.739 1.00 0.00 N ATOM 336 C2 DA B 11 22.375 15.421 24.535 1.00 0.00 C ATOM 337 N3 DA B 11 21.333 14.893 25.159 1.00 0.00 N ATOM 338 C4 DA B 11 21.228 13.566 24.915 1.00 0.00 C ATOM 0 H5' DA B 11 18.385 10.164 29.177 1.00 0.00 H new ATOM 0 H5'' DA B 11 16.728 10.729 29.264 1.00 0.00 H new ATOM 0 H4' DA B 11 17.966 12.571 28.878 1.00 0.00 H new ATOM 0 H3' DA B 11 16.587 11.715 26.309 1.00 0.00 H new ATOM 0 H2' DA B 11 17.892 13.139 25.023 1.00 0.00 H new ATOM 0 H2'' DA B 11 17.778 14.409 26.226 1.00 0.00 H new ATOM 0 H1' DA B 11 19.807 13.853 27.129 1.00 0.00 H new ATOM 0 H8 DA B 11 19.902 10.632 25.029 1.00 0.00 H new ATOM 0 H61 DA B 11 24.732 13.605 22.312 1.00 0.00 H new ATOM 0 H62 DA B 11 23.998 12.005 22.464 1.00 0.00 H new ATOM 0 H2 DA B 11 22.539 16.476 24.695 1.00 0.00 H new ATOM 350 P DC B 12 14.685 13.586 26.681 1.00 0.00 P ATOM 351 OP1 DC B 12 13.756 14.238 27.631 1.00 0.00 O ATOM 352 OP2 DC B 12 14.241 12.385 25.940 1.00 0.00 O ATOM 353 O5' DC B 12 15.166 14.696 25.620 1.00 0.00 O ATOM 354 C5' DC B 12 15.526 15.997 26.030 1.00 0.00 C ATOM 355 C4' DC B 12 16.061 16.805 24.851 1.00 0.00 C ATOM 356 O4' DC B 12 17.275 16.246 24.399 1.00 0.00 O ATOM 357 C3' DC B 12 15.103 16.832 23.663 1.00 0.00 C ATOM 358 O3' DC B 12 14.451 18.082 23.678 1.00 0.00 O ATOM 359 C2' DC B 12 16.012 16.596 22.460 1.00 0.00 C ATOM 360 C1' DC B 12 17.419 16.626 23.049 1.00 0.00 C ATOM 361 N1 DC B 12 18.361 15.676 22.427 1.00 0.00 N ATOM 362 C2 DC B 12 19.565 16.146 21.934 1.00 0.00 C ATOM 363 O2 DC B 12 19.850 17.342 21.949 1.00 0.00 O ATOM 364 N3 DC B 12 20.487 15.297 21.411 1.00 0.00 N ATOM 365 C4 DC B 12 20.205 13.988 21.420 1.00 0.00 C ATOM 366 N4 DC B 12 21.141 13.195 20.882 1.00 0.00 N ATOM 367 C5 DC B 12 18.989 13.453 21.955 1.00 0.00 C ATOM 368 C6 DC B 12 18.092 14.338 22.441 1.00 0.00 C ATOM 0 H5' DC B 12 16.283 15.941 26.812 1.00 0.00 H new ATOM 0 H5'' DC B 12 14.660 16.501 26.460 1.00 0.00 H new ATOM 0 H4' DC B 12 16.193 17.823 25.217 1.00 0.00 H new ATOM 0 H3' DC B 12 14.308 16.086 23.662 1.00 0.00 H new ATOM 0 H2' DC B 12 15.800 15.640 21.981 1.00 0.00 H new ATOM 0 H2'' DC B 12 15.880 17.368 21.702 1.00 0.00 H new ATOM 0 H1' DC B 12 17.831 17.622 22.889 1.00 0.00 H new ATOM 0 H41 DC B 12 20.998 12.185 20.852 1.00 0.00 H new ATOM 0 H42 DC B 12 21.996 13.601 20.502 1.00 0.00 H new ATOM 0 H5 DC B 12 18.798 12.390 21.969 1.00 0.00 H new ATOM 0 H6 DC B 12 17.155 13.984 22.844 1.00 0.00 H new ATOM 380 P DG B 13 13.062 18.357 22.912 1.00 0.00 P ATOM 381 OP1 DG B 13 12.500 19.603 23.481 1.00 0.00 O ATOM 382 OP2 DG B 13 12.225 17.136 22.921 1.00 0.00 O ATOM 383 O5' DG B 13 13.501 18.636 21.389 1.00 0.00 O ATOM 384 C5' DG B 13 14.320 19.739 21.071 1.00 0.00 C ATOM 385 C4' DG B 13 14.662 19.775 19.584 1.00 0.00 C ATOM 386 O4' DG B 13 15.396 18.641 19.180 1.00 0.00 O ATOM 387 C3' DG B 13 13.414 19.807 18.705 1.00 0.00 C ATOM 388 O3' DG B 13 13.061 21.147 18.445 1.00 0.00 O ATOM 389 C2' DG B 13 13.814 18.983 17.485 1.00 0.00 C ATOM 390 C1' DG B 13 15.248 18.552 17.781 1.00 0.00 C ATOM 391 N9 DG B 13 15.502 17.187 17.285 1.00 0.00 N ATOM 392 C8 DG B 13 14.930 16.016 17.711 1.00 0.00 C ATOM 393 N7 DG B 13 15.418 14.952 17.137 1.00 0.00 N ATOM 394 C5 DG B 13 16.354 15.454 16.239 1.00 0.00 C ATOM 395 C6 DG B 13 17.230 14.796 15.337 1.00 0.00 C ATOM 396 O6 DG B 13 17.400 13.593 15.157 1.00 0.00 O ATOM 397 N1 DG B 13 18.004 15.662 14.577 1.00 0.00 N ATOM 398 C2 DG B 13 17.915 17.037 14.680 1.00 0.00 C ATOM 399 N2 DG B 13 18.741 17.779 13.931 1.00 0.00 N ATOM 400 N3 DG B 13 17.099 17.677 15.526 1.00 0.00 N ATOM 401 C4 DG B 13 16.365 16.824 16.279 1.00 0.00 C ATOM 0 H5' DG B 13 15.239 19.691 21.655 1.00 0.00 H new ATOM 0 H5'' DG B 13 13.813 20.662 21.351 1.00 0.00 H new ATOM 0 H4' DG B 13 15.249 20.685 19.458 1.00 0.00 H new ATOM 0 H3' DG B 13 12.513 19.384 19.149 1.00 0.00 H new ATOM 0 H2' DG B 13 13.158 18.122 17.353 1.00 0.00 H new ATOM 0 H2'' DG B 13 13.756 19.572 16.570 1.00 0.00 H new ATOM 0 H1' DG B 13 15.974 19.188 17.274 1.00 0.00 H new ATOM 0 H8 DG B 13 14.147 15.978 18.454 1.00 0.00 H new ATOM 0 H1 DG B 13 18.668 15.265 13.912 1.00 0.00 H new ATOM 0 H21 DG B 13 18.701 18.797 13.983 1.00 0.00 H new ATOM 0 H22 DG B 13 19.410 17.326 13.308 1.00 0.00 H new ATOM 413 P DT B 14 11.801 21.537 17.521 1.00 0.00 P ATOM 414 OP1 DT B 14 11.379 22.908 17.888 1.00 0.00 O ATOM 415 OP2 DT B 14 10.803 20.448 17.596 1.00 0.00 O ATOM 416 O5' DT B 14 12.392 21.552 16.023 1.00 0.00 O ATOM 417 C5' DT B 14 13.536 22.295 15.668 1.00 0.00 C ATOM 418 C4' DT B 14 14.064 21.894 14.294 1.00 0.00 C ATOM 419 O4' DT B 14 14.607 20.594 14.364 1.00 0.00 O ATOM 420 C3' DT B 14 12.994 21.863 13.206 1.00 0.00 C ATOM 421 O3' DT B 14 12.981 23.091 12.514 1.00 0.00 O ATOM 422 C2' DT B 14 13.373 20.640 12.376 1.00 0.00 C ATOM 423 C1' DT B 14 14.612 20.064 13.057 1.00 0.00 C ATOM 424 N1 DT B 14 14.606 18.590 13.115 1.00 0.00 N ATOM 425 C2 DT B 14 15.537 17.901 12.358 1.00 0.00 C ATOM 426 O2 DT B 14 16.329 18.442 11.590 1.00 0.00 O ATOM 427 N3 DT B 14 15.539 16.519 12.476 1.00 0.00 N ATOM 428 C4 DT B 14 14.656 15.788 13.260 1.00 0.00 C ATOM 429 O4 DT B 14 14.773 14.565 13.292 1.00 0.00 O ATOM 430 C5 DT B 14 13.685 16.582 13.973 1.00 0.00 C ATOM 431 C7 DT B 14 12.640 15.910 14.833 1.00 0.00 C ATOM 432 C6 DT B 14 13.699 17.930 13.892 1.00 0.00 C ATOM 0 H5' DT B 14 14.315 22.144 16.416 1.00 0.00 H new ATOM 0 H5'' DT B 14 13.295 23.358 15.669 1.00 0.00 H new ATOM 0 H4' DT B 14 14.802 22.651 14.029 1.00 0.00 H new ATOM 0 H3' DT B 14 11.967 21.765 13.558 1.00 0.00 H new ATOM 0 H2' DT B 14 12.562 19.912 12.353 1.00 0.00 H new ATOM 0 H2'' DT B 14 13.583 20.915 11.342 1.00 0.00 H new ATOM 0 H1' DT B 14 15.504 20.332 12.491 1.00 0.00 H new ATOM 0 H3 DT B 14 16.241 16.001 11.948 1.00 0.00 H new ATOM 0 H71 DT B 14 12.370 16.569 15.658 1.00 0.00 H new ATOM 0 H72 DT B 14 11.755 15.699 14.232 1.00 0.00 H new ATOM 0 H73 DT B 14 13.040 14.977 15.229 1.00 0.00 H new ATOM 0 H6 DT B 14 12.975 18.499 14.456 1.00 0.00 H new ATOM 445 P DC B 15 12.017 23.382 11.259 1.00 0.00 P ATOM 446 OP1 DC B 15 11.921 24.852 11.117 1.00 0.00 O ATOM 447 OP2 DC B 15 10.761 22.617 11.426 1.00 0.00 O ATOM 448 O5' DC B 15 12.781 22.773 9.979 1.00 0.00 O ATOM 449 C5' DC B 15 14.083 23.190 9.635 1.00 0.00 C ATOM 450 C4' DC B 15 14.710 22.232 8.625 1.00 0.00 C ATOM 451 O4' DC B 15 14.925 20.966 9.207 1.00 0.00 O ATOM 452 C3' DC B 15 13.864 22.032 7.370 1.00 0.00 C ATOM 453 O3' DC B 15 14.529 22.668 6.302 1.00 0.00 O ATOM 454 C2' DC B 15 13.795 20.516 7.209 1.00 0.00 C ATOM 455 C1' DC B 15 14.855 20.002 8.180 1.00 0.00 C ATOM 456 N1 DC B 15 14.491 18.702 8.772 1.00 0.00 N ATOM 457 C2 DC B 15 15.307 17.601 8.589 1.00 0.00 C ATOM 458 O2 DC B 15 16.353 17.665 7.946 1.00 0.00 O ATOM 459 N3 DC B 15 14.956 16.384 9.079 1.00 0.00 N ATOM 460 C4 DC B 15 13.810 16.286 9.764 1.00 0.00 C ATOM 461 N4 DC B 15 13.497 15.065 10.219 1.00 0.00 N ATOM 462 C5 DC B 15 12.948 17.407 9.991 1.00 0.00 C ATOM 463 C6 DC B 15 13.329 18.598 9.481 1.00 0.00 C ATOM 0 H5' DC B 15 14.703 23.238 10.530 1.00 0.00 H new ATOM 0 H5'' DC B 15 14.049 24.196 9.216 1.00 0.00 H new ATOM 0 H4' DC B 15 15.651 22.697 8.333 1.00 0.00 H new ATOM 0 H3' DC B 15 12.860 22.453 7.412 1.00 0.00 H new ATOM 0 H2' DC B 15 12.805 20.131 7.456 1.00 0.00 H new ATOM 0 H2'' DC B 15 14.009 20.212 6.184 1.00 0.00 H new ATOM 0 H1' DC B 15 15.800 19.855 7.657 1.00 0.00 H new ATOM 0 H41 DC B 15 12.637 14.923 10.749 1.00 0.00 H new ATOM 0 H42 DC B 15 14.119 14.278 10.036 1.00 0.00 H new ATOM 0 H5 DC B 15 12.029 17.304 10.549 1.00 0.00 H new ATOM 0 H6 DC B 15 12.712 19.471 9.635 1.00 0.00 H new ATOM 475 P DT B 16 13.838 22.931 4.871 1.00 0.00 P ATOM 476 OP1 DT B 16 14.649 23.967 4.194 1.00 0.00 O ATOM 477 OP2 DT B 16 12.392 23.166 5.077 1.00 0.00 O ATOM 478 O5' DT B 16 13.987 21.552 4.054 1.00 0.00 O ATOM 479 C5' DT B 16 15.239 21.149 3.547 1.00 0.00 C ATOM 480 C4' DT B 16 15.299 19.671 3.170 1.00 0.00 C ATOM 481 O4' DT B 16 15.238 18.894 4.345 1.00 0.00 O ATOM 482 C3' DT B 16 14.180 19.113 2.296 1.00 0.00 C ATOM 483 O3' DT B 16 14.304 19.321 0.907 1.00 0.00 O ATOM 484 C2' DT B 16 14.241 17.623 2.621 1.00 0.00 C ATOM 485 C1' DT B 16 14.929 17.567 3.983 1.00 0.00 C ATOM 486 N1 DT B 16 14.074 16.945 5.011 1.00 0.00 N ATOM 487 C2 DT B 16 14.382 15.660 5.418 1.00 0.00 C ATOM 488 O2 DT B 16 15.312 14.996 4.966 1.00 0.00 O ATOM 489 N3 DT B 16 13.546 15.092 6.370 1.00 0.00 N ATOM 490 C4 DT B 16 12.363 15.655 6.827 1.00 0.00 C ATOM 491 O4 DT B 16 11.624 14.969 7.529 1.00 0.00 O ATOM 492 C5 DT B 16 12.119 16.998 6.357 1.00 0.00 C ATOM 493 C7 DT B 16 10.887 17.741 6.816 1.00 0.00 C ATOM 494 C6 DT B 16 12.964 17.585 5.482 1.00 0.00 C ATOM 0 H5' DT B 16 16.007 21.357 4.292 1.00 0.00 H new ATOM 0 H5'' DT B 16 15.476 21.749 2.669 1.00 0.00 H new ATOM 0 H4' DT B 16 16.223 19.613 2.595 1.00 0.00 H new ATOM 0 H3' DT B 16 13.239 19.619 2.514 1.00 0.00 H new ATOM 0 H2' DT B 16 13.245 17.182 2.659 1.00 0.00 H new ATOM 0 H2'' DT B 16 14.804 17.073 1.867 1.00 0.00 H new ATOM 0 HO3' DT B 16 13.536 18.922 0.447 1.00 0.00 H new ATOM 0 H1' DT B 16 15.826 16.952 3.915 1.00 0.00 H new ATOM 0 H3 DT B 16 13.823 14.192 6.763 1.00 0.00 H new ATOM 0 H71 DT B 16 10.086 17.029 7.015 1.00 0.00 H new ATOM 0 H72 DT B 16 11.115 18.295 7.727 1.00 0.00 H new ATOM 0 H73 DT B 16 10.570 18.436 6.038 1.00 0.00 H new ATOM 0 H6 DT B 16 12.755 18.590 5.145 1.00 0.00 H new TER 508 DT B 16 HETATM 509 O7 RSD B 17 11.413 4.515 12.743 1.00 0.00 O HETATM 510 O1 RSD B 17 12.839 2.751 11.335 1.00 0.00 O HETATM 511 O4 RSD B 17 13.010 0.668 13.366 1.00 0.00 O HETATM 512 O5 RSD B 17 12.452 3.684 15.338 1.00 0.00 O HETATM 513 O2 RSD B 17 14.385 4.875 14.810 1.00 0.00 O HETATM 514 O12 RSD B 17 15.456 8.149 15.988 1.00 0.00 O HETATM 515 O9 RSD B 17 15.953 8.936 18.036 1.00 0.00 O HETATM 516 O52 RSD B 17 16.731 3.769 15.869 1.00 0.00 O HETATM 517 O53 RSD B 17 17.793 5.267 16.772 1.00 0.00 O HETATM 518 O16 RSD B 17 17.259 13.039 19.317 1.00 0.00 O HETATM 519 O24 RSD B 17 22.099 14.166 16.016 1.00 0.00 O HETATM 520 O22 RSD B 17 18.070 15.444 19.152 1.00 0.00 O HETATM 521 O28 RSD B 17 18.357 17.906 18.717 1.00 0.00 O HETATM 522 O23 RSD B 17 17.194 10.812 20.033 1.00 0.00 O HETATM 523 O35 RSD B 17 19.253 20.551 14.843 1.00 0.00 O HETATM 524 O36 RSD B 17 22.245 20.710 17.003 1.00 0.00 O HETATM 525 O33 RSD B 17 14.460 12.915 18.853 1.00 0.00 O HETATM 526 O50 RSD B 17 18.241 21.683 21.430 1.00 0.00 O HETATM 527 O44 RSD B 17 20.551 23.072 21.746 1.00 0.00 O HETATM 528 O47 RSD B 17 20.083 25.035 19.692 1.00 0.00 O HETATM 529 O45 RSD B 17 18.172 22.167 18.500 1.00 0.00 O HETATM 530 O31 RSD B 17 19.816 20.472 18.444 1.00 0.00 O HETATM 531 N10 RSD B 17 16.726 4.791 16.497 1.00 0.00 N HETATM 532 N39 RSD B 17 14.708 11.011 16.596 1.00 0.00 N HETATM 533 C1 RSD B 17 13.243 2.995 12.663 1.00 0.00 C HETATM 534 C2 RSD B 17 13.020 4.696 14.526 1.00 0.00 C HETATM 535 C3 RSD B 17 14.762 2.869 12.587 1.00 0.00 C HETATM 536 C4 RSD B 17 12.587 1.991 13.607 1.00 0.00 C HETATM 537 C5 RSD B 17 12.842 2.357 15.067 1.00 0.00 C HETATM 538 C6 RSD B 17 12.054 1.478 16.034 1.00 0.00 C HETATM 539 C7 RSD B 17 12.785 4.400 13.046 1.00 0.00 C HETATM 540 C8 RSD B 17 10.858 5.811 12.773 1.00 0.00 C HETATM 541 C9 RSD B 17 14.712 5.905 15.755 1.00 0.00 C HETATM 542 C10 RSD B 17 15.465 5.387 16.977 1.00 0.00 C HETATM 543 C11 RSD B 17 15.618 6.610 17.877 1.00 0.00 C HETATM 544 C12 RSD B 17 16.160 7.853 17.191 1.00 0.00 C HETATM 545 C13 RSD B 17 14.649 4.371 17.772 1.00 0.00 C HETATM 546 C14 RSD B 17 15.422 7.073 15.076 1.00 0.00 C HETATM 547 C15 RSD B 17 14.714 7.590 13.827 1.00 0.00 C HETATM 548 C16 RSD B 17 18.454 12.755 18.645 1.00 0.00 C HETATM 549 C17 RSD B 17 20.683 12.104 17.089 1.00 0.00 C HETATM 550 C18 RSD B 17 19.257 13.774 18.120 1.00 0.00 C HETATM 551 C19 RSD B 17 18.750 11.414 18.372 1.00 0.00 C HETATM 552 C20 RSD B 17 19.878 11.085 17.611 1.00 0.00 C HETATM 553 C21 RSD B 17 20.360 13.447 17.321 1.00 0.00 C HETATM 554 C22 RSD B 17 18.962 15.130 18.368 1.00 0.00 C HETATM 555 C23 RSD B 17 17.777 10.355 18.834 1.00 0.00 C HETATM 556 C24 RSD B 17 21.118 14.457 16.696 1.00 0.00 C HETATM 557 C25 RSD B 17 19.673 16.148 17.701 1.00 0.00 C HETATM 558 C26 RSD B 17 21.007 18.130 16.184 1.00 0.00 C HETATM 559 C27 RSD B 17 20.728 15.803 16.847 1.00 0.00 C HETATM 560 C28 RSD B 17 19.324 17.506 17.841 1.00 0.00 C HETATM 561 C29 RSD B 17 19.977 18.484 17.064 1.00 0.00 C HETATM 562 C30 RSD B 17 21.397 16.788 16.110 1.00 0.00 C HETATM 563 C31 RSD B 17 19.470 19.902 17.173 1.00 0.00 C HETATM 564 C32 RSD B 17 16.470 12.019 19.874 1.00 0.00 C HETATM 565 C33 RSD B 17 15.275 11.769 18.956 1.00 0.00 C HETATM 566 C34 RSD B 17 18.419 9.029 19.234 1.00 0.00 C HETATM 567 C35 RSD B 17 19.955 20.802 16.040 1.00 0.00 C HETATM 568 C36 RSD B 17 21.454 20.597 15.841 1.00 0.00 C HETATM 569 C37 RSD B 17 21.678 19.178 15.327 1.00 0.00 C HETATM 570 C38 RSD B 17 21.996 21.738 14.984 1.00 0.00 C HETATM 571 C39 RSD B 17 15.757 11.302 17.586 1.00 0.00 C HETATM 572 C40 RSD B 17 16.711 10.124 17.766 1.00 0.00 C HETATM 573 C41 RSD B 17 17.977 21.144 14.735 1.00 0.00 C HETATM 574 C42 RSD B 17 14.242 12.246 15.945 1.00 0.00 C HETATM 575 C43 RSD B 17 13.531 10.306 17.125 1.00 0.00 C HETATM 576 C44 RSD B 17 20.176 22.722 20.432 1.00 0.00 C HETATM 577 C45 RSD B 17 18.775 21.075 19.171 1.00 0.00 C HETATM 578 C46 RSD B 17 21.498 22.469 19.713 1.00 0.00 C HETATM 579 C47 RSD B 17 19.352 23.833 19.786 1.00 0.00 C HETATM 580 C48 RSD B 17 18.859 23.395 18.409 1.00 0.00 C HETATM 581 C49 RSD B 17 17.885 24.406 17.809 1.00 0.00 C HETATM 582 C50 RSD B 17 19.317 21.466 20.544 1.00 0.00 C HETATM 583 C51 RSD B 17 17.841 20.527 22.132 1.00 0.00 C HETATM 0 H513 RSD B 17 17.527 19.761 21.423 1.00 0.00 H new HETATM 0 H512 RSD B 17 18.677 20.153 22.723 1.00 0.00 H new HETATM 0 H511 RSD B 17 17.010 20.772 22.793 1.00 0.00 H new HETATM 0 H493 RSD B 17 17.570 24.066 16.822 1.00 0.00 H new HETATM 0 H492 RSD B 17 17.013 24.499 18.456 1.00 0.00 H new HETATM 0 H491 RSD B 17 18.376 25.375 17.720 1.00 0.00 H new HETATM 0 H472 RSD B 17 20.741 25.075 20.417 1.00 0.00 H new HETATM 0 H471 RSD B 17 18.490 24.023 20.425 1.00 0.00 H new HETATM 0 H463 RSD B 17 22.104 23.375 19.735 1.00 0.00 H new HETATM 0 H462 RSD B 17 22.035 21.662 20.211 1.00 0.00 H new HETATM 0 H461 RSD B 17 21.302 22.189 18.678 1.00 0.00 H new HETATM 0 H433 RSD B 17 13.839 9.348 17.544 1.00 0.00 H new HETATM 0 H432 RSD B 17 13.065 10.909 17.904 1.00 0.00 H new HETATM 0 H431 RSD B 17 12.816 10.138 16.320 1.00 0.00 H new HETATM 0 H423 RSD B 17 13.836 12.923 16.697 1.00 0.00 H new HETATM 0 H422 RSD B 17 15.078 12.728 15.438 1.00 0.00 H new HETATM 0 H421 RSD B 17 13.467 12.004 15.218 1.00 0.00 H new HETATM 0 H413 RSD B 17 17.338 20.782 15.540 1.00 0.00 H new HETATM 0 H412 RSD B 17 18.072 22.227 14.807 1.00 0.00 H new HETATM 0 H411 RSD B 17 17.534 20.882 13.774 1.00 0.00 H new HETATM 0 H392 RSD B 17 15.163 10.384 15.932 1.00 0.00 H new HETATM 0 H391 RSD B 17 16.276 12.154 17.145 1.00 0.00 H new HETATM 0 H383 RSD B 17 21.857 22.684 15.507 1.00 0.00 H new HETATM 0 H382 RSD B 17 23.058 21.580 14.797 1.00 0.00 H new HETATM 0 H381 RSD B 17 21.461 21.766 14.035 1.00 0.00 H new HETATM 0 H372 RSD B 17 22.748 18.976 15.287 1.00 0.00 H new HETATM 0 H371 RSD B 17 21.301 19.102 14.307 1.00 0.00 H new HETATM 0 H343 RSD B 17 19.159 9.204 20.015 1.00 0.00 H new HETATM 0 H342 RSD B 17 17.651 8.351 19.607 1.00 0.00 H new HETATM 0 H341 RSD B 17 18.906 8.584 18.366 1.00 0.00 H new HETATM 0 H332 RSD B 17 14.956 13.630 18.402 1.00 0.00 H new HETATM 0 H331 RSD B 17 14.662 10.980 19.392 1.00 0.00 H new HETATM 0 H32A RSD B 17 15.154 3.607 11.887 1.00 0.00 H new HETATM 0 H31A RSD B 17 15.191 3.041 13.574 1.00 0.00 H new HETATM 0 H301 RSD B 17 21.341 16.496 15.061 1.00 0.00 H new HETATM 0 H153 RSD B 17 13.706 7.913 14.088 1.00 0.00 H new HETATM 0 H152 RSD B 17 15.270 8.433 13.416 1.00 0.00 H new HETATM 0 H151 RSD B 17 14.659 6.794 13.084 1.00 0.00 H new HETATM 0 H133 RSD B 17 14.413 3.517 17.137 1.00 0.00 H new HETATM 0 H132 RSD B 17 15.227 4.034 18.633 1.00 0.00 H new HETATM 0 H131 RSD B 17 13.724 4.835 18.115 1.00 0.00 H new HETATM 0 H112 RSD B 17 16.280 6.353 18.704 1.00 0.00 H new HETATM 0 H111 RSD B 17 14.646 6.847 18.309 1.00 0.00 H new HETATM 0 H9 RSD B 17 13.767 6.282 16.146 1.00 0.00 H new HETATM 0 H83 RSD B 17 10.974 6.233 13.771 1.00 0.00 H new HETATM 0 H82 RSD B 17 11.372 6.444 12.049 1.00 0.00 H new HETATM 0 H81 RSD B 17 9.799 5.759 12.522 1.00 0.00 H new HETATM 0 H7 RSD B 17 13.369 5.126 12.480 1.00 0.00 H new HETATM 0 H63 RSD B 17 12.297 1.757 17.059 1.00 0.00 H new HETATM 0 H62 RSD B 17 10.986 1.616 15.863 1.00 0.00 H new HETATM 0 H61 RSD B 17 12.315 0.432 15.871 1.00 0.00 H new HETATM 0 H50 RSD B 17 19.939 20.658 20.930 1.00 0.00 H new HETATM 0 H5 RSD B 17 13.913 2.217 15.212 1.00 0.00 H new HETATM 0 H48 RSD B 17 19.743 23.309 17.777 1.00 0.00 H new HETATM 0 H45 RSD B 17 17.966 20.353 19.282 1.00 0.00 H new HETATM 0 H44 RSD B 17 19.821 22.855 22.363 1.00 0.00 H new HETATM 0 H42 RSD B 17 13.233 0.563 12.417 1.00 0.00 H new HETATM 0 H41 RSD B 17 11.516 2.040 13.408 1.00 0.00 H new HETATM 0 H40 RSD B 17 17.262 10.009 16.833 1.00 0.00 H new HETATM 0 H36 RSD B 17 22.524 19.818 17.297 1.00 0.00 H new HETATM 0 H35 RSD B 17 19.763 21.840 16.312 1.00 0.00 H new HETATM 0 H33 RSD B 17 15.027 1.869 12.245 1.00 0.00 H new HETATM 0 H32 RSD B 17 16.145 12.343 20.863 1.00 0.00 H new HETATM 0 H31 RSD B 17 18.385 19.844 17.087 1.00 0.00 H new HETATM 0 H30 RSD B 17 22.448 16.744 16.397 1.00 0.00 H new HETATM 0 H28 RSD B 17 18.091 17.148 19.279 1.00 0.00 H new HETATM 0 H20 RSD B 17 20.128 10.040 17.426 1.00 0.00 H new HETATM 0 H2 RSD B 17 12.519 5.636 14.759 1.00 0.00 H new HETATM 0 H17 RSD B 17 21.565 11.852 16.500 1.00 0.00 H new HETATM 0 H14 RSD B 17 16.405 6.708 14.780 1.00 0.00 H new HETATM 0 H12 RSD B 17 17.211 7.675 16.964 1.00 0.00 H new HETATM 0 H1 RSD B 17 11.953 3.143 11.185 1.00 0.00 H new CONECT 509 539 540 CONECT 510 533 584 CONECT 511 536 585 CONECT 512 534 537 CONECT 513 534 541 CONECT 514 544 546 CONECT 515 544 572 CONECT 516 531 CONECT 517 531 CONECT 518 548 564 CONECT 519 556 CONECT 520 554 CONECT 521 560 586 CONECT 522 555 564 CONECT 523 567 573 CONECT 524 568 587 CONECT 525 565 588 CONECT 526 582 583 CONECT 527 576 589 CONECT 528 579 590 CONECT 529 577 580 CONECT 530 563 577 CONECT 531 516 517 542 CONECT 532 571 574 575 591 CONECT 533 510 535 536 539 CONECT 534 512 513 539 592 CONECT 535 533 593 594 595 CONECT 536 511 533 537 596 CONECT 537 512 536 538 597 CONECT 538 537 598 599 600 CONECT 539 509 533 534 601 CONECT 540 509 602 603 604 CONECT 541 513 542 546 605 CONECT 542 531 541 543 545 CONECT 543 542 544 606 607 CONECT 544 514 515 543 608 CONECT 545 542 609 610 611 CONECT 546 514 541 547 612 CONECT 547 546 613 614 615 CONECT 548 518 550 551 CONECT 549 552 553 616 CONECT 550 548 553 554 CONECT 551 548 552 555 CONECT 552 549 551 617 CONECT 553 549 550 556 CONECT 554 520 550 557 CONECT 555 522 551 566 572 CONECT 556 519 553 559 CONECT 557 554 559 560 CONECT 558 561 562 569 CONECT 559 556 557 562 CONECT 560 521 557 561 CONECT 561 558 560 563 CONECT 562 558 559 618 CONECT 563 530 561 567 619 CONECT 564 518 522 565 620 CONECT 565 525 564 571 621 CONECT 566 555 622 623 624 CONECT 567 523 563 568 625 CONECT 568 524 567 569 570 CONECT 569 558 568 626 627 CONECT 570 568 628 629 630 CONECT 571 532 565 572 631 CONECT 572 515 555 571 632 CONECT 573 523 633 634 635 CONECT 574 532 636 637 638 CONECT 575 532 639 640 641 CONECT 576 527 578 579 582 CONECT 577 529 530 582 642 CONECT 578 576 643 644 645 CONECT 579 528 576 580 646 CONECT 580 529 579 581 647 CONECT 581 580 648 649 650 CONECT 582 526 576 577 651 CONECT 583 526 652 653 654 CONECT 584 510 CONECT 585 511 CONECT 586 521 CONECT 587 524 CONECT 588 525 CONECT 589 527 CONECT 590 528 CONECT 591 532 CONECT 592 534 CONECT 593 535 CONECT 594 535 CONECT 595 535 CONECT 596 536 CONECT 597 537 CONECT 598 538 CONECT 599 538 CONECT 600 538 CONECT 601 539 CONECT 602 540 CONECT 603 540 CONECT 604 540 CONECT 605 541 CONECT 606 543 CONECT 607 543 CONECT 608 544 CONECT 609 545 CONECT 610 545 CONECT 611 545 CONECT 612 546 CONECT 613 547 CONECT 614 547 CONECT 615 547 CONECT 616 549 CONECT 617 552 CONECT 618 562 CONECT 619 563 CONECT 620 564 CONECT 621 565 CONECT 622 566 CONECT 623 566 CONECT 624 566 CONECT 625 567 CONECT 626 569 CONECT 627 569 CONECT 628 570 CONECT 629 570 CONECT 630 570 CONECT 631 571 CONECT 632 572 CONECT 633 573 CONECT 634 573 CONECT 635 573 CONECT 636 574 CONECT 637 574 CONECT 638 574 CONECT 639 575 CONECT 640 575 CONECT 641 575 CONECT 642 577 CONECT 643 578 CONECT 644 578 CONECT 645 578 CONECT 646 579 CONECT 647 580 CONECT 648 581 CONECT 649 581 CONECT 650 581 CONECT 651 582 CONECT 652 583 CONECT 653 583 CONECT 654 583 END