USER MOD reduce.3.24.130724 H: found=0, std=0, add=207, rem=0, adj=8 USER MOD reduce.3.24.130724 removed 4595 hydrogens (4438 hets) HEADER DNA 12-FEB-02 1L0R TITLE NMR SOLUTION STRUCTURE OF NOGALAMYCIN INTERCALATION BETWEEN TITLE 2 CO-AXIALLY STACKED HAIRPINS COMPND MOL_ID: 1; COMPND 2 MOLECULE: 5'-D(*AP*CP*GP*AP*AP*GP*TP*GP*CP*GP*AP*AP*GP*C)- COMPND 3 3'; COMPND 4 CHAIN: A; COMPND 5 ENGINEERED: YES; COMPND 6 OTHER_DETAILS: CO-AXIALLY STACKED DNA HAIRPIN SOURCE MOL_ID: 1; SOURCE 2 SYNTHETIC: YES; SOURCE 3 OTHER_DETAILS: THIS SEQUENCE WAS SYNTHESIZED BY SOLID SOURCE 4 PHASE USING PHOSPHORAMIDITE CHEMISTRY. KEYWDS GAA LOOP, SINGLE STRAND BREAK, DRUG-DNA RECOGNITION, KEYWDS 2 NOGALAMYCIN INTERCALATION EXPDTA SOLUTION NMR AUTHOR H.E.L.WILLIAMS,M.L.COLGRAVE,M.S.SEARLE REVDAT 4 24-FEB-09 1L0R 1 VERSN REVDAT 3 21-SEP-04 1L0R 1 ATOM REVDAT 2 01-APR-03 1L0R 1 JRNL REVDAT 1 19-JUN-02 1L0R 0 JRNL AUTH H.E.L.WILLIAMS,M.L.COLGRAVE,M.S.SEARLE JRNL TITL DRUG RECOGNITION OF A DNA SINGLE STRAND BREAK: JRNL TITL 2 NOGALAMYCIN INTERCALATION BETWEEN COAXIALLY JRNL TITL 3 STACKED HAIRPINS. JRNL REF EUR.J.BIOCHEM. V. 269 1726 2002 JRNL REFN ISSN 0014-2956 JRNL PMID 11895443 JRNL DOI 10.1046/J.1432-1327.2002.02819.X REMARK 1 REMARK 2 REMARK 2 RESOLUTION. NOT APPLICABLE. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 PROGRAM : AMBER 6 REMARK 3 AUTHORS : PEARLMAN,CASE,CALDWELL,ROSS,CHEATHAM,FERGUSON, REMARK 3 SEIBEL,SINGH,WEINER,KOLLMAN REMARK 3 REMARK 3 OTHER REFINEMENT REMARKS: NULL REMARK 4 REMARK 4 1L0R COMPLIES WITH FORMAT V. 3.15, 01-DEC-08 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 22-FEB-02. REMARK 100 THE RCSB ID CODE IS RCSB015539. REMARK 210 REMARK 210 EXPERIMENTAL DETAILS REMARK 210 EXPERIMENT TYPE : NMR REMARK 210 TEMPERATURE (KELVIN) : 278 REMARK 210 PH : 6.4 REMARK 210 IONIC STRENGTH : 100MM NA+ 10MM PO4- REMARK 210 PRESSURE : ATMOSPHERIC ATM REMARK 210 SAMPLE CONTENTS : 3MM HAIRPIN; 10MM PHOSPHATE, REMARK 210 100MM NACL; 0.6MM NAN3; 0.6MM REMARK 210 NA4 EDTA; 2MM REMARK 210 TRIMETHYLISILYLPROPANOATE D2O; REMARK 210 3MM HAIRPIN; 10MM PHOSPHATE, REMARK 210 100MM NACL; 0.6MM NAN3; 0.6MM REMARK 210 NA4 EDTA; 2MM REMARK 210 TRIMETHYLISILYLPROPANOATE 10% REMARK 210 D2O, 90% H2O REMARK 210 REMARK 210 NMR EXPERIMENTS CONDUCTED : 2D NOESY, 2D NOESY WITH REMARK 210 WATERGATE SUPPRESION, DQF- REMARK 210 COSY, TOCSY REMARK 210 SPECTROMETER FIELD STRENGTH : 500 MHZ, 600 MHZ REMARK 210 SPECTROMETER MODEL : AVANCE DRX, AVANCE REMARK 210 SPECTROMETER MANUFACTURER : BRUKER REMARK 210 REMARK 210 STRUCTURE DETERMINATION. REMARK 210 SOFTWARE USED : XWINNMR 2.6-3.1, ANSIG 3.3, REMARK 210 AMBER 6 REMARK 210 METHOD USED : RESTRAINED MOLECULAR DYNAMICS REMARK 210 REMARK 210 CONFORMERS, NUMBER CALCULATED : NULL REMARK 210 CONFORMERS, NUMBER SUBMITTED : 1 REMARK 210 CONFORMERS, SELECTION CRITERIA : NULL REMARK 210 REMARK 210 BEST REPRESENTATIVE CONFORMER IN THIS ENSEMBLE : NULL REMARK 210 REMARK 210 REMARK: NULL REMARK 215 REMARK 215 NMR STUDY REMARK 215 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM SOLUTION REMARK 215 NMR DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE THAT REMARK 215 CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES ON REMARK 215 THESE RECORDS ARE MEANINGLESS. REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 DA A 1 O4' - C1' - N9 ANGL. DEV. = 3.9 DEGREES REMARK 500 DA A 1 C4 - C5 - C6 ANGL. DEV. = -3.4 DEGREES REMARK 500 DA A 1 C5 - C6 - N1 ANGL. DEV. = 3.4 DEGREES REMARK 500 DA A 1 N1 - C6 - N6 ANGL. DEV. = -5.9 DEGREES REMARK 500 DC A 2 N3 - C2 - O2 ANGL. DEV. = -4.2 DEGREES REMARK 500 DG A 3 O4' - C1' - N9 ANGL. DEV. = 4.4 DEGREES REMARK 500 DA A 4 C4 - C5 - C6 ANGL. DEV. = -3.1 DEGREES REMARK 500 DA A 4 C5 - C6 - N1 ANGL. DEV. = 4.0 DEGREES REMARK 500 DA A 4 N1 - C6 - N6 ANGL. DEV. = -5.4 DEGREES REMARK 500 DA A 5 O4' - C1' - N9 ANGL. DEV. = 4.0 DEGREES REMARK 500 DA A 5 C5 - C6 - N1 ANGL. DEV. = 3.9 DEGREES REMARK 500 DA A 5 N1 - C6 - N6 ANGL. DEV. = -4.8 DEGREES REMARK 500 DG A 8 C1' - O4' - C4' ANGL. DEV. = -7.6 DEGREES REMARK 500 DG A 8 O4' - C1' - N9 ANGL. DEV. = 5.9 DEGREES REMARK 500 DC A 9 O4' - C1' - N1 ANGL. DEV. = 6.7 DEGREES REMARK 500 DG A 10 O4' - C1' - N9 ANGL. DEV. = 4.4 DEGREES REMARK 500 DA A 11 O4' - C1' - N9 ANGL. DEV. = 2.0 DEGREES REMARK 500 DA A 11 C4 - C5 - C6 ANGL. DEV. = -3.4 DEGREES REMARK 500 DA A 11 C5 - C6 - N1 ANGL. DEV. = 3.8 DEGREES REMARK 500 DA A 11 N1 - C6 - N6 ANGL. DEV. = -4.6 DEGREES REMARK 500 DA A 12 O4' - C1' - N9 ANGL. DEV. = 5.3 DEGREES REMARK 500 DA A 12 C5 - C6 - N1 ANGL. DEV. = 3.9 DEGREES REMARK 500 DA A 12 N1 - C6 - N6 ANGL. DEV. = -4.4 DEGREES REMARK 500 DG A 13 O4' - C1' - N9 ANGL. DEV. = 2.1 DEGREES REMARK 500 DC A 14 O4' - C1' - N1 ANGL. DEV. = 6.4 DEGREES REMARK 500 DC A 14 N3 - C2 - O2 ANGL. DEV. = -4.5 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: PLANAR GROUPS REMARK 500 REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS REMARK 500 AN RMSD GREATER THAN THIS VALUE REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 M RES CSSEQI RMS TYPE REMARK 500 DG A 3 0.06 SIDE_CHAIN REMARK 500 DT A 7 0.08 SIDE_CHAIN REMARK 500 DG A 8 0.05 SIDE_CHAIN REMARK 500 DC A 9 0.19 SIDE_CHAIN REMARK 500 DG A 10 0.05 SIDE_CHAIN REMARK 500 REMARK 500 REMARK: NULL REMARK 620 REMARK 620 METAL COORDINATION REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE): REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 NA A 16 NA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 DA A 5 O4' REMARK 620 2 DA A 5 N3 70.9 REMARK 620 N 1 REMARK 800 REMARK 800 SITE REMARK 800 SITE_IDENTIFIER: AC1 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NA A 16 REMARK 800 SITE_IDENTIFIER: AC2 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NA A 18 REMARK 800 SITE_IDENTIFIER: AC3 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NA A 19 REMARK 800 SITE_IDENTIFIER: AC4 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NA A 22 REMARK 800 SITE_IDENTIFIER: AC5 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NGP A 15 DBREF 1L0R A 1 14 PDB 1L0R 1L0R 1 14 SEQRES 1 A 14 DA DC DG DA DA DG DT DG DC DG DA DA DG SEQRES 2 A 14 DC HET NA A 16 1 HET NA A 17 1 HET NA A 18 1 HET NA A 19 1 HET NA A 20 1 HET NA A 21 1 HET NA A 22 1 HET NA A 23 1 HET NA A 24 1 HET NA A 25 1 HET NA A 26 1 HET NA A 27 1 HET NGP A 15 106 HETNAM NA SODIUM ION HETNAM NGP NOGALAMYCIN (PROTONATED FORM) FORMUL 2 NA 12(NA 1+) FORMUL 14 NGP C39 H52 N O16 1+ FORMUL 15 HOH *2194(H2 O) LINK NA NA A 16 O4' DA A 5 1555 1555 2.44 LINK NA NA A 16 N3 DA A 5 1555 1555 2.53 LINK NA NA A 18 O HOH A 825 1555 1555 2.48 LINK NA NA A 19 O HOH A1100 1555 1555 2.46 LINK NA NA A 22 O HOH A1917 1555 1555 2.49 SITE *** AC1 2 DA A 5 DG A 6 SITE *** AC2 1 HOH A 825 SITE *** AC3 1 HOH A1100 SITE *** AC4 1 HOH A1917 SITE *** AC5 8 DA A 1 DC A 2 DT A 7 DG A 8 SITE *** AC5 8 DC A 9 DG A 13 DC A 14 HOH A1360 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000 USER MOD ----------------------------------------------------------------- USER MOD scores for adjustable sidechains, with "set" totals for H,N and Q USER MOD "o" means original, "f" means flipped, "180deg" is methyl default USER MOD "!" flags a clash with an overlap of 0.40A or greater USER MOD flip categories: "K"=keep, "C"=clashes, "X"=uncertain, "F"=flip USER MOD NoAdj-H: A 15 NGPH221 : A 15 NGP C21 : A 15 NGP C18 :(H bumps) USER MOD NoAdj-H: A 15 NGPH119 : A 15 NGP C19 : A 15 NGP C6 :(H bumps) USER MOD Single : A 1 DA O5' : rot -77:sc= 1.24 USER MOD Single : A 7 DT C7 :methyl -30:sc= -1.83 (180deg=-2.89!) USER MOD Single : A 14 DC O3' : rot 145:sc= 2.15 USER MOD Single : A 15 NGP O15 : rot 24:sc= 0.57 USER MOD Single : A 15 NGP O16 : rot 180:sc= -0.116 USER MOD Single : A 15 NGP O4 : rot 176:sc= 1.03 USER MOD Single : A 15 NGP O6 : rot 19:sc= 1.15 USER MOD Single : A 15 NGP O9 : rot 150:sc= 0 USER MOD ----------------------------------------------------------------- ATOM 1 O5' DA A 1 2.029 1.584 -0.507 1.00 0.00 O ATOM 2 C5' DA A 1 2.238 0.474 -1.365 1.00 0.00 C ATOM 3 C4' DA A 1 0.924 0.052 -2.032 1.00 0.00 C ATOM 4 O4' DA A 1 0.426 1.029 -2.918 1.00 0.00 O ATOM 5 C3' DA A 1 1.071 -1.211 -2.882 1.00 0.00 C ATOM 6 O3' DA A 1 0.746 -2.343 -2.089 1.00 0.00 O ATOM 7 C2' DA A 1 0.058 -0.979 -4.002 1.00 0.00 C ATOM 8 C1' DA A 1 -0.565 0.354 -3.662 1.00 0.00 C ATOM 9 N9 DA A 1 -1.011 1.134 -4.838 1.00 0.00 N ATOM 10 C8 DA A 1 -0.509 2.320 -5.317 1.00 0.00 C ATOM 11 N7 DA A 1 -1.049 2.728 -6.438 1.00 0.00 N ATOM 12 C5 DA A 1 -2.014 1.734 -6.693 1.00 0.00 C ATOM 13 C6 DA A 1 -2.982 1.509 -7.704 1.00 0.00 C ATOM 14 N6 DA A 1 -3.179 2.256 -8.773 1.00 0.00 N ATOM 15 N1 DA A 1 -3.810 0.470 -7.644 1.00 0.00 N ATOM 16 C2 DA A 1 -3.696 -0.369 -6.626 1.00 0.00 C ATOM 17 N3 DA A 1 -2.843 -0.303 -5.607 1.00 0.00 N ATOM 18 C4 DA A 1 -2.018 0.781 -5.706 1.00 0.00 C ATOM 0 H5' DA A 1 2.647 -0.360 -0.796 1.00 0.00 H new ATOM 0 H5'' DA A 1 2.973 0.731 -2.128 1.00 0.00 H new ATOM 0 H4' DA A 1 0.250 -0.108 -1.191 1.00 0.00 H new ATOM 0 H3' DA A 1 2.073 -1.394 -3.269 1.00 0.00 H new ATOM 0 H2' DA A 1 0.541 -0.956 -4.979 1.00 0.00 H new ATOM 0 H2'' DA A 1 -0.689 -1.772 -4.035 1.00 0.00 H new ATOM 0 HO5' DA A 1 1.952 2.401 -1.042 1.00 0.00 H new ATOM 0 H1' DA A 1 -1.490 0.215 -3.102 1.00 0.00 H new ATOM 0 H8 DA A 1 0.269 2.872 -4.810 1.00 0.00 H new ATOM 0 H61 DA A 1 -3.906 2.005 -9.443 1.00 0.00 H new ATOM 0 H62 DA A 1 -2.604 3.084 -8.929 1.00 0.00 H new ATOM 0 H2 DA A 1 -4.377 -1.207 -6.622 1.00 0.00 H new ATOM 31 P DC A 2 1.271 -3.810 -2.423 1.00 0.00 P ATOM 32 OP1 DC A 2 1.422 -4.510 -1.128 1.00 0.00 O ATOM 33 OP2 DC A 2 2.443 -3.717 -3.324 1.00 0.00 O ATOM 34 O5' DC A 2 0.088 -4.499 -3.241 1.00 0.00 O ATOM 35 C5' DC A 2 -1.082 -5.029 -2.626 1.00 0.00 C ATOM 36 C4' DC A 2 -1.797 -6.105 -3.468 1.00 0.00 C ATOM 37 O4' DC A 2 -2.443 -5.524 -4.591 1.00 0.00 O ATOM 38 C3' DC A 2 -0.872 -7.212 -4.007 1.00 0.00 C ATOM 39 O3' DC A 2 -1.626 -8.421 -4.158 1.00 0.00 O ATOM 40 C2' DC A 2 -0.445 -6.585 -5.335 1.00 0.00 C ATOM 41 C1' DC A 2 -1.727 -5.877 -5.761 1.00 0.00 C ATOM 42 N1 DC A 2 -1.597 -4.679 -6.637 1.00 0.00 N ATOM 43 C2 DC A 2 -2.566 -4.486 -7.628 1.00 0.00 C ATOM 44 O2 DC A 2 -3.505 -5.276 -7.779 1.00 0.00 O ATOM 45 N3 DC A 2 -2.509 -3.412 -8.451 1.00 0.00 N ATOM 46 C4 DC A 2 -1.533 -2.543 -8.291 1.00 0.00 C ATOM 47 N4 DC A 2 -1.493 -1.548 -9.126 1.00 0.00 N ATOM 48 C5 DC A 2 -0.557 -2.653 -7.270 1.00 0.00 C ATOM 49 C6 DC A 2 -0.622 -3.732 -6.451 1.00 0.00 C ATOM 0 H5' DC A 2 -1.778 -4.214 -2.429 1.00 0.00 H new ATOM 0 H5'' DC A 2 -0.811 -5.457 -1.661 1.00 0.00 H new ATOM 0 H4' DC A 2 -2.507 -6.557 -2.775 1.00 0.00 H new ATOM 0 H3' DC A 2 -0.025 -7.497 -3.383 1.00 0.00 H new ATOM 0 H2' DC A 2 0.386 -5.891 -5.213 1.00 0.00 H new ATOM 0 H2'' DC A 2 -0.130 -7.335 -6.060 1.00 0.00 H new ATOM 0 H1' DC A 2 -2.244 -6.598 -6.394 1.00 0.00 H new ATOM 0 H41 DC A 2 -0.758 -0.845 -9.047 1.00 0.00 H new ATOM 0 H42 DC A 2 -2.197 -1.470 -9.860 1.00 0.00 H new ATOM 0 H5 DC A 2 0.212 -1.904 -7.148 1.00 0.00 H new ATOM 0 H6 DC A 2 0.095 -3.846 -5.651 1.00 0.00 H new ATOM 61 P DG A 3 -0.985 -9.792 -4.708 1.00 0.00 P ATOM 62 OP1 DG A 3 -1.977 -10.861 -4.442 1.00 0.00 O ATOM 63 OP2 DG A 3 0.376 -9.944 -4.161 1.00 0.00 O ATOM 64 O5' DG A 3 -0.871 -9.604 -6.290 1.00 0.00 O ATOM 65 C5' DG A 3 -2.004 -9.423 -7.132 1.00 0.00 C ATOM 66 C4' DG A 3 -1.609 -8.895 -8.520 1.00 0.00 C ATOM 67 O4' DG A 3 -1.174 -7.539 -8.445 1.00 0.00 O ATOM 68 C3' DG A 3 -0.478 -9.709 -9.170 1.00 0.00 C ATOM 69 O3' DG A 3 -0.743 -9.922 -10.545 1.00 0.00 O ATOM 70 C2' DG A 3 0.703 -8.759 -9.051 1.00 0.00 C ATOM 71 C1' DG A 3 -0.010 -7.426 -9.247 1.00 0.00 C ATOM 72 N9 DG A 3 0.817 -6.248 -8.894 1.00 0.00 N ATOM 73 C8 DG A 3 1.773 -6.122 -7.910 1.00 0.00 C ATOM 74 N7 DG A 3 2.421 -4.990 -7.928 1.00 0.00 N ATOM 75 C5 DG A 3 1.874 -4.325 -9.032 1.00 0.00 C ATOM 76 C6 DG A 3 2.201 -3.059 -9.624 1.00 0.00 C ATOM 77 O6 DG A 3 3.084 -2.265 -9.295 1.00 0.00 O ATOM 78 N1 DG A 3 1.401 -2.719 -10.695 1.00 0.00 N ATOM 79 C2 DG A 3 0.408 -3.513 -11.170 1.00 0.00 C ATOM 80 N2 DG A 3 -0.285 -3.065 -12.180 1.00 0.00 N ATOM 81 N3 DG A 3 0.098 -4.716 -10.686 1.00 0.00 N ATOM 82 C4 DG A 3 0.868 -5.069 -9.608 1.00 0.00 C ATOM 0 H5' DG A 3 -2.697 -8.725 -6.662 1.00 0.00 H new ATOM 0 H5'' DG A 3 -2.530 -10.371 -7.241 1.00 0.00 H new ATOM 0 H4' DG A 3 -2.507 -8.984 -9.131 1.00 0.00 H new ATOM 0 H3' DG A 3 -0.336 -10.688 -8.712 1.00 0.00 H new ATOM 0 H2' DG A 3 1.198 -8.829 -8.082 1.00 0.00 H new ATOM 0 H2'' DG A 3 1.463 -8.941 -9.811 1.00 0.00 H new ATOM 0 H1' DG A 3 -0.241 -7.247 -10.297 1.00 0.00 H new ATOM 0 H8 DG A 3 1.970 -6.897 -7.184 1.00 0.00 H new ATOM 0 H1 DG A 3 1.564 -1.823 -11.154 1.00 0.00 H new ATOM 0 H21 DG A 3 -1.041 -3.628 -12.570 1.00 0.00 H new ATOM 0 H22 DG A 3 -0.071 -2.152 -12.580 1.00 0.00 H new ATOM 94 P DA A 4 -1.594 -11.161 -11.054 1.00 0.00 P ATOM 95 OP1 DA A 4 -2.731 -11.415 -10.130 1.00 0.00 O ATOM 96 OP2 DA A 4 -0.645 -12.255 -11.340 1.00 0.00 O ATOM 97 O5' DA A 4 -2.182 -10.663 -12.450 1.00 0.00 O ATOM 98 C5' DA A 4 -3.355 -9.853 -12.533 1.00 0.00 C ATOM 99 C4' DA A 4 -3.305 -8.866 -13.707 1.00 0.00 C ATOM 100 O4' DA A 4 -2.362 -7.858 -13.371 1.00 0.00 O ATOM 101 C3' DA A 4 -2.871 -9.501 -15.037 1.00 0.00 C ATOM 102 O3' DA A 4 -3.666 -9.094 -16.138 1.00 0.00 O ATOM 103 C2' DA A 4 -1.466 -8.936 -15.210 1.00 0.00 C ATOM 104 C1' DA A 4 -1.488 -7.609 -14.452 1.00 0.00 C ATOM 105 N9 DA A 4 -0.164 -7.241 -13.887 1.00 0.00 N ATOM 106 C8 DA A 4 0.565 -7.952 -12.963 1.00 0.00 C ATOM 107 N7 DA A 4 1.694 -7.395 -12.604 1.00 0.00 N ATOM 108 C5 DA A 4 1.689 -6.196 -13.344 1.00 0.00 C ATOM 109 C6 DA A 4 2.569 -5.088 -13.454 1.00 0.00 C ATOM 110 N6 DA A 4 3.691 -4.940 -12.773 1.00 0.00 N ATOM 111 N1 DA A 4 2.318 -4.071 -14.284 1.00 0.00 N ATOM 112 C2 DA A 4 1.197 -4.132 -14.998 1.00 0.00 C ATOM 113 N3 DA A 4 0.272 -5.088 -15.007 1.00 0.00 N ATOM 114 C4 DA A 4 0.574 -6.102 -14.141 1.00 0.00 C ATOM 0 H5' DA A 4 -3.477 -9.299 -11.602 1.00 0.00 H new ATOM 0 H5'' DA A 4 -4.229 -10.495 -12.639 1.00 0.00 H new ATOM 0 H4' DA A 4 -4.314 -8.483 -13.857 1.00 0.00 H new ATOM 0 H3' DA A 4 -2.951 -10.588 -15.012 1.00 0.00 H new ATOM 0 H2' DA A 4 -0.714 -9.612 -14.804 1.00 0.00 H new ATOM 0 H2'' DA A 4 -1.225 -8.787 -16.263 1.00 0.00 H new ATOM 0 H1' DA A 4 -1.781 -6.795 -15.116 1.00 0.00 H new ATOM 0 H8 DA A 4 0.231 -8.898 -12.564 1.00 0.00 H new ATOM 0 H61 DA A 4 4.267 -4.110 -12.913 1.00 0.00 H new ATOM 0 H62 DA A 4 3.981 -5.656 -12.107 1.00 0.00 H new ATOM 0 H2 DA A 4 1.014 -3.296 -15.657 1.00 0.00 H new ATOM 126 P DA A 5 -5.108 -9.710 -16.455 1.00 0.00 P ATOM 127 OP1 DA A 5 -5.601 -10.462 -15.277 1.00 0.00 O ATOM 128 OP2 DA A 5 -5.021 -10.416 -17.756 1.00 0.00 O ATOM 129 O5' DA A 5 -6.007 -8.398 -16.597 1.00 0.00 O ATOM 130 C5' DA A 5 -5.653 -7.363 -17.507 1.00 0.00 C ATOM 131 C4' DA A 5 -6.444 -6.067 -17.240 1.00 0.00 C ATOM 132 O4' DA A 5 -6.315 -5.722 -15.869 1.00 0.00 O ATOM 133 C3' DA A 5 -5.851 -4.880 -18.032 1.00 0.00 C ATOM 134 O3' DA A 5 -6.712 -3.757 -18.242 1.00 0.00 O ATOM 135 C2' DA A 5 -4.756 -4.436 -17.066 1.00 0.00 C ATOM 136 C1' DA A 5 -5.486 -4.581 -15.729 1.00 0.00 C ATOM 137 N9 DA A 5 -4.554 -4.699 -14.576 1.00 0.00 N ATOM 138 C8 DA A 5 -3.343 -4.066 -14.411 1.00 0.00 C ATOM 139 N7 DA A 5 -2.722 -4.357 -13.302 1.00 0.00 N ATOM 140 C5 DA A 5 -3.606 -5.244 -12.673 1.00 0.00 C ATOM 141 C6 DA A 5 -3.587 -5.964 -11.456 1.00 0.00 C ATOM 142 N6 DA A 5 -2.596 -5.942 -10.590 1.00 0.00 N ATOM 143 N1 DA A 5 -4.620 -6.719 -11.074 1.00 0.00 N ATOM 144 C2 DA A 5 -5.668 -6.776 -11.884 1.00 0.00 C ATOM 145 N3 DA A 5 -5.826 -6.188 -13.066 1.00 0.00 N ATOM 146 C4 DA A 5 -4.741 -5.432 -13.417 1.00 0.00 C ATOM 0 H5' DA A 5 -5.839 -7.698 -18.528 1.00 0.00 H new ATOM 0 H5'' DA A 5 -4.585 -7.159 -17.428 1.00 0.00 H new ATOM 0 H4' DA A 5 -7.479 -6.246 -17.533 1.00 0.00 H new ATOM 0 H3' DA A 5 -5.580 -5.191 -19.041 1.00 0.00 H new ATOM 0 H2' DA A 5 -3.870 -5.068 -17.125 1.00 0.00 H new ATOM 0 H2'' DA A 5 -4.430 -3.412 -17.251 1.00 0.00 H new ATOM 0 H1' DA A 5 -6.072 -3.689 -15.506 1.00 0.00 H new ATOM 0 H8 DA A 5 -2.939 -3.382 -15.143 1.00 0.00 H new ATOM 0 H61 DA A 5 -2.656 -6.490 -9.732 1.00 0.00 H new ATOM 0 H62 DA A 5 -1.768 -5.377 -10.777 1.00 0.00 H new ATOM 0 H2 DA A 5 -6.498 -7.376 -11.540 1.00 0.00 H new ATOM 158 P DG A 6 -8.180 -3.906 -18.854 1.00 0.00 P ATOM 159 OP1 DG A 6 -8.208 -5.109 -19.700 1.00 0.00 O ATOM 160 OP2 DG A 6 -8.581 -2.605 -19.435 1.00 0.00 O ATOM 161 O5' DG A 6 -9.093 -4.196 -17.583 1.00 0.00 O ATOM 162 C5' DG A 6 -9.468 -3.150 -16.702 1.00 0.00 C ATOM 163 C4' DG A 6 -9.910 -3.722 -15.351 1.00 0.00 C ATOM 164 O4' DG A 6 -8.749 -3.934 -14.546 1.00 0.00 O ATOM 165 C3' DG A 6 -10.823 -2.746 -14.596 1.00 0.00 C ATOM 166 O3' DG A 6 -11.756 -3.497 -13.828 1.00 0.00 O ATOM 167 C2' DG A 6 -9.801 -1.976 -13.763 1.00 0.00 C ATOM 168 C1' DG A 6 -8.781 -3.063 -13.422 1.00 0.00 C ATOM 169 N9 DG A 6 -7.424 -2.522 -13.182 1.00 0.00 N ATOM 170 C8 DG A 6 -6.718 -1.653 -13.979 1.00 0.00 C ATOM 171 N7 DG A 6 -5.534 -1.349 -13.528 1.00 0.00 N ATOM 172 C5 DG A 6 -5.439 -2.079 -12.340 1.00 0.00 C ATOM 173 C6 DG A 6 -4.373 -2.175 -11.382 1.00 0.00 C ATOM 174 O6 DG A 6 -3.284 -1.602 -11.375 1.00 0.00 O ATOM 175 N1 DG A 6 -4.651 -3.029 -10.341 1.00 0.00 N ATOM 176 C2 DG A 6 -5.821 -3.691 -10.196 1.00 0.00 C ATOM 177 N2 DG A 6 -5.918 -4.455 -9.145 1.00 0.00 N ATOM 178 N3 DG A 6 -6.842 -3.630 -11.050 1.00 0.00 N ATOM 179 C4 DG A 6 -6.591 -2.803 -12.115 1.00 0.00 C ATOM 0 H5' DG A 6 -10.279 -2.569 -17.141 1.00 0.00 H new ATOM 0 H5'' DG A 6 -8.629 -2.468 -16.559 1.00 0.00 H new ATOM 0 H4' DG A 6 -10.455 -4.648 -15.538 1.00 0.00 H new ATOM 0 H3' DG A 6 -11.439 -2.078 -15.197 1.00 0.00 H new ATOM 0 H2' DG A 6 -9.351 -1.157 -14.325 1.00 0.00 H new ATOM 0 H2'' DG A 6 -10.248 -1.542 -12.869 1.00 0.00 H new ATOM 0 H1' DG A 6 -9.076 -3.565 -12.501 1.00 0.00 H new ATOM 0 H8 DG A 6 -7.112 -1.255 -14.903 1.00 0.00 H new ATOM 0 H1 DG A 6 -3.930 -3.172 -9.634 1.00 0.00 H new ATOM 0 H21 DG A 6 -6.774 -4.983 -8.975 1.00 0.00 H new ATOM 0 H22 DG A 6 -5.138 -4.525 -8.492 1.00 0.00 H new ATOM 191 P DT A 7 -12.870 -2.811 -12.918 1.00 0.00 P ATOM 192 OP1 DT A 7 -13.929 -3.810 -12.678 1.00 0.00 O ATOM 193 OP2 DT A 7 -13.224 -1.484 -13.475 1.00 0.00 O ATOM 194 O5' DT A 7 -12.127 -2.565 -11.545 1.00 0.00 O ATOM 195 C5' DT A 7 -11.661 -3.659 -10.770 1.00 0.00 C ATOM 196 C4' DT A 7 -10.734 -3.182 -9.653 1.00 0.00 C ATOM 197 O4' DT A 7 -9.583 -2.543 -10.150 1.00 0.00 O ATOM 198 C3' DT A 7 -11.365 -2.144 -8.733 1.00 0.00 C ATOM 199 O3' DT A 7 -12.168 -2.843 -7.801 1.00 0.00 O ATOM 200 C2' DT A 7 -10.136 -1.438 -8.143 1.00 0.00 C ATOM 201 C1' DT A 7 -8.989 -1.901 -9.040 1.00 0.00 C ATOM 202 N1 DT A 7 -8.099 -0.813 -9.508 1.00 0.00 N ATOM 203 C2 DT A 7 -6.823 -0.757 -8.944 1.00 0.00 C ATOM 204 O2 DT A 7 -6.489 -1.401 -7.953 1.00 0.00 O ATOM 205 N3 DT A 7 -5.910 0.058 -9.561 1.00 0.00 N ATOM 206 C4 DT A 7 -6.130 0.802 -10.696 1.00 0.00 C ATOM 207 O4 DT A 7 -5.208 1.499 -11.125 1.00 0.00 O ATOM 208 C5 DT A 7 -7.490 0.704 -11.240 1.00 0.00 C ATOM 209 C7 DT A 7 -7.856 1.443 -12.521 1.00 0.00 C ATOM 210 C6 DT A 7 -8.439 -0.035 -10.597 1.00 0.00 C ATOM 0 H5' DT A 7 -11.132 -4.364 -11.411 1.00 0.00 H new ATOM 0 H5'' DT A 7 -12.509 -4.193 -10.341 1.00 0.00 H new ATOM 0 H4' DT A 7 -10.507 -4.103 -9.116 1.00 0.00 H new ATOM 0 H3' DT A 7 -12.030 -1.408 -9.185 1.00 0.00 H new ATOM 0 H2' DT A 7 -10.248 -0.354 -8.164 1.00 0.00 H new ATOM 0 H2'' DT A 7 -9.971 -1.722 -7.104 1.00 0.00 H new ATOM 0 H1' DT A 7 -8.344 -2.560 -8.459 1.00 0.00 H new ATOM 0 H3 DT A 7 -4.983 0.118 -9.140 1.00 0.00 H new ATOM 0 H71 DT A 7 -7.254 2.348 -12.603 1.00 0.00 H new ATOM 0 H72 DT A 7 -7.663 0.800 -13.380 1.00 0.00 H new ATOM 0 H73 DT A 7 -8.912 1.710 -12.498 1.00 0.00 H new ATOM 0 H6 DT A 7 -9.462 -0.012 -10.942 1.00 0.00 H new ATOM 223 P DG A 8 -13.447 -2.202 -7.125 1.00 0.00 P ATOM 224 OP1 DG A 8 -14.201 -3.303 -6.481 1.00 0.00 O ATOM 225 OP2 DG A 8 -14.136 -1.335 -8.101 1.00 0.00 O ATOM 226 O5' DG A 8 -12.834 -1.310 -5.961 1.00 0.00 O ATOM 227 C5' DG A 8 -11.983 -1.919 -4.997 1.00 0.00 C ATOM 228 C4' DG A 8 -11.405 -0.951 -4.019 1.00 0.00 C ATOM 229 O4' DG A 8 -10.690 0.046 -4.727 1.00 0.00 O ATOM 230 C3' DG A 8 -12.360 -0.285 -3.046 1.00 0.00 C ATOM 231 O3' DG A 8 -12.239 -0.980 -1.813 1.00 0.00 O ATOM 232 C2' DG A 8 -11.756 1.116 -3.030 1.00 0.00 C ATOM 233 C1' DG A 8 -10.427 0.989 -3.738 1.00 0.00 C ATOM 234 N9 DG A 8 -9.907 2.280 -4.252 1.00 0.00 N ATOM 235 C8 DG A 8 -10.505 3.072 -5.188 1.00 0.00 C ATOM 236 N7 DG A 8 -9.946 4.240 -5.370 1.00 0.00 N ATOM 237 C5 DG A 8 -8.893 4.233 -4.447 1.00 0.00 C ATOM 238 C6 DG A 8 -7.930 5.245 -4.091 1.00 0.00 C ATOM 239 O6 DG A 8 -7.776 6.384 -4.539 1.00 0.00 O ATOM 240 N1 DG A 8 -7.072 4.853 -3.084 1.00 0.00 N ATOM 241 C2 DG A 8 -7.129 3.648 -2.474 1.00 0.00 C ATOM 242 N2 DG A 8 -6.248 3.425 -1.541 1.00 0.00 N ATOM 243 N3 DG A 8 -7.971 2.670 -2.791 1.00 0.00 N ATOM 244 C4 DG A 8 -8.848 3.026 -3.776 1.00 0.00 C ATOM 0 H5' DG A 8 -11.171 -2.431 -5.513 1.00 0.00 H new ATOM 0 H5'' DG A 8 -12.546 -2.679 -4.455 1.00 0.00 H new ATOM 0 H4' DG A 8 -10.769 -1.565 -3.381 1.00 0.00 H new ATOM 0 H3' DG A 8 -13.426 -0.275 -3.274 1.00 0.00 H new ATOM 0 H2' DG A 8 -12.405 1.829 -3.538 1.00 0.00 H new ATOM 0 H2'' DG A 8 -11.625 1.475 -2.009 1.00 0.00 H new ATOM 0 H1' DG A 8 -9.619 0.678 -3.076 1.00 0.00 H new ATOM 0 H8 DG A 8 -11.378 2.757 -5.740 1.00 0.00 H new ATOM 0 H1 DG A 8 -6.353 5.511 -2.782 1.00 0.00 H new ATOM 0 H21 DG A 8 -6.244 2.533 -1.046 1.00 0.00 H new ATOM 0 H22 DG A 8 -5.563 4.142 -1.305 1.00 0.00 H new ATOM 256 P DC A 9 -13.212 -0.755 -0.576 1.00 0.00 P ATOM 257 OP1 DC A 9 -13.783 -2.078 -0.236 1.00 0.00 O ATOM 258 OP2 DC A 9 -14.144 0.349 -0.897 1.00 0.00 O ATOM 259 O5' DC A 9 -12.221 -0.281 0.589 1.00 0.00 O ATOM 260 C5' DC A 9 -11.490 -1.214 1.382 1.00 0.00 C ATOM 261 C4' DC A 9 -10.583 -0.594 2.470 1.00 0.00 C ATOM 262 O4' DC A 9 -9.451 0.118 1.944 1.00 0.00 O ATOM 263 C3' DC A 9 -11.371 0.384 3.349 1.00 0.00 C ATOM 264 O3' DC A 9 -10.913 0.352 4.698 1.00 0.00 O ATOM 265 C2' DC A 9 -10.990 1.676 2.649 1.00 0.00 C ATOM 266 C1' DC A 9 -9.505 1.469 2.399 1.00 0.00 C ATOM 267 N1 DC A 9 -9.122 2.485 1.389 1.00 0.00 N ATOM 268 C2 DC A 9 -8.806 3.788 1.801 1.00 0.00 C ATOM 269 O2 DC A 9 -8.294 4.011 2.901 1.00 0.00 O ATOM 270 N3 DC A 9 -9.039 4.847 0.984 1.00 0.00 N ATOM 271 C4 DC A 9 -9.641 4.620 -0.166 1.00 0.00 C ATOM 272 N4 DC A 9 -9.888 5.645 -0.928 1.00 0.00 N ATOM 273 C5 DC A 9 -9.932 3.324 -0.648 1.00 0.00 C ATOM 274 C6 DC A 9 -9.579 2.271 0.127 1.00 0.00 C ATOM 0 H5' DC A 9 -10.872 -1.821 0.721 1.00 0.00 H new ATOM 0 H5'' DC A 9 -12.198 -1.888 1.864 1.00 0.00 H new ATOM 0 H4' DC A 9 -10.220 -1.445 3.046 1.00 0.00 H new ATOM 0 H3' DC A 9 -12.441 0.196 3.436 1.00 0.00 H new ATOM 0 H2' DC A 9 -11.545 1.817 1.721 1.00 0.00 H new ATOM 0 H2'' DC A 9 -11.182 2.550 3.271 1.00 0.00 H new ATOM 0 H1' DC A 9 -8.821 1.595 3.238 1.00 0.00 H new ATOM 0 H41 DC A 9 -10.352 5.512 -1.826 1.00 0.00 H new ATOM 0 H42 DC A 9 -9.617 6.581 -0.627 1.00 0.00 H new ATOM 0 H5 DC A 9 -10.419 3.178 -1.601 1.00 0.00 H new ATOM 0 H6 DC A 9 -9.660 1.265 -0.256 1.00 0.00 H new ATOM 286 P DG A 10 -11.895 0.725 5.907 1.00 0.00 P ATOM 287 OP1 DG A 10 -11.202 0.438 7.178 1.00 0.00 O ATOM 288 OP2 DG A 10 -13.208 0.098 5.667 1.00 0.00 O ATOM 289 O5' DG A 10 -12.085 2.306 5.757 1.00 0.00 O ATOM 290 C5' DG A 10 -11.108 3.216 6.254 1.00 0.00 C ATOM 291 C4' DG A 10 -11.431 4.676 5.910 1.00 0.00 C ATOM 292 O4' DG A 10 -11.372 4.868 4.500 1.00 0.00 O ATOM 293 C3' DG A 10 -12.834 5.113 6.366 1.00 0.00 C ATOM 294 O3' DG A 10 -12.845 6.158 7.327 1.00 0.00 O ATOM 295 C2' DG A 10 -13.456 5.669 5.086 1.00 0.00 C ATOM 296 C1' DG A 10 -12.246 5.936 4.188 1.00 0.00 C ATOM 297 N9 DG A 10 -12.582 5.999 2.740 1.00 0.00 N ATOM 298 C8 DG A 10 -13.527 5.277 2.056 1.00 0.00 C ATOM 299 N7 DG A 10 -13.742 5.668 0.828 1.00 0.00 N ATOM 300 C5 DG A 10 -12.846 6.732 0.673 1.00 0.00 C ATOM 301 C6 DG A 10 -12.596 7.605 -0.443 1.00 0.00 C ATOM 302 O6 DG A 10 -13.107 7.613 -1.565 1.00 0.00 O ATOM 303 N1 DG A 10 -11.638 8.562 -0.190 1.00 0.00 N ATOM 304 C2 DG A 10 -10.972 8.664 0.983 1.00 0.00 C ATOM 305 N2 DG A 10 -10.097 9.623 1.077 1.00 0.00 N ATOM 306 N3 DG A 10 -11.151 7.874 2.037 1.00 0.00 N ATOM 307 C4 DG A 10 -12.116 6.925 1.829 1.00 0.00 C ATOM 0 H5' DG A 10 -10.133 2.957 5.842 1.00 0.00 H new ATOM 0 H5'' DG A 10 -11.035 3.109 7.336 1.00 0.00 H new ATOM 0 H4' DG A 10 -10.689 5.275 6.438 1.00 0.00 H new ATOM 0 H3' DG A 10 -13.345 4.273 6.837 1.00 0.00 H new ATOM 0 H2' DG A 10 -14.144 4.956 4.631 1.00 0.00 H new ATOM 0 H2'' DG A 10 -14.022 6.580 5.278 1.00 0.00 H new ATOM 0 H1' DG A 10 -11.805 6.916 4.371 1.00 0.00 H new ATOM 0 H8 DG A 10 -14.055 4.446 2.500 1.00 0.00 H new ATOM 0 H1 DG A 10 -11.419 9.231 -0.928 1.00 0.00 H new ATOM 0 H21 DG A 10 -9.566 9.746 1.939 1.00 0.00 H new ATOM 0 H22 DG A 10 -9.942 10.251 0.289 1.00 0.00 H new ATOM 319 P DA A 11 -12.705 5.928 8.903 1.00 0.00 P ATOM 320 OP1 DA A 11 -12.565 4.490 9.215 1.00 0.00 O ATOM 321 OP2 DA A 11 -13.824 6.688 9.509 1.00 0.00 O ATOM 322 O5' DA A 11 -11.328 6.657 9.270 1.00 0.00 O ATOM 323 C5' DA A 11 -11.287 8.057 9.524 1.00 0.00 C ATOM 324 C4' DA A 11 -9.926 8.659 9.140 1.00 0.00 C ATOM 325 O4' DA A 11 -9.824 8.679 7.719 1.00 0.00 O ATOM 326 C3' DA A 11 -9.811 10.117 9.603 1.00 0.00 C ATOM 327 O3' DA A 11 -8.440 10.453 9.767 1.00 0.00 O ATOM 328 C2' DA A 11 -10.459 10.847 8.429 1.00 0.00 C ATOM 329 C1' DA A 11 -9.981 10.010 7.244 1.00 0.00 C ATOM 330 N9 DA A 11 -10.935 10.041 6.110 1.00 0.00 N ATOM 331 C8 DA A 11 -11.988 9.197 5.839 1.00 0.00 C ATOM 332 N7 DA A 11 -12.626 9.457 4.723 1.00 0.00 N ATOM 333 C5 DA A 11 -11.920 10.569 4.226 1.00 0.00 C ATOM 334 C6 DA A 11 -12.021 11.387 3.075 1.00 0.00 C ATOM 335 N6 DA A 11 -12.901 11.210 2.108 1.00 0.00 N ATOM 336 N1 DA A 11 -11.243 12.459 2.911 1.00 0.00 N ATOM 337 C2 DA A 11 -10.341 12.712 3.852 1.00 0.00 C ATOM 338 N3 DA A 11 -10.090 12.020 4.954 1.00 0.00 N ATOM 339 C4 DA A 11 -10.925 10.953 5.085 1.00 0.00 C ATOM 0 H5' DA A 11 -11.483 8.242 10.580 1.00 0.00 H new ATOM 0 H5'' DA A 11 -12.078 8.553 8.961 1.00 0.00 H new ATOM 0 H4' DA A 11 -9.148 8.056 9.609 1.00 0.00 H new ATOM 0 H3' DA A 11 -10.277 10.353 10.560 1.00 0.00 H new ATOM 0 H2' DA A 11 -11.546 10.864 8.507 1.00 0.00 H new ATOM 0 H2'' DA A 11 -10.129 11.883 8.358 1.00 0.00 H new ATOM 0 H1' DA A 11 -9.044 10.416 6.862 1.00 0.00 H new ATOM 0 H8 DA A 11 -12.267 8.385 6.494 1.00 0.00 H new ATOM 0 H61 DA A 11 -12.913 11.842 1.308 1.00 0.00 H new ATOM 0 H62 DA A 11 -13.569 10.441 2.161 1.00 0.00 H new ATOM 0 H2 DA A 11 -9.735 13.593 3.700 1.00 0.00 H new ATOM 351 P DA A 12 -7.957 11.755 10.557 1.00 0.00 P ATOM 352 OP1 DA A 12 -7.297 11.302 11.797 1.00 0.00 O ATOM 353 OP2 DA A 12 -9.055 12.741 10.638 1.00 0.00 O ATOM 354 O5' DA A 12 -6.804 12.301 9.601 1.00 0.00 O ATOM 355 C5' DA A 12 -7.078 12.953 8.370 1.00 0.00 C ATOM 356 C4' DA A 12 -5.853 12.775 7.462 1.00 0.00 C ATOM 357 O4' DA A 12 -5.918 11.489 6.845 1.00 0.00 O ATOM 358 C3' DA A 12 -5.796 13.790 6.316 1.00 0.00 C ATOM 359 O3' DA A 12 -4.442 14.003 5.918 1.00 0.00 O ATOM 360 C2' DA A 12 -6.570 13.051 5.236 1.00 0.00 C ATOM 361 C1' DA A 12 -6.009 11.644 5.434 1.00 0.00 C ATOM 362 N9 DA A 12 -6.835 10.603 4.773 1.00 0.00 N ATOM 363 C8 DA A 12 -7.543 10.727 3.601 1.00 0.00 C ATOM 364 N7 DA A 12 -8.242 9.673 3.281 1.00 0.00 N ATOM 365 C5 DA A 12 -7.922 8.761 4.297 1.00 0.00 C ATOM 366 C6 DA A 12 -8.286 7.425 4.579 1.00 0.00 C ATOM 367 N6 DA A 12 -9.144 6.727 3.868 1.00 0.00 N ATOM 368 N1 DA A 12 -7.734 6.748 5.588 1.00 0.00 N ATOM 369 C2 DA A 12 -6.861 7.393 6.350 1.00 0.00 C ATOM 370 N3 DA A 12 -6.434 8.650 6.232 1.00 0.00 N ATOM 371 C4 DA A 12 -7.017 9.293 5.175 1.00 0.00 C ATOM 0 H5' DA A 12 -7.281 14.011 8.535 1.00 0.00 H new ATOM 0 H5'' DA A 12 -7.966 12.528 7.902 1.00 0.00 H new ATOM 0 H4' DA A 12 -4.979 12.907 8.100 1.00 0.00 H new ATOM 0 H3' DA A 12 -6.193 14.777 6.554 1.00 0.00 H new ATOM 0 H2' DA A 12 -7.648 13.096 5.389 1.00 0.00 H new ATOM 0 H2'' DA A 12 -6.373 13.443 4.238 1.00 0.00 H new ATOM 0 H1' DA A 12 -5.035 11.519 4.961 1.00 0.00 H new ATOM 0 H8 DA A 12 -7.522 11.622 2.996 1.00 0.00 H new ATOM 0 H61 DA A 12 -9.360 5.765 4.130 1.00 0.00 H new ATOM 0 H62 DA A 12 -9.593 7.147 3.055 1.00 0.00 H new ATOM 0 H2 DA A 12 -6.443 6.828 7.170 1.00 0.00 H new ATOM 383 P DG A 13 -4.036 15.215 4.955 1.00 0.00 P ATOM 384 OP1 DG A 13 -2.613 15.502 5.216 1.00 0.00 O ATOM 385 OP2 DG A 13 -5.014 16.300 5.166 1.00 0.00 O ATOM 386 O5' DG A 13 -4.183 14.665 3.449 1.00 0.00 O ATOM 387 C5' DG A 13 -3.117 14.000 2.766 1.00 0.00 C ATOM 388 C4' DG A 13 -2.927 12.519 3.147 1.00 0.00 C ATOM 389 O4' DG A 13 -4.093 11.799 2.759 1.00 0.00 O ATOM 390 C3' DG A 13 -1.735 11.909 2.382 1.00 0.00 C ATOM 391 O3' DG A 13 -0.981 11.016 3.204 1.00 0.00 O ATOM 392 C2' DG A 13 -2.448 11.174 1.248 1.00 0.00 C ATOM 393 C1' DG A 13 -3.688 10.689 1.982 1.00 0.00 C ATOM 394 N9 DG A 13 -4.777 10.273 1.071 1.00 0.00 N ATOM 395 C8 DG A 13 -5.328 10.973 0.020 1.00 0.00 C ATOM 396 N7 DG A 13 -6.304 10.359 -0.596 1.00 0.00 N ATOM 397 C5 DG A 13 -6.410 9.154 0.122 1.00 0.00 C ATOM 398 C6 DG A 13 -7.308 8.044 -0.036 1.00 0.00 C ATOM 399 O6 DG A 13 -8.196 7.887 -0.876 1.00 0.00 O ATOM 400 N1 DG A 13 -7.123 7.046 0.898 1.00 0.00 N ATOM 401 C2 DG A 13 -6.164 7.081 1.857 1.00 0.00 C ATOM 402 N2 DG A 13 -6.150 6.091 2.705 1.00 0.00 N ATOM 403 N3 DG A 13 -5.283 8.066 2.033 1.00 0.00 N ATOM 404 C4 DG A 13 -5.472 9.087 1.135 1.00 0.00 C ATOM 0 H5' DG A 13 -2.188 14.534 2.966 1.00 0.00 H new ATOM 0 H5'' DG A 13 -3.297 14.064 1.693 1.00 0.00 H new ATOM 0 H4' DG A 13 -2.748 12.456 4.220 1.00 0.00 H new ATOM 0 H3' DG A 13 -1.002 12.641 2.043 1.00 0.00 H new ATOM 0 H2' DG A 13 -2.689 11.831 0.413 1.00 0.00 H new ATOM 0 H2'' DG A 13 -1.854 10.353 0.846 1.00 0.00 H new ATOM 0 H1' DG A 13 -3.465 9.802 2.574 1.00 0.00 H new ATOM 0 H8 DG A 13 -4.981 11.953 -0.272 1.00 0.00 H new ATOM 0 H1 DG A 13 -7.742 6.236 0.866 1.00 0.00 H new ATOM 0 H21 DG A 13 -5.451 6.065 3.447 1.00 0.00 H new ATOM 0 H22 DG A 13 -6.838 5.342 2.626 1.00 0.00 H new ATOM 416 P DC A 14 0.390 10.362 2.689 1.00 0.00 P ATOM 417 OP1 DC A 14 1.253 10.067 3.857 1.00 0.00 O ATOM 418 OP2 DC A 14 0.941 11.176 1.581 1.00 0.00 O ATOM 419 O5' DC A 14 -0.066 8.985 2.037 1.00 0.00 O ATOM 420 C5' DC A 14 -0.398 7.840 2.812 1.00 0.00 C ATOM 421 C4' DC A 14 -0.701 6.613 1.935 1.00 0.00 C ATOM 422 O4' DC A 14 -1.997 6.718 1.338 1.00 0.00 O ATOM 423 C3' DC A 14 0.309 6.424 0.798 1.00 0.00 C ATOM 424 O3' DC A 14 0.659 5.064 0.579 1.00 0.00 O ATOM 425 C2' DC A 14 -0.460 6.973 -0.368 1.00 0.00 C ATOM 426 C1' DC A 14 -1.833 6.451 -0.045 1.00 0.00 C ATOM 427 N1 DC A 14 -2.915 6.981 -0.912 1.00 0.00 N ATOM 428 C2 DC A 14 -3.870 6.098 -1.429 1.00 0.00 C ATOM 429 O2 DC A 14 -3.874 4.901 -1.136 1.00 0.00 O ATOM 430 N3 DC A 14 -4.801 6.526 -2.316 1.00 0.00 N ATOM 431 C4 DC A 14 -4.741 7.775 -2.725 1.00 0.00 C ATOM 432 N4 DC A 14 -5.585 8.107 -3.655 1.00 0.00 N ATOM 433 C5 DC A 14 -3.781 8.714 -2.261 1.00 0.00 C ATOM 434 C6 DC A 14 -2.871 8.274 -1.356 1.00 0.00 C ATOM 0 H5' DC A 14 -1.265 8.063 3.434 1.00 0.00 H new ATOM 0 H5'' DC A 14 0.427 7.608 3.486 1.00 0.00 H new ATOM 0 H4' DC A 14 -0.644 5.758 2.609 1.00 0.00 H new ATOM 0 H3' DC A 14 1.266 6.908 0.994 1.00 0.00 H new ATOM 0 H2' DC A 14 -0.428 8.062 -0.413 1.00 0.00 H new ATOM 0 H2'' DC A 14 -0.088 6.604 -1.324 1.00 0.00 H new ATOM 0 HO3' DC A 14 0.808 4.915 -0.378 1.00 0.00 H new ATOM 0 H1' DC A 14 -1.915 5.385 -0.256 1.00 0.00 H new ATOM 0 H41 DC A 14 -5.594 9.060 -4.019 1.00 0.00 H new ATOM 0 H42 DC A 14 -6.239 7.415 -4.021 1.00 0.00 H new ATOM 0 H5 DC A 14 -3.776 9.735 -2.614 1.00 0.00 H new ATOM 0 H6 DC A 14 -2.111 8.946 -0.986 1.00 0.00 H new TER 447 DC A 14 HETATM 448 NA NA A 16 -7.779 -7.042 -14.429 1.00 0.00 NA HETATM 449 NA NA A 17 37.966 20.888 -0.911 1.00 0.00 NA HETATM 450 NA NA A 18 -1.239 7.301 17.867 1.00 0.00 NA HETATM 451 NA NA A 19 34.306 -7.061 16.390 1.00 0.00 NA HETATM 452 NA NA A 20 -0.140 39.926 -19.613 1.00 0.00 NA HETATM 453 NA NA A 21 -20.242 -21.804 -18.148 1.00 0.00 NA HETATM 454 NA NA A 22 -8.339 -42.086 -23.972 1.00 0.00 NA HETATM 455 NA NA A 23 -29.123 3.481 -1.627 1.00 0.00 NA HETATM 456 NA NA A 24 -7.924 -24.397 22.383 1.00 0.00 NA HETATM 457 NA NA A 25 18.009 5.450 19.018 1.00 0.00 NA HETATM 458 NA NA A 26 20.560 -7.421 2.946 1.00 0.00 NA HETATM 459 NA NA A 27 -1.007 -19.298 -31.394 1.00 0.00 NA HETATM 460 C1 NGP A 15 -7.271 3.624 -8.293 1.00 0.00 C HETATM 461 C2 NGP A 15 -7.127 5.005 -8.521 1.00 0.00 C HETATM 462 C3 NGP A 15 -6.221 5.749 -7.734 1.00 0.00 C HETATM 463 C4 NGP A 15 -5.462 5.115 -6.723 1.00 0.00 C HETATM 464 C5 NGP A 15 -5.098 3.105 -5.274 1.00 0.00 C HETATM 465 C6 NGP A 15 -5.108 1.258 -3.596 1.00 0.00 C HETATM 466 C7 NGP A 15 -5.796 -0.142 -1.547 1.00 0.00 C HETATM 467 C8 NGP A 15 -7.178 -0.411 -1.066 1.00 0.00 C HETATM 468 C9 NGP A 15 -7.633 -1.726 -1.678 1.00 0.00 C HETATM 469 C10 NGP A 15 -7.620 -1.622 -3.197 1.00 0.00 C HETATM 470 C11 NGP A 15 -7.240 0.048 -4.995 1.00 0.00 C HETATM 471 C12 NGP A 15 -7.193 1.792 -6.675 1.00 0.00 C HETATM 472 C13 NGP A 15 -9.005 -1.875 -1.082 1.00 0.00 C HETATM 473 C14 NGP A 15 -7.171 -2.888 -3.888 1.00 0.00 C HETATM 474 C15 NGP A 15 -5.631 -3.789 -5.417 1.00 0.00 C HETATM 475 C16 NGP A 15 -6.706 3.039 -7.136 1.00 0.00 C HETATM 476 C17 NGP A 15 -5.730 3.752 -6.383 1.00 0.00 C HETATM 477 C18 NGP A 15 -5.562 1.835 -4.818 1.00 0.00 C HETATM 478 C19 NGP A 15 -5.840 0.194 -3.023 1.00 0.00 C HETATM 479 C20 NGP A 15 -6.835 -0.460 -3.769 1.00 0.00 C HETATM 480 C21 NGP A 15 -6.638 1.211 -5.509 1.00 0.00 C HETATM 481 C22 NGP A 15 -7.429 6.751 -10.366 1.00 0.00 C HETATM 482 C23 NGP A 15 -12.138 6.763 -8.276 1.00 0.00 C HETATM 483 C24 NGP A 15 -12.636 4.519 -7.760 1.00 0.00 C HETATM 484 C25 NGP A 15 -5.041 -2.338 2.296 1.00 0.00 C HETATM 485 C26 NGP A 15 -5.033 0.413 5.195 1.00 0.00 C HETATM 486 C27 NGP A 15 -3.391 3.697 2.902 1.00 0.00 C HETATM 487 C28 NGP A 15 -5.808 2.217 2.081 1.00 0.00 C HETATM 488 C29 NGP A 15 -1.405 1.833 0.165 1.00 0.00 C HETATM 489 C30 NGP A 15 -8.876 3.475 -10.015 1.00 0.00 C HETATM 490 C31 NGP A 15 -10.187 3.607 -9.236 1.00 0.00 C HETATM 491 C32 NGP A 15 -10.388 4.978 -8.547 1.00 0.00 C HETATM 492 C33 NGP A 15 -9.422 6.096 -8.982 1.00 0.00 C HETATM 493 C34 NGP A 15 -8.060 5.628 -9.557 1.00 0.00 C HETATM 494 C1' NGP A 15 -4.156 0.412 -0.002 1.00 0.00 C HETATM 495 C2' NGP A 15 -3.631 1.499 0.951 1.00 0.00 C HETATM 496 C3' NGP A 15 -4.435 1.551 2.284 1.00 0.00 C HETATM 497 C4' NGP A 15 -4.638 0.109 2.862 1.00 0.00 C HETATM 498 C5' NGP A 15 -5.135 -0.896 1.797 1.00 0.00 C HETATM 499 N1 NGP A 15 -11.808 5.368 -8.637 1.00 0.00 N HETATM 500 O1 NGP A 15 -7.888 2.841 -9.246 1.00 0.00 O HETATM 501 O2 NGP A 15 -8.358 4.672 -10.541 1.00 0.00 O HETATM 502 O4 NGP A 15 -4.588 5.901 -6.034 1.00 0.00 O HETATM 503 O5 NGP A 15 -4.185 3.674 -4.675 1.00 0.00 O HETATM 504 O6 NGP A 15 -4.036 1.765 -2.924 1.00 0.00 O HETATM 505 O7 NGP A 15 -5.348 0.836 -0.631 1.00 0.00 O HETATM 506 O9 NGP A 15 -6.876 -2.824 -1.235 1.00 0.00 O HETATM 507 O10 NGP A 15 -5.842 -2.964 -4.280 1.00 0.00 O HETATM 508 O14 NGP A 15 -8.010 -3.753 -4.151 1.00 0.00 O HETATM 509 O12 NGP A 15 -8.169 1.249 -7.206 1.00 0.00 O HETATM 510 O15 NGP A 15 -10.364 2.582 -8.264 1.00 0.00 O HETATM 511 O16 NGP A 15 -9.228 6.954 -7.862 1.00 0.00 O HETATM 512 O1' NGP A 15 -4.297 -0.848 0.652 1.00 0.00 O HETATM 513 O2' NGP A 15 -2.230 1.296 1.192 1.00 0.00 O HETATM 514 O3' NGP A 15 -3.700 2.342 3.247 1.00 0.00 O HETATM 515 O4' NGP A 15 -5.575 0.022 3.945 1.00 0.00 O HETATM 0 H293 NGP A 15 -1.649 1.357 -0.784 1.00 0.00 H new HETATM 0 H292 NGP A 15 -1.575 2.907 0.086 1.00 0.00 H new HETATM 0 H291 NGP A 15 -0.358 1.648 0.405 1.00 0.00 H new HETATM 0 H283 NGP A 15 -5.668 3.236 1.720 1.00 0.00 H new HETATM 0 H282 NGP A 15 -6.384 1.649 1.350 1.00 0.00 H new HETATM 0 H281 NGP A 15 -6.346 2.239 3.029 1.00 0.00 H new HETATM 0 H273 NGP A 15 -2.783 3.713 1.997 1.00 0.00 H new HETATM 0 H272 NGP A 15 -4.315 4.248 2.727 1.00 0.00 H new HETATM 0 H271 NGP A 15 -2.839 4.164 3.718 1.00 0.00 H new HETATM 0 H263 NGP A 15 -4.188 -0.230 5.442 1.00 0.00 H new HETATM 0 H262 NGP A 15 -4.696 1.448 5.138 1.00 0.00 H new HETATM 0 H261 NGP A 15 -5.797 0.322 5.967 1.00 0.00 H new HETATM 0 H253 NGP A 15 -4.004 -2.574 2.533 1.00 0.00 H new HETATM 0 H252 NGP A 15 -5.653 -2.454 3.190 1.00 0.00 H new HETATM 0 H251 NGP A 15 -5.399 -3.015 1.521 1.00 0.00 H new HETATM 0 H243 NGP A 15 -12.392 4.726 -6.718 1.00 0.00 H new HETATM 0 H242 NGP A 15 -13.690 4.734 -7.935 1.00 0.00 H new HETATM 0 H241 NGP A 15 -12.438 3.469 -7.978 1.00 0.00 H new HETATM 0 H233 NGP A 15 -13.200 6.940 -8.443 1.00 0.00 H new HETATM 0 H232 NGP A 15 -11.903 6.932 -7.225 1.00 0.00 H new HETATM 0 H231 NGP A 15 -11.555 7.446 -8.893 1.00 0.00 H new HETATM 0 H22A NGP A 15 -8.157 7.139 -11.079 1.00 0.00 H new HETATM 0 H223 NGP A 15 -7.115 7.551 -9.695 1.00 0.00 H new HETATM 0 H222 NGP A 15 -6.562 6.369 -10.905 1.00 0.00 H new HETATM 0 H153 NGP A 15 -5.964 -4.803 -5.197 1.00 0.00 H new HETATM 0 H152 NGP A 15 -6.197 -3.396 -6.262 1.00 0.00 H new HETATM 0 H151 NGP A 15 -4.570 -3.801 -5.666 1.00 0.00 H new HETATM 0 H133 NGP A 15 -8.928 -1.909 0.005 1.00 0.00 H new HETATM 0 H132 NGP A 15 -9.623 -1.026 -1.375 1.00 0.00 H new HETATM 0 H131 NGP A 15 -9.460 -2.797 -1.443 1.00 0.00 H new HETATM 0 HO9 NGP A 15 -7.435 -3.629 -1.235 1.00 0.00 H new HETATM 0 HO6 NGP A 15 -3.864 2.681 -3.226 1.00 0.00 H new HETATM 0 HO4 NGP A 15 -4.172 5.378 -5.317 1.00 0.00 H new HETATM 0 HN1 NGP A 15 -12.005 5.253 -9.631 1.00 0.00 H new HETATM 0 H82 NGP A 15 -7.200 -0.468 0.022 1.00 0.00 H new HETATM 0 H81 NGP A 15 -7.848 0.398 -1.356 1.00 0.00 H new HETATM 0 H7 NGP A 15 -5.079 -0.963 -1.544 1.00 0.00 H new HETATM 0 H5' NGP A 15 -6.166 -0.621 1.576 1.00 0.00 H new HETATM 0 H4' NGP A 15 -3.639 -0.139 3.220 1.00 0.00 H new HETATM 0 H33 NGP A 15 -9.889 6.608 -9.823 1.00 0.00 H new HETATM 0 H32 NGP A 15 -10.115 4.840 -7.501 1.00 0.00 H new HETATM 0 H31 NGP A 15 -10.944 3.507 -10.014 1.00 0.00 H new HETATM 0 H30 NGP A 15 -9.148 2.863 -10.875 1.00 0.00 H new HETATM 0 H3 NGP A 15 -6.106 6.819 -7.907 1.00 0.00 H new HETATM 0 H2' NGP A 15 -3.771 2.467 0.471 1.00 0.00 H new HETATM 0 H16 NGP A 15 -8.614 7.678 -8.107 1.00 0.00 H new HETATM 0 H15 NGP A 15 -9.490 2.222 -8.005 1.00 0.00 H new HETATM 0 H11 NGP A 15 -8.025 -0.454 -5.560 1.00 0.00 H new HETATM 0 H10 NGP A 15 -8.674 -1.440 -3.409 1.00 0.00 H new HETATM 0 H1' NGP A 15 -3.413 0.259 -0.785 1.00 0.00 H new HETATM 566 O HOH A 28 -58.980 -20.095 -49.698 1.00 0.00 O HETATM 569 O HOH A 29 31.058 49.763 -1.110 1.00 0.00 O HETATM 572 O HOH A 30 -70.779 -56.840 -11.465 1.00 0.00 O HETATM 575 O HOH A 31 24.029 16.127 -23.795 1.00 0.00 O HETATM 578 O HOH A 32 15.318 28.920 65.096 1.00 0.00 O HETATM 581 O HOH A 33 43.406 20.813 32.668 1.00 0.00 O HETATM 584 O HOH A 34 -24.009 -14.976 9.779 1.00 0.00 O HETATM 587 O HOH A 35 6.701 -25.770 30.415 1.00 0.00 O HETATM 590 O HOH A 36 -40.295 -22.380 1.000 1.00 0.00 O HETATM 593 O HOH A 37 -15.928 22.495 -40.991 1.00 0.00 O HETATM 596 O HOH A 38 42.368 -15.888 -15.664 1.00 0.00 O HETATM 599 O HOH A 39 22.155 36.893 -6.303 1.00 0.00 O HETATM 602 O HOH A 40 14.420 -45.231 24.248 1.00 0.00 O HETATM 605 O HOH A 41 -15.755 -21.404 46.234 1.00 0.00 O HETATM 608 O HOH A 42 33.611 24.267 -33.983 1.00 0.00 O HETATM 611 O HOH A 43 52.509 46.376 33.935 1.00 0.00 O HETATM 614 O HOH A 44 -12.871 -29.399 -24.758 1.00 0.00 O HETATM 617 O HOH A 45 42.358 60.192 -7.269 1.00 0.00 O HETATM 620 O HOH A 46 41.911 20.096 49.710 1.00 0.00 O HETATM 623 O HOH A 47 5.739 22.663 35.718 1.00 0.00 O HETATM 626 O HOH A 48 5.224 13.040 -48.703 1.00 0.00 O HETATM 629 O HOH A 49 14.806 52.565 -58.539 1.00 0.00 O HETATM 632 O HOH A 50 35.954 -0.654 -35.947 1.00 0.00 O HETATM 635 O HOH A 51 -24.256 -40.629 -17.825 1.00 0.00 O HETATM 638 O HOH A 52 -26.769 -37.574 16.374 1.00 0.00 O HETATM 641 O HOH A 53 14.539 -36.125 -25.767 1.00 0.00 O HETATM 644 O HOH A 54 -40.543 32.674 26.332 1.00 0.00 O HETATM 647 O HOH A 55 -70.992 11.997 -14.507 1.00 0.00 O HETATM 650 O HOH A 56 12.023 9.168 27.664 1.00 0.00 O HETATM 653 O HOH A 57 20.667 -64.173 41.586 1.00 0.00 O HETATM 656 O HOH A 58 -32.807 30.139 -38.356 1.00 0.00 O HETATM 659 O HOH A 59 82.587 4.320 17.880 1.00 0.00 O HETATM 662 O HOH A 60 18.740 -6.312 21.031 1.00 0.00 O HETATM 665 O HOH A 61 -0.968 -31.860 -10.023 1.00 0.00 O HETATM 668 O HOH A 62 -2.932 34.468 14.672 1.00 0.00 O HETATM 671 O HOH A 63 76.035 -24.952 -22.549 1.00 0.00 O HETATM 674 O HOH A 64 -17.719 -14.608 -11.713 1.00 0.00 O HETATM 677 O HOH A 65 -5.895 10.302 21.244 1.00 0.00 O HETATM 680 O HOH A 66 -58.523 38.613 -27.230 1.00 0.00 O HETATM 683 O HOH A 67 14.174 57.582 -6.902 1.00 0.00 O HETATM 686 O HOH A 68 1.591 3.902 23.759 1.00 0.00 O HETATM 689 O HOH A 69 -21.628 13.258 -15.779 1.00 0.00 O HETATM 692 O HOH A 70 -46.142 -34.195 25.684 1.00 0.00 O HETATM 695 O HOH A 71 -18.746 -39.306 -23.408 1.00 0.00 O HETATM 698 O HOH A 72 20.373 -40.553 6.680 1.00 0.00 O HETATM 701 O HOH A 73 59.625 -12.594 16.277 1.00 0.00 O HETATM 704 O HOH A 74 5.724 28.344 35.516 1.00 0.00 O HETATM 707 O HOH A 75 -50.036 3.418 51.682 1.00 0.00 O HETATM 710 O HOH A 76 4.511 -14.112 16.239 1.00 0.00 O HETATM 713 O HOH A 77 -44.117 -29.192 -38.126 1.00 0.00 O HETATM 716 O HOH A 78 25.818 30.642 50.078 1.00 0.00 O HETATM 719 O HOH A 79 -49.628 25.950 58.603 1.00 0.00 O HETATM 722 O HOH A 80 43.865 -13.104 46.685 1.00 0.00 O HETATM 725 O HOH A 81 30.491 -19.364 29.631 1.00 0.00 O HETATM 728 O HOH A 82 -59.147 31.019 9.778 1.00 0.00 O HETATM 731 O HOH A 83 -39.188 34.001 10.406 1.00 0.00 O HETATM 734 O HOH A 84 -25.065 9.574 -5.906 1.00 0.00 O HETATM 737 O HOH A 85 60.727 18.256 33.890 1.00 0.00 O HETATM 740 O HOH A 86 5.092 28.858 -10.740 1.00 0.00 O HETATM 743 O HOH A 87 16.059 -29.423 22.800 1.00 0.00 O HETATM 746 O HOH A 88 -6.149 -14.564 -23.258 1.00 0.00 O HETATM 749 O HOH A 89 32.809 11.027 22.705 1.00 0.00 O HETATM 752 O HOH A 90 20.040 1.075 21.790 1.00 0.00 O HETATM 755 O HOH A 91 51.837 32.262 6.085 1.00 0.00 O HETATM 758 O HOH A 92 16.058 -32.378 43.993 1.00 0.00 O HETATM 761 O HOH A 93 46.927 -5.691 -23.441 1.00 0.00 O HETATM 764 O HOH A 94 -8.994 28.283 65.426 1.00 0.00 O HETATM 767 O HOH A 95 -30.052 11.461 -10.538 1.00 0.00 O HETATM 770 O HOH A 96 59.170 -0.745 -21.504 1.00 0.00 O HETATM 773 O HOH A 97 14.829 13.631 25.441 1.00 0.00 O HETATM 776 O HOH A 98 31.103 -52.900 -28.600 1.00 0.00 O HETATM 779 O HOH A 99 -12.130 72.148 30.112 1.00 0.00 O HETATM 782 O HOH A 100 -12.677 64.397 59.871 1.00 0.00 O HETATM 785 O HOH A 101 -20.594 1.967 3.266 1.00 0.00 O HETATM 788 O HOH A 102 14.508 -63.846 16.825 1.00 0.00 O HETATM 791 O HOH A 103 -2.120 -52.761 -47.585 1.00 0.00 O HETATM 794 O HOH A 104 -2.199 -0.912 20.929 1.00 0.00 O HETATM 797 O HOH A 105 21.522 -28.159 16.483 1.00 0.00 O HETATM 800 O HOH A 106 -0.974 -50.566 74.855 1.00 0.00 O HETATM 803 O HOH A 107 0.082 -24.055 18.937 1.00 0.00 O HETATM 806 O HOH A 108 -32.364 19.971 20.924 1.00 0.00 O HETATM 809 O HOH A 109 17.435 41.320 9.076 1.00 0.00 O HETATM 812 O HOH A 110 7.068 65.351 33.570 1.00 0.00 O HETATM 815 O HOH A 111 6.196 -1.704 -17.705 1.00 0.00 O HETATM 818 O HOH A 112 32.707 -27.459 -13.858 1.00 0.00 O HETATM 821 O HOH A 113 -43.189 4.580 40.335 1.00 0.00 O HETATM 824 O HOH A 114 35.188 35.189 5.331 1.00 0.00 O HETATM 827 O HOH A 115 -4.487 17.422 7.499 1.00 0.00 O HETATM 830 O HOH A 116 10.407 -54.906 42.571 1.00 0.00 O HETATM 833 O HOH A 117 -19.231 -8.973 39.341 1.00 0.00 O HETATM 836 O HOH A 118 10.030 -16.528 28.292 1.00 0.00 O HETATM 839 O HOH A 119 10.422 -12.716 35.758 1.00 0.00 O HETATM 842 O HOH A 120 -11.541 26.927 -12.504 1.00 0.00 O HETATM 845 O HOH A 121 5.932 1.106 -42.393 1.00 0.00 O HETATM 848 O HOH A 122 -33.297 7.918 7.672 1.00 0.00 O HETATM 851 O HOH A 123 -27.694 -2.703 20.225 1.00 0.00 O HETATM 854 O HOH A 124 -28.960 -24.776 1.913 1.00 0.00 O HETATM 857 O HOH A 125 5.109 -22.680 -7.467 1.00 0.00 O HETATM 860 O HOH A 126 1.600 -9.430 -31.956 1.00 0.00 O HETATM 863 O HOH A 127 -71.300 34.010 14.400 1.00 0.00 O HETATM 866 O HOH A 128 -15.430 30.179 -7.753 1.00 0.00 O HETATM 869 O HOH A 129 -21.709 -21.222 -69.430 1.00 0.00 O HETATM 872 O HOH A 130 -14.608 -25.284 -35.632 1.00 0.00 O HETATM 875 O HOH A 131 21.703 -15.488 -34.652 1.00 0.00 O HETATM 878 O HOH A 132 24.933 -47.098 -42.622 1.00 0.00 O HETATM 881 O HOH A 133 26.330 -65.967 -80.291 1.00 0.00 O HETATM 884 O HOH A 134 -20.914 -61.500 22.832 1.00 0.00 O HETATM 887 O HOH A 135 40.165 -51.393 29.455 1.00 0.00 O HETATM 890 O HOH A 136 29.377 7.742 -22.107 1.00 0.00 O HETATM 893 O HOH A 137 17.365 44.753 8.963 1.00 0.00 O HETATM 896 O HOH A 138 47.109 -2.923 33.435 1.00 0.00 O HETATM 899 O HOH A 139 -47.643 -19.057 -14.928 1.00 0.00 O HETATM 902 O HOH A 140 -28.458 -5.892 27.382 1.00 0.00 O HETATM 905 O HOH A 141 59.499 -10.016 32.334 1.00 0.00 O HETATM 908 O HOH A 142 43.246 16.182 7.035 1.00 0.00 O HETATM 911 O HOH A 143 -3.360 29.677 2.517 1.00 0.00 O HETATM 914 O HOH A 144 10.346 34.834 11.830 1.00 0.00 O HETATM 917 O HOH A 145 26.252 -16.208 10.077 1.00 0.00 O HETATM 920 O HOH A 146 25.166 -0.963 22.423 1.00 0.00 O HETATM 923 O HOH A 147 8.171 -21.958 40.422 1.00 0.00 O HETATM 926 O HOH A 148 17.269 12.148 25.648 1.00 0.00 O HETATM 929 O HOH A 149 -5.251 6.442 16.529 1.00 0.00 O HETATM 932 O HOH A 150 83.372 -31.293 -0.507 1.00 0.00 O HETATM 935 O HOH A 151 -48.936 -19.508 20.540 1.00 0.00 O HETATM 938 O HOH A 152 16.385 -24.068 -40.358 1.00 0.00 O HETATM 941 O HOH A 153 3.002 -60.746 14.547 1.00 0.00 O HETATM 944 O HOH A 154 21.957 85.088 12.914 1.00 0.00 O HETATM 947 O HOH A 155 -16.153 -53.588 -3.064 1.00 0.00 O HETATM 950 O HOH A 156 57.210 5.581 26.357 1.00 0.00 O HETATM 953 O HOH A 157 2.357 -12.250 72.774 1.00 0.00 O HETATM 956 O HOH A 158 22.321 -29.934 78.707 1.00 0.00 O HETATM 959 O HOH A 159 27.255 13.395 -55.221 1.00 0.00 O HETATM 962 O HOH A 160 14.064 28.718 26.536 1.00 0.00 O HETATM 965 O HOH A 161 27.786 -20.300 33.919 1.00 0.00 O HETATM 968 O HOH A 162 22.217 27.170 -6.289 1.00 0.00 O HETATM 971 O HOH A 163 23.857 5.040 81.176 1.00 0.00 O HETATM 974 O HOH A 164 -21.689 2.083 9.160 1.00 0.00 O HETATM 977 O HOH A 165 28.763 -46.178 -11.305 1.00 0.00 O HETATM 980 O HOH A 166 -41.544 17.314 -56.236 1.00 0.00 O HETATM 983 O HOH A 167 27.329 -18.103 -69.151 1.00 0.00 O HETATM 986 O HOH A 168 5.851 -14.016 -9.004 1.00 0.00 O HETATM 989 O HOH A 169 -30.675 15.953 -19.189 1.00 0.00 O HETATM 992 O HOH A 170 -30.954 3.922 12.190 1.00 0.00 O HETATM 995 O HOH A 171 -47.834 -92.741 41.281 1.00 0.00 O HETATM 998 O HOH A 172 -36.012 23.680 0.322 1.00 0.00 O HETATM 1001 O HOH A 173 -32.479 -27.377 4.042 1.00 0.00 O HETATM 1004 O HOH A 174 -15.914 58.335 41.565 1.00 0.00 O HETATM 1007 O HOH A 175 -42.498 -43.732 -41.548 1.00 0.00 O HETATM 1010 O HOH A 176 0.381 1.139 -13.352 1.00 0.00 O HETATM 1013 O HOH A 177 30.063 -21.324 11.123 1.00 0.00 O HETATM 1016 O HOH A 178 37.151 63.330 39.380 1.00 0.00 O HETATM 1019 O HOH A 179 63.777 1.131 26.450 1.00 0.00 O HETATM 1022 O HOH A 180 43.719 29.201 75.862 1.00 0.00 O HETATM 1025 O HOH A 181 26.669 11.669 -0.897 1.00 0.00 O HETATM 1028 O HOH A 182 3.788 10.470 -45.656 1.00 0.00 O HETATM 1031 O HOH A 183 -57.130 34.346 11.700 1.00 0.00 O HETATM 1034 O HOH A 184 -6.754 -8.470 -23.570 1.00 0.00 O HETATM 1037 O HOH A 185 15.624 -11.478 36.530 1.00 0.00 O HETATM 1040 O HOH A 186 -33.799 22.784 46.224 1.00 0.00 O HETATM 1043 O HOH A 187 -32.024 65.230 -4.804 1.00 0.00 O HETATM 1046 O HOH A 188 20.317 -58.050 17.345 1.00 0.00 O HETATM 1049 O HOH A 189 46.451 -14.862 -3.341 1.00 0.00 O HETATM 1052 O HOH A 190 47.715 -14.445 -24.049 1.00 0.00 O HETATM 1055 O HOH A 191 -16.878 39.228 13.826 1.00 0.00 O HETATM 1058 O HOH A 192 -61.033 -9.572 3.044 1.00 0.00 O HETATM 1061 O HOH A 193 23.749 18.889 -29.025 1.00 0.00 O HETATM 1064 O HOH A 194 -0.592 63.329 24.946 1.00 0.00 O HETATM 1067 O HOH A 195 21.625 -14.292 2.196 1.00 0.00 O HETATM 1070 O HOH A 196 5.335 -5.937 -63.252 1.00 0.00 O HETATM 1073 O HOH A 197 17.844 -65.327 11.752 1.00 0.00 O HETATM 1076 O HOH A 198 7.252 38.712 39.379 1.00 0.00 O HETATM 1079 O HOH A 199 7.118 13.180 -31.684 1.00 0.00 O HETATM 1082 O HOH A 200 18.110 -27.523 -36.652 1.00 0.00 O HETATM 1085 O HOH A 201 72.879 5.487 31.624 1.00 0.00 O HETATM 1088 O HOH A 202 -30.560 9.212 -75.749 1.00 0.00 O HETATM 1091 O HOH A 203 18.530 -0.504 -70.887 1.00 0.00 O HETATM 1094 O HOH A 204 34.940 -9.699 4.466 1.00 0.00 O HETATM 1097 O HOH A 205 0.871 -25.181 -30.094 1.00 0.00 O HETATM 1100 O HOH A 206 33.474 -14.671 -16.907 1.00 0.00 O HETATM 1103 O HOH A 207 53.375 29.333 31.990 1.00 0.00 O HETATM 1106 O HOH A 208 -35.455 -58.753 -0.775 1.00 0.00 O HETATM 1109 O HOH A 209 -3.832 16.992 21.092 1.00 0.00 O HETATM 1112 O HOH A 210 -93.406 52.569 65.063 1.00 0.00 O HETATM 1115 O HOH A 211 26.310 -36.459 -31.537 1.00 0.00 O HETATM 1118 O HOH A 212 -46.088 -6.910 1.748 1.00 0.00 O HETATM 1121 O HOH A 213 -56.010 51.813 -42.835 1.00 0.00 O HETATM 1124 O HOH A 214 -20.137 24.787 -61.267 1.00 0.00 O HETATM 1127 O HOH A 215 24.293 -57.493 -12.535 1.00 0.00 O HETATM 1130 O HOH A 216 -18.768 23.966 11.299 1.00 0.00 O HETATM 1133 O HOH A 217 39.416 39.078 -2.355 1.00 0.00 O HETATM 1136 O HOH A 218 -20.257 28.136 -56.861 1.00 0.00 O HETATM 1139 O HOH A 219 -13.985 -25.933 46.615 1.00 0.00 O HETATM 1142 O HOH A 220 -32.482 -18.884 -7.688 1.00 0.00 O HETATM 1145 O HOH A 221 -20.239 73.366 -4.825 1.00 0.00 O HETATM 1148 O HOH A 222 87.942 -6.940 -30.005 1.00 0.00 O HETATM 1151 O HOH A 223 20.957 57.801 53.227 1.00 0.00 O HETATM 1154 O HOH A 224 -4.174 -17.268 13.384 1.00 0.00 O HETATM 1157 O HOH A 225 39.760 16.429 14.172 1.00 0.00 O HETATM 1160 O HOH A 226 15.200 4.167 -71.302 1.00 0.00 O HETATM 1163 O HOH A 227 -8.680 -6.033 14.330 1.00 0.00 O HETATM 1166 O HOH A 228 39.194 -19.505 30.484 1.00 0.00 O HETATM 1169 O HOH A 229 -33.826 6.374 21.181 1.00 0.00 O HETATM 1172 O HOH A 230 32.687 -13.528 47.902 1.00 0.00 O HETATM 1175 O HOH A 231 -38.277 0.632 17.975 1.00 0.00 O HETATM 1178 O HOH A 232 8.738 23.611 15.258 1.00 0.00 O HETATM 1181 O HOH A 233 28.566 0.824 -22.339 1.00 0.00 O HETATM 1184 O HOH A 234 -14.932 43.905 -48.810 1.00 0.00 O HETATM 1187 O HOH A 235 -25.508 14.009 10.961 1.00 0.00 O HETATM 1190 O HOH A 236 -39.940 79.394 -11.655 1.00 0.00 O HETATM 1193 O HOH A 237 5.431 50.442 -29.526 1.00 0.00 O HETATM 1196 O HOH A 238 37.861 -4.083 -51.516 1.00 0.00 O HETATM 1199 O HOH A 239 23.124 19.308 -25.821 1.00 0.00 O HETATM 1202 O HOH A 240 -74.462 41.050 39.536 1.00 0.00 O HETATM 1205 O HOH A 241 -12.655 -14.823 51.979 1.00 0.00 O HETATM 1208 O HOH A 242 10.274 -12.032 -38.964 1.00 0.00 O HETATM 1211 O HOH A 243 3.999 32.584 -72.883 1.00 0.00 O HETATM 1214 O HOH A 244 -7.767 -18.112 26.872 1.00 0.00 O HETATM 1217 O HOH A 245 12.572 -17.707 -70.518 1.00 0.00 O HETATM 1220 O HOH A 246 18.497 -52.763 5.643 1.00 0.00 O HETATM 1223 O HOH A 247 8.640 -25.162 48.588 1.00 0.00 O HETATM 1226 O HOH A 248 -27.070 -67.921 -41.243 1.00 0.00 O HETATM 1229 O HOH A 249 7.717 21.311 20.430 1.00 0.00 O HETATM 1232 O HOH A 250 -14.354 108.707 3.984 1.00 0.00 O HETATM 1235 O HOH A 251 -43.483 66.577 -55.515 1.00 0.00 O HETATM 1238 O HOH A 252 -18.146 25.497 20.191 1.00 0.00 O HETATM 1241 O HOH A 253 31.942 20.477 -56.069 1.00 0.00 O HETATM 1244 O HOH A 254 -82.718 2.396 -12.299 1.00 0.00 O HETATM 1247 O HOH A 255 -5.466 -23.210 -70.222 1.00 0.00 O HETATM 1250 O HOH A 256 39.347 -17.344 6.672 1.00 0.00 O HETATM 1253 O HOH A 257 26.080 50.198 -32.705 1.00 0.00 O HETATM 1256 O HOH A 258 -34.594 59.901 14.377 1.00 0.00 O HETATM 1259 O HOH A 259 -26.051 -10.903 56.857 1.00 0.00 O HETATM 1262 O HOH A 260 -2.554 47.350 13.379 1.00 0.00 O HETATM 1265 O HOH A 261 -20.408 9.239 12.251 1.00 0.00 O HETATM 1268 O HOH A 262 -63.682 -68.540 11.958 1.00 0.00 O HETATM 1271 O HOH A 263 7.231 64.643 -17.421 1.00 0.00 O HETATM 1274 O HOH A 264 17.475 4.494 -35.288 1.00 0.00 O HETATM 1277 O HOH A 265 -62.160 32.169 58.256 1.00 0.00 O HETATM 1280 O HOH A 266 -20.421 -27.715 35.449 1.00 0.00 O HETATM 1283 O HOH A 267 15.897 -46.206 -30.128 1.00 0.00 O HETATM 1286 O HOH A 268 -21.503 -26.075 -65.943 1.00 0.00 O HETATM 1289 O HOH A 269 -26.012 -12.290 -26.754 1.00 0.00 O HETATM 1292 O HOH A 270 25.174 0.899 -42.150 1.00 0.00 O HETATM 1295 O HOH A 271 21.488 18.913 24.315 1.00 0.00 O HETATM 1298 O HOH A 272 28.949 0.000 15.992 1.00 0.00 O HETATM 1301 O HOH A 273 22.912 22.072 -22.585 1.00 0.00 O HETATM 1304 O HOH A 274 -18.059 14.149 -33.814 1.00 0.00 O HETATM 1307 O HOH A 275 30.625 -71.556 20.915 1.00 0.00 O HETATM 1310 O HOH A 276 -26.214 26.099 27.435 1.00 0.00 O HETATM 1313 O HOH A 277 15.022 -31.468 -0.599 1.00 0.00 O HETATM 1316 O HOH A 278 50.273 -47.966 -26.355 1.00 0.00 O HETATM 1319 O HOH A 279 36.118 -32.255 85.912 1.00 0.00 O HETATM 1322 O HOH A 280 58.384 -18.784 -30.350 1.00 0.00 O HETATM 1325 O HOH A 281 23.599 -27.908 29.480 1.00 0.00 O HETATM 1328 O HOH A 282 29.431 7.474 -81.178 1.00 0.00 O HETATM 1331 O HOH A 283 48.699 -36.475 23.327 1.00 0.00 O HETATM 1334 O HOH A 284 -71.953 9.207 5.889 1.00 0.00 O HETATM 1337 O HOH A 285 25.608 -16.399 23.124 1.00 0.00 O HETATM 1340 O HOH A 286 54.531 36.017 0.316 1.00 0.00 O HETATM 1343 O HOH A 287 -16.044 21.098 55.131 1.00 0.00 O HETATM 1346 O HOH A 288 50.304 1.661 29.289 1.00 0.00 O HETATM 1349 O HOH A 289 -42.451 1.545 36.714 1.00 0.00 O HETATM 1352 O HOH A 290 6.835 26.206 23.578 1.00 0.00 O HETATM 1355 O HOH A 291 8.284 49.851 30.407 1.00 0.00 O HETATM 1358 O HOH A 292 6.491 -36.316 -32.658 1.00 0.00 O HETATM 1361 O HOH A 293 18.965 -23.368 -3.648 1.00 0.00 O HETATM 1364 O HOH A 294 -19.956 48.926 14.513 1.00 0.00 O HETATM 1367 O HOH A 295 -33.328 -17.840 -16.339 1.00 0.00 O HETATM 1370 O HOH A 296 12.170 -49.157 -35.679 1.00 0.00 O HETATM 1373 O HOH A 297 57.759 -84.693 -47.990 1.00 0.00 O HETATM 1376 O HOH A 298 46.865 3.091 8.521 1.00 0.00 O HETATM 1379 O HOH A 299 -2.435 40.843 -13.596 1.00 0.00 O HETATM 1382 O HOH A 300 30.929 46.371 11.832 1.00 0.00 O HETATM 1385 O HOH A 301 -13.390 -57.959 10.326 1.00 0.00 O HETATM 1388 O HOH A 302 84.281 -24.440 -35.365 1.00 0.00 O HETATM 1391 O HOH A 303 -22.006 8.790 -49.976 1.00 0.00 O HETATM 1394 O HOH A 304 -10.815 23.286 50.483 1.00 0.00 O HETATM 1397 O HOH A 305 25.873 -7.910 -35.910 1.00 0.00 O HETATM 1400 O HOH A 306 -20.783 -49.071 1.667 1.00 0.00 O HETATM 1403 O HOH A 307 -11.638 20.017 -53.624 1.00 0.00 O HETATM 1406 O HOH A 308 12.312 -12.273 -8.768 1.00 0.00 O HETATM 1409 O HOH A 309 20.105 20.098 -27.447 1.00 0.00 O HETATM 1412 O HOH A 310 10.805 17.319 19.863 1.00 0.00 O HETATM 1415 O HOH A 311 4.841 2.461 2.387 1.00 0.00 O HETATM 1418 O HOH A 312 -47.276 16.263 6.980 1.00 0.00 O HETATM 1421 O HOH A 313 -36.557 24.004 62.997 1.00 0.00 O HETATM 1424 O HOH A 314 27.762 -4.985 -39.460 1.00 0.00 O HETATM 1427 O HOH A 315 -33.459 8.883 42.668 1.00 0.00 O HETATM 1430 O HOH A 316 -1.518 1.562 -33.074 1.00 0.00 O HETATM 1433 O HOH A 317 49.557 -9.544 9.870 1.00 0.00 O HETATM 1436 O HOH A 318 1.162 -10.291 -16.327 1.00 0.00 O HETATM 1439 O HOH A 319 15.511 -36.621 -34.494 1.00 0.00 O HETATM 1442 O HOH A 320 6.655 -26.029 -4.756 1.00 0.00 O HETATM 1445 O HOH A 321 20.126 -38.899 -25.586 1.00 0.00 O HETATM 1448 O HOH A 322 22.761 23.124 -16.392 1.00 0.00 O HETATM 1451 O HOH A 323 19.433 30.456 14.718 1.00 0.00 O HETATM 1454 O HOH A 324 -51.969 15.786 -21.737 1.00 0.00 O HETATM 1457 O HOH A 325 -15.393 -34.123 6.332 1.00 0.00 O HETATM 1460 O HOH A 326 -13.050 23.630 -11.855 1.00 0.00 O HETATM 1463 O HOH A 327 -0.521 82.933 -31.629 1.00 0.00 O HETATM 1466 O HOH A 328 -49.178 -37.701 -44.680 1.00 0.00 O HETATM 1469 O HOH A 329 -16.618 20.480 32.962 1.00 0.00 O HETATM 1472 O HOH A 330 -59.477 -27.790 -59.270 1.00 0.00 O HETATM 1475 O HOH A 331 12.358 32.635 -10.918 1.00 0.00 O HETATM 1478 O HOH A 332 -48.459 66.659 0.973 1.00 0.00 O HETATM 1481 O HOH A 333 -16.058 32.886 10.557 1.00 0.00 O HETATM 1484 O HOH A 334 37.497 23.377 -4.604 1.00 0.00 O HETATM 1487 O HOH A 335 -12.267 58.511 11.803 1.00 0.00 O HETATM 1490 O HOH A 336 -31.255 17.784 -3.702 1.00 0.00 O HETATM 1493 O HOH A 337 43.264 35.290 -23.016 1.00 0.00 O HETATM 1496 O HOH A 338 -54.217 17.293 34.227 1.00 0.00 O HETATM 1499 O HOH A 339 -5.474 -38.652 -36.335 1.00 0.00 O HETATM 1502 O HOH A 340 3.060 52.999 -28.042 1.00 0.00 O HETATM 1505 O HOH A 341 15.614 -7.015 -4.716 1.00 0.00 O HETATM 1508 O HOH A 342 20.429 17.479 27.199 1.00 0.00 O HETATM 1511 O HOH A 343 -32.926 2.481 -6.163 1.00 0.00 O HETATM 1514 O HOH A 344 -41.116 34.208 28.471 1.00 0.00 O HETATM 1517 O HOH A 345 46.014 40.405 4.176 1.00 0.00 O HETATM 1520 O HOH A 346 -19.066 -21.176 36.190 1.00 0.00 O HETATM 1523 O HOH A 347 26.806 -40.368 29.066 1.00 0.00 O HETATM 1526 O HOH A 348 26.414 -11.924 -33.169 1.00 0.00 O HETATM 1529 O HOH A 349 36.489 48.505 14.828 1.00 0.00 O HETATM 1532 O HOH A 350 -11.003 20.611 -2.230 1.00 0.00 O HETATM 1535 O HOH A 351 -28.314 -8.318 -42.852 1.00 0.00 O HETATM 1538 O HOH A 352 -34.772 71.241 47.393 1.00 0.00 O HETATM 1541 O HOH A 353 66.181 5.239 30.589 1.00 0.00 O HETATM 1544 O HOH A 354 -80.561 -34.711 -25.698 1.00 0.00 O HETATM 1547 O HOH A 355 33.949 27.739 11.350 1.00 0.00 O HETATM 1550 O HOH A 356 4.161 27.966 14.124 1.00 0.00 O HETATM 1553 O HOH A 357 22.244 -55.356 9.162 1.00 0.00 O HETATM 1556 O HOH A 358 7.905 -34.910 -17.705 1.00 0.00 O HETATM 1559 O HOH A 359 25.268 -37.424 -38.232 1.00 0.00 O HETATM 1562 O HOH A 360 -43.975 -7.652 -26.094 1.00 0.00 O HETATM 1565 O HOH A 361 36.074 32.088 20.748 1.00 0.00 O HETATM 1568 O HOH A 362 36.210 -26.858 31.245 1.00 0.00 O HETATM 1571 O HOH A 363 44.919 -45.577 -33.129 1.00 0.00 O HETATM 1574 O HOH A 364 -18.103 -22.045 31.072 1.00 0.00 O HETATM 1577 O HOH A 365 -46.798 -40.936 -28.104 1.00 0.00 O HETATM 1580 O HOH A 366 18.140 63.252 2.848 1.00 0.00 O HETATM 1583 O HOH A 367 36.552 -11.250 42.658 1.00 0.00 O HETATM 1586 O HOH A 368 80.548 -4.756 -33.224 1.00 0.00 O HETATM 1589 O HOH A 369 -3.234 20.970 -4.530 1.00 0.00 O HETATM 1592 O HOH A 370 50.616 -23.087 -11.427 1.00 0.00 O HETATM 1595 O HOH A 371 64.319 -51.118 -73.837 1.00 0.00 O HETATM 1598 O HOH A 372 -18.922 -27.390 -54.772 1.00 0.00 O HETATM 1601 O HOH A 373 21.559 24.418 33.386 1.00 0.00 O HETATM 1604 O HOH A 374 34.983 6.494 32.704 1.00 0.00 O HETATM 1607 O HOH A 375 13.608 7.310 4.199 1.00 0.00 O HETATM 1610 O HOH A 376 28.319 1.797 7.154 1.00 0.00 O HETATM 1613 O HOH A 377 33.294 -12.070 -20.353 1.00 0.00 O HETATM 1616 O HOH A 378 4.729 6.663 65.181 1.00 0.00 O HETATM 1619 O HOH A 379 2.832 11.335 -20.869 1.00 0.00 O HETATM 1622 O HOH A 380 -7.063 -10.985 -26.383 1.00 0.00 O HETATM 1625 O HOH A 381 35.400 -12.771 39.756 1.00 0.00 O HETATM 1628 O HOH A 382 -5.189 23.412 16.338 1.00 0.00 O HETATM 1631 O HOH A 383 -24.554 -25.002 -24.703 1.00 0.00 O HETATM 1634 O HOH A 384 2.207 -16.366 -58.843 1.00 0.00 O HETATM 1637 O HOH A 385 20.839 -11.694 61.598 1.00 0.00 O HETATM 1640 O HOH A 386 -40.117 -9.928 -61.378 1.00 0.00 O HETATM 1643 O HOH A 387 -31.130 -22.815 -1.055 1.00 0.00 O HETATM 1646 O HOH A 388 4.242 -34.190 11.794 1.00 0.00 O HETATM 1649 O HOH A 389 -51.841 -16.628 38.971 1.00 0.00 O HETATM 1652 O HOH A 390 16.892 16.745 -3.848 1.00 0.00 O HETATM 1655 O HOH A 391 3.968 7.843 16.865 1.00 0.00 O HETATM 1658 O HOH A 392 -6.233 16.890 14.693 1.00 0.00 O HETATM 1661 O HOH A 393 -33.980 26.690 -38.475 1.00 0.00 O HETATM 1664 O HOH A 394 -24.657 47.890 -35.992 1.00 0.00 O HETATM 1667 O HOH A 395 0.339 17.141 -35.757 1.00 0.00 O HETATM 1670 O HOH A 396 14.791 -8.495 -13.666 1.00 0.00 O HETATM 1673 O HOH A 397 14.077 3.421 21.402 1.00 0.00 O HETATM 1676 O HOH A 398 26.500 -12.972 -9.604 1.00 0.00 O HETATM 1679 O HOH A 399 0.568 -90.121 -33.153 1.00 0.00 O HETATM 1682 O HOH A 400 54.439 21.221 25.356 1.00 0.00 O HETATM 1685 O HOH A 401 23.209 -23.893 -3.964 1.00 0.00 O HETATM 1688 O HOH A 402 -23.385 -42.533 -25.680 1.00 0.00 O HETATM 1691 O HOH A 403 -33.568 -61.873 -44.249 1.00 0.00 O HETATM 1694 O HOH A 404 -23.011 23.589 -43.256 1.00 0.00 O HETATM 1697 O HOH A 405 -16.196 20.106 -5.963 1.00 0.00 O HETATM 1700 O HOH A 406 58.905 4.014 -96.982 1.00 0.00 O HETATM 1703 O HOH A 407 -22.178 -60.716 -12.105 1.00 0.00 O HETATM 1706 O HOH A 408 30.295 23.028 10.389 1.00 0.00 O HETATM 1709 O HOH A 409 22.079 -31.808 -18.403 1.00 0.00 O HETATM 1712 O HOH A 410 -0.892 18.024 45.786 1.00 0.00 O HETATM 1715 O HOH A 411 46.541 -35.873 -24.205 1.00 0.00 O HETATM 1718 O HOH A 412 -1.859 14.455 -39.580 1.00 0.00 O HETATM 1721 O HOH A 413 -39.881 34.162 -39.524 1.00 0.00 O HETATM 1724 O HOH A 414 17.630 11.594 -11.876 1.00 0.00 O HETATM 1727 O HOH A 415 -1.994 43.867 -42.858 1.00 0.00 O HETATM 1730 O HOH A 416 -1.043 -16.050 56.374 1.00 0.00 O HETATM 1733 O HOH A 417 13.012 -24.653 -0.038 1.00 0.00 O HETATM 1736 O HOH A 418 -24.737 -23.731 -2.468 1.00 0.00 O HETATM 1739 O HOH A 419 49.616 -22.624 -22.451 1.00 0.00 O HETATM 1742 O HOH A 420 49.309 2.001 16.314 1.00 0.00 O HETATM 1745 O HOH A 421 -23.490 13.690 -3.889 1.00 0.00 O HETATM 1748 O HOH A 422 9.500 -7.197 -6.549 1.00 0.00 O HETATM 1751 O HOH A 423 39.700 -10.562 -1.807 1.00 0.00 O HETATM 1754 O HOH A 424 -7.324 -9.017 -34.487 1.00 0.00 O HETATM 1757 O HOH A 425 77.199 58.485 -23.312 1.00 0.00 O HETATM 1760 O HOH A 426 7.154 -38.249 -22.581 1.00 0.00 O HETATM 1763 O HOH A 427 -0.264 11.380 44.535 1.00 0.00 O HETATM 1766 O HOH A 428 -61.938 -26.860 -3.700 1.00 0.00 O HETATM 1769 O HOH A 429 43.286 4.017 18.234 1.00 0.00 O HETATM 1772 O HOH A 430 64.972 -36.047 13.399 1.00 0.00 O HETATM 1775 O HOH A 431 -17.232 -28.499 48.483 1.00 0.00 O HETATM 1778 O HOH A 432 29.580 -53.833 -45.983 1.00 0.00 O HETATM 1781 O HOH A 433 -9.496 50.741 11.111 1.00 0.00 O HETATM 1784 O HOH A 434 -3.245 41.162 -44.593 1.00 0.00 O HETATM 1787 O HOH A 435 -36.518 5.536 -6.949 1.00 0.00 O HETATM 1790 O HOH A 436 57.110 16.754 29.716 1.00 0.00 O HETATM 1793 O HOH A 437 -14.725 34.022 40.769 1.00 0.00 O HETATM 1796 O HOH A 438 -15.043 21.993 -18.988 1.00 0.00 O HETATM 1799 O HOH A 439 24.293 12.629 36.911 1.00 0.00 O HETATM 1802 O HOH A 440 -27.275 -23.905 46.095 1.00 0.00 O HETATM 1805 O HOH A 441 -41.447 -21.381 27.927 1.00 0.00 O HETATM 1808 O HOH A 442 4.353 50.708 -4.593 1.00 0.00 O HETATM 1811 O HOH A 443 55.871 25.577 -49.260 1.00 0.00 O HETATM 1814 O HOH A 444 -27.338 48.912 14.523 1.00 0.00 O HETATM 1817 O HOH A 445 50.671 -52.471 4.917 1.00 0.00 O HETATM 1820 O HOH A 446 -25.053 44.040 -26.668 1.00 0.00 O HETATM 1823 O HOH A 447 18.483 42.807 -34.016 1.00 0.00 O HETATM 1826 O HOH A 448 -40.423 -47.393 -37.331 1.00 0.00 O HETATM 1829 O HOH A 449 -6.194 88.492 -2.631 1.00 0.00 O HETATM 1832 O HOH A 450 15.837 -7.436 23.931 1.00 0.00 O HETATM 1835 O HOH A 451 4.331 -23.539 -18.655 1.00 0.00 O HETATM 1838 O HOH A 452 -79.575 13.107 36.990 1.00 0.00 O HETATM 1841 O HOH A 453 -0.344 58.189 -27.222 1.00 0.00 O HETATM 1844 O HOH A 454 -13.598 51.056 -22.019 1.00 0.00 O HETATM 1847 O HOH A 455 -32.058 67.156 -40.391 1.00 0.00 O HETATM 1850 O HOH A 456 -19.555 -64.649 -9.168 1.00 0.00 O HETATM 1853 O HOH A 457 43.571 -48.045 -19.331 1.00 0.00 O HETATM 1856 O HOH A 458 -26.224 7.960 -21.635 1.00 0.00 O HETATM 1859 O HOH A 459 13.049 -43.285 -42.761 1.00 0.00 O HETATM 1862 O HOH A 460 24.304 4.311 -35.739 1.00 0.00 O HETATM 1865 O HOH A 461 -27.587 -13.377 -30.719 1.00 0.00 O HETATM 1868 O HOH A 462 -27.790 45.710 34.796 1.00 0.00 O HETATM 1871 O HOH A 463 10.524 -38.870 -12.843 1.00 0.00 O HETATM 1874 O HOH A 464 27.358 -24.678 -29.639 1.00 0.00 O HETATM 1877 O HOH A 465 -32.573 8.047 -17.906 1.00 0.00 O HETATM 1880 O HOH A 466 -51.859 -4.008 -39.173 1.00 0.00 O HETATM 1883 O HOH A 467 17.132 2.255 -57.194 1.00 0.00 O HETATM 1886 O HOH A 468 20.367 -27.703 -3.322 1.00 0.00 O HETATM 1889 O HOH A 469 23.025 1.921 -35.361 1.00 0.00 O HETATM 1892 O HOH A 470 40.090 16.071 -16.292 1.00 0.00 O HETATM 1895 O HOH A 471 47.353 13.189 -47.857 1.00 0.00 O HETATM 1898 O HOH A 472 -42.846 -9.041 -48.967 1.00 0.00 O HETATM 1901 O HOH A 473 -59.579 34.002 -19.204 1.00 0.00 O HETATM 1904 O HOH A 474 -10.475 -59.316 -21.936 1.00 0.00 O HETATM 1907 O HOH A 475 17.870 -15.302 18.780 1.00 0.00 O HETATM 1910 O HOH A 476 9.814 2.183 -3.682 1.00 0.00 O HETATM 1913 O HOH A 477 -0.985 6.032 -34.805 1.00 0.00 O HETATM 1916 O HOH A 478 -4.883 -7.212 -4.873 1.00 0.00 O HETATM 1919 O HOH A 479 -12.152 -34.702 -32.937 1.00 0.00 O HETATM 1922 O HOH A 480 46.210 -14.738 61.895 1.00 0.00 O HETATM 1925 O HOH A 481 39.178 -9.639 32.837 1.00 0.00 O HETATM 1928 O HOH A 482 60.451 -53.082 -39.750 1.00 0.00 O HETATM 1931 O HOH A 483 -64.830 8.405 -9.856 1.00 0.00 O HETATM 1934 O HOH A 484 17.078 12.004 -74.261 1.00 0.00 O HETATM 1937 O HOH A 485 9.532 8.411 17.320 1.00 0.00 O HETATM 1940 O HOH A 486 1.155 53.163 7.082 1.00 0.00 O HETATM 1943 O HOH A 487 26.245 -69.212 18.569 1.00 0.00 O HETATM 1946 O HOH A 488 -30.268 -20.021 -50.082 1.00 0.00 O HETATM 1949 O HOH A 489 79.108 4.195 -31.020 1.00 0.00 O HETATM 1952 O HOH A 490 -66.189 -11.787 10.590 1.00 0.00 O HETATM 1955 O HOH A 491 55.329 0.782 -2.950 1.00 0.00 O HETATM 1958 O HOH A 492 28.221 -13.726 -32.095 1.00 0.00 O HETATM 1961 O HOH A 493 3.013 -21.566 -35.477 1.00 0.00 O HETATM 1964 O HOH A 494 -31.792 -4.871 13.530 1.00 0.00 O HETATM 1967 O HOH A 495 -29.398 -15.712 62.641 1.00 0.00 O HETATM 1970 O HOH A 496 -20.806 -4.423 -4.520 1.00 0.00 O HETATM 1973 O HOH A 497 36.513 -3.906 -42.684 1.00 0.00 O HETATM 1976 O HOH A 498 10.926 -21.041 -22.869 1.00 0.00 O HETATM 1979 O HOH A 499 -25.023 5.605 -62.799 1.00 0.00 O HETATM 1982 O HOH A 500 -2.100 -13.328 -29.291 1.00 0.00 O HETATM 1985 O HOH A 501 -21.116 22.587 -23.617 1.00 0.00 O HETATM 1988 O HOH A 502 -12.072 -7.772 -0.385 1.00 0.00 O HETATM 1991 O HOH A 503 19.730 34.064 20.944 1.00 0.00 O HETATM 1994 O HOH A 504 -54.503 31.412 -58.719 1.00 0.00 O HETATM 1997 O HOH A 505 -20.181 -22.775 21.609 1.00 0.00 O HETATM 2000 O HOH A 506 -16.227 -2.096 -9.519 1.00 0.00 O HETATM 2003 O HOH A 507 -34.570 -15.462 5.632 1.00 0.00 O HETATM 2006 O HOH A 508 -8.017 -0.366 -18.111 1.00 0.00 O HETATM 2009 O HOH A 509 19.677 17.709 -7.272 1.00 0.00 O HETATM 2012 O HOH A 510 56.223 -48.599 -6.688 1.00 0.00 O HETATM 2015 O HOH A 511 35.714 -6.603 34.827 1.00 0.00 O HETATM 2018 O HOH A 512 -19.334 24.530 46.086 1.00 0.00 O HETATM 2021 O HOH A 513 40.124 -34.150 -7.571 1.00 0.00 O HETATM 2024 O HOH A 514 -42.659 -14.068 -11.169 1.00 0.00 O HETATM 2027 O HOH A 515 0.133 -4.462 -26.849 1.00 0.00 O HETATM 2030 O HOH A 516 -15.909 26.440 -7.047 1.00 0.00 O HETATM 2033 O HOH A 517 8.466 46.606 -35.479 1.00 0.00 O HETATM 2036 O HOH A 518 37.639 -36.348 40.444 1.00 0.00 O HETATM 2039 O HOH A 519 -31.719 -30.876 -8.834 1.00 0.00 O HETATM 2042 O HOH A 520 19.648 10.181 0.380 1.00 0.00 O HETATM 2045 O HOH A 521 -30.841 11.186 -28.085 1.00 0.00 O HETATM 2048 O HOH A 522 73.541 31.990 -28.032 1.00 0.00 O HETATM 2051 O HOH A 523 4.534 6.258 26.967 1.00 0.00 O HETATM 2054 O HOH A 524 -14.417 -11.121 12.814 1.00 0.00 O HETATM 2057 O HOH A 525 46.585 -35.448 24.734 1.00 0.00 O HETATM 2060 O HOH A 526 -21.773 12.233 -19.284 1.00 0.00 O HETATM 2063 O HOH A 527 -7.247 34.299 63.990 1.00 0.00 O HETATM 2066 O HOH A 528 58.864 30.967 26.034 1.00 0.00 O HETATM 2069 O HOH A 529 -40.284 44.170 -43.067 1.00 0.00 O HETATM 2072 O HOH A 530 59.691 27.746 51.971 1.00 0.00 O HETATM 2075 O HOH A 531 12.917 -14.004 -41.489 1.00 0.00 O HETATM 2078 O HOH A 532 25.753 -49.585 36.573 1.00 0.00 O HETATM 2081 O HOH A 533 -5.561 -7.545 18.780 1.00 0.00 O HETATM 2084 O HOH A 534 7.813 -54.963 15.400 1.00 0.00 O HETATM 2087 O HOH A 535 24.183 13.352 -23.719 1.00 0.00 O HETATM 2090 O HOH A 536 -36.848 -23.537 72.234 1.00 0.00 O HETATM 2093 O HOH A 537 -22.560 -2.770 -64.632 1.00 0.00 O HETATM 2096 O HOH A 538 8.171 5.811 5.203 1.00 0.00 O HETATM 2099 O HOH A 539 25.860 -31.434 17.119 1.00 0.00 O HETATM 2102 O HOH A 540 15.246 31.291 19.667 1.00 0.00 O HETATM 2105 O HOH A 541 47.937 -58.039 31.799 1.00 0.00 O HETATM 2108 O HOH A 542 -32.372 -1.608 43.449 1.00 0.00 O HETATM 2111 O HOH A 543 19.670 -19.566 12.496 1.00 0.00 O HETATM 2114 O HOH A 544 14.715 45.021 19.287 1.00 0.00 O HETATM 2117 O HOH A 545 8.650 -0.899 3.220 1.00 0.00 O HETATM 2120 O HOH A 546 -4.046 -4.403 13.734 1.00 0.00 O HETATM 2123 O HOH A 547 5.266 32.111 -7.910 1.00 0.00 O HETATM 2126 O HOH A 548 -3.388 -21.725 -14.734 1.00 0.00 O HETATM 2129 O HOH A 549 -44.095 10.065 -14.462 1.00 0.00 O HETATM 2132 O HOH A 550 8.352 10.695 -52.427 1.00 0.00 O HETATM 2135 O HOH A 551 -28.559 -2.378 -42.020 1.00 0.00 O HETATM 2138 O HOH A 552 -13.880 -54.440 3.925 1.00 0.00 O HETATM 2141 O HOH A 553 -11.291 16.871 19.032 1.00 0.00 O HETATM 2144 O HOH A 554 -26.216 25.014 -4.083 1.00 0.00 O HETATM 2147 O HOH A 555 50.583 30.318 -40.631 1.00 0.00 O HETATM 2150 O HOH A 556 24.293 -42.729 -41.907 1.00 0.00 O HETATM 2153 O HOH A 557 29.464 -28.786 -17.029 1.00 0.00 O HETATM 2156 O HOH A 558 30.465 26.245 -25.594 1.00 0.00 O HETATM 2159 O HOH A 559 -37.302 34.260 39.009 1.00 0.00 O HETATM 2162 O HOH A 560 -22.395 20.919 56.105 1.00 0.00 O HETATM 2165 O HOH A 561 -67.640 62.659 5.036 1.00 0.00 O HETATM 2168 O HOH A 562 -51.649 35.304 -5.481 1.00 0.00 O HETATM 2171 O HOH A 563 -24.982 51.204 -3.018 1.00 0.00 O HETATM 2174 O HOH A 564 10.187 13.462 -10.641 1.00 0.00 O HETATM 2177 O HOH A 565 29.014 14.978 37.924 1.00 0.00 O HETATM 2180 O HOH A 566 -29.505 -36.517 -37.526 1.00 0.00 O HETATM 2183 O HOH A 567 12.686 -22.231 -29.263 1.00 0.00 O HETATM 2186 O HOH A 568 -45.389 18.749 -19.034 1.00 0.00 O HETATM 2189 O HOH A 569 42.786 38.601 29.741 1.00 0.00 O HETATM 2192 O HOH A 570 -38.244 40.910 18.268 1.00 0.00 O HETATM 2195 O HOH A 571 -9.497 34.450 66.642 1.00 0.00 O HETATM 2198 O HOH A 572 6.106 -15.723 -43.430 1.00 0.00 O HETATM 2201 O HOH A 573 57.703 24.148 51.156 1.00 0.00 O HETATM 2204 O HOH A 574 35.007 -26.683 -69.021 1.00 0.00 O HETATM 2207 O HOH A 575 17.235 -24.248 1.417 1.00 0.00 O HETATM 2210 O HOH A 576 16.028 23.314 -58.893 1.00 0.00 O HETATM 2213 O HOH A 577 51.994 12.820 18.313 1.00 0.00 O HETATM 2216 O HOH A 578 -22.561 -28.466 -10.305 1.00 0.00 O HETATM 2219 O HOH A 579 -17.362 -3.230 -43.573 1.00 0.00 O HETATM 2222 O HOH A 580 -7.084 -0.562 -25.624 1.00 0.00 O HETATM 2225 O HOH A 581 -1.376 -22.409 37.891 1.00 0.00 O HETATM 2228 O HOH A 582 67.668 22.014 -44.068 1.00 0.00 O HETATM 2231 O HOH A 583 14.994 -30.511 -31.219 1.00 0.00 O HETATM 2234 O HOH A 584 29.246 -23.078 46.764 1.00 0.00 O HETATM 2237 O HOH A 585 -43.851 8.900 36.356 1.00 0.00 O HETATM 2240 O HOH A 586 -17.778 27.870 37.502 1.00 0.00 O HETATM 2243 O HOH A 587 14.023 -10.212 71.215 1.00 0.00 O HETATM 2246 O HOH A 588 -38.335 -8.775 54.836 1.00 0.00 O HETATM 2249 O HOH A 589 16.842 -16.464 36.370 1.00 0.00 O HETATM 2252 O HOH A 590 64.127 -14.599 -13.798 1.00 0.00 O HETATM 2255 O HOH A 591 21.325 38.193 14.542 1.00 0.00 O HETATM 2258 O HOH A 592 -20.025 -8.879 4.343 1.00 0.00 O HETATM 2261 O HOH A 593 -26.694 -60.930 -12.463 1.00 0.00 O HETATM 2264 O HOH A 594 10.284 -1.015 45.803 1.00 0.00 O HETATM 2267 O HOH A 595 41.436 -16.846 54.636 1.00 0.00 O HETATM 2270 O HOH A 596 7.148 55.924 8.714 1.00 0.00 O HETATM 2273 O HOH A 597 -24.113 -61.043 -17.466 1.00 0.00 O HETATM 2276 O HOH A 598 3.341 21.455 -28.385 1.00 0.00 O HETATM 2279 O HOH A 599 -71.058 -19.704 18.375 1.00 0.00 O HETATM 2282 O HOH A 600 23.097 27.525 91.815 1.00 0.00 O HETATM 2285 O HOH A 601 -27.328 -0.386 -65.467 1.00 0.00 O HETATM 2288 O HOH A 602 -16.686 6.905 59.386 1.00 0.00 O HETATM 2291 O HOH A 603 54.465 -17.950 86.407 1.00 0.00 O HETATM 2294 O HOH A 604 -26.669 -19.332 1.878 1.00 0.00 O HETATM 2297 O HOH A 605 46.190 -21.032 15.553 1.00 0.00 O HETATM 2300 O HOH A 606 11.590 3.462 31.689 1.00 0.00 O HETATM 2303 O HOH A 607 20.975 -22.980 4.569 1.00 0.00 O HETATM 2306 O HOH A 608 21.097 -2.151 -51.165 1.00 0.00 O HETATM 2309 O HOH A 609 -23.869 -47.668 -57.063 1.00 0.00 O HETATM 2312 O HOH A 610 10.709 -0.245 7.386 1.00 0.00 O HETATM 2315 O HOH A 611 -17.995 -18.385 7.883 1.00 0.00 O HETATM 2318 O HOH A 612 -30.272 8.357 25.306 1.00 0.00 O HETATM 2321 O HOH A 613 16.646 39.226 -63.258 1.00 0.00 O HETATM 2324 O HOH A 614 5.040 -63.633 -2.234 1.00 0.00 O HETATM 2327 O HOH A 615 -1.731 34.900 43.107 1.00 0.00 O HETATM 2330 O HOH A 616 -17.777 -4.274 47.494 1.00 0.00 O HETATM 2333 O HOH A 617 -49.807 -8.232 41.707 1.00 0.00 O HETATM 2336 O HOH A 618 4.787 -60.417 -32.676 1.00 0.00 O HETATM 2339 O HOH A 619 -26.410 26.801 5.516 1.00 0.00 O HETATM 2342 O HOH A 620 69.240 -21.370 -0.479 1.00 0.00 O HETATM 2345 O HOH A 621 -23.790 -50.692 -69.616 1.00 0.00 O HETATM 2348 O HOH A 622 19.229 48.880 27.189 1.00 0.00 O HETATM 2351 O HOH A 623 47.485 43.618 -14.446 1.00 0.00 O HETATM 2354 O HOH A 624 -33.942 4.191 27.211 1.00 0.00 O HETATM 2357 O HOH A 625 6.355 -21.520 -52.179 1.00 0.00 O HETATM 2360 O HOH A 626 16.686 -3.160 23.472 1.00 0.00 O HETATM 2363 O HOH A 627 32.812 -27.274 33.184 1.00 0.00 O HETATM 2366 O HOH A 628 -55.679 -23.783 -8.693 1.00 0.00 O HETATM 2369 O HOH A 629 -60.007 44.243 45.210 1.00 0.00 O HETATM 2372 O HOH A 630 17.996 -46.098 24.698 1.00 0.00 O HETATM 2375 O HOH A 631 16.957 21.995 -6.883 1.00 0.00 O HETATM 2378 O HOH A 632 -12.373 -14.291 -7.111 1.00 0.00 O HETATM 2381 O HOH A 633 -55.156 54.956 -53.987 1.00 0.00 O HETATM 2384 O HOH A 634 30.251 -9.371 -39.627 1.00 0.00 O HETATM 2387 O HOH A 635 -16.036 -30.513 36.105 1.00 0.00 O HETATM 2390 O HOH A 636 14.417 10.419 -21.495 1.00 0.00 O HETATM 2393 O HOH A 637 -39.499 15.377 65.621 1.00 0.00 O HETATM 2396 O HOH A 638 19.924 29.086 -22.800 1.00 0.00 O HETATM 2399 O HOH A 639 9.488 10.519 25.454 1.00 0.00 O HETATM 2402 O HOH A 640 7.171 -41.193 -0.537 1.00 0.00 O HETATM 2405 O HOH A 641 70.445 -20.947 -5.444 1.00 0.00 O HETATM 2408 O HOH A 642 23.258 -45.772 41.757 1.00 0.00 O HETATM 2411 O HOH A 643 7.300 27.973 29.586 1.00 0.00 O HETATM 2414 O HOH A 644 -72.489 55.484 43.203 1.00 0.00 O HETATM 2417 O HOH A 645 43.173 -34.482 35.904 1.00 0.00 O HETATM 2420 O HOH A 646 -24.669 -42.577 73.816 1.00 0.00 O HETATM 2423 O HOH A 647 -8.545 27.034 0.837 1.00 0.00 O HETATM 2426 O HOH A 648 -24.473 13.660 104.800 1.00 0.00 O HETATM 2429 O HOH A 649 -37.861 8.089 39.900 1.00 0.00 O HETATM 2432 O HOH A 650 -27.696 22.493 -62.415 1.00 0.00 O HETATM 2435 O HOH A 651 4.116 -10.656 7.376 1.00 0.00 O HETATM 2438 O HOH A 652 68.241 -30.205 23.872 1.00 0.00 O HETATM 2441 O HOH A 653 -5.530 49.926 15.903 1.00 0.00 O HETATM 2444 O HOH A 654 19.860 3.840 25.272 1.00 0.00 O HETATM 2447 O HOH A 655 -56.675 -4.978 -51.002 1.00 0.00 O HETATM 2450 O HOH A 656 2.447 -25.322 -4.586 1.00 0.00 O HETATM 2453 O HOH A 657 -7.033 40.463 10.531 1.00 0.00 O HETATM 2456 O HOH A 658 -20.005 36.635 -29.754 1.00 0.00 O HETATM 2459 O HOH A 659 2.517 -45.100 30.393 1.00 0.00 O HETATM 2462 O HOH A 660 20.489 -14.004 19.888 1.00 0.00 O HETATM 2465 O HOH A 661 36.510 36.714 7.167 1.00 0.00 O HETATM 2468 O HOH A 662 44.774 -35.819 40.968 1.00 0.00 O HETATM 2471 O HOH A 663 48.053 -3.105 4.643 1.00 0.00 O HETATM 2474 O HOH A 664 -27.738 22.424 56.226 1.00 0.00 O HETATM 2477 O HOH A 665 -39.926 -40.481 18.427 1.00 0.00 O HETATM 2480 O HOH A 666 -47.237 -19.138 68.810 1.00 0.00 O HETATM 2483 O HOH A 667 -25.204 33.868 56.597 1.00 0.00 O HETATM 2486 O HOH A 668 15.823 -52.844 -40.772 1.00 0.00 O HETATM 2489 O HOH A 669 -51.357 -18.819 -39.907 1.00 0.00 O HETATM 2492 O HOH A 670 18.550 29.446 -12.129 1.00 0.00 O HETATM 2495 O HOH A 671 4.830 -4.931 28.642 1.00 0.00 O HETATM 2498 O HOH A 672 67.330 -45.960 6.118 1.00 0.00 O HETATM 2501 O HOH A 673 -22.372 -1.286 6.615 1.00 0.00 O HETATM 2504 O HOH A 674 67.772 -33.680 -13.044 1.00 0.00 O HETATM 2507 O HOH A 675 15.103 -74.949 26.534 1.00 0.00 O HETATM 2510 O HOH A 676 -71.707 -5.163 11.832 1.00 0.00 O HETATM 2513 O HOH A 677 29.957 20.780 8.889 1.00 0.00 O HETATM 2516 O HOH A 678 17.060 7.447 6.892 1.00 0.00 O HETATM 2519 O HOH A 679 -20.958 -47.558 -12.201 1.00 0.00 O HETATM 2522 O HOH A 680 56.951 -15.110 26.536 1.00 0.00 O HETATM 2525 O HOH A 681 47.672 46.405 25.468 1.00 0.00 O HETATM 2528 O HOH A 682 6.919 41.129 90.073 1.00 0.00 O HETATM 2531 O HOH A 683 14.176 22.664 -52.227 1.00 0.00 O HETATM 2534 O HOH A 684 16.606 -11.594 4.713 1.00 0.00 O HETATM 2537 O HOH A 685 -95.240 58.768 -59.823 1.00 0.00 O HETATM 2540 O HOH A 686 5.807 37.675 22.092 1.00 0.00 O HETATM 2543 O HOH A 687 12.274 24.913 34.264 1.00 0.00 O HETATM 2546 O HOH A 688 -26.661 43.825 27.253 1.00 0.00 O HETATM 2549 O HOH A 689 -31.882 32.360 -20.912 1.00 0.00 O HETATM 2552 O HOH A 690 0.523 52.134 -6.614 1.00 0.00 O HETATM 2555 O HOH A 691 -11.523 17.280 -4.406 1.00 0.00 O HETATM 2558 O HOH A 692 -8.521 21.271 -15.955 1.00 0.00 O HETATM 2561 O HOH A 693 5.613 -11.893 71.545 1.00 0.00 O HETATM 2564 O HOH A 694 -44.881 -60.970 30.049 1.00 0.00 O HETATM 2567 O HOH A 695 36.432 31.606 -32.971 1.00 0.00 O HETATM 2570 O HOH A 696 20.586 -10.412 -13.150 1.00 0.00 O HETATM 2573 O HOH A 697 -7.041 -17.585 4.622 1.00 0.00 O HETATM 2576 O HOH A 698 -6.265 44.335 -47.295 1.00 0.00 O HETATM 2579 O HOH A 699 -26.407 29.855 37.128 1.00 0.00 O HETATM 2582 O HOH A 700 -18.239 2.435 -10.082 1.00 0.00 O HETATM 2585 O HOH A 701 20.550 -2.418 -30.916 1.00 0.00 O HETATM 2588 O HOH A 702 43.262 45.595 -44.881 1.00 0.00 O HETATM 2591 O HOH A 703 -29.699 8.367 -15.267 1.00 0.00 O HETATM 2594 O HOH A 704 21.210 49.683 2.441 1.00 0.00 O HETATM 2597 O HOH A 705 -40.717 48.173 37.076 1.00 0.00 O HETATM 2600 O HOH A 706 5.041 -44.299 51.431 1.00 0.00 O HETATM 2603 O HOH A 707 -21.236 34.043 -0.710 1.00 0.00 O HETATM 2606 O HOH A 708 -17.916 2.427 59.779 1.00 0.00 O HETATM 2609 O HOH A 709 -17.226 -62.930 -14.474 1.00 0.00 O HETATM 2612 O HOH A 710 28.183 29.652 1.000 1.00 0.00 O HETATM 2615 O HOH A 711 13.952 6.845 -47.997 1.00 0.00 O HETATM 2618 O HOH A 712 0.764 20.445 -28.382 1.00 0.00 O HETATM 2621 O HOH A 713 -34.824 -37.023 30.972 1.00 0.00 O HETATM 2624 O HOH A 714 -10.156 -11.875 42.563 1.00 0.00 O HETATM 2627 O HOH A 715 26.869 3.247 37.965 1.00 0.00 O HETATM 2630 O HOH A 716 32.171 36.339 12.804 1.00 0.00 O HETATM 2633 O HOH A 717 -33.480 18.085 -31.621 1.00 0.00 O HETATM 2636 O HOH A 718 21.375 -39.332 -33.090 1.00 0.00 O HETATM 2639 O HOH A 719 29.341 -46.275 36.305 1.00 0.00 O HETATM 2642 O HOH A 720 -76.551 4.179 44.312 1.00 0.00 O HETATM 2645 O HOH A 721 37.176 -30.595 43.679 1.00 0.00 O HETATM 2648 O HOH A 722 -30.995 4.240 33.845 1.00 0.00 O HETATM 2651 O HOH A 723 24.307 -32.955 10.407 1.00 0.00 O HETATM 2654 O HOH A 724 93.824 0.306 38.125 1.00 0.00 O HETATM 2657 O HOH A 725 -3.440 -12.329 -6.097 1.00 0.00 O HETATM 2660 O HOH A 726 12.143 33.521 2.181 1.00 0.00 O HETATM 2663 O HOH A 727 2.537 -22.782 -8.312 1.00 0.00 O HETATM 2666 O HOH A 728 0.202 11.803 36.126 1.00 0.00 O HETATM 2669 O HOH A 729 13.834 -26.009 -16.564 1.00 0.00 O HETATM 2672 O HOH A 730 -27.435 -19.420 55.501 1.00 0.00 O HETATM 2675 O HOH A 731 -10.093 -24.055 18.050 1.00 0.00 O HETATM 2678 O HOH A 732 -2.601 -19.164 26.805 1.00 0.00 O HETATM 2681 O HOH A 733 -26.857 10.029 -17.440 1.00 0.00 O HETATM 2684 O HOH A 734 22.057 -17.672 -45.532 1.00 0.00 O HETATM 2687 O HOH A 735 17.839 -4.369 -29.661 1.00 0.00 O HETATM 2690 O HOH A 736 35.565 -21.044 82.531 1.00 0.00 O HETATM 2693 O HOH A 737 33.505 47.338 40.273 1.00 0.00 O HETATM 2696 O HOH A 738 21.874 20.362 -13.786 1.00 0.00 O HETATM 2699 O HOH A 739 -19.672 -19.984 11.156 1.00 0.00 O HETATM 2702 O HOH A 740 31.104 -41.597 -32.055 1.00 0.00 O HETATM 2705 O HOH A 741 31.142 25.911 -43.447 1.00 0.00 O HETATM 2708 O HOH A 742 -9.231 -20.415 18.950 1.00 0.00 O HETATM 2711 O HOH A 743 -23.621 -54.148 22.375 1.00 0.00 O HETATM 2714 O HOH A 744 -69.292 27.860 -35.823 1.00 0.00 O HETATM 2717 O HOH A 745 -15.433 -5.248 -52.567 1.00 0.00 O HETATM 2720 O HOH A 746 56.590 -13.728 10.791 1.00 0.00 O HETATM 2723 O HOH A 747 -33.585 36.645 15.570 1.00 0.00 O HETATM 2726 O HOH A 748 37.984 -21.615 -22.120 1.00 0.00 O HETATM 2729 O HOH A 749 45.176 18.436 16.168 1.00 0.00 O HETATM 2732 O HOH A 750 -46.327 45.558 43.609 1.00 0.00 O HETATM 2735 O HOH A 751 1.732 21.641 -25.622 1.00 0.00 O HETATM 2738 O HOH A 752 -67.369 -5.180 -17.879 1.00 0.00 O HETATM 2741 O HOH A 753 27.055 79.820 1.000 1.00 0.00 O HETATM 2744 O HOH A 754 -27.985 38.047 -56.077 1.00 0.00 O HETATM 2747 O HOH A 755 -38.350 54.202 -80.328 1.00 0.00 O HETATM 2750 O HOH A 756 -42.287 -12.462 -54.219 1.00 0.00 O HETATM 2753 O HOH A 757 5.215 55.707 -19.586 1.00 0.00 O HETATM 2756 O HOH A 758 -7.292 -28.509 -32.010 1.00 0.00 O HETATM 2759 O HOH A 759 28.255 -2.505 66.411 1.00 0.00 O HETATM 2762 O HOH A 760 -15.171 5.559 19.647 1.00 0.00 O HETATM 2765 O HOH A 761 7.005 23.450 40.742 1.00 0.00 O HETATM 2768 O HOH A 762 -11.930 -6.455 21.953 1.00 0.00 O HETATM 2771 O HOH A 763 51.833 15.745 -31.964 1.00 0.00 O HETATM 2774 O HOH A 764 -41.629 -13.713 -41.999 1.00 0.00 O HETATM 2777 O HOH A 765 -44.111 69.929 5.217 1.00 0.00 O HETATM 2780 O HOH A 766 -27.635 -35.456 10.614 1.00 0.00 O HETATM 2783 O HOH A 767 12.313 9.206 90.188 1.00 0.00 O HETATM 2786 O HOH A 768 5.302 15.246 58.529 1.00 0.00 O HETATM 2789 O HOH A 769 20.873 0.027 24.217 1.00 0.00 O HETATM 2792 O HOH A 770 12.955 -45.894 1.009 1.00 0.00 O HETATM 2795 O HOH A 771 31.897 -18.185 1.323 1.00 0.00 O HETATM 2798 O HOH A 772 66.562 32.703 23.629 1.00 0.00 O HETATM 2801 O HOH A 773 -14.203 35.246 -11.326 1.00 0.00 O HETATM 2804 O HOH A 774 -4.582 1.879 8.043 1.00 0.00 O HETATM 2807 O HOH A 775 24.578 26.510 -30.493 1.00 0.00 O HETATM 2810 O HOH A 776 40.783 -9.354 -27.154 1.00 0.00 O HETATM 2813 O HOH A 777 -11.430 -56.971 -9.504 1.00 0.00 O HETATM 2816 O HOH A 778 -22.219 29.421 35.158 1.00 0.00 O HETATM 2819 O HOH A 779 -9.340 45.425 49.887 1.00 0.00 O HETATM 2822 O HOH A 780 5.078 -21.756 -39.253 1.00 0.00 O HETATM 2825 O HOH A 781 -9.420 -34.080 8.766 1.00 0.00 O HETATM 2828 O HOH A 782 1.124 47.229 22.610 1.00 0.00 O HETATM 2831 O HOH A 783 -26.220 -6.587 13.759 1.00 0.00 O HETATM 2834 O HOH A 784 22.659 34.284 8.607 1.00 0.00 O HETATM 2837 O HOH A 785 -9.154 -9.825 28.809 1.00 0.00 O HETATM 2840 O HOH A 786 4.862 -15.964 -13.902 1.00 0.00 O HETATM 2843 O HOH A 787 12.450 15.961 14.206 1.00 0.00 O HETATM 2846 O HOH A 788 -16.500 -60.306 -39.909 1.00 0.00 O HETATM 2849 O HOH A 789 27.641 23.382 -58.066 1.00 0.00 O HETATM 2852 O HOH A 790 7.570 -3.998 -15.884 1.00 0.00 O HETATM 2855 O HOH A 791 30.189 11.565 23.552 1.00 0.00 O HETATM 2858 O HOH A 792 18.885 -9.237 53.497 1.00 0.00 O HETATM 2861 O HOH A 793 7.178 -10.984 -29.703 1.00 0.00 O HETATM 2864 O HOH A 794 34.159 -3.820 39.388 1.00 0.00 O HETATM 2867 O HOH A 795 12.303 -18.682 -16.718 1.00 0.00 O HETATM 2870 O HOH A 796 27.616 12.675 41.608 1.00 0.00 O HETATM 2873 O HOH A 797 -44.744 -9.886 -6.718 1.00 0.00 O HETATM 2876 O HOH A 798 24.238 -2.713 -19.794 1.00 0.00 O HETATM 2879 O HOH A 799 -3.106 -32.169 -15.206 1.00 0.00 O HETATM 2882 O HOH A 800 -11.645 23.772 -9.384 1.00 0.00 O HETATM 2885 O HOH A 801 22.219 -28.171 -11.245 1.00 0.00 O HETATM 2888 O HOH A 802 -31.434 36.084 -4.487 1.00 0.00 O HETATM 2891 O HOH A 803 8.798 -10.417 -43.432 1.00 0.00 O HETATM 2894 O HOH A 804 4.093 5.482 20.151 1.00 0.00 O HETATM 2897 O HOH A 805 22.848 31.768 3.666 1.00 0.00 O HETATM 2900 O HOH A 806 15.066 51.728 19.870 1.00 0.00 O HETATM 2903 O HOH A 807 17.974 40.232 33.566 1.00 0.00 O HETATM 2906 O HOH A 808 -50.601 63.407 -9.169 1.00 0.00 O HETATM 2909 O HOH A 809 -62.048 13.847 -49.445 1.00 0.00 O HETATM 2912 O HOH A 810 53.352 30.007 63.721 1.00 0.00 O HETATM 2915 O HOH A 811 4.180 -67.315 -29.636 1.00 0.00 O HETATM 2918 O HOH A 812 16.967 68.634 -13.097 1.00 0.00 O HETATM 2921 O HOH A 813 -31.699 -82.124 -19.518 1.00 0.00 O HETATM 2924 O HOH A 814 -16.569 -6.585 -71.257 1.00 0.00 O HETATM 2927 O HOH A 815 -17.485 5.122 -10.445 1.00 0.00 O HETATM 2930 O HOH A 816 -46.286 -44.585 12.640 1.00 0.00 O HETATM 2933 O HOH A 817 -17.581 -9.511 -22.909 1.00 0.00 O HETATM 2936 O HOH A 818 20.409 36.903 -29.933 1.00 0.00 O HETATM 2939 O HOH A 819 33.848 -10.412 13.823 1.00 0.00 O HETATM 2942 O HOH A 820 -56.789 12.639 -49.941 1.00 0.00 O HETATM 2945 O HOH A 821 28.971 -43.765 -20.937 1.00 0.00 O HETATM 2948 O HOH A 822 -11.727 -62.243 -5.701 1.00 0.00 O HETATM 2951 O HOH A 823 -55.179 -17.754 -17.864 1.00 0.00 O HETATM 2954 O HOH A 824 41.207 -35.155 -9.764 1.00 0.00 O HETATM 2957 O HOH A 825 -2.207 8.924 16.257 1.00 0.00 O HETATM 2960 O HOH A 826 -6.691 -42.652 -31.000 1.00 0.00 O HETATM 2963 O HOH A 827 -20.701 -34.514 5.751 1.00 0.00 O HETATM 2966 O HOH A 828 59.702 -5.706 9.792 1.00 0.00 O HETATM 2969 O HOH A 829 13.011 6.165 10.944 1.00 0.00 O HETATM 2972 O HOH A 830 -7.726 3.914 -50.883 1.00 0.00 O HETATM 2975 O HOH A 831 13.797 1.380 -68.821 1.00 0.00 O HETATM 2978 O HOH A 832 41.421 -36.013 -40.259 1.00 0.00 O HETATM 2981 O HOH A 833 53.017 0.864 6.479 1.00 0.00 O HETATM 2984 O HOH A 834 -17.035 -55.200 37.355 1.00 0.00 O HETATM 2987 O HOH A 835 11.698 -48.407 -30.860 1.00 0.00 O HETATM 2990 O HOH A 836 81.533 28.165 66.576 1.00 0.00 O HETATM 2993 O HOH A 837 -12.095 19.911 35.518 1.00 0.00 O HETATM 2996 O HOH A 838 47.167 -9.144 37.968 1.00 0.00 O HETATM 2999 O HOH A 839 15.381 -14.625 -12.844 1.00 0.00 O HETATM 3002 O HOH A 840 -1.629 -54.148 -8.325 1.00 0.00 O HETATM 3005 O HOH A 841 3.663 13.784 -41.600 1.00 0.00 O HETATM 3008 O HOH A 842 31.535 -48.823 -26.268 1.00 0.00 O HETATM 3011 O HOH A 843 12.807 -11.836 16.688 1.00 0.00 O HETATM 3014 O HOH A 844 1.849 21.546 -22.399 1.00 0.00 O HETATM 3017 O HOH A 845 9.694 -34.428 -0.455 1.00 0.00 O HETATM 3020 O HOH A 846 -26.821 17.345 -18.150 1.00 0.00 O HETATM 3023 O HOH A 847 -37.473 67.034 -55.329 1.00 0.00 O HETATM 3026 O HOH A 848 -16.984 -32.554 23.044 1.00 0.00 O HETATM 3029 O HOH A 849 -49.791 95.501 -33.964 1.00 0.00 O HETATM 3032 O HOH A 850 61.146 24.306 92.813 1.00 0.00 O HETATM 3035 O HOH A 851 43.784 -4.229 12.847 1.00 0.00 O HETATM 3038 O HOH A 852 9.085 -10.600 -8.793 1.00 0.00 O HETATM 3041 O HOH A 853 -5.044 15.343 -11.421 1.00 0.00 O HETATM 3044 O HOH A 854 50.065 8.951 -25.490 1.00 0.00 O HETATM 3047 O HOH A 855 28.133 14.377 31.327 1.00 0.00 O HETATM 3050 O HOH A 856 3.047 -66.124 -46.569 1.00 0.00 O HETATM 3053 O HOH A 857 40.736 -30.269 -41.840 1.00 0.00 O HETATM 3056 O HOH A 858 25.439 -7.982 -22.970 1.00 0.00 O HETATM 3059 O HOH A 859 34.429 7.606 28.135 1.00 0.00 O HETATM 3062 O HOH A 860 -32.202 -4.894 31.431 1.00 0.00 O HETATM 3065 O HOH A 861 -18.849 -26.605 -4.967 1.00 0.00 O HETATM 3068 O HOH A 862 -59.868 -9.273 43.898 1.00 0.00 O HETATM 3071 O HOH A 863 9.374 -15.434 12.697 1.00 0.00 O HETATM 3074 O HOH A 864 -3.369 21.127 -19.321 1.00 0.00 O HETATM 3077 O HOH A 865 -7.387 24.210 20.343 1.00 0.00 O HETATM 3080 O HOH A 866 -45.299 12.716 27.687 1.00 0.00 O HETATM 3083 O HOH A 867 -21.206 -13.333 -34.139 1.00 0.00 O HETATM 3086 O HOH A 868 50.820 12.269 -0.087 1.00 0.00 O HETATM 3089 O HOH A 869 -25.693 83.221 -18.561 1.00 0.00 O HETATM 3092 O HOH A 870 -69.115 -13.657 9.963 1.00 0.00 O HETATM 3095 O HOH A 871 32.544 -47.996 14.833 1.00 0.00 O HETATM 3098 O HOH A 872 -79.782 -56.323 -12.852 1.00 0.00 O HETATM 3101 O HOH A 873 22.441 4.070 -94.327 1.00 0.00 O HETATM 3104 O HOH A 874 -37.955 77.319 8.349 1.00 0.00 O HETATM 3107 O HOH A 875 0.111 -2.409 7.430 1.00 0.00 O HETATM 3110 O HOH A 876 -12.932 -64.654 37.266 1.00 0.00 O HETATM 3113 O HOH A 877 52.021 2.944 9.328 1.00 0.00 O HETATM 3116 O HOH A 878 39.880 34.354 33.696 1.00 0.00 O HETATM 3119 O HOH A 879 27.186 -53.994 -47.298 1.00 0.00 O HETATM 3122 O HOH A 880 -32.199 -0.493 -37.516 1.00 0.00 O HETATM 3125 O HOH A 881 9.801 -3.121 10.875 1.00 0.00 O HETATM 3128 O HOH A 882 55.753 14.339 15.094 1.00 0.00 O HETATM 3131 O HOH A 883 -31.244 -28.738 50.424 1.00 0.00 O HETATM 3134 O HOH A 884 -44.939 -29.894 23.344 1.00 0.00 O HETATM 3137 O HOH A 885 11.502 15.734 -0.341 1.00 0.00 O HETATM 3140 O HOH A 886 -18.310 42.308 -28.505 1.00 0.00 O HETATM 3143 O HOH A 887 42.181 5.121 37.445 1.00 0.00 O HETATM 3146 O HOH A 888 35.284 -32.808 25.409 1.00 0.00 O HETATM 3149 O HOH A 889 -6.904 27.538 -6.917 1.00 0.00 O HETATM 3152 O HOH A 890 20.055 85.543 -3.436 1.00 0.00 O HETATM 3155 O HOH A 891 25.788 -2.828 -23.199 1.00 0.00 O HETATM 3158 O HOH A 892 -30.949 59.135 -8.217 1.00 0.00 O HETATM 3161 O HOH A 893 38.515 17.360 20.185 1.00 0.00 O HETATM 3164 O HOH A 894 10.754 -8.661 12.517 1.00 0.00 O HETATM 3167 O HOH A 895 25.876 41.040 -45.158 1.00 0.00 O HETATM 3170 O HOH A 896 -21.471 -8.504 34.355 1.00 0.00 O HETATM 3173 O HOH A 897 -0.348 3.548 34.572 1.00 0.00 O HETATM 3176 O HOH A 898 4.374 -8.499 -35.917 1.00 0.00 O HETATM 3179 O HOH A 899 17.036 -33.974 -42.234 1.00 0.00 O HETATM 3182 O HOH A 900 -51.352 21.057 69.529 1.00 0.00 O HETATM 3185 O HOH A 901 7.232 -27.464 -32.914 1.00 0.00 O HETATM 3188 O HOH A 902 -22.707 -46.889 -5.594 1.00 0.00 O HETATM 3191 O HOH A 903 -38.212 -40.501 -40.254 1.00 0.00 O HETATM 3194 O HOH A 904 5.016 36.745 9.211 1.00 0.00 O HETATM 3197 O HOH A 905 -44.735 10.462 20.514 1.00 0.00 O HETATM 3200 O HOH A 906 -9.275 -49.048 -24.992 1.00 0.00 O HETATM 3203 O HOH A 907 24.548 -73.996 9.161 1.00 0.00 O HETATM 3206 O HOH A 908 23.851 0.707 -70.908 1.00 0.00 O HETATM 3209 O HOH A 909 19.769 -27.319 27.654 1.00 0.00 O HETATM 3212 O HOH A 910 -24.445 1.726 -15.493 1.00 0.00 O HETATM 3215 O HOH A 911 -15.193 -28.363 34.075 1.00 0.00 O HETATM 3218 O HOH A 912 -64.285 37.550 -6.191 1.00 0.00 O HETATM 3221 O HOH A 913 23.651 -11.125 5.215 1.00 0.00 O HETATM 3224 O HOH A 914 9.673 25.212 19.307 1.00 0.00 O HETATM 3227 O HOH A 915 -33.301 22.664 0.645 1.00 0.00 O HETATM 3230 O HOH A 916 7.634 56.723 14.544 1.00 0.00 O HETATM 3233 O HOH A 917 -53.549 -4.781 0.072 1.00 0.00 O HETATM 3236 O HOH A 918 -25.134 44.890 11.289 1.00 0.00 O HETATM 3239 O HOH A 919 -13.304 52.747 48.132 1.00 0.00 O HETATM 3242 O HOH A 920 59.845 16.452 -53.105 1.00 0.00 O HETATM 3245 O HOH A 921 3.519 5.705 5.389 1.00 0.00 O HETATM 3248 O HOH A 922 30.130 9.820 -25.893 1.00 0.00 O HETATM 3251 O HOH A 923 -49.232 27.478 29.489 1.00 0.00 O HETATM 3254 O HOH A 924 0.049 6.032 -14.610 1.00 0.00 O HETATM 3257 O HOH A 925 -3.734 -22.244 -10.286 1.00 0.00 O HETATM 3260 O HOH A 926 0.617 25.386 34.892 1.00 0.00 O HETATM 3263 O HOH A 927 59.422 -44.848 -37.805 1.00 0.00 O HETATM 3266 O HOH A 928 16.900 1.277 -23.734 1.00 0.00 O HETATM 3269 O HOH A 929 38.568 7.756 23.025 1.00 0.00 O HETATM 3272 O HOH A 930 -58.218 16.373 18.294 1.00 0.00 O HETATM 3275 O HOH A 931 -110.910 2.231 -19.033 1.00 0.00 O HETATM 3278 O HOH A 932 16.820 12.907 -2.233 1.00 0.00 O HETATM 3281 O HOH A 933 -16.008 24.411 -18.333 1.00 0.00 O HETATM 3284 O HOH A 934 -13.297 37.523 -10.148 1.00 0.00 O HETATM 3287 O HOH A 935 35.278 15.858 30.060 1.00 0.00 O HETATM 3290 O HOH A 936 -13.733 -73.328 19.494 1.00 0.00 O HETATM 3293 O HOH A 937 24.666 -35.411 19.986 1.00 0.00 O HETATM 3296 O HOH A 938 -5.246 -33.138 27.802 1.00 0.00 O HETATM 3299 O HOH A 939 -70.739 50.745 -3.043 1.00 0.00 O HETATM 3302 O HOH A 940 -23.656 27.488 1.898 1.00 0.00 O HETATM 3305 O HOH A 941 46.959 2.246 -18.233 1.00 0.00 O HETATM 3308 O HOH A 942 24.751 -14.029 -50.611 1.00 0.00 O HETATM 3311 O HOH A 943 0.653 -23.187 50.041 1.00 0.00 O HETATM 3314 O HOH A 944 -87.918 56.446 35.583 1.00 0.00 O HETATM 3317 O HOH A 945 -30.574 117.253 41.151 1.00 0.00 O HETATM 3320 O HOH A 946 16.703 5.969 -1.435 1.00 0.00 O HETATM 3323 O HOH A 947 19.132 4.517 -6.433 1.00 0.00 O HETATM 3326 O HOH A 948 16.143 -29.512 30.400 1.00 0.00 O HETATM 3329 O HOH A 949 -8.256 -8.033 -1.849 1.00 0.00 O HETATM 3332 O HOH A 950 7.541 59.128 -45.419 1.00 0.00 O HETATM 3335 O HOH A 951 -51.789 1.236 43.954 1.00 0.00 O HETATM 3338 O HOH A 952 36.177 57.022 -30.901 1.00 0.00 O HETATM 3341 O HOH A 953 -31.584 -11.234 2.125 1.00 0.00 O HETATM 3344 O HOH A 954 -62.841 -8.670 44.737 1.00 0.00 O HETATM 3347 O HOH A 955 47.917 -21.672 4.422 1.00 0.00 O HETATM 3350 O HOH A 956 45.655 19.894 -35.839 1.00 0.00 O HETATM 3353 O HOH A 957 44.616 6.575 -42.174 1.00 0.00 O HETATM 3356 O HOH A 958 -13.778 30.814 -23.684 1.00 0.00 O HETATM 3359 O HOH A 959 25.192 -38.576 -51.461 1.00 0.00 O HETATM 3362 O HOH A 960 -53.927 -62.705 37.256 1.00 0.00 O HETATM 3365 O HOH A 961 0.407 -28.632 5.996 1.00 0.00 O HETATM 3368 O HOH A 962 34.205 50.961 34.621 1.00 0.00 O HETATM 3371 O HOH A 963 -54.619 4.288 37.292 1.00 0.00 O HETATM 3374 O HOH A 964 -26.954 -33.832 -28.529 1.00 0.00 O HETATM 3377 O HOH A 965 103.417 21.514 -31.749 1.00 0.00 O HETATM 3380 O HOH A 966 16.562 18.368 23.527 1.00 0.00 O HETATM 3383 O HOH A 967 12.485 -30.913 -32.885 1.00 0.00 O HETATM 3386 O HOH A 968 36.046 -15.983 31.705 1.00 0.00 O HETATM 3389 O HOH A 969 20.060 16.455 23.893 1.00 0.00 O HETATM 3392 O HOH A 970 2.110 -48.062 48.957 1.00 0.00 O HETATM 3395 O HOH A 971 -31.724 -10.362 -14.321 1.00 0.00 O HETATM 3398 O HOH A 972 15.413 11.664 -60.770 1.00 0.00 O HETATM 3401 O HOH A 973 22.656 -2.565 -26.292 1.00 0.00 O HETATM 3404 O HOH A 974 9.874 -76.806 2.294 1.00 0.00 O HETATM 3407 O HOH A 975 -9.826 -42.051 -13.228 1.00 0.00 O HETATM 3410 O HOH A 976 -50.619 25.122 -0.226 1.00 0.00 O HETATM 3413 O HOH A 977 6.627 -21.540 -58.321 1.00 0.00 O HETATM 3416 O HOH A 978 52.465 2.806 35.077 1.00 0.00 O HETATM 3419 O HOH A 979 50.551 15.896 4.020 1.00 0.00 O HETATM 3422 O HOH A 980 74.608 18.369 -52.344 1.00 0.00 O HETATM 3425 O HOH A 981 13.738 -29.893 -27.176 1.00 0.00 O HETATM 3428 O HOH A 982 -67.352 15.989 -38.525 1.00 0.00 O HETATM 3431 O HOH A 983 37.800 -15.262 39.424 1.00 0.00 O HETATM 3434 O HOH A 984 21.457 -4.912 -37.937 1.00 0.00 O HETATM 3437 O HOH A 985 -37.901 24.042 -58.118 1.00 0.00 O HETATM 3440 O HOH A 986 38.400 29.215 3.284 1.00 0.00 O HETATM 3443 O HOH A 987 -5.047 25.098 -9.098 1.00 0.00 O HETATM 3446 O HOH A 988 -41.191 29.411 -2.570 1.00 0.00 O HETATM 3449 O HOH A 989 67.276 12.837 19.837 1.00 0.00 O HETATM 3452 O HOH A 990 12.914 26.436 -27.584 1.00 0.00 O HETATM 3455 O HOH A 991 4.493 72.745 -50.954 1.00 0.00 O HETATM 3458 O HOH A 992 27.589 -46.379 32.709 1.00 0.00 O HETATM 3461 O HOH A 993 -73.588 -9.015 16.717 1.00 0.00 O HETATM 3464 O HOH A 994 9.144 69.123 -6.973 1.00 0.00 O HETATM 3467 O HOH A 995 21.167 -42.029 -55.697 1.00 0.00 O HETATM 3470 O HOH A 996 30.271 3.928 20.931 1.00 0.00 O HETATM 3473 O HOH A 997 -27.793 2.650 -80.472 1.00 0.00 O HETATM 3476 O HOH A 998 -27.436 11.851 -59.388 1.00 0.00 O HETATM 3479 O HOH A 999 -32.553 34.502 -53.627 1.00 0.00 O HETATM 3482 O HOH A1000 -73.536 -40.663 8.790 1.00 0.00 O HETATM 3485 O HOH A1001 -37.395 25.037 -22.543 1.00 0.00 O HETATM 3488 O HOH A1002 -28.409 17.595 -7.287 1.00 0.00 O HETATM 3491 O HOH A1003 -16.403 38.815 53.941 1.00 0.00 O HETATM 3494 O HOH A1004 19.215 -79.865 29.533 1.00 0.00 O HETATM 3497 O HOH A1005 27.586 4.313 -84.077 1.00 0.00 O HETATM 3500 O HOH A1006 -30.550 -19.407 55.902 1.00 0.00 O HETATM 3503 O HOH A1007 -7.037 26.349 -13.518 1.00 0.00 O HETATM 3506 O HOH A1008 -38.246 16.939 38.139 1.00 0.00 O HETATM 3509 O HOH A1009 -11.309 -64.840 -21.266 1.00 0.00 O HETATM 3512 O HOH A1010 73.759 -16.897 13.279 1.00 0.00 O HETATM 3515 O HOH A1011 -5.445 3.192 39.799 1.00 0.00 O HETATM 3518 O HOH A1012 48.843 14.836 10.277 1.00 0.00 O HETATM 3521 O HOH A1013 -17.753 -16.358 -1.414 1.00 0.00 O HETATM 3524 O HOH A1014 -17.442 -21.579 13.452 1.00 0.00 O HETATM 3527 O HOH A1015 67.501 34.544 -15.361 1.00 0.00 O HETATM 3530 O HOH A1016 14.873 22.721 -38.275 1.00 0.00 O HETATM 3533 O HOH A1017 11.057 2.749 -36.298 1.00 0.00 O HETATM 3536 O HOH A1018 45.465 20.818 -32.062 1.00 0.00 O HETATM 3539 O HOH A1019 -74.103 14.434 -7.966 1.00 0.00 O HETATM 3542 O HOH A1020 -2.378 -14.014 21.959 1.00 0.00 O HETATM 3545 O HOH A1021 16.209 60.161 42.428 1.00 0.00 O HETATM 3548 O HOH A1022 49.366 -24.442 17.171 1.00 0.00 O HETATM 3551 O HOH A1023 8.251 -18.496 4.431 1.00 0.00 O HETATM 3554 O HOH A1024 17.609 27.196 18.048 1.00 0.00 O HETATM 3557 O HOH A1025 27.395 44.998 24.187 1.00 0.00 O HETATM 3560 O HOH A1026 -16.317 17.409 3.124 1.00 0.00 O HETATM 3563 O HOH A1027 24.362 8.759 -35.229 1.00 0.00 O HETATM 3566 O HOH A1028 -17.924 -20.792 9.200 1.00 0.00 O HETATM 3569 O HOH A1029 3.344 -34.411 -18.727 1.00 0.00 O HETATM 3572 O HOH A1030 16.907 -0.835 -6.291 1.00 0.00 O HETATM 3575 O HOH A1031 5.897 -42.312 5.577 1.00 0.00 O HETATM 3578 O HOH A1032 16.957 -25.389 -25.064 1.00 0.00 O HETATM 3581 O HOH A1033 -17.135 -16.952 25.623 1.00 0.00 O HETATM 3584 O HOH A1034 -10.513 45.055 -40.354 1.00 0.00 O HETATM 3587 O HOH A1035 15.079 10.447 -46.530 1.00 0.00 O HETATM 3590 O HOH A1036 -0.249 23.984 24.643 1.00 0.00 O HETATM 3593 O HOH A1037 -11.275 -54.231 23.675 1.00 0.00 O HETATM 3596 O HOH A1038 47.158 -16.365 -17.864 1.00 0.00 O HETATM 3599 O HOH A1039 41.472 29.854 -25.338 1.00 0.00 O HETATM 3602 O HOH A1040 -17.230 -27.740 -11.825 1.00 0.00 O HETATM 3605 O HOH A1041 60.635 18.417 -13.973 1.00 0.00 O HETATM 3608 O HOH A1042 49.618 19.644 -5.682 1.00 0.00 O HETATM 3611 O HOH A1043 -28.494 -46.322 -39.174 1.00 0.00 O HETATM 3614 O HOH A1044 -26.036 -7.446 -33.987 1.00 0.00 O HETATM 3617 O HOH A1045 -47.387 19.382 20.092 1.00 0.00 O HETATM 3620 O HOH A1046 -60.889 3.292 -9.603 1.00 0.00 O HETATM 3623 O HOH A1047 -41.877 65.654 31.731 1.00 0.00 O HETATM 3626 O HOH A1048 -44.530 -40.948 -1.496 1.00 0.00 O HETATM 3629 O HOH A1049 28.656 -16.807 31.632 1.00 0.00 O HETATM 3632 O HOH A1050 5.103 -13.062 64.591 1.00 0.00 O HETATM 3635 O HOH A1051 18.886 -47.765 3.314 1.00 0.00 O HETATM 3638 O HOH A1052 14.248 -30.678 45.220 1.00 0.00 O HETATM 3641 O HOH A1053 16.451 6.974 32.999 1.00 0.00 O HETATM 3644 O HOH A1054 5.638 52.640 16.442 1.00 0.00 O HETATM 3647 O HOH A1055 1.162 3.806 -1.753 1.00 0.00 O HETATM 3650 O HOH A1056 -41.919 -15.656 35.588 1.00 0.00 O HETATM 3653 O HOH A1057 -11.760 -45.395 29.532 1.00 0.00 O HETATM 3656 O HOH A1058 16.438 -1.033 25.120 1.00 0.00 O HETATM 3659 O HOH A1059 -12.437 -53.200 -17.421 1.00 0.00 O HETATM 3662 O HOH A1060 -4.037 -47.116 27.978 1.00 0.00 O HETATM 3665 O HOH A1061 -27.967 10.696 -32.997 1.00 0.00 O HETATM 3668 O HOH A1062 -27.541 48.178 35.855 1.00 0.00 O HETATM 3671 O HOH A1063 -66.574 -30.413 -53.500 1.00 0.00 O HETATM 3674 O HOH A1064 -21.226 2.835 -44.704 1.00 0.00 O HETATM 3677 O HOH A1065 -1.808 -27.509 -7.984 1.00 0.00 O HETATM 3680 O HOH A1066 61.895 -3.594 -30.528 1.00 0.00 O HETATM 3683 O HOH A1067 67.550 83.987 30.993 1.00 0.00 O HETATM 3686 O HOH A1068 -0.591 -33.794 3.445 1.00 0.00 O HETATM 3689 O HOH A1069 -1.340 -14.442 33.064 1.00 0.00 O HETATM 3692 O HOH A1070 15.074 26.423 17.291 1.00 0.00 O HETATM 3695 O HOH A1071 -19.082 27.758 21.385 1.00 0.00 O HETATM 3698 O HOH A1072 -83.534 -5.306 -62.250 1.00 0.00 O HETATM 3701 O HOH A1073 5.854 8.969 19.895 1.00 0.00 O HETATM 3704 O HOH A1074 8.387 17.793 -14.363 1.00 0.00 O HETATM 3707 O HOH A1075 46.340 -29.714 -13.971 1.00 0.00 O HETATM 3710 O HOH A1076 2.128 -0.304 11.043 1.00 0.00 O HETATM 3713 O HOH A1077 -69.009 65.427 67.346 1.00 0.00 O HETATM 3716 O HOH A1078 21.164 14.583 82.046 1.00 0.00 O HETATM 3719 O HOH A1079 33.811 -15.331 11.138 1.00 0.00 O HETATM 3722 O HOH A1080 -51.640 40.223 7.497 1.00 0.00 O HETATM 3725 O HOH A1081 10.666 4.871 94.262 1.00 0.00 O HETATM 3728 O HOH A1082 -0.140 104.542 1.197 1.00 0.00 O HETATM 3731 O HOH A1083 14.547 7.460 -35.437 1.00 0.00 O HETATM 3734 O HOH A1084 6.846 -67.544 -51.359 1.00 0.00 O HETATM 3737 O HOH A1085 -26.790 -18.137 9.311 1.00 0.00 O HETATM 3740 O HOH A1086 25.982 9.124 -22.507 1.00 0.00 O HETATM 3743 O HOH A1087 -0.730 -28.901 -20.742 1.00 0.00 O HETATM 3746 O HOH A1088 20.246 -9.161 24.366 1.00 0.00 O HETATM 3749 O HOH A1089 -3.607 -5.776 -81.069 1.00 0.00 O HETATM 3752 O HOH A1090 -29.888 17.950 -21.027 1.00 0.00 O HETATM 3755 O HOH A1091 20.495 37.364 -23.625 1.00 0.00 O HETATM 3758 O HOH A1092 -47.048 -64.042 52.779 1.00 0.00 O HETATM 3761 O HOH A1093 -1.082 2.705 8.241 1.00 0.00 O HETATM 3764 O HOH A1094 -68.543 32.722 0.606 1.00 0.00 O HETATM 3767 O HOH A1095 20.481 38.023 1.394 1.00 0.00 O HETATM 3770 O HOH A1096 29.059 -5.654 4.969 1.00 0.00 O HETATM 3773 O HOH A1097 9.650 -0.154 -26.701 1.00 0.00 O HETATM 3776 O HOH A1098 -18.212 90.372 31.023 1.00 0.00 O HETATM 3779 O HOH A1099 -61.403 19.208 -24.949 1.00 0.00 O HETATM 3782 O HOH A1100 36.013 -5.302 16.245 1.00 0.00 O HETATM 3785 O HOH A1101 1.665 20.740 -5.737 1.00 0.00 O HETATM 3788 O HOH A1102 38.822 -9.620 -46.333 1.00 0.00 O HETATM 3791 O HOH A1103 35.145 -71.417 -21.263 1.00 0.00 O HETATM 3794 O HOH A1104 -37.274 -1.895 -1.112 1.00 0.00 O HETATM 3797 O HOH A1105 -8.237 28.158 -94.510 1.00 0.00 O HETATM 3800 O HOH A1106 16.657 -6.499 -51.443 1.00 0.00 O HETATM 3803 O HOH A1107 34.792 -11.202 -45.114 1.00 0.00 O HETATM 3806 O HOH A1108 88.481 11.872 -44.609 1.00 0.00 O HETATM 3809 O HOH A1109 14.826 -33.033 -32.174 1.00 0.00 O HETATM 3812 O HOH A1110 -6.470 40.666 -75.575 1.00 0.00 O HETATM 3815 O HOH A1111 48.351 26.073 41.038 1.00 0.00 O HETATM 3818 O HOH A1112 3.191 -30.148 17.561 1.00 0.00 O HETATM 3821 O HOH A1113 31.348 -25.367 -16.590 1.00 0.00 O HETATM 3824 O HOH A1114 11.288 -26.370 -20.075 1.00 0.00 O HETATM 3827 O HOH A1115 34.766 -34.350 16.107 1.00 0.00 O HETATM 3830 O HOH A1116 83.281 44.145 -39.378 1.00 0.00 O HETATM 3833 O HOH A1117 -2.873 -15.421 -27.745 1.00 0.00 O HETATM 3836 O HOH A1118 21.370 -6.889 -35.949 1.00 0.00 O HETATM 3839 O HOH A1119 14.547 -7.940 -10.978 1.00 0.00 O HETATM 3842 O HOH A1120 28.335 51.201 -35.658 1.00 0.00 O HETATM 3845 O HOH A1121 64.414 -42.315 28.487 1.00 0.00 O HETATM 3848 O HOH A1122 -0.084 16.196 1.925 1.00 0.00 O HETATM 3851 O HOH A1123 16.963 9.740 -52.638 1.00 0.00 O HETATM 3854 O HOH A1124 -13.633 18.486 -59.475 1.00 0.00 O HETATM 3857 O HOH A1125 69.112 -19.854 43.099 1.00 0.00 O HETATM 3860 O HOH A1126 53.975 44.816 11.491 1.00 0.00 O HETATM 3863 O HOH A1127 21.232 -41.738 -11.657 1.00 0.00 O HETATM 3866 O HOH A1128 9.403 17.466 -42.697 1.00 0.00 O HETATM 3869 O HOH A1129 -38.246 -45.129 -19.118 1.00 0.00 O HETATM 3872 O HOH A1130 -3.498 41.903 -21.248 1.00 0.00 O HETATM 3875 O HOH A1131 15.644 -4.767 2.012 1.00 0.00 O HETATM 3878 O HOH A1132 4.375 17.043 67.945 1.00 0.00 O HETATM 3881 O HOH A1133 -5.844 19.686 6.322 1.00 0.00 O HETATM 3884 O HOH A1134 -22.944 30.336 -13.662 1.00 0.00 O HETATM 3887 O HOH A1135 -50.076 38.270 -47.953 1.00 0.00 O HETATM 3890 O HOH A1136 47.429 18.512 -0.628 1.00 0.00 O HETATM 3893 O HOH A1137 18.289 27.976 -4.863 1.00 0.00 O HETATM 3896 O HOH A1138 -56.088 14.618 -55.248 1.00 0.00 O HETATM 3899 O HOH A1139 -13.257 -26.078 26.822 1.00 0.00 O HETATM 3902 O HOH A1140 71.388 29.060 22.588 1.00 0.00 O HETATM 3905 O HOH A1141 10.431 -40.303 4.791 1.00 0.00 O HETATM 3908 O HOH A1142 -21.717 -69.118 41.259 1.00 0.00 O HETATM 3911 O HOH A1143 -2.094 4.584 -29.895 1.00 0.00 O HETATM 3914 O HOH A1144 -32.654 -46.045 44.982 1.00 0.00 O HETATM 3917 O HOH A1145 -15.864 -34.878 -8.075 1.00 0.00 O HETATM 3920 O HOH A1146 -56.154 48.815 49.833 1.00 0.00 O HETATM 3923 O HOH A1147 -15.164 11.669 40.817 1.00 0.00 O HETATM 3926 O HOH A1148 -20.456 18.673 21.134 1.00 0.00 O HETATM 3929 O HOH A1149 -27.220 -21.061 -7.563 1.00 0.00 O HETATM 3932 O HOH A1150 -23.666 -23.590 -5.940 1.00 0.00 O HETATM 3935 O HOH A1151 -22.777 19.384 -33.972 1.00 0.00 O HETATM 3938 O HOH A1152 -40.049 -6.643 34.832 1.00 0.00 O HETATM 3941 O HOH A1153 17.858 -14.826 60.270 1.00 0.00 O HETATM 3944 O HOH A1154 35.449 -5.858 0.587 1.00 0.00 O HETATM 3947 O HOH A1155 1.467 0.472 22.695 1.00 0.00 O HETATM 3950 O HOH A1156 7.643 -4.104 74.281 1.00 0.00 O HETATM 3953 O HOH A1157 -5.242 -17.835 -37.649 1.00 0.00 O HETATM 3956 O HOH A1158 -29.294 41.428 -4.262 1.00 0.00 O HETATM 3959 O HOH A1159 -6.238 32.247 -43.943 1.00 0.00 O HETATM 3962 O HOH A1160 -7.915 17.580 -21.331 1.00 0.00 O HETATM 3965 O HOH A1161 -23.548 30.648 -4.308 1.00 0.00 O HETATM 3968 O HOH A1162 -22.733 -5.553 -8.627 1.00 0.00 O HETATM 3971 O HOH A1163 -16.138 44.326 31.239 1.00 0.00 O HETATM 3974 O HOH A1164 17.611 31.428 -26.948 1.00 0.00 O HETATM 3977 O HOH A1165 -29.358 43.719 49.255 1.00 0.00 O HETATM 3980 O HOH A1166 45.765 61.832 -20.769 1.00 0.00 O HETATM 3983 O HOH A1167 -10.339 36.169 -16.936 1.00 0.00 O HETATM 3986 O HOH A1168 4.244 18.301 44.892 1.00 0.00 O HETATM 3989 O HOH A1169 -32.942 45.704 6.221 1.00 0.00 O HETATM 3992 O HOH A1170 19.837 -8.162 72.938 1.00 0.00 O HETATM 3995 O HOH A1171 -38.642 40.370 -67.418 1.00 0.00 O HETATM 3998 O HOH A1172 -85.064 31.729 -2.362 1.00 0.00 O HETATM 4001 O HOH A1173 14.011 25.085 -74.055 1.00 0.00 O HETATM 4004 O HOH A1174 -42.441 -62.070 -12.643 1.00 0.00 O HETATM 4007 O HOH A1175 21.080 -27.498 22.379 1.00 0.00 O HETATM 4010 O HOH A1176 22.275 -33.635 35.891 1.00 0.00 O HETATM 4013 O HOH A1177 -20.670 -39.093 42.163 1.00 0.00 O HETATM 4016 O HOH A1178 -23.689 -8.360 26.414 1.00 0.00 O HETATM 4019 O HOH A1179 -10.025 41.645 42.905 1.00 0.00 O HETATM 4022 O HOH A1180 -46.075 20.496 -10.631 1.00 0.00 O HETATM 4025 O HOH A1181 9.228 4.215 -43.603 1.00 0.00 O HETATM 4028 O HOH A1182 56.231 9.841 33.407 1.00 0.00 O HETATM 4031 O HOH A1183 -58.360 -18.046 -6.449 1.00 0.00 O HETATM 4034 O HOH A1184 7.039 35.395 30.669 1.00 0.00 O HETATM 4037 O HOH A1185 2.946 38.440 -25.583 1.00 0.00 O HETATM 4040 O HOH A1186 -29.296 33.316 10.704 1.00 0.00 O HETATM 4043 O HOH A1187 -35.240 45.237 -7.681 1.00 0.00 O HETATM 4046 O HOH A1188 14.553 -42.763 2.228 1.00 0.00 O HETATM 4049 O HOH A1189 -22.823 45.850 -47.917 1.00 0.00 O HETATM 4052 O HOH A1190 0.535 -50.970 23.380 1.00 0.00 O HETATM 4055 O HOH A1191 34.076 21.306 62.576 1.00 0.00 O HETATM 4058 O HOH A1192 -13.006 -44.370 16.225 1.00 0.00 O HETATM 4061 O HOH A1193 6.516 -12.158 2.116 1.00 0.00 O HETATM 4064 O HOH A1194 -27.436 10.862 55.981 1.00 0.00 O HETATM 4067 O HOH A1195 -32.534 47.146 -47.929 1.00 0.00 O HETATM 4070 O HOH A1196 -47.845 -7.671 5.879 1.00 0.00 O HETATM 4073 O HOH A1197 -34.592 -29.529 67.608 1.00 0.00 O HETATM 4076 O HOH A1198 19.125 -1.302 16.791 1.00 0.00 O HETATM 4079 O HOH A1199 -4.535 20.128 17.833 1.00 0.00 O HETATM 4082 O HOH A1200 -7.437 14.690 45.993 1.00 0.00 O HETATM 4085 O HOH A1201 62.232 26.128 10.654 1.00 0.00 O HETATM 4088 O HOH A1202 -4.355 8.100 21.876 1.00 0.00 O HETATM 4091 O HOH A1203 51.723 28.629 14.069 1.00 0.00 O HETATM 4094 O HOH A1204 -25.715 -16.070 7.702 1.00 0.00 O HETATM 4097 O HOH A1205 53.085 22.654 -29.196 1.00 0.00 O HETATM 4100 O HOH A1206 -30.683 -0.776 4.898 1.00 0.00 O HETATM 4103 O HOH A1207 -37.575 41.392 -4.419 1.00 0.00 O HETATM 4106 O HOH A1208 -31.944 -2.402 6.681 1.00 0.00 O HETATM 4109 O HOH A1209 52.341 41.310 4.655 1.00 0.00 O HETATM 4112 O HOH A1210 -0.230 -18.210 41.706 1.00 0.00 O HETATM 4115 O HOH A1211 -67.593 22.401 53.905 1.00 0.00 O HETATM 4118 O HOH A1212 -21.974 56.443 -17.666 1.00 0.00 O HETATM 4121 O HOH A1213 36.658 39.440 -37.670 1.00 0.00 O HETATM 4124 O HOH A1214 -5.744 13.162 -4.663 1.00 0.00 O HETATM 4127 O HOH A1215 17.617 -67.358 62.233 1.00 0.00 O HETATM 4130 O HOH A1216 2.248 45.557 -16.249 1.00 0.00 O HETATM 4133 O HOH A1217 -12.664 9.623 -25.350 1.00 0.00 O HETATM 4136 O HOH A1218 -16.828 25.244 -42.719 1.00 0.00 O HETATM 4139 O HOH A1219 44.603 -1.579 -59.637 1.00 0.00 O HETATM 4142 O HOH A1220 -6.672 10.858 -3.462 1.00 0.00 O HETATM 4145 O HOH A1221 4.069 40.302 -19.870 1.00 0.00 O HETATM 4148 O HOH A1222 -4.837 1.092 10.567 1.00 0.00 O HETATM 4151 O HOH A1223 10.457 -18.740 11.340 1.00 0.00 O HETATM 4154 O HOH A1224 22.328 31.109 35.576 1.00 0.00 O HETATM 4157 O HOH A1225 -18.617 -1.178 37.938 1.00 0.00 O HETATM 4160 O HOH A1226 9.216 -24.937 1.000 1.00 0.00 O HETATM 4163 O HOH A1227 77.898 0.321 26.143 1.00 0.00 O HETATM 4166 O HOH A1228 -37.492 -7.672 14.066 1.00 0.00 O HETATM 4169 O HOH A1229 3.996 24.637 25.570 1.00 0.00 O HETATM 4172 O HOH A1230 11.027 37.244 10.920 1.00 0.00 O HETATM 4175 O HOH A1231 -2.932 9.453 36.645 1.00 0.00 O HETATM 4178 O HOH A1232 5.492 15.460 49.254 1.00 0.00 O HETATM 4181 O HOH A1233 29.392 23.882 12.729 1.00 0.00 O HETATM 4184 O HOH A1234 -4.019 21.818 -58.458 1.00 0.00 O HETATM 4187 O HOH A1235 13.155 -42.408 -18.635 1.00 0.00 O HETATM 4190 O HOH A1236 5.563 -5.799 -53.339 1.00 0.00 O HETATM 4193 O HOH A1237 30.753 -48.193 101.429 1.00 0.00 O HETATM 4196 O HOH A1238 12.064 -29.124 -22.842 1.00 0.00 O HETATM 4199 O HOH A1239 19.954 -12.734 57.262 1.00 0.00 O HETATM 4202 O HOH A1240 89.734 3.341 18.088 1.00 0.00 O HETATM 4205 O HOH A1241 0.408 -19.584 14.257 1.00 0.00 O HETATM 4208 O HOH A1242 -62.537 7.558 63.727 1.00 0.00 O HETATM 4211 O HOH A1243 -26.446 -36.337 -33.315 1.00 0.00 O HETATM 4214 O HOH A1244 5.259 23.011 42.777 1.00 0.00 O HETATM 4217 O HOH A1245 0.264 0.572 -17.287 1.00 0.00 O HETATM 4220 O HOH A1246 -0.556 41.560 15.920 1.00 0.00 O HETATM 4223 O HOH A1247 10.083 5.318 35.242 1.00 0.00 O HETATM 4226 O HOH A1248 -52.661 74.326 42.555 1.00 0.00 O HETATM 4229 O HOH A1249 45.352 26.841 -26.321 1.00 0.00 O HETATM 4232 O HOH A1250 -3.575 46.058 -23.928 1.00 0.00 O HETATM 4235 O HOH A1251 -16.652 14.454 55.432 1.00 0.00 O HETATM 4238 O HOH A1252 27.107 15.105 28.347 1.00 0.00 O HETATM 4241 O HOH A1253 3.534 7.933 1.302 1.00 0.00 O HETATM 4244 O HOH A1254 -13.931 51.590 -12.891 1.00 0.00 O HETATM 4247 O HOH A1255 -24.994 11.799 0.338 1.00 0.00 O HETATM 4250 O HOH A1256 -20.785 -26.690 -6.852 1.00 0.00 O HETATM 4253 O HOH A1257 45.316 -50.154 17.607 1.00 0.00 O HETATM 4256 O HOH A1258 42.912 -67.401 -3.886 1.00 0.00 O HETATM 4259 O HOH A1259 -29.289 -19.518 -26.979 1.00 0.00 O HETATM 4262 O HOH A1260 -11.362 15.143 -2.724 1.00 0.00 O HETATM 4265 O HOH A1261 -12.174 16.190 -0.368 1.00 0.00 O HETATM 4268 O HOH A1262 4.034 -64.088 -10.251 1.00 0.00 O HETATM 4271 O HOH A1263 77.079 -12.116 -36.792 1.00 0.00 O HETATM 4274 O HOH A1264 -61.834 -15.660 39.477 1.00 0.00 O HETATM 4277 O HOH A1265 -44.894 -32.398 -34.247 1.00 0.00 O HETATM 4280 O HOH A1266 -25.179 32.600 -35.049 1.00 0.00 O HETATM 4283 O HOH A1267 25.974 -16.077 -43.520 1.00 0.00 O HETATM 4286 O HOH A1268 22.010 -41.693 -18.874 1.00 0.00 O HETATM 4289 O HOH A1269 -20.098 -2.532 13.496 1.00 0.00 O HETATM 4292 O HOH A1270 -52.214 -25.632 46.235 1.00 0.00 O HETATM 4295 O HOH A1271 -8.019 -38.752 19.021 1.00 0.00 O HETATM 4298 O HOH A1272 -42.723 -13.339 -19.605 1.00 0.00 O HETATM 4301 O HOH A1273 -51.559 6.213 -24.818 1.00 0.00 O HETATM 4304 O HOH A1274 -27.214 -60.027 32.185 1.00 0.00 O HETATM 4307 O HOH A1275 -37.910 89.270 -15.924 1.00 0.00 O HETATM 4310 O HOH A1276 -51.025 -22.293 48.801 1.00 0.00 O HETATM 4313 O HOH A1277 -15.191 118.725 -12.260 1.00 0.00 O HETATM 4316 O HOH A1278 -26.170 -4.489 -7.255 1.00 0.00 O HETATM 4319 O HOH A1279 -14.769 8.959 2.600 1.00 0.00 O HETATM 4322 O HOH A1280 -18.368 30.541 37.400 1.00 0.00 O HETATM 4325 O HOH A1281 38.098 -6.417 25.758 1.00 0.00 O HETATM 4328 O HOH A1282 -19.119 8.584 54.153 1.00 0.00 O HETATM 4331 O HOH A1283 12.234 -15.969 30.023 1.00 0.00 O HETATM 4334 O HOH A1284 2.069 0.409 -11.419 1.00 0.00 O HETATM 4337 O HOH A1285 9.273 51.710 -38.578 1.00 0.00 O HETATM 4340 O HOH A1286 -20.957 77.867 -29.365 1.00 0.00 O HETATM 4343 O HOH A1287 -19.444 17.819 56.675 1.00 0.00 O HETATM 4346 O HOH A1288 -54.328 32.739 3.442 1.00 0.00 O HETATM 4349 O HOH A1289 -4.601 -7.065 14.185 1.00 0.00 O HETATM 4352 O HOH A1290 57.822 -41.979 8.035 1.00 0.00 O HETATM 4355 O HOH A1291 -41.515 -32.659 86.778 1.00 0.00 O HETATM 4358 O HOH A1292 -2.924 -8.060 7.029 1.00 0.00 O HETATM 4361 O HOH A1293 62.840 18.971 -10.484 1.00 0.00 O HETATM 4364 O HOH A1294 -36.819 4.596 66.531 1.00 0.00 O HETATM 4367 O HOH A1295 21.926 -5.098 67.769 1.00 0.00 O HETATM 4370 O HOH A1296 34.625 -13.323 -3.648 1.00 0.00 O HETATM 4373 O HOH A1297 5.900 -26.390 9.720 1.00 0.00 O HETATM 4376 O HOH A1298 33.587 -76.088 -31.237 1.00 0.00 O HETATM 4379 O HOH A1299 -10.476 -2.417 27.994 1.00 0.00 O HETATM 4382 O HOH A1300 -58.867 -6.600 -50.383 1.00 0.00 O HETATM 4385 O HOH A1301 -106.470 -13.450 -20.442 1.00 0.00 O HETATM 4388 O HOH A1302 32.030 74.047 -39.355 1.00 0.00 O HETATM 4391 O HOH A1303 12.638 53.971 -22.959 1.00 0.00 O HETATM 4394 O HOH A1304 41.181 -43.602 -8.435 1.00 0.00 O HETATM 4397 O HOH A1305 38.600 48.136 -55.035 1.00 0.00 O HETATM 4400 O HOH A1306 -33.926 -54.033 16.433 1.00 0.00 O HETATM 4403 O HOH A1307 -33.388 43.739 49.977 1.00 0.00 O HETATM 4406 O HOH A1308 -45.996 8.968 -28.834 1.00 0.00 O HETATM 4409 O HOH A1309 -14.394 -20.551 -5.838 1.00 0.00 O HETATM 4412 O HOH A1310 -3.352 -15.854 5.273 1.00 0.00 O HETATM 4415 O HOH A1311 12.788 -7.465 8.610 1.00 0.00 O HETATM 4418 O HOH A1312 -32.788 12.961 51.897 1.00 0.00 O HETATM 4421 O HOH A1313 -6.734 9.327 -16.444 1.00 0.00 O HETATM 4424 O HOH A1314 -2.675 26.571 -30.266 1.00 0.00 O HETATM 4427 O HOH A1315 -35.466 25.701 37.491 1.00 0.00 O HETATM 4430 O HOH A1316 16.218 28.690 41.007 1.00 0.00 O HETATM 4433 O HOH A1317 8.206 50.730 -89.397 1.00 0.00 O HETATM 4436 O HOH A1318 32.283 23.001 -23.787 1.00 0.00 O HETATM 4439 O HOH A1319 1.026 42.182 -60.891 1.00 0.00 O HETATM 4442 O HOH A1320 -7.513 -17.981 37.792 1.00 0.00 O HETATM 4445 O HOH A1321 13.060 22.538 -45.712 1.00 0.00 O HETATM 4448 O HOH A1322 -7.334 -23.651 -17.402 1.00 0.00 O HETATM 4451 O HOH A1323 -11.525 24.932 -1.795 1.00 0.00 O HETATM 4454 O HOH A1324 23.603 43.512 33.220 1.00 0.00 O HETATM 4457 O HOH A1325 -42.197 5.032 -43.241 1.00 0.00 O HETATM 4460 O HOH A1326 -37.239 18.960 20.844 1.00 0.00 O HETATM 4463 O HOH A1327 -22.067 0.794 -23.697 1.00 0.00 O HETATM 4466 O HOH A1328 -5.334 20.709 -64.865 1.00 0.00 O HETATM 4469 O HOH A1329 -24.589 38.323 -29.384 1.00 0.00 O HETATM 4472 O HOH A1330 16.132 -17.524 -46.312 1.00 0.00 O HETATM 4475 O HOH A1331 -28.742 -16.514 0.826 1.00 0.00 O HETATM 4478 O HOH A1332 -5.341 24.873 -48.008 1.00 0.00 O HETATM 4481 O HOH A1333 42.952 0.839 -36.106 1.00 0.00 O HETATM 4484 O HOH A1334 -15.312 -32.319 47.818 1.00 0.00 O HETATM 4487 O HOH A1335 33.297 20.309 2.769 1.00 0.00 O HETATM 4490 O HOH A1336 -28.691 -16.556 19.332 1.00 0.00 O HETATM 4493 O HOH A1337 35.008 37.079 -24.953 1.00 0.00 O HETATM 4496 O HOH A1338 16.009 11.846 41.638 1.00 0.00 O HETATM 4499 O HOH A1339 38.018 -31.956 -49.906 1.00 0.00 O HETATM 4502 O HOH A1340 30.522 -16.722 45.981 1.00 0.00 O HETATM 4505 O HOH A1341 -62.910 -29.162 42.376 1.00 0.00 O HETATM 4508 O HOH A1342 54.699 -58.976 -26.905 1.00 0.00 O HETATM 4511 O HOH A1343 43.766 31.422 6.303 1.00 0.00 O HETATM 4514 O HOH A1344 -4.874 0.961 -24.107 1.00 0.00 O HETATM 4517 O HOH A1345 -39.187 -3.716 -26.594 1.00 0.00 O HETATM 4520 O HOH A1346 -0.310 22.258 2.825 1.00 0.00 O HETATM 4523 O HOH A1347 -13.688 24.057 71.777 1.00 0.00 O HETATM 4526 O HOH A1348 51.652 -14.416 -32.292 1.00 0.00 O HETATM 4529 O HOH A1349 -18.883 -19.222 43.612 1.00 0.00 O HETATM 4532 O HOH A1350 -67.840 -24.670 44.290 1.00 0.00 O HETATM 4535 O HOH A1351 -14.747 30.120 -16.559 1.00 0.00 O HETATM 4538 O HOH A1352 43.000 10.055 7.701 1.00 0.00 O HETATM 4541 O HOH A1353 1.015 -19.518 9.093 1.00 0.00 O HETATM 4544 O HOH A1354 4.799 -7.982 7.827 1.00 0.00 O HETATM 4547 O HOH A1355 15.153 32.471 -11.175 1.00 0.00 O HETATM 4550 O HOH A1356 79.971 18.510 46.101 1.00 0.00 O HETATM 4553 O HOH A1357 -25.039 18.036 -4.521 1.00 0.00 O HETATM 4556 O HOH A1358 -56.564 40.101 59.994 1.00 0.00 O HETATM 4559 O HOH A1359 -24.951 14.291 -33.989 1.00 0.00 O HETATM 4562 O HOH A1360 -3.340 -1.858 -3.307 1.00 0.00 O HETATM 4565 O HOH A1361 -0.477 27.960 31.107 1.00 0.00 O HETATM 4568 O HOH A1362 -27.431 14.088 -22.956 1.00 0.00 O HETATM 4571 O HOH A1363 3.437 -12.332 -24.003 1.00 0.00 O HETATM 4574 O HOH A1364 28.856 22.293 6.180 1.00 0.00 O HETATM 4577 O HOH A1365 15.036 26.535 53.714 1.00 0.00 O HETATM 4580 O HOH A1366 14.737 -87.695 -27.598 1.00 0.00 O HETATM 4583 O HOH A1367 -14.666 2.021 75.736 1.00 0.00 O HETATM 4586 O HOH A1368 1.028 1.362 -22.783 1.00 0.00 O HETATM 4589 O HOH A1369 11.844 5.172 -8.681 1.00 0.00 O HETATM 4592 O HOH A1370 2.154 -36.365 8.379 1.00 0.00 O HETATM 4595 O HOH A1371 19.929 14.121 76.076 1.00 0.00 O HETATM 4598 O HOH A1372 -2.867 -0.090 36.783 1.00 0.00 O HETATM 4601 O HOH A1373 7.865 -3.228 -19.229 1.00 0.00 O HETATM 4604 O HOH A1374 17.760 -21.947 -22.576 1.00 0.00 O HETATM 4607 O HOH A1375 -90.069 15.553 49.776 1.00 0.00 O HETATM 4610 O HOH A1376 40.035 52.885 -30.337 1.00 0.00 O HETATM 4613 O HOH A1377 0.401 -21.736 20.509 1.00 0.00 O HETATM 4616 O HOH A1378 7.610 12.900 11.755 1.00 0.00 O HETATM 4619 O HOH A1379 2.023 -7.006 30.168 1.00 0.00 O HETATM 4622 O HOH A1380 39.229 -33.868 -23.201 1.00 0.00 O HETATM 4625 O HOH A1381 8.875 -62.829 -9.594 1.00 0.00 O HETATM 4628 O HOH A1382 -6.072 -41.130 2.258 1.00 0.00 O HETATM 4631 O HOH A1383 27.644 47.771 33.997 1.00 0.00 O HETATM 4634 O HOH A1384 19.006 -23.417 21.238 1.00 0.00 O HETATM 4637 O HOH A1385 13.130 19.073 -3.085 1.00 0.00 O HETATM 4640 O HOH A1386 6.590 20.140 24.036 1.00 0.00 O HETATM 4643 O HOH A1387 -45.451 12.189 -5.038 1.00 0.00 O HETATM 4646 O HOH A1388 -1.365 5.056 29.184 1.00 0.00 O HETATM 4649 O HOH A1389 18.047 -59.491 -8.048 1.00 0.00 O HETATM 4652 O HOH A1390 -3.679 42.534 -52.029 1.00 0.00 O HETATM 4655 O HOH A1391 17.035 -42.338 -9.828 1.00 0.00 O HETATM 4658 O HOH A1392 -12.680 11.486 -11.297 1.00 0.00 O HETATM 4661 O HOH A1393 -57.354 -1.562 40.787 1.00 0.00 O HETATM 4664 O HOH A1394 14.941 -0.275 15.048 1.00 0.00 O HETATM 4667 O HOH A1395 -26.369 -19.621 -9.777 1.00 0.00 O HETATM 4670 O HOH A1396 13.166 25.748 -65.638 1.00 0.00 O HETATM 4673 O HOH A1397 58.384 0.579 27.435 1.00 0.00 O HETATM 4676 O HOH A1398 -34.322 -1.044 -28.257 1.00 0.00 O HETATM 4679 O HOH A1399 -28.724 28.972 66.364 1.00 0.00 O HETATM 4682 O HOH A1400 -55.656 41.063 19.116 1.00 0.00 O HETATM 4685 O HOH A1401 14.017 13.833 -38.738 1.00 0.00 O HETATM 4688 O HOH A1402 -29.721 38.637 -39.986 1.00 0.00 O HETATM 4691 O HOH A1403 20.290 -26.538 18.318 1.00 0.00 O HETATM 4694 O HOH A1404 -36.908 14.753 8.480 1.00 0.00 O HETATM 4697 O HOH A1405 32.940 -16.279 -7.623 1.00 0.00 O HETATM 4700 O HOH A1406 7.999 -24.457 -14.952 1.00 0.00 O HETATM 4703 O HOH A1407 -29.269 -27.328 1.013 1.00 0.00 O HETATM 4706 O HOH A1408 -24.580 -6.612 20.152 1.00 0.00 O HETATM 4709 O HOH A1409 16.420 21.875 -9.553 1.00 0.00 O HETATM 4712 O HOH A1410 -34.849 -8.454 15.374 1.00 0.00 O HETATM 4715 O HOH A1411 38.246 11.745 24.921 1.00 0.00 O HETATM 4718 O HOH A1412 -28.348 -17.044 -30.336 1.00 0.00 O HETATM 4721 O HOH A1413 -20.113 -11.349 0.105 1.00 0.00 O HETATM 4724 O HOH A1414 14.163 1.969 19.008 1.00 0.00 O HETATM 4727 O HOH A1415 19.354 27.277 26.881 1.00 0.00 O HETATM 4730 O HOH A1416 -23.330 -28.393 37.996 1.00 0.00 O HETATM 4733 O HOH A1417 20.095 32.504 -76.597 1.00 0.00 O HETATM 4736 O HOH A1418 48.930 8.543 -31.292 1.00 0.00 O HETATM 4739 O HOH A1419 48.153 19.395 -65.082 1.00 0.00 O HETATM 4742 O HOH A1420 2.514 -6.851 -1.863 1.00 0.00 O HETATM 4745 O HOH A1421 24.443 -14.461 -13.266 1.00 0.00 O HETATM 4748 O HOH A1422 13.814 -56.074 -34.586 1.00 0.00 O HETATM 4751 O HOH A1423 35.145 9.804 -17.199 1.00 0.00 O HETATM 4754 O HOH A1424 -35.108 7.090 13.567 1.00 0.00 O HETATM 4757 O HOH A1425 -14.257 14.893 31.614 1.00 0.00 O HETATM 4760 O HOH A1426 -19.708 6.775 -14.525 1.00 0.00 O HETATM 4763 O HOH A1427 2.547 19.462 15.901 1.00 0.00 O HETATM 4766 O HOH A1428 -9.471 18.774 -61.882 1.00 0.00 O HETATM 4769 O HOH A1429 -4.227 -20.368 -16.894 1.00 0.00 O HETATM 4772 O HOH A1430 41.924 -21.716 -18.602 1.00 0.00 O HETATM 4775 O HOH A1431 -1.226 38.148 12.467 1.00 0.00 O HETATM 4778 O HOH A1432 -42.924 4.629 34.487 1.00 0.00 O HETATM 4781 O HOH A1433 -40.989 19.552 11.410 1.00 0.00 O HETATM 4784 O HOH A1434 58.631 -63.353 -13.824 1.00 0.00 O HETATM 4787 O HOH A1435 -35.117 18.551 -4.575 1.00 0.00 O HETATM 4790 O HOH A1436 31.703 -23.895 -77.749 1.00 0.00 O HETATM 4793 O HOH A1437 -54.173 51.790 -24.841 1.00 0.00 O HETATM 4796 O HOH A1438 27.841 -19.876 -7.718 1.00 0.00 O HETATM 4799 O HOH A1439 -15.167 26.570 -21.802 1.00 0.00 O HETATM 4802 O HOH A1440 -47.035 3.446 -16.499 1.00 0.00 O HETATM 4805 O HOH A1441 -8.579 8.781 -3.396 1.00 0.00 O HETATM 4808 O HOH A1442 25.910 -63.463 -43.097 1.00 0.00 O HETATM 4811 O HOH A1443 -48.070 60.524 -19.837 1.00 0.00 O HETATM 4814 O HOH A1444 -33.696 -15.172 18.433 1.00 0.00 O HETATM 4817 O HOH A1445 26.412 26.279 -4.115 1.00 0.00 O HETATM 4820 O HOH A1446 23.870 5.134 -11.652 1.00 0.00 O HETATM 4823 O HOH A1447 -13.531 28.075 26.758 1.00 0.00 O HETATM 4826 O HOH A1448 31.714 66.851 35.371 1.00 0.00 O HETATM 4829 O HOH A1449 -22.166 -29.478 -4.131 1.00 0.00 O HETATM 4832 O HOH A1450 9.083 -33.706 48.742 1.00 0.00 O HETATM 4835 O HOH A1451 -0.886 -2.999 16.558 1.00 0.00 O HETATM 4838 O HOH A1452 -44.343 58.813 -96.142 1.00 0.00 O HETATM 4841 O HOH A1453 -4.683 -85.180 20.458 1.00 0.00 O HETATM 4844 O HOH A1454 -27.594 25.140 38.736 1.00 0.00 O HETATM 4847 O HOH A1455 6.160 26.940 -1.966 1.00 0.00 O HETATM 4850 O HOH A1456 -11.988 -8.671 -32.978 1.00 0.00 O HETATM 4853 O HOH A1457 -12.652 49.653 -33.949 1.00 0.00 O HETATM 4856 O HOH A1458 28.129 -33.255 10.540 1.00 0.00 O HETATM 4859 O HOH A1459 40.356 37.569 -27.436 1.00 0.00 O HETATM 4862 O HOH A1460 -36.462 43.883 52.423 1.00 0.00 O HETATM 4865 O HOH A1461 35.215 -16.987 -52.702 1.00 0.00 O HETATM 4868 O HOH A1462 7.770 -31.716 -21.043 1.00 0.00 O HETATM 4871 O HOH A1463 1.495 -64.953 -8.049 1.00 0.00 O HETATM 4874 O HOH A1464 15.051 -19.466 -26.803 1.00 0.00 O HETATM 4877 O HOH A1465 -15.658 -2.742 -4.367 1.00 0.00 O HETATM 4880 O HOH A1466 52.091 -26.805 15.761 1.00 0.00 O HETATM 4883 O HOH A1467 13.336 28.284 16.349 1.00 0.00 O HETATM 4886 O HOH A1468 -27.675 -25.244 18.427 1.00 0.00 O HETATM 4889 O HOH A1469 -20.605 9.402 -14.121 1.00 0.00 O HETATM 4892 O HOH A1470 -5.501 32.391 33.431 1.00 0.00 O HETATM 4895 O HOH A1471 16.748 19.861 -15.033 1.00 0.00 O HETATM 4898 O HOH A1472 16.145 -22.965 8.401 1.00 0.00 O HETATM 4901 O HOH A1473 25.246 56.621 26.807 1.00 0.00 O HETATM 4904 O HOH A1474 42.054 -14.252 3.985 1.00 0.00 O HETATM 4907 O HOH A1475 22.912 -13.076 22.705 1.00 0.00 O HETATM 4910 O HOH A1476 -19.665 36.291 48.172 1.00 0.00 O HETATM 4913 O HOH A1477 21.236 -17.066 5.831 1.00 0.00 O HETATM 4916 O HOH A1478 -16.363 22.923 23.140 1.00 0.00 O HETATM 4919 O HOH A1479 -17.285 22.947 19.438 1.00 0.00 O HETATM 4922 O HOH A1480 -62.859 -2.368 -13.815 1.00 0.00 O HETATM 4925 O HOH A1481 -18.915 55.663 8.754 1.00 0.00 O HETATM 4928 O HOH A1482 11.223 -69.533 50.417 1.00 0.00 O HETATM 4931 O HOH A1483 20.287 -8.499 -19.090 1.00 0.00 O HETATM 4934 O HOH A1484 5.953 17.724 3.109 1.00 0.00 O HETATM 4937 O HOH A1485 0.222 39.238 4.976 1.00 0.00 O HETATM 4940 O HOH A1486 22.651 7.747 19.296 1.00 0.00 O HETATM 4943 O HOH A1487 -45.254 -11.324 -37.366 1.00 0.00 O HETATM 4946 O HOH A1488 -22.108 -3.895 21.629 1.00 0.00 O HETATM 4949 O HOH A1489 14.352 -4.047 8.590 1.00 0.00 O HETATM 4952 O HOH A1490 26.717 82.555 -8.648 1.00 0.00 O HETATM 4955 O HOH A1491 -32.126 -22.246 83.510 1.00 0.00 O HETATM 4958 O HOH A1492 -31.000 2.551 -16.793 1.00 0.00 O HETATM 4961 O HOH A1493 32.526 22.285 -13.437 1.00 0.00 O HETATM 4964 O HOH A1494 24.955 18.707 4.900 1.00 0.00 O HETATM 4967 O HOH A1495 34.058 16.849 -0.362 1.00 0.00 O HETATM 4970 O HOH A1496 -62.136 -28.082 -24.267 1.00 0.00 O HETATM 4973 O HOH A1497 -5.040 12.514 49.206 1.00 0.00 O HETATM 4976 O HOH A1498 1.063 -51.464 11.205 1.00 0.00 O HETATM 4979 O HOH A1499 -0.517 -44.994 -54.598 1.00 0.00 O HETATM 4982 O HOH A1500 -47.687 31.687 -35.073 1.00 0.00 O HETATM 4985 O HOH A1501 -58.671 7.582 -6.084 1.00 0.00 O HETATM 4988 O HOH A1502 38.146 23.485 12.227 1.00 0.00 O HETATM 4991 O HOH A1503 -16.644 1.983 -46.248 1.00 0.00 O HETATM 4994 O HOH A1504 23.734 -19.775 -6.631 1.00 0.00 O HETATM 4997 O HOH A1505 -22.819 -22.417 -32.715 1.00 0.00 O HETATM 5000 O HOH A1506 0.590 -23.944 -43.727 1.00 0.00 O HETATM 5003 O HOH A1507 33.043 -35.864 25.905 1.00 0.00 O HETATM 5006 O HOH A1508 -19.789 64.962 30.216 1.00 0.00 O HETATM 5009 O HOH A1509 -2.201 -7.583 0.841 1.00 0.00 O HETATM 5012 O HOH A1510 2.690 -22.646 -70.938 1.00 0.00 O HETATM 5015 O HOH A1511 -26.273 -15.182 35.063 1.00 0.00 O HETATM 5018 O HOH A1512 4.511 21.376 -89.901 1.00 0.00 O HETATM 5021 O HOH A1513 7.674 76.396 -1.277 1.00 0.00 O HETATM 5024 O HOH A1514 -34.675 26.433 11.155 1.00 0.00 O HETATM 5027 O HOH A1515 -56.270 13.252 30.276 1.00 0.00 O HETATM 5030 O HOH A1516 14.989 -5.333 -17.443 1.00 0.00 O HETATM 5033 O HOH A1517 28.840 -12.354 -64.462 1.00 0.00 O HETATM 5036 O HOH A1518 50.524 -19.729 -10.217 1.00 0.00 O HETATM 5039 O HOH A1519 -25.782 -52.261 1.047 1.00 0.00 O HETATM 5042 O HOH A1520 -5.367 9.688 -9.494 1.00 0.00 O HETATM 5045 O HOH A1521 13.422 -29.160 14.450 1.00 0.00 O HETATM 5048 O HOH A1522 45.391 -49.411 27.522 1.00 0.00 O HETATM 5051 O HOH A1523 7.560 -7.290 1.901 1.00 0.00 O HETATM 5054 O HOH A1524 14.681 -20.024 34.549 1.00 0.00 O HETATM 5057 O HOH A1525 12.880 36.144 -54.425 1.00 0.00 O HETATM 5060 O HOH A1526 -31.837 -33.599 17.581 1.00 0.00 O HETATM 5063 O HOH A1527 36.516 37.893 -19.106 1.00 0.00 O HETATM 5066 O HOH A1528 22.649 -18.092 36.280 1.00 0.00 O HETATM 5069 O HOH A1529 -21.380 -7.497 -63.400 1.00 0.00 O HETATM 5072 O HOH A1530 -45.116 19.183 -81.333 1.00 0.00 O HETATM 5075 O HOH A1531 32.719 -43.887 -24.226 1.00 0.00 O HETATM 5078 O HOH A1532 28.513 50.834 24.886 1.00 0.00 O HETATM 5081 O HOH A1533 -39.406 -1.641 -24.752 1.00 0.00 O HETATM 5084 O HOH A1534 -48.503 -35.047 10.848 1.00 0.00 O HETATM 5087 O HOH A1535 -6.642 6.498 -29.358 1.00 0.00 O HETATM 5090 O HOH A1536 17.029 51.527 2.158 1.00 0.00 O HETATM 5093 O HOH A1537 3.520 65.204 64.983 1.00 0.00 O HETATM 5096 O HOH A1538 40.713 13.091 10.471 1.00 0.00 O HETATM 5099 O HOH A1539 -16.696 -7.565 -42.454 1.00 0.00 O HETATM 5102 O HOH A1540 14.078 -42.165 -36.253 1.00 0.00 O HETATM 5105 O HOH A1541 45.911 6.150 -0.888 1.00 0.00 O HETATM 5108 O HOH A1542 9.114 -39.487 -10.015 1.00 0.00 O HETATM 5111 O HOH A1543 44.201 -43.161 -48.376 1.00 0.00 O HETATM 5114 O HOH A1544 -4.815 33.390 36.915 1.00 0.00 O HETATM 5117 O HOH A1545 12.247 -30.510 2.097 1.00 0.00 O HETATM 5120 O HOH A1546 1.305 -4.866 -49.157 1.00 0.00 O HETATM 5123 O HOH A1547 -21.802 37.479 49.443 1.00 0.00 O HETATM 5126 O HOH A1548 -53.021 8.520 -21.827 1.00 0.00 O HETATM 5129 O HOH A1549 61.381 6.510 20.808 1.00 0.00 O HETATM 5132 O HOH A1550 57.857 -21.861 6.558 1.00 0.00 O HETATM 5135 O HOH A1551 36.323 -63.120 19.005 1.00 0.00 O HETATM 5138 O HOH A1552 -28.991 -36.775 54.323 1.00 0.00 O HETATM 5141 O HOH A1553 47.342 25.032 24.425 1.00 0.00 O HETATM 5144 O HOH A1554 -25.006 -83.991 -6.833 1.00 0.00 O HETATM 5147 O HOH A1555 9.068 -22.172 60.610 1.00 0.00 O HETATM 5150 O HOH A1556 -8.889 -49.237 -45.063 1.00 0.00 O HETATM 5153 O HOH A1557 -24.851 15.454 -74.922 1.00 0.00 O HETATM 5156 O HOH A1558 -23.446 22.349 -11.448 1.00 0.00 O HETATM 5159 O HOH A1559 41.597 -78.819 16.049 1.00 0.00 O HETATM 5162 O HOH A1560 17.492 19.197 -42.628 1.00 0.00 O HETATM 5165 O HOH A1561 -62.911 25.686 -14.299 1.00 0.00 O HETATM 5168 O HOH A1562 16.342 18.231 -6.094 1.00 0.00 O HETATM 5171 O HOH A1563 58.165 -15.775 -9.487 1.00 0.00 O HETATM 5174 O HOH A1564 33.249 -27.569 20.073 1.00 0.00 O HETATM 5177 O HOH A1565 -5.460 34.755 39.195 1.00 0.00 O HETATM 5180 O HOH A1566 30.698 -28.790 9.742 1.00 0.00 O HETATM 5183 O HOH A1567 -12.969 33.171 -17.589 1.00 0.00 O HETATM 5186 O HOH A1568 19.580 -6.861 -44.909 1.00 0.00 O HETATM 5189 O HOH A1569 20.100 20.516 17.259 1.00 0.00 O HETATM 5192 O HOH A1570 2.748 -0.609 49.104 1.00 0.00 O HETATM 5195 O HOH A1571 -10.241 13.547 20.941 1.00 0.00 O HETATM 5198 O HOH A1572 27.640 -39.741 -33.137 1.00 0.00 O HETATM 5201 O HOH A1573 -28.785 43.760 -12.688 1.00 0.00 O HETATM 5204 O HOH A1574 -53.087 10.320 -15.853 1.00 0.00 O HETATM 5207 O HOH A1575 -37.686 28.216 -20.307 1.00 0.00 O HETATM 5210 O HOH A1576 -29.986 -27.908 -21.478 1.00 0.00 O HETATM 5213 O HOH A1577 -27.195 -10.178 -47.505 1.00 0.00 O HETATM 5216 O HOH A1578 -26.704 -41.543 -70.703 1.00 0.00 O HETATM 5219 O HOH A1579 23.887 46.795 39.325 1.00 0.00 O HETATM 5222 O HOH A1580 -24.874 52.915 -50.754 1.00 0.00 O HETATM 5225 O HOH A1581 -24.102 5.764 7.985 1.00 0.00 O HETATM 5228 O HOH A1582 31.859 -26.039 -50.579 1.00 0.00 O HETATM 5231 O HOH A1583 11.302 -4.727 -31.182 1.00 0.00 O HETATM 5234 O HOH A1584 -23.082 26.689 -3.123 1.00 0.00 O HETATM 5237 O HOH A1585 4.118 -7.047 -15.908 1.00 0.00 O HETATM 5240 O HOH A1586 21.449 -25.011 -17.890 1.00 0.00 O HETATM 5243 O HOH A1587 9.512 57.870 -16.289 1.00 0.00 O HETATM 5246 O HOH A1588 -9.438 -40.315 3.121 1.00 0.00 O HETATM 5249 O HOH A1589 -24.717 25.068 -24.444 1.00 0.00 O HETATM 5252 O HOH A1590 -2.097 16.371 12.971 1.00 0.00 O HETATM 5255 O HOH A1591 -5.952 10.462 18.518 1.00 0.00 O HETATM 5258 O HOH A1592 -9.878 -32.088 -43.474 1.00 0.00 O HETATM 5261 O HOH A1593 -7.228 1.451 22.970 1.00 0.00 O HETATM 5264 O HOH A1594 52.031 -71.991 17.236 1.00 0.00 O HETATM 5267 O HOH A1595 20.981 -24.672 9.007 1.00 0.00 O HETATM 5270 O HOH A1596 2.020 44.158 34.833 1.00 0.00 O HETATM 5273 O HOH A1597 47.924 -6.285 45.245 1.00 0.00 O HETATM 5276 O HOH A1598 58.175 -34.902 -40.978 1.00 0.00 O HETATM 5279 O HOH A1599 -47.833 -76.854 87.182 1.00 0.00 O HETATM 5282 O HOH A1600 3.857 -35.483 -32.278 1.00 0.00 O HETATM 5285 O HOH A1601 53.571 15.245 28.856 1.00 0.00 O HETATM 5288 O HOH A1602 -41.104 62.478 -1.279 1.00 0.00 O HETATM 5291 O HOH A1603 -15.094 -2.623 7.969 1.00 0.00 O HETATM 5294 O HOH A1604 40.325 -0.719 -27.283 1.00 0.00 O HETATM 5297 O HOH A1605 6.871 -47.034 -27.032 1.00 0.00 O HETATM 5300 O HOH A1606 32.670 11.863 6.793 1.00 0.00 O HETATM 5303 O HOH A1607 13.605 -3.671 0.615 1.00 0.00 O HETATM 5306 O HOH A1608 6.212 -45.174 -22.827 1.00 0.00 O HETATM 5309 O HOH A1609 4.053 109.063 24.160 1.00 0.00 O HETATM 5312 O HOH A1610 -19.849 -0.371 -3.920 1.00 0.00 O HETATM 5315 O HOH A1611 -14.481 18.621 44.556 1.00 0.00 O HETATM 5318 O HOH A1612 -12.543 5.318 12.706 1.00 0.00 O HETATM 5321 O HOH A1613 -38.272 -20.860 24.268 1.00 0.00 O HETATM 5324 O HOH A1614 8.724 38.753 -53.671 1.00 0.00 O HETATM 5327 O HOH A1615 45.125 -2.473 -21.138 1.00 0.00 O HETATM 5330 O HOH A1616 13.068 -13.851 62.889 1.00 0.00 O HETATM 5333 O HOH A1617 34.158 -7.014 -37.587 1.00 0.00 O HETATM 5336 O HOH A1618 -51.825 59.278 -27.495 1.00 0.00 O HETATM 5339 O HOH A1619 -12.322 -16.595 -0.459 1.00 0.00 O HETATM 5342 O HOH A1620 -73.258 -1.174 8.109 1.00 0.00 O HETATM 5345 O HOH A1621 29.592 14.732 -55.295 1.00 0.00 O HETATM 5348 O HOH A1622 7.421 -1.513 5.581 1.00 0.00 O HETATM 5351 O HOH A1623 -16.392 -3.395 -11.943 1.00 0.00 O HETATM 5354 O HOH A1624 5.813 66.220 11.692 1.00 0.00 O HETATM 5357 O HOH A1625 24.300 -18.582 29.331 1.00 0.00 O HETATM 5360 O HOH A1626 -32.458 56.130 -48.787 1.00 0.00 O HETATM 5363 O HOH A1627 9.958 -12.923 32.266 1.00 0.00 O HETATM 5366 O HOH A1628 -80.988 19.662 0.675 1.00 0.00 O HETATM 5369 O HOH A1629 74.872 19.024 -6.092 1.00 0.00 O HETATM 5372 O HOH A1630 -2.844 45.052 29.093 1.00 0.00 O HETATM 5375 O HOH A1631 62.619 0.379 12.314 1.00 0.00 O HETATM 5378 O HOH A1632 -77.678 14.910 -2.828 1.00 0.00 O HETATM 5381 O HOH A1633 -42.686 -40.515 -47.181 1.00 0.00 O HETATM 5384 O HOH A1634 99.022 -23.840 31.281 1.00 0.00 O HETATM 5387 O HOH A1635 25.570 -40.062 7.150 1.00 0.00 O HETATM 5390 O HOH A1636 17.957 42.065 16.958 1.00 0.00 O HETATM 5393 O HOH A1637 -59.232 69.267 -2.071 1.00 0.00 O HETATM 5396 O HOH A1638 21.697 -21.941 -20.121 1.00 0.00 O HETATM 5399 O HOH A1639 -38.633 -13.956 8.330 1.00 0.00 O HETATM 5402 O HOH A1640 26.811 -9.932 -17.913 1.00 0.00 O HETATM 5405 O HOH A1641 -25.179 17.076 -79.783 1.00 0.00 O HETATM 5408 O HOH A1642 2.216 45.073 -0.298 1.00 0.00 O HETATM 5411 O HOH A1643 12.876 -71.424 9.232 1.00 0.00 O HETATM 5414 O HOH A1644 13.304 13.759 -43.576 1.00 0.00 O HETATM 5417 O HOH A1645 5.235 39.037 43.647 1.00 0.00 O HETATM 5420 O HOH A1646 20.985 -77.329 80.767 1.00 0.00 O HETATM 5423 O HOH A1647 -37.044 -66.852 -2.516 1.00 0.00 O HETATM 5426 O HOH A1648 -4.116 -16.963 36.338 1.00 0.00 O HETATM 5429 O HOH A1649 -18.703 22.911 8.688 1.00 0.00 O HETATM 5432 O HOH A1650 7.392 -18.368 -34.886 1.00 0.00 O HETATM 5435 O HOH A1651 21.421 -0.196 17.820 1.00 0.00 O HETATM 5438 O HOH A1652 14.858 0.806 35.062 1.00 0.00 O HETATM 5441 O HOH A1653 -0.613 -10.524 -38.078 1.00 0.00 O HETATM 5444 O HOH A1654 18.999 -11.855 89.160 1.00 0.00 O HETATM 5447 O HOH A1655 -93.761 -25.369 -3.462 1.00 0.00 O HETATM 5450 O HOH A1656 33.500 26.118 -36.060 1.00 0.00 O HETATM 5453 O HOH A1657 -26.530 -49.499 10.478 1.00 0.00 O HETATM 5456 O HOH A1658 71.646 53.351 27.151 1.00 0.00 O HETATM 5459 O HOH A1659 -25.586 23.840 -12.023 1.00 0.00 O HETATM 5462 O HOH A1660 -24.290 -34.007 -11.427 1.00 0.00 O HETATM 5465 O HOH A1661 -10.636 -6.885 -39.222 1.00 0.00 O HETATM 5468 O HOH A1662 1.021 -13.863 21.291 1.00 0.00 O HETATM 5471 O HOH A1663 -1.113 10.692 -25.435 1.00 0.00 O HETATM 5474 O HOH A1664 46.909 -23.624 -44.381 1.00 0.00 O HETATM 5477 O HOH A1665 -17.986 -56.831 -14.284 1.00 0.00 O HETATM 5480 O HOH A1666 -40.308 -41.629 10.142 1.00 0.00 O HETATM 5483 O HOH A1667 -15.256 -17.019 -43.604 1.00 0.00 O HETATM 5486 O HOH A1668 -19.744 -5.416 44.109 1.00 0.00 O HETATM 5489 O HOH A1669 26.840 -7.624 36.986 1.00 0.00 O HETATM 5492 O HOH A1670 -36.087 73.436 -15.633 1.00 0.00 O HETATM 5495 O HOH A1671 31.655 -6.474 5.137 1.00 0.00 O HETATM 5498 O HOH A1672 -14.146 -31.083 -79.442 1.00 0.00 O HETATM 5501 O HOH A1673 -29.894 -34.166 54.032 1.00 0.00 O HETATM 5504 O HOH A1674 40.044 13.991 -10.977 1.00 0.00 O HETATM 5507 O HOH A1675 1.489 42.329 27.654 1.00 0.00 O HETATM 5510 O HOH A1676 6.382 -4.199 -10.282 1.00 0.00 O HETATM 5513 O HOH A1677 10.683 2.668 24.231 1.00 0.00 O HETATM 5516 O HOH A1678 -44.823 -23.365 1.000 1.00 0.00 O HETATM 5519 O HOH A1679 -44.591 -18.490 6.456 1.00 0.00 O HETATM 5522 O HOH A1680 -34.581 -37.235 18.072 1.00 0.00 O HETATM 5525 O HOH A1681 -12.219 42.828 14.320 1.00 0.00 O HETATM 5528 O HOH A1682 6.335 -39.350 1.208 1.00 0.00 O HETATM 5531 O HOH A1683 22.900 -6.021 -14.597 1.00 0.00 O HETATM 5534 O HOH A1684 -42.658 15.719 68.897 1.00 0.00 O HETATM 5537 O HOH A1685 -16.579 -1.024 30.288 1.00 0.00 O HETATM 5540 O HOH A1686 -2.929 12.418 -86.843 1.00 0.00 O HETATM 5543 O HOH A1687 -29.928 -36.862 0.491 1.00 0.00 O HETATM 5546 O HOH A1688 16.266 20.935 -27.405 1.00 0.00 O HETATM 5549 O HOH A1689 25.266 10.369 -42.914 1.00 0.00 O HETATM 5552 O HOH A1690 52.961 -30.866 -30.113 1.00 0.00 O HETATM 5555 O HOH A1691 -48.634 -25.008 15.804 1.00 0.00 O HETATM 5558 O HOH A1692 29.367 11.690 15.991 1.00 0.00 O HETATM 5561 O HOH A1693 15.670 -13.732 14.951 1.00 0.00 O HETATM 5564 O HOH A1694 58.666 -38.967 15.115 1.00 0.00 O HETATM 5567 O HOH A1695 -68.281 7.586 29.946 1.00 0.00 O HETATM 5570 O HOH A1696 44.641 6.638 -31.385 1.00 0.00 O HETATM 5573 O HOH A1697 77.745 15.583 44.867 1.00 0.00 O HETATM 5576 O HOH A1698 28.859 21.790 30.672 1.00 0.00 O HETATM 5579 O HOH A1699 -63.988 55.893 17.116 1.00 0.00 O HETATM 5582 O HOH A1700 25.548 -31.633 83.017 1.00 0.00 O HETATM 5585 O HOH A1701 -17.277 6.413 -4.601 1.00 0.00 O HETATM 5588 O HOH A1702 33.446 -46.985 -47.367 1.00 0.00 O HETATM 5591 O HOH A1703 -55.241 10.954 29.023 1.00 0.00 O HETATM 5594 O HOH A1704 -35.805 16.598 36.918 1.00 0.00 O HETATM 5597 O HOH A1705 -40.661 22.434 41.365 1.00 0.00 O HETATM 5600 O HOH A1706 -23.628 24.557 20.741 1.00 0.00 O HETATM 5603 O HOH A1707 -5.038 7.881 -75.912 1.00 0.00 O HETATM 5606 O HOH A1708 22.384 68.830 27.410 1.00 0.00 O HETATM 5609 O HOH A1709 -23.289 -36.538 14.038 1.00 0.00 O HETATM 5612 O HOH A1710 -25.649 13.546 18.097 1.00 0.00 O HETATM 5615 O HOH A1711 -22.260 23.911 8.251 1.00 0.00 O HETATM 5618 O HOH A1712 -52.079 31.702 22.078 1.00 0.00 O HETATM 5621 O HOH A1713 -27.254 4.956 77.212 1.00 0.00 O HETATM 5624 O HOH A1714 -16.746 9.205 -6.651 1.00 0.00 O HETATM 5627 O HOH A1715 -14.128 -37.046 14.342 1.00 0.00 O HETATM 5630 O HOH A1716 -25.110 -45.340 -6.501 1.00 0.00 O HETATM 5633 O HOH A1717 -10.220 21.491 21.840 1.00 0.00 O HETATM 5636 O HOH A1718 -4.148 76.236 14.288 1.00 0.00 O HETATM 5639 O HOH A1719 15.314 33.628 -20.796 1.00 0.00 O HETATM 5642 O HOH A1720 -6.408 -3.759 6.913 1.00 0.00 O HETATM 5645 O HOH A1721 -44.740 35.408 -39.868 1.00 0.00 O HETATM 5648 O HOH A1722 59.298 3.447 -22.162 1.00 0.00 O HETATM 5651 O HOH A1723 -5.728 -16.992 -70.046 1.00 0.00 O HETATM 5654 O HOH A1724 3.597 56.168 45.945 1.00 0.00 O HETATM 5657 O HOH A1725 -8.071 24.683 14.410 1.00 0.00 O HETATM 5660 O HOH A1726 -0.110 -38.111 33.360 1.00 0.00 O HETATM 5663 O HOH A1727 -33.221 15.020 -9.906 1.00 0.00 O HETATM 5666 O HOH A1728 3.017 3.107 -11.160 1.00 0.00 O HETATM 5669 O HOH A1729 -27.688 -31.340 43.935 1.00 0.00 O HETATM 5672 O HOH A1730 -2.030 -30.069 5.839 1.00 0.00 O HETATM 5675 O HOH A1731 -50.858 27.532 -51.146 1.00 0.00 O HETATM 5678 O HOH A1732 -39.401 32.210 63.863 1.00 0.00 O HETATM 5681 O HOH A1733 6.273 6.720 21.266 1.00 0.00 O HETATM 5684 O HOH A1734 -53.095 24.607 40.393 1.00 0.00 O HETATM 5687 O HOH A1735 0.090 -66.162 39.414 1.00 0.00 O HETATM 5690 O HOH A1736 -1.552 -22.603 -22.109 1.00 0.00 O HETATM 5693 O HOH A1737 46.003 -11.574 -48.336 1.00 0.00 O HETATM 5696 O HOH A1738 -69.554 10.777 46.475 1.00 0.00 O HETATM 5699 O HOH A1739 -0.597 -6.761 7.497 1.00 0.00 O HETATM 5702 O HOH A1740 21.498 25.166 53.534 1.00 0.00 O HETATM 5705 O HOH A1741 57.784 11.875 -28.482 1.00 0.00 O HETATM 5708 O HOH A1742 -53.627 15.270 18.964 1.00 0.00 O HETATM 5711 O HOH A1743 6.564 39.851 -7.953 1.00 0.00 O HETATM 5714 O HOH A1744 27.902 -22.215 21.631 1.00 0.00 O HETATM 5717 O HOH A1745 18.508 -47.324 -3.499 1.00 0.00 O HETATM 5720 O HOH A1746 -12.055 -22.398 81.255 1.00 0.00 O HETATM 5723 O HOH A1747 29.425 -15.418 -33.903 1.00 0.00 O HETATM 5726 O HOH A1748 -24.873 -7.303 -1.673 1.00 0.00 O HETATM 5729 O HOH A1749 -29.030 -28.679 59.776 1.00 0.00 O HETATM 5732 O HOH A1750 -51.437 41.550 -41.547 1.00 0.00 O HETATM 5735 O HOH A1751 -1.660 -16.130 13.798 1.00 0.00 O HETATM 5738 O HOH A1752 -18.710 -36.752 -24.436 1.00 0.00 O HETATM 5741 O HOH A1753 3.461 -46.496 4.776 1.00 0.00 O HETATM 5744 O HOH A1754 68.665 -30.740 31.731 1.00 0.00 O HETATM 5747 O HOH A1755 5.651 68.166 -12.595 1.00 0.00 O HETATM 5750 O HOH A1756 28.919 -22.720 25.635 1.00 0.00 O HETATM 5753 O HOH A1757 11.664 10.940 -14.122 1.00 0.00 O HETATM 5756 O HOH A1758 -6.740 23.987 -5.432 1.00 0.00 O HETATM 5759 O HOH A1759 23.777 -1.166 32.148 1.00 0.00 O HETATM 5762 O HOH A1760 14.255 -30.211 -21.529 1.00 0.00 O HETATM 5765 O HOH A1761 -59.167 -19.373 81.332 1.00 0.00 O HETATM 5768 O HOH A1762 3.115 -91.533 66.871 1.00 0.00 O HETATM 5771 O HOH A1763 -3.657 -0.221 23.382 1.00 0.00 O HETATM 5774 O HOH A1764 42.775 -30.091 8.442 1.00 0.00 O HETATM 5777 O HOH A1765 -36.912 -17.830 6.056 1.00 0.00 O HETATM 5780 O HOH A1766 -0.108 9.172 -19.855 1.00 0.00 O HETATM 5783 O HOH A1767 35.680 -13.964 -1.274 1.00 0.00 O HETATM 5786 O HOH A1768 38.819 -13.467 -31.050 1.00 0.00 O HETATM 5789 O HOH A1769 32.277 26.379 9.515 1.00 0.00 O HETATM 5792 O HOH A1770 -11.666 12.059 30.176 1.00 0.00 O HETATM 5795 O HOH A1771 19.679 7.427 36.998 1.00 0.00 O HETATM 5798 O HOH A1772 -9.467 -3.253 21.362 1.00 0.00 O HETATM 5801 O HOH A1773 -1.195 20.754 45.815 1.00 0.00 O HETATM 5804 O HOH A1774 31.900 -44.782 23.643 1.00 0.00 O HETATM 5807 O HOH A1775 25.709 -3.645 -42.104 1.00 0.00 O HETATM 5810 O HOH A1776 16.035 -44.380 48.129 1.00 0.00 O HETATM 5813 O HOH A1777 11.813 -38.989 27.664 1.00 0.00 O HETATM 5816 O HOH A1778 44.933 5.536 16.707 1.00 0.00 O HETATM 5819 O HOH A1779 -1.506 -5.215 20.976 1.00 0.00 O HETATM 5822 O HOH A1780 62.249 -63.271 -24.735 1.00 0.00 O HETATM 5825 O HOH A1781 18.964 -34.017 16.119 1.00 0.00 O HETATM 5828 O HOH A1782 36.571 -79.571 62.852 1.00 0.00 O HETATM 5831 O HOH A1783 40.935 -21.940 41.772 1.00 0.00 O HETATM 5834 O HOH A1784 -58.850 36.015 21.190 1.00 0.00 O HETATM 5837 O HOH A1785 4.587 -26.801 31.825 1.00 0.00 O HETATM 5840 O HOH A1786 -9.653 25.164 -68.056 1.00 0.00 O HETATM 5843 O HOH A1787 26.671 -13.362 0.539 1.00 0.00 O HETATM 5846 O HOH A1788 0.814 -29.311 -31.354 1.00 0.00 O HETATM 5849 O HOH A1789 -21.002 -43.385 31.712 1.00 0.00 O HETATM 5852 O HOH A1790 54.734 -15.430 -46.944 1.00 0.00 O HETATM 5855 O HOH A1791 10.283 -32.294 43.093 1.00 0.00 O HETATM 5858 O HOH A1792 14.350 19.319 -49.064 1.00 0.00 O HETATM 5861 O HOH A1793 27.227 20.719 -39.247 1.00 0.00 O HETATM 5864 O HOH A1794 3.507 -63.956 -15.437 1.00 0.00 O HETATM 5867 O HOH A1795 -43.791 29.518 48.115 1.00 0.00 O HETATM 5870 O HOH A1796 -12.076 -11.330 -48.428 1.00 0.00 O HETATM 5873 O HOH A1797 10.391 -34.227 3.351 1.00 0.00 O HETATM 5876 O HOH A1798 3.305 6.774 33.502 1.00 0.00 O HETATM 5879 O HOH A1799 10.007 55.864 -8.652 1.00 0.00 O HETATM 5882 O HOH A1800 0.638 10.098 -58.850 1.00 0.00 O HETATM 5885 O HOH A1801 -45.362 11.923 23.846 1.00 0.00 O HETATM 5888 O HOH A1802 42.818 24.800 5.627 1.00 0.00 O HETATM 5891 O HOH A1803 67.826 -21.801 -28.032 1.00 0.00 O HETATM 5894 O HOH A1804 0.291 -21.044 32.619 1.00 0.00 O HETATM 5897 O HOH A1805 17.785 -1.558 7.583 1.00 0.00 O HETATM 5900 O HOH A1806 -10.059 -8.991 61.551 1.00 0.00 O HETATM 5903 O HOH A1807 39.492 109.148 20.158 1.00 0.00 O HETATM 5906 O HOH A1808 40.936 -15.425 -24.373 1.00 0.00 O HETATM 5909 O HOH A1809 -32.126 -40.769 -35.660 1.00 0.00 O HETATM 5912 O HOH A1810 23.168 -13.062 -19.128 1.00 0.00 O HETATM 5915 O HOH A1811 -9.195 -43.277 -16.156 1.00 0.00 O HETATM 5918 O HOH A1812 -16.851 4.462 -54.597 1.00 0.00 O HETATM 5921 O HOH A1813 -35.724 -9.973 -26.616 1.00 0.00 O HETATM 5924 O HOH A1814 -24.807 -27.079 8.774 1.00 0.00 O HETATM 5927 O HOH A1815 93.230 -9.079 9.004 1.00 0.00 O HETATM 5930 O HOH A1816 -19.985 -43.166 11.498 1.00 0.00 O HETATM 5933 O HOH A1817 -16.041 -2.672 3.120 1.00 0.00 O HETATM 5936 O HOH A1818 37.584 -24.208 73.276 1.00 0.00 O HETATM 5939 O HOH A1819 33.198 -12.621 18.650 1.00 0.00 O HETATM 5942 O HOH A1820 -40.266 -44.465 28.101 1.00 0.00 O HETATM 5945 O HOH A1821 -17.011 11.521 63.960 1.00 0.00 O HETATM 5948 O HOH A1822 8.517 64.996 -2.929 1.00 0.00 O HETATM 5951 O HOH A1823 6.486 -16.954 10.473 1.00 0.00 O HETATM 5954 O HOH A1824 14.650 19.830 -10.421 1.00 0.00 O HETATM 5957 O HOH A1825 -1.733 -71.463 -26.199 1.00 0.00 O HETATM 5960 O HOH A1826 -5.660 23.505 90.235 1.00 0.00 O HETATM 5963 O HOH A1827 51.914 -44.473 -20.774 1.00 0.00 O HETATM 5966 O HOH A1828 5.392 -5.586 -33.747 1.00 0.00 O HETATM 5969 O HOH A1829 11.015 -22.348 -16.144 1.00 0.00 O HETATM 5972 O HOH A1830 50.556 -35.190 -17.093 1.00 0.00 O HETATM 5975 O HOH A1831 8.373 -23.041 -29.445 1.00 0.00 O HETATM 5978 O HOH A1832 -41.195 -11.400 4.423 1.00 0.00 O HETATM 5981 O HOH A1833 45.109 11.602 8.501 1.00 0.00 O HETATM 5984 O HOH A1834 -16.028 1.604 -21.144 1.00 0.00 O HETATM 5987 O HOH A1835 -20.153 -53.378 41.375 1.00 0.00 O HETATM 5990 O HOH A1836 -58.729 3.932 -41.182 1.00 0.00 O HETATM 5993 O HOH A1837 -42.964 -9.324 4.572 1.00 0.00 O HETATM 5996 O HOH A1838 31.398 -5.137 21.817 1.00 0.00 O HETATM 5999 O HOH A1839 -11.187 -47.904 24.994 1.00 0.00 O HETATM 6002 O HOH A1840 -58.685 -52.185 14.233 1.00 0.00 O HETATM 6005 O HOH A1841 13.356 -40.284 -26.970 1.00 0.00 O HETATM 6008 O HOH A1842 57.586 15.444 46.098 1.00 0.00 O HETATM 6011 O HOH A1843 -52.091 3.254 29.619 1.00 0.00 O HETATM 6014 O HOH A1844 -3.956 9.972 26.610 1.00 0.00 O HETATM 6017 O HOH A1845 -22.371 -32.292 5.633 1.00 0.00 O HETATM 6020 O HOH A1846 -2.011 -21.931 21.902 1.00 0.00 O HETATM 6023 O HOH A1847 -33.148 23.992 28.325 1.00 0.00 O HETATM 6026 O HOH A1848 18.829 49.018 5.781 1.00 0.00 O HETATM 6029 O HOH A1849 9.145 37.177 18.503 1.00 0.00 O HETATM 6032 O HOH A1850 11.892 39.399 53.170 1.00 0.00 O HETATM 6035 O HOH A1851 -6.953 37.316 20.136 1.00 0.00 O HETATM 6038 O HOH A1852 -33.040 17.648 88.596 1.00 0.00 O HETATM 6041 O HOH A1853 20.691 40.888 46.395 1.00 0.00 O HETATM 6044 O HOH A1854 -74.697 52.316 34.155 1.00 0.00 O HETATM 6047 O HOH A1855 -8.193 12.036 14.233 1.00 0.00 O HETATM 6050 O HOH A1856 10.782 -21.220 1.869 1.00 0.00 O HETATM 6053 O HOH A1857 -27.897 47.742 -62.364 1.00 0.00 O HETATM 6056 O HOH A1858 12.453 23.120 -18.900 1.00 0.00 O HETATM 6059 O HOH A1859 -33.509 13.645 54.489 1.00 0.00 O HETATM 6062 O HOH A1860 -57.034 -19.736 -18.561 1.00 0.00 O HETATM 6065 O HOH A1861 -10.604 81.140 54.092 1.00 0.00 O HETATM 6068 O HOH A1862 6.854 73.591 7.692 1.00 0.00 O HETATM 6071 O HOH A1863 -28.651 10.008 14.141 1.00 0.00 O HETATM 6074 O HOH A1864 7.765 -54.133 34.124 1.00 0.00 O HETATM 6077 O HOH A1865 39.485 -14.556 3.161 1.00 0.00 O HETATM 6080 O HOH A1866 -32.473 21.422 43.110 1.00 0.00 O HETATM 6083 O HOH A1867 46.749 -21.917 -13.342 1.00 0.00 O HETATM 6086 O HOH A1868 32.365 -21.105 14.409 1.00 0.00 O HETATM 6089 O HOH A1869 27.861 69.146 34.582 1.00 0.00 O HETATM 6092 O HOH A1870 -49.842 -52.178 15.392 1.00 0.00 O HETATM 6095 O HOH A1871 -3.449 -35.090 28.268 1.00 0.00 O HETATM 6098 O HOH A1872 16.012 -34.815 11.818 1.00 0.00 O HETATM 6101 O HOH A1873 -15.284 -49.013 -12.304 1.00 0.00 O HETATM 6104 O HOH A1874 -17.025 -0.860 -20.680 1.00 0.00 O HETATM 6107 O HOH A1875 12.755 -53.931 -20.737 1.00 0.00 O HETATM 6110 O HOH A1876 11.991 3.875 12.511 1.00 0.00 O HETATM 6113 O HOH A1877 -1.352 12.720 10.263 1.00 0.00 O HETATM 6116 O HOH A1878 8.352 -30.128 -9.908 1.00 0.00 O HETATM 6119 O HOH A1879 -3.423 -20.702 -5.314 1.00 0.00 O HETATM 6122 O HOH A1880 48.886 15.173 48.433 1.00 0.00 O HETATM 6125 O HOH A1881 -9.915 41.239 29.889 1.00 0.00 O HETATM 6128 O HOH A1882 -21.205 4.195 -8.417 1.00 0.00 O HETATM 6131 O HOH A1883 -23.357 24.050 -26.578 1.00 0.00 O HETATM 6134 O HOH A1884 9.298 4.967 -16.179 1.00 0.00 O HETATM 6137 O HOH A1885 3.433 -37.534 31.298 1.00 0.00 O HETATM 6140 O HOH A1886 -31.386 27.778 17.922 1.00 0.00 O HETATM 6143 O HOH A1887 14.409 -71.732 -66.168 1.00 0.00 O HETATM 6146 O HOH A1888 -62.270 -16.410 -33.658 1.00 0.00 O HETATM 6149 O HOH A1889 -69.257 -1.109 -19.579 1.00 0.00 O HETATM 6152 O HOH A1890 -27.073 27.042 -38.697 1.00 0.00 O HETATM 6155 O HOH A1891 55.573 14.565 8.009 1.00 0.00 O HETATM 6158 O HOH A1892 1.661 17.442 -67.500 1.00 0.00 O HETATM 6161 O HOH A1893 -8.259 30.430 34.143 1.00 0.00 O HETATM 6164 O HOH A1894 46.931 42.857 12.866 1.00 0.00 O HETATM 6167 O HOH A1895 26.617 70.782 -28.266 1.00 0.00 O HETATM 6170 O HOH A1896 2.701 -41.253 33.896 1.00 0.00 O HETATM 6173 O HOH A1897 -56.933 -31.939 -23.739 1.00 0.00 O HETATM 6176 O HOH A1898 -41.893 -13.412 -59.886 1.00 0.00 O HETATM 6179 O HOH A1899 -14.792 -22.711 0.188 1.00 0.00 O HETATM 6182 O HOH A1900 -1.738 -26.338 10.941 1.00 0.00 O HETATM 6185 O HOH A1901 -37.087 53.757 -32.153 1.00 0.00 O HETATM 6188 O HOH A1902 3.529 -51.709 -22.196 1.00 0.00 O HETATM 6191 O HOH A1903 -24.268 28.111 -14.465 1.00 0.00 O HETATM 6194 O HOH A1904 84.591 16.341 27.191 1.00 0.00 O HETATM 6197 O HOH A1905 -66.477 -25.531 -58.119 1.00 0.00 O HETATM 6200 O HOH A1906 -8.179 -11.478 40.657 1.00 0.00 O HETATM 6203 O HOH A1907 1.862 -34.003 2.219 1.00 0.00 O HETATM 6206 O HOH A1908 72.921 22.246 4.389 1.00 0.00 O HETATM 6209 O HOH A1909 -78.527 8.787 -43.796 1.00 0.00 O HETATM 6212 O HOH A1910 -29.092 7.511 71.534 1.00 0.00 O HETATM 6215 O HOH A1911 -21.580 17.570 -11.854 1.00 0.00 O HETATM 6218 O HOH A1912 -0.524 -18.228 67.293 1.00 0.00 O HETATM 6221 O HOH A1913 -23.439 69.218 -36.775 1.00 0.00 O HETATM 6224 O HOH A1914 42.308 -45.076 -53.316 1.00 0.00 O HETATM 6227 O HOH A1915 -12.226 -11.166 27.141 1.00 0.00 O HETATM 6230 O HOH A1916 -21.817 25.211 5.943 1.00 0.00 O HETATM 6233 O HOH A1917 -9.905 -40.393 -24.913 1.00 0.00 O HETATM 6236 O HOH A1918 13.606 -41.201 11.677 1.00 0.00 O HETATM 6239 O HOH A1919 -1.002 30.557 31.945 1.00 0.00 O HETATM 6242 O HOH A1920 -16.217 -30.041 -0.651 1.00 0.00 O HETATM 6245 O HOH A1921 91.331 5.660 -27.521 1.00 0.00 O HETATM 6248 O HOH A1922 -24.238 -36.229 27.485 1.00 0.00 O HETATM 6251 O HOH A1923 -22.222 36.071 -19.150 1.00 0.00 O HETATM 6254 O HOH A1924 -4.163 -16.398 24.072 1.00 0.00 O HETATM 6257 O HOH A1925 -53.458 -14.364 -17.197 1.00 0.00 O HETATM 6260 O HOH A1926 -23.145 7.193 -25.412 1.00 0.00 O HETATM 6263 O HOH A1927 -5.370 9.777 -6.779 1.00 0.00 O HETATM 6266 O HOH A1928 48.719 -3.213 -17.733 1.00 0.00 O HETATM 6269 O HOH A1929 -14.845 1.141 30.278 1.00 0.00 O HETATM 6272 O HOH A1930 26.723 -29.287 -20.211 1.00 0.00 O HETATM 6275 O HOH A1931 59.516 -44.788 -8.155 1.00 0.00 O HETATM 6278 O HOH A1932 -17.821 -45.345 56.443 1.00 0.00 O HETATM 6281 O HOH A1933 -10.697 14.713 1.348 1.00 0.00 O HETATM 6284 O HOH A1934 20.584 -30.323 11.428 1.00 0.00 O HETATM 6287 O HOH A1935 -10.125 76.699 -16.156 1.00 0.00 O HETATM 6290 O HOH A1936 -33.927 -7.807 1.443 1.00 0.00 O HETATM 6293 O HOH A1937 -8.813 -25.677 -10.884 1.00 0.00 O HETATM 6296 O HOH A1938 6.709 -34.878 1.914 1.00 0.00 O HETATM 6299 O HOH A1939 8.162 24.031 77.634 1.00 0.00 O HETATM 6302 O HOH A1940 7.087 11.823 16.360 1.00 0.00 O HETATM 6305 O HOH A1941 16.748 14.915 -16.785 1.00 0.00 O HETATM 6308 O HOH A1942 20.920 -6.642 -60.891 1.00 0.00 O HETATM 6311 O HOH A1943 -34.160 12.733 10.379 1.00 0.00 O HETATM 6314 O HOH A1944 0.743 0.776 13.126 1.00 0.00 O HETATM 6317 O HOH A1945 -55.903 -15.444 18.729 1.00 0.00 O HETATM 6320 O HOH A1946 9.673 -6.290 -11.622 1.00 0.00 O HETATM 6323 O HOH A1947 18.839 -3.144 38.602 1.00 0.00 O HETATM 6326 O HOH A1948 -26.335 20.328 -1.174 1.00 0.00 O HETATM 6329 O HOH A1949 66.232 -7.906 77.782 1.00 0.00 O HETATM 6332 O HOH A1950 -42.318 30.643 26.622 1.00 0.00 O HETATM 6335 O HOH A1951 -58.312 -17.078 -45.292 1.00 0.00 O HETATM 6338 O HOH A1952 54.597 16.679 -15.684 1.00 0.00 O HETATM 6341 O HOH A1953 -38.705 -24.480 9.465 1.00 0.00 O HETATM 6344 O HOH A1954 -23.808 -1.296 -6.296 1.00 0.00 O HETATM 6347 O HOH A1955 32.384 -26.598 24.221 1.00 0.00 O HETATM 6350 O HOH A1956 14.509 36.702 56.171 1.00 0.00 O HETATM 6353 O HOH A1957 17.033 -1.519 -0.352 1.00 0.00 O HETATM 6356 O HOH A1958 -27.847 -35.794 -5.257 1.00 0.00 O HETATM 6359 O HOH A1959 -81.631 -41.032 -88.587 1.00 0.00 O HETATM 6362 O HOH A1960 18.406 -4.618 -21.397 1.00 0.00 O HETATM 6365 O HOH A1961 -14.582 2.473 -44.604 1.00 0.00 O HETATM 6368 O HOH A1962 4.682 -37.365 12.944 1.00 0.00 O HETATM 6371 O HOH A1963 -1.642 -31.861 15.152 1.00 0.00 O HETATM 6374 O HOH A1964 -9.952 -48.429 -78.789 1.00 0.00 O HETATM 6377 O HOH A1965 -2.938 2.514 33.774 1.00 0.00 O HETATM 6380 O HOH A1966 -14.821 -23.199 31.772 1.00 0.00 O HETATM 6383 O HOH A1967 38.696 -25.867 -37.610 1.00 0.00 O HETATM 6386 O HOH A1968 6.393 11.634 5.648 1.00 0.00 O HETATM 6389 O HOH A1969 22.788 -49.075 -25.272 1.00 0.00 O HETATM 6392 O HOH A1970 -49.485 -45.096 76.372 1.00 0.00 O HETATM 6395 O HOH A1971 -10.168 -12.369 53.168 1.00 0.00 O HETATM 6398 O HOH A1972 -43.673 -44.804 -30.087 1.00 0.00 O HETATM 6401 O HOH A1973 19.293 32.692 0.453 1.00 0.00 O HETATM 6404 O HOH A1974 7.258 16.049 -72.584 1.00 0.00 O HETATM 6407 O HOH A1975 5.970 56.901 -2.014 1.00 0.00 O HETATM 6410 O HOH A1976 14.358 22.376 -30.592 1.00 0.00 O HETATM 6413 O HOH A1977 30.210 41.232 -33.426 1.00 0.00 O HETATM 6416 O HOH A1978 8.292 -67.787 -33.532 1.00 0.00 O HETATM 6419 O HOH A1979 6.042 -7.116 81.399 1.00 0.00 O HETATM 6422 O HOH A1980 28.676 32.257 30.002 1.00 0.00 O HETATM 6425 O HOH A1981 -47.289 -52.581 14.242 1.00 0.00 O HETATM 6428 O HOH A1982 -19.569 -17.962 -29.864 1.00 0.00 O HETATM 6431 O HOH A1983 -24.387 -2.886 17.359 1.00 0.00 O HETATM 6434 O HOH A1984 15.416 25.330 28.917 1.00 0.00 O HETATM 6437 O HOH A1985 -64.199 -27.511 -17.785 1.00 0.00 O HETATM 6440 O HOH A1986 6.094 48.000 32.467 1.00 0.00 O HETATM 6443 O HOH A1987 52.879 3.604 39.928 1.00 0.00 O HETATM 6446 O HOH A1988 43.384 -27.139 55.159 1.00 0.00 O HETATM 6449 O HOH A1989 5.361 35.039 -19.986 1.00 0.00 O HETATM 6452 O HOH A1990 19.413 -11.488 10.735 1.00 0.00 O HETATM 6455 O HOH A1991 50.830 6.498 -43.971 1.00 0.00 O HETATM 6458 O HOH A1992 52.013 -67.601 30.805 1.00 0.00 O HETATM 6461 O HOH A1993 -41.585 -26.529 -40.760 1.00 0.00 O HETATM 6464 O HOH A1994 23.727 39.310 -25.955 1.00 0.00 O HETATM 6467 O HOH A1995 -102.760 26.385 56.867 1.00 0.00 O HETATM 6470 O HOH A1996 38.268 -44.460 -3.475 1.00 0.00 O HETATM 6473 O HOH A1997 82.599 -21.885 36.151 1.00 0.00 O HETATM 6476 O HOH A1998 -46.460 55.735 8.255 1.00 0.00 O HETATM 6479 O HOH A1999 39.585 25.341 13.731 1.00 0.00 O HETATM 6482 O HOH A2000 -77.802 -10.459 -56.195 1.00 0.00 O HETATM 6485 O HOH A2001 -43.249 18.750 58.342 1.00 0.00 O HETATM 6488 O HOH A2002 15.464 20.692 -1.604 1.00 0.00 O HETATM 6491 O HOH A2003 -37.539 -27.983 -10.627 1.00 0.00 O HETATM 6494 O HOH A2004 7.885 6.223 -62.801 1.00 0.00 O HETATM 6497 O HOH A2005 13.918 -44.841 -36.634 1.00 0.00 O HETATM 6500 O HOH A2006 26.445 -57.275 -59.261 1.00 0.00 O HETATM 6503 O HOH A2007 27.957 -51.959 18.968 1.00 0.00 O HETATM 6506 O HOH A2008 -22.710 -5.978 55.724 1.00 0.00 O HETATM 6509 O HOH A2009 62.526 7.733 -40.441 1.00 0.00 O HETATM 6512 O HOH A2010 52.260 -34.586 23.196 1.00 0.00 O HETATM 6515 O HOH A2011 -24.606 30.392 15.539 1.00 0.00 O HETATM 6518 O HOH A2012 21.070 44.279 67.338 1.00 0.00 O HETATM 6521 O HOH A2013 34.059 30.777 36.786 1.00 0.00 O HETATM 6524 O HOH A2014 9.404 28.872 34.643 1.00 0.00 O HETATM 6527 O HOH A2015 68.389 -31.972 21.801 1.00 0.00 O HETATM 6530 O HOH A2016 0.744 -37.645 3.749 1.00 0.00 O HETATM 6533 O HOH A2017 5.879 62.397 -17.339 1.00 0.00 O HETATM 6536 O HOH A2018 -8.732 -48.537 4.361 1.00 0.00 O HETATM 6539 O HOH A2019 -80.465 6.627 -29.506 1.00 0.00 O HETATM 6542 O HOH A2020 12.529 10.984 -51.426 1.00 0.00 O HETATM 6545 O HOH A2021 40.554 15.851 -35.348 1.00 0.00 O HETATM 6548 O HOH A2022 11.965 -7.310 -5.342 1.00 0.00 O HETATM 6551 O HOH A2023 -38.629 17.854 44.289 1.00 0.00 O HETATM 6554 O HOH A2024 36.745 14.038 28.558 1.00 0.00 O HETATM 6557 O HOH A2025 17.933 2.135 27.382 1.00 0.00 O HETATM 6560 O HOH A2026 -28.686 27.963 -34.918 1.00 0.00 O HETATM 6563 O HOH A2027 -8.754 -5.678 45.454 1.00 0.00 O HETATM 6566 O HOH A2028 -18.090 15.076 47.248 1.00 0.00 O HETATM 6569 O HOH A2029 11.507 -28.383 23.797 1.00 0.00 O HETATM 6572 O HOH A2030 5.353 -37.195 -5.644 1.00 0.00 O HETATM 6575 O HOH A2031 -11.328 47.841 11.958 1.00 0.00 O HETATM 6578 O HOH A2032 -2.456 20.578 16.109 1.00 0.00 O HETATM 6581 O HOH A2033 8.214 -20.603 -4.065 1.00 0.00 O HETATM 6584 O HOH A2034 -29.250 -26.434 27.761 1.00 0.00 O HETATM 6587 O HOH A2035 -29.005 27.923 -14.291 1.00 0.00 O HETATM 6590 O HOH A2036 -50.805 -6.134 -1.864 1.00 0.00 O HETATM 6593 O HOH A2037 -68.041 49.344 -17.129 1.00 0.00 O HETATM 6596 O HOH A2038 -25.481 43.485 1.000 1.00 0.00 O HETATM 6599 O HOH A2039 15.167 54.240 32.624 1.00 0.00 O HETATM 6602 O HOH A2040 15.934 4.928 -3.801 1.00 0.00 O HETATM 6605 O HOH A2041 34.948 -1.949 -31.683 1.00 0.00 O HETATM 6608 O HOH A2042 -60.275 -33.397 62.379 1.00 0.00 O HETATM 6611 O HOH A2043 37.677 -6.814 -19.575 1.00 0.00 O HETATM 6614 O HOH A2044 11.278 18.828 -53.009 1.00 0.00 O HETATM 6617 O HOH A2045 -27.088 18.145 -58.954 1.00 0.00 O HETATM 6620 O HOH A2046 23.976 31.122 -38.868 1.00 0.00 O HETATM 6623 O HOH A2047 0.867 31.941 -77.062 1.00 0.00 O HETATM 6626 O HOH A2048 -21.907 -49.944 -14.999 1.00 0.00 O HETATM 6629 O HOH A2049 20.424 -20.969 -14.761 1.00 0.00 O HETATM 6632 O HOH A2050 22.775 11.967 17.967 1.00 0.00 O HETATM 6635 O HOH A2051 2.003 10.770 28.695 1.00 0.00 O HETATM 6638 O HOH A2052 0.733 56.401 -71.090 1.00 0.00 O HETATM 6641 O HOH A2053 14.237 -3.725 -22.356 1.00 0.00 O HETATM 6644 O HOH A2054 22.153 13.306 -58.585 1.00 0.00 O HETATM 6647 O HOH A2055 -24.833 44.700 59.988 1.00 0.00 O HETATM 6650 O HOH A2056 -3.140 44.060 -5.680 1.00 0.00 O HETATM 6653 O HOH A2057 20.093 -13.506 -25.530 1.00 0.00 O HETATM 6656 O HOH A2058 -53.319 -42.873 -47.035 1.00 0.00 O HETATM 6659 O HOH A2059 16.841 22.748 -22.097 1.00 0.00 O HETATM 6662 O HOH A2060 31.520 -18.160 -4.359 1.00 0.00 O HETATM 6665 O HOH A2061 13.421 -1.875 -4.272 1.00 0.00 O HETATM 6668 O HOH A2062 -67.515 4.340 -14.788 1.00 0.00 O HETATM 6671 O HOH A2063 -41.740 -8.245 -45.113 1.00 0.00 O HETATM 6674 O HOH A2064 -8.335 -87.678 -41.093 1.00 0.00 O HETATM 6677 O HOH A2065 -50.196 -14.496 -16.490 1.00 0.00 O HETATM 6680 O HOH A2066 -36.013 8.484 -47.842 1.00 0.00 O HETATM 6683 O HOH A2067 -5.274 22.326 -17.703 1.00 0.00 O HETATM 6686 O HOH A2068 -0.985 -21.779 6.016 1.00 0.00 O HETATM 6689 O HOH A2069 54.222 9.351 -50.509 1.00 0.00 O HETATM 6692 O HOH A2070 3.177 58.769 -36.258 1.00 0.00 O HETATM 6695 O HOH A2071 -0.558 25.131 27.094 1.00 0.00 O HETATM 6698 O HOH A2072 54.944 3.071 -18.232 1.00 0.00 O HETATM 6701 O HOH A2073 -63.963 23.738 -11.749 1.00 0.00 O HETATM 6704 O HOH A2074 61.977 29.008 5.388 1.00 0.00 O HETATM 6707 O HOH A2075 17.868 -17.712 -65.701 1.00 0.00 O HETATM 6710 O HOH A2076 -58.316 7.568 1.626 1.00 0.00 O HETATM 6713 O HOH A2077 36.573 -58.470 -25.579 1.00 0.00 O HETATM 6716 O HOH A2078 -21.905 -19.506 -4.411 1.00 0.00 O HETATM 6719 O HOH A2079 3.372 -10.292 22.240 1.00 0.00 O HETATM 6722 O HOH A2080 15.143 -10.773 21.756 1.00 0.00 O HETATM 6725 O HOH A2081 2.110 15.134 57.085 1.00 0.00 O HETATM 6728 O HOH A2082 18.689 -46.908 50.228 1.00 0.00 O HETATM 6731 O HOH A2083 24.727 -6.548 -17.992 1.00 0.00 O HETATM 6734 O HOH A2084 -24.741 -18.973 -28.973 1.00 0.00 O HETATM 6737 O HOH A2085 39.306 -42.812 27.956 1.00 0.00 O HETATM 6740 O HOH A2086 -27.571 0.099 7.828 1.00 0.00 O HETATM 6743 O HOH A2087 4.146 -36.872 26.525 1.00 0.00 O HETATM 6746 O HOH A2088 -20.753 -1.398 19.325 1.00 0.00 O HETATM 6749 O HOH A2089 50.706 -16.174 12.190 1.00 0.00 O HETATM 6752 O HOH A2090 15.813 15.493 16.494 1.00 0.00 O HETATM 6755 O HOH A2091 -18.403 -3.252 -4.987 1.00 0.00 O HETATM 6758 O HOH A2092 1.396 24.301 7.816 1.00 0.00 O HETATM 6761 O HOH A2093 -13.537 29.796 14.008 1.00 0.00 O HETATM 6764 O HOH A2094 39.324 -59.725 3.582 1.00 0.00 O HETATM 6767 O HOH A2095 -55.809 21.975 12.240 1.00 0.00 O HETATM 6770 O HOH A2096 34.694 8.342 -30.875 1.00 0.00 O HETATM 6773 O HOH A2097 5.076 -38.760 -3.303 1.00 0.00 O HETATM 6776 O HOH A2098 -8.546 55.024 -30.956 1.00 0.00 O HETATM 6779 O HOH A2099 -73.891 -32.681 6.048 1.00 0.00 O HETATM 6782 O HOH A2100 72.861 -29.707 -18.805 1.00 0.00 O HETATM 6785 O HOH A2101 16.851 11.046 23.145 1.00 0.00 O HETATM 6788 O HOH A2102 -17.466 -7.291 -57.078 1.00 0.00 O HETATM 6791 O HOH A2103 5.462 -11.594 23.480 1.00 0.00 O HETATM 6794 O HOH A2104 -33.078 -2.840 -5.841 1.00 0.00 O HETATM 6797 O HOH A2105 25.734 13.913 49.232 1.00 0.00 O HETATM 6800 O HOH A2106 10.420 -17.246 -20.120 1.00 0.00 O HETATM 6803 O HOH A2107 -37.056 -18.163 -3.031 1.00 0.00 O HETATM 6806 O HOH A2108 5.545 -22.102 19.859 1.00 0.00 O HETATM 6809 O HOH A2109 63.047 18.316 48.537 1.00 0.00 O HETATM 6812 O HOH A2110 28.886 -0.999 -32.262 1.00 0.00 O HETATM 6815 O HOH A2111 29.258 44.557 -28.536 1.00 0.00 O HETATM 6818 O HOH A2112 2.940 -30.705 -4.741 1.00 0.00 O HETATM 6821 O HOH A2113 -49.283 -60.046 -20.665 1.00 0.00 O HETATM 6824 O HOH A2114 -30.418 -6.079 -58.719 1.00 0.00 O HETATM 6827 O HOH A2115 -42.270 -16.441 28.882 1.00 0.00 O HETATM 6830 O HOH A2116 -41.884 -25.130 -21.368 1.00 0.00 O HETATM 6833 O HOH A2117 4.340 -43.606 43.616 1.00 0.00 O HETATM 6836 O HOH A2118 -18.288 10.599 19.623 1.00 0.00 O HETATM 6839 O HOH A2119 22.899 -23.341 20.672 1.00 0.00 O HETATM 6842 O HOH A2120 23.069 9.272 23.644 1.00 0.00 O HETATM 6845 O HOH A2121 -2.455 -31.209 -19.084 1.00 0.00 O HETATM 6848 O HOH A2122 1.701 28.167 13.050 1.00 0.00 O HETATM 6851 O HOH A2123 45.023 -3.919 51.885 1.00 0.00 O HETATM 6854 O HOH A2124 -4.842 -55.632 -24.252 1.00 0.00 O HETATM 6857 O HOH A2125 -7.262 41.095 42.844 1.00 0.00 O HETATM 6860 O HOH A2126 -0.052 19.274 36.111 1.00 0.00 O HETATM 6863 O HOH A2127 3.489 62.142 35.471 1.00 0.00 O HETATM 6866 O HOH A2128 0.350 -41.481 27.346 1.00 0.00 O HETATM 6869 O HOH A2129 -52.866 60.839 8.773 1.00 0.00 O HETATM 6872 O HOH A2130 -42.549 19.525 51.993 1.00 0.00 O HETATM 6875 O HOH A2131 3.782 -10.151 -17.031 1.00 0.00 O HETATM 6878 O HOH A2132 -17.463 34.226 -2.817 1.00 0.00 O HETATM 6881 O HOH A2133 -3.555 -20.106 -37.610 1.00 0.00 O HETATM 6884 O HOH A2134 10.098 65.573 8.002 1.00 0.00 O HETATM 6887 O HOH A2135 -18.637 26.320 -25.426 1.00 0.00 O HETATM 6890 O HOH A2136 69.682 -52.593 30.172 1.00 0.00 O HETATM 6893 O HOH A2137 -30.573 16.047 42.827 1.00 0.00 O HETATM 6896 O HOH A2138 10.153 37.429 -23.002 1.00 0.00 O HETATM 6899 O HOH A2139 7.145 -42.552 -61.533 1.00 0.00 O HETATM 6902 O HOH A2140 -21.962 -3.495 -32.032 1.00 0.00 O HETATM 6905 O HOH A2141 -18.221 -12.709 16.847 1.00 0.00 O HETATM 6908 O HOH A2142 48.630 -3.652 -41.794 1.00 0.00 O HETATM 6911 O HOH A2143 14.612 8.571 56.297 1.00 0.00 O HETATM 6914 O HOH A2144 -49.464 -25.950 -6.999 1.00 0.00 O HETATM 6917 O HOH A2145 -40.241 -19.061 23.683 1.00 0.00 O HETATM 6920 O HOH A2146 12.360 -10.865 -52.753 1.00 0.00 O HETATM 6923 O HOH A2147 -16.661 9.790 -2.204 1.00 0.00 O HETATM 6926 O HOH A2148 -35.158 41.369 -10.560 1.00 0.00 O HETATM 6929 O HOH A2149 -23.135 -14.993 -38.098 1.00 0.00 O HETATM 6932 O HOH A2150 -65.690 25.288 -10.280 1.00 0.00 O HETATM 6935 O HOH A2151 1.855 4.143 2.778 1.00 0.00 O HETATM 6938 O HOH A2152 38.176 -39.151 -87.166 1.00 0.00 O HETATM 6941 O HOH A2153 20.221 -17.805 21.384 1.00 0.00 O HETATM 6944 O HOH A2154 9.204 35.966 16.095 1.00 0.00 O HETATM 6947 O HOH A2155 -26.962 22.470 5.329 1.00 0.00 O HETATM 6950 O HOH A2156 30.625 -16.076 50.327 1.00 0.00 O HETATM 6953 O HOH A2157 30.954 40.376 -85.003 1.00 0.00 O HETATM 6956 O HOH A2158 4.117 55.474 0.576 1.00 0.00 O HETATM 6959 O HOH A2159 -28.534 12.243 29.265 1.00 0.00 O HETATM 6962 O HOH A2160 -2.623 -74.557 -29.059 1.00 0.00 O HETATM 6965 O HOH A2161 38.452 -2.913 67.506 1.00 0.00 O HETATM 6968 O HOH A2162 89.770 9.134 14.182 1.00 0.00 O HETATM 6971 O HOH A2163 41.294 -8.722 -45.240 1.00 0.00 O HETATM 6974 O HOH A2164 10.182 6.797 21.314 1.00 0.00 O HETATM 6977 O HOH A2165 -14.577 11.660 -5.498 1.00 0.00 O HETATM 6980 O HOH A2166 20.257 0.671 39.105 1.00 0.00 O HETATM 6983 O HOH A2167 -10.392 -16.090 39.938 1.00 0.00 O HETATM 6986 O HOH A2168 -32.945 19.536 36.787 1.00 0.00 O HETATM 6989 O HOH A2169 -34.994 -21.118 3.882 1.00 0.00 O HETATM 6992 O HOH A2170 -30.552 11.798 13.337 1.00 0.00 O HETATM 6995 O HOH A2171 -6.183 73.381 -39.357 1.00 0.00 O HETATM 6998 O HOH A2172 25.291 -11.714 -46.295 1.00 0.00 O HETATM 7001 O HOH A2173 -5.965 5.544 18.928 1.00 0.00 O HETATM 7004 O HOH A2174 6.372 -53.186 102.874 1.00 0.00 O HETATM 7007 O HOH A2175 -2.225 -24.844 -36.357 1.00 0.00 O HETATM 7010 O HOH A2176 7.547 -9.168 -76.727 1.00 0.00 O HETATM 7013 O HOH A2177 20.746 -19.409 0.391 1.00 0.00 O HETATM 7016 O HOH A2178 -14.678 -16.701 -55.268 1.00 0.00 O HETATM 7019 O HOH A2179 7.973 -48.167 -3.295 1.00 0.00 O HETATM 7022 O HOH A2180 41.102 -4.536 -19.710 1.00 0.00 O HETATM 7025 O HOH A2181 -27.659 -3.337 8.847 1.00 0.00 O HETATM 7028 O HOH A2182 37.400 22.591 -18.478 1.00 0.00 O HETATM 7031 O HOH A2183 10.116 -56.917 -28.155 1.00 0.00 O HETATM 7034 O HOH A2184 -34.057 -32.630 -35.173 1.00 0.00 O HETATM 7037 O HOH A2185 60.801 -14.063 -37.374 1.00 0.00 O HETATM 7040 O HOH A2186 -12.562 23.593 2.656 1.00 0.00 O HETATM 7043 O HOH A2187 -13.111 -25.086 -14.250 1.00 0.00 O HETATM 7046 O HOH A2188 17.483 -5.554 18.762 1.00 0.00 O HETATM 7049 O HOH A2189 -20.338 -2.839 -27.294 1.00 0.00 O HETATM 7052 O HOH A2190 30.183 -12.468 25.632 1.00 0.00 O HETATM 7055 O HOH A2191 -19.774 -49.534 -75.546 1.00 0.00 O HETATM 7058 O HOH A2192 -9.150 -21.975 16.502 1.00 0.00 O HETATM 7061 O HOH A2193 -33.319 15.262 -19.645 1.00 0.00 O HETATM 7064 O HOH A2194 44.630 -15.677 43.760 1.00 0.00 O HETATM 7067 O HOH A2195 -17.582 -13.453 62.667 1.00 0.00 O HETATM 7070 O HOH A2196 42.547 -74.359 -33.684 1.00 0.00 O HETATM 7073 O HOH A2197 27.621 -31.886 15.082 1.00 0.00 O HETATM 7076 O HOH A2198 3.397 -1.137 15.245 1.00 0.00 O HETATM 7079 O HOH A2199 36.705 -35.458 25.646 1.00 0.00 O HETATM 7082 O HOH A2200 17.783 34.973 10.079 1.00 0.00 O HETATM 7085 O HOH A2201 -11.190 -62.255 40.223 1.00 0.00 O HETATM 7088 O HOH A2202 -15.997 -57.636 -18.299 1.00 0.00 O HETATM 7091 O HOH A2203 -14.329 -27.643 -17.219 1.00 0.00 O HETATM 7094 O HOH A2204 -28.394 18.497 28.750 1.00 0.00 O HETATM 7097 O HOH A2205 -49.109 38.425 -0.991 1.00 0.00 O HETATM 7100 O HOH A2206 -14.872 -49.681 6.227 1.00 0.00 O HETATM 7103 O HOH A2207 6.441 21.550 -73.944 1.00 0.00 O HETATM 7106 O HOH A2208 21.338 9.069 -42.778 1.00 0.00 O HETATM 7109 O HOH A2209 -48.127 39.922 53.388 1.00 0.00 O HETATM 7112 O HOH A2210 -17.518 10.264 -28.831 1.00 0.00 O HETATM 7115 O HOH A2211 -25.217 -45.661 -16.287 1.00 0.00 O HETATM 7118 O HOH A2212 3.161 -60.794 -34.793 1.00 0.00 O HETATM 7121 O HOH A2213 -87.815 -53.354 -37.351 1.00 0.00 O HETATM 7124 O HOH A2214 -4.677 -7.636 -64.911 1.00 0.00 O HETATM 7127 O HOH A2215 8.799 -9.269 54.735 1.00 0.00 O HETATM 7130 O HOH A2216 -3.075 -3.972 11.170 1.00 0.00 O HETATM 7133 O HOH A2217 -17.194 18.205 -11.916 1.00 0.00 O HETATM 7136 O HOH A2218 -11.770 -5.050 -1.421 1.00 0.00 O HETATM 7139 O HOH A2219 39.159 -21.887 31.784 1.00 0.00 O HETATM 7142 O HOH A2220 27.670 -52.682 -34.853 1.00 0.00 O HETATM 7145 O HOH A2221 2.717 -53.294 1.660 1.00 0.00 O CONECT 132 448 CONECT 145 448 CONECT 448 132 145 CONECT 450 2957 CONECT 451 3782 CONECT 454 6233 CONECT 460 461 475 500 CONECT 461 460 462 493 CONECT 462 461 463 516 CONECT 463 462 476 502 CONECT 464 476 477 503 CONECT 465 477 478 504 CONECT 466 467 478 505 517 CONECT 467 466 468 518 519 CONECT 468 467 469 472 506 CONECT 469 468 473 479 520 CONECT 470 479 480 521 CONECT 471 475 480 509 CONECT 472 468 522 523 524 CONECT 473 469 507 508 CONECT 474 507 525 526 527 CONECT 475 460 471 476 CONECT 476 463 464 475 CONECT 477 464 465 480 CONECT 478 465 466 479 CONECT 479 469 470 478 CONECT 480 470 471 477 CONECT 481 493 528 529 530 CONECT 482 499 531 532 533 CONECT 483 499 534 535 536 CONECT 484 498 537 538 539 CONECT 485 515 540 541 542 CONECT 486 514 543 544 545 CONECT 487 496 546 547 548 CONECT 488 513 549 550 551 CONECT 489 490 500 501 552 CONECT 490 489 491 510 553 CONECT 491 490 492 499 554 CONECT 492 491 493 511 555 CONECT 493 461 481 492 501 CONECT 494 495 505 512 556 CONECT 495 494 496 513 557 CONECT 496 487 495 497 514 CONECT 497 496 498 515 558 CONECT 498 484 497 512 559 CONECT 499 482 483 491 560 CONECT 500 460 489 CONECT 501 489 493 CONECT 502 463 561 CONECT 503 464 CONECT 504 465 562 CONECT 505 466 494 CONECT 506 468 563 CONECT 507 473 474 CONECT 508 473 CONECT 509 471 CONECT 510 490 564 CONECT 511 492 565 CONECT 512 494 498 CONECT 513 488 495 CONECT 514 486 496 CONECT 515 485 497 CONECT 516 462 CONECT 517 466 CONECT 518 467 CONECT 519 467 CONECT 520 469 CONECT 521 470 CONECT 522 472 CONECT 523 472 CONECT 524 472 CONECT 525 474 CONECT 526 474 CONECT 527 474 CONECT 528 481 CONECT 529 481 CONECT 530 481 CONECT 531 482 CONECT 532 482 CONECT 533 482 CONECT 534 483 CONECT 535 483 CONECT 536 483 CONECT 537 484 CONECT 538 484 CONECT 539 484 CONECT 540 485 CONECT 541 485 CONECT 542 485 CONECT 543 486 CONECT 544 486 CONECT 545 486 CONECT 546 487 CONECT 547 487 CONECT 548 487 CONECT 549 488 CONECT 550 488 CONECT 551 488 CONECT 552 489 CONECT 553 490 CONECT 554 491 CONECT 555 492 CONECT 556 494 CONECT 557 495 CONECT 558 497 CONECT 559 498 CONECT 560 499 CONECT 561 502 CONECT 562 504 CONECT 563 506 CONECT 564 510 CONECT 565 511 CONECT 2957 450 CONECT 3782 451 CONECT 6233 454 END