USER MOD reduce.3.24.130724 H: found=0, std=0, add=68, rem=0, adj=0 USER MOD reduce.3.24.130724 removed 73 hydrogens (49 hets) HEADER HYDROLASE INHIBITOR, TOXIN 14-FEB-96 1EVB TITLE NMR STRUCTURE OF CYANOBACTERIAL TOXIN, PHOSPHATASE-1/-2A INHIBITOR COMPND MOL_ID: 1; COMPND 2 MOLECULE: MICROCYSTIN-LR; COMPND 3 CHAIN: A SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: MICROCYSTIS; SOURCE 3 ORGANISM_TAXID: 1125 KEYWDS TOXIN, HYDROLASE INHIBITOR EXPDTA SOLUTION NMR AUTHOR J.R.BAGU,B.D.SYKES REVDAT 3 13-JUL-11 1EVB 1 VERSN REVDAT 2 24-FEB-09 1EVB 1 VERSN REVDAT 1 08-NOV-96 1EVB 0 JRNL AUTH J.R.BAGU,F.D.SONNICHSEN,D.WILLIAMS,R.J.ANDERSEN,B.D.SYKES, JRNL AUTH 2 C.F.HOLMES JRNL TITL COMPARISON OF THE SOLUTION STRUCTURES OF MICROCYSTIN-LR AND JRNL TITL 2 MOTUPORIN. JRNL REF NAT.STRUCT.BIOL. V. 2 114 1995 JRNL REFN ISSN 1072-8368 JRNL PMID 7749913 JRNL DOI 10.1038/NSB0295-114 REMARK 1 REMARK 1 REFERENCE 1 REMARK 1 AUTH J.GOLDBERG,H.HUANG,Y.KWON,P.GREENGARD,A.C.NAIRN,J.KURIYAN REMARK 1 TITL THREE-DIMENSIONAL STRUCTURE OF THE CATALYTIC SUBUNIT OF REMARK 1 TITL 2 PROTEIN SERINE/THREONINE PHOSPHATASE-1 REMARK 1 REF NATURE V. 376 745 1995 REMARK 1 REFN ISSN 0028-0836 REMARK 2 REMARK 2 RESOLUTION. NOT APPLICABLE. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 PROGRAM : DGII REMARK 3 AUTHORS : HAVEL REMARK 3 REMARK 3 OTHER REFINEMENT REMARKS: NULL REMARK 4 REMARK 4 1EVB COMPLIES WITH FORMAT V. 3.15, 01-DEC-08 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY BNL. REMARK 210 REMARK 210 EXPERIMENTAL DETAILS REMARK 210 EXPERIMENT TYPE : NMR REMARK 210 TEMPERATURE (KELVIN) : 278 REMARK 210 PH : 7 REMARK 210 IONIC STRENGTH : NULL REMARK 210 PRESSURE : NULL REMARK 210 SAMPLE CONTENTS : NULL REMARK 210 REMARK 210 NMR EXPERIMENTS CONDUCTED : NULL REMARK 210 SPECTROMETER FIELD STRENGTH : NULL REMARK 210 SPECTROMETER MODEL : NULL REMARK 210 SPECTROMETER MANUFACTURER : NULL REMARK 210 REMARK 210 STRUCTURE DETERMINATION. REMARK 210 SOFTWARE USED : NULL REMARK 210 METHOD USED : NULL REMARK 210 REMARK 210 CONFORMERS, NUMBER CALCULATED : NULL REMARK 210 CONFORMERS, NUMBER SUBMITTED : 1 REMARK 210 CONFORMERS, SELECTION CRITERIA : NULL REMARK 210 REMARK 210 BEST REPRESENTATIVE CONFORMER IN THIS ENSEMBLE : NULL REMARK 210 REMARK 210 REMARK: NULL REMARK 215 REMARK 215 NMR STUDY REMARK 215 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM SOLUTION REMARK 215 NMR DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE THAT REMARK 215 CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES ON REMARK 215 THESE RECORDS ARE MEANINGLESS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (RES=RESIDUE NAME; REMARK 470 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE): REMARK 470 RES CSSEQI ATOMS REMARK 470 ACB A 3 OD1 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 CG ACB A 3 N ARG A 4 1.32 REMARK 500 HG2 FGA A 6 HM2 DAM A 7 1.37 REMARK 500 N DAL A 1 O DAM A 7 2.18 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 ARG A 4 NE - CZ - NH1 ANGL. DEV. = 4.4 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: PLANAR GROUPS REMARK 500 REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS REMARK 500 AN RMSD GREATER THAN THIS VALUE REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 M RES CSSEQI RMS TYPE REMARK 500 ARG A 4 0.11 SIDE CHAIN REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: 1EVA RELATED DB: PDB DBREF 1EVB A 1 7 NOR NOR00109 NOR00109 1 7 SEQRES 1 A 7 DAL LEU ACB ARG 1ZN FGA DAM HET DAL A 1 10 HET ACB A 3 15 HET 1ZN A 5 50 HET FGA A 6 14 HET DAM A 7 11 HETNAM DAL D-ALANINE HETNAM ACB 3-METHYL-BETA-D-ASPARTIC ACID HETNAM 1ZN (2S,3S,4E,6E,8S,9S)-3-AMINO-9-METHOXY-2,6,8-TRIMETHYL- HETNAM 2 1ZN 10-PHENYLDECA-4,6-DIENOIC ACID HETNAM FGA GAMMA-D-GLUTAMIC ACID HETNAM DAM N-METHYL-ALPHA-BETA-DEHYDROALANINE HETSYN ACB (3S)-3-METHYL-D-ASPARTIC ACID; D-METHYL ASPARTIC ACID HETSYN FGA D-GLUTAMIC ACID FORMUL 1 DAL C3 H7 N O2 FORMUL 1 ACB C5 H9 N O4 FORMUL 1 1ZN C20 H29 N O3 FORMUL 1 FGA C5 H9 N O4 FORMUL 1 DAM C4 H7 N O2 LINK N DAL A 1 C DAM A 7 1555 1555 1.32 LINK C DAL A 1 N LEU A 2 1555 1555 1.32 LINK C ACB A 3 N ARG A 4 1555 1555 3.91 LINK CD FGA A 6 N DAM A 7 1555 1555 1.32 LINK C ARG A 4 N1 1ZN A 5 1555 1555 1.32 LINK C20 1ZN A 5 N FGA A 6 1555 1555 1.32 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000 HETATM 1 N DAL A 1 7.902 0.279 10.158 1.00 0.00 N HETATM 2 CA DAL A 1 8.669 0.056 8.936 1.00 0.00 C HETATM 3 CB DAL A 1 8.403 1.190 8.044 1.00 0.00 C HETATM 4 C DAL A 1 8.477 -1.252 8.207 1.00 0.00 C HETATM 5 O DAL A 1 9.081 -1.473 7.195 1.00 0.00 O HETATM 0 HB3 DAL A 1 7.337 1.237 7.824 1.00 0.00 H new HETATM 0 HB2 DAL A 1 8.715 2.115 8.529 1.00 0.00 H new HETATM 0 HB1 DAL A 1 8.960 1.061 7.116 1.00 0.00 H new HETATM 0 HA DAL A 1 9.709 -0.018 9.253 1.00 0.00 H new ATOM 11 N LEU A 2 7.636 -2.143 8.700 1.00 0.00 N ATOM 12 CA LEU A 2 7.339 -3.447 8.112 1.00 0.00 C ATOM 13 C LEU A 2 6.113 -3.320 7.239 1.00 0.00 C ATOM 14 O LEU A 2 6.086 -3.792 6.122 1.00 0.00 O ATOM 15 CB LEU A 2 7.145 -4.476 9.213 1.00 0.00 C ATOM 16 CG LEU A 2 8.050 -4.448 10.383 1.00 0.00 C ATOM 17 CD1 LEU A 2 7.613 -5.133 11.554 1.00 0.00 C ATOM 18 CD2 LEU A 2 9.292 -4.947 10.051 1.00 0.00 C ATOM 0 H LEU A 2 7.115 -1.974 9.561 1.00 0.00 H new ATOM 0 HA LEU A 2 8.170 -3.785 7.492 1.00 0.00 H new ATOM 0 HB2 LEU A 2 6.125 -4.375 9.583 1.00 0.00 H new ATOM 0 HB3 LEU A 2 7.223 -5.464 8.759 1.00 0.00 H new ATOM 0 HG LEU A 2 8.072 -3.389 10.641 1.00 0.00 H new ATOM 0 HD11 LEU A 2 8.367 -5.035 12.335 1.00 0.00 H new ATOM 0 HD12 LEU A 2 6.674 -4.701 11.899 1.00 0.00 H new ATOM 0 HD13 LEU A 2 7.464 -6.188 11.324 1.00 0.00 H new ATOM 0 HD21 LEU A 2 9.942 -4.917 10.926 1.00 0.00 H new ATOM 0 HD22 LEU A 2 9.191 -5.977 9.709 1.00 0.00 H new ATOM 0 HD23 LEU A 2 9.727 -4.342 9.255 1.00 0.00 H new HETATM 30 C ACB A 3 2.638 -3.270 7.687 1.00 0.00 C HETATM 31 O ACB A 3 2.629 -3.590 8.878 1.00 0.00 O HETATM 32 OXT ACB A 3 1.684 -3.577 6.970 1.00 0.00 O HETATM 33 CA ACB A 3 3.808 -2.461 7.080 1.00 0.00 C HETATM 34 N ACB A 3 5.084 -2.679 7.762 1.00 0.00 N HETATM 35 CB ACB A 3 3.477 -1.052 6.649 1.00 0.00 C HETATM 36 CG ACB A 3 2.762 -0.196 7.667 1.00 0.00 C HETATM 37 C4 ACB A 3 4.692 -0.322 6.099 1.00 0.00 C HETATM 38 OD2 ACB A 3 3.126 -0.166 8.827 1.00 0.00 O HETATM 0 HB3 ACB A 3 2.750 -1.204 5.851 1.00 0.00 H new HETATM 0 HA ACB A 3 3.985 -2.907 6.101 1.00 0.00 H new HETATM 0 H43 ACB A 3 5.463 -0.269 6.867 1.00 0.00 H new HETATM 0 H42 ACB A 3 5.078 -0.860 5.233 1.00 0.00 H new HETATM 0 H41 ACB A 3 4.406 0.687 5.802 1.00 0.00 H new ATOM 45 N ARG A 4 1.734 0.505 7.225 1.00 0.00 N ATOM 46 CA ARG A 4 0.887 1.339 8.072 1.00 0.00 C ATOM 47 C ARG A 4 -0.394 0.636 8.454 1.00 0.00 C ATOM 48 O ARG A 4 -1.215 1.224 8.997 1.00 0.00 O ATOM 49 CB ARG A 4 0.409 2.640 7.423 1.00 0.00 C ATOM 50 CG ARG A 4 1.574 3.390 6.951 1.00 0.00 C ATOM 51 CD ARG A 4 1.419 4.263 5.808 1.00 0.00 C ATOM 52 NE ARG A 4 1.108 5.614 6.121 1.00 0.00 N ATOM 53 CZ ARG A 4 1.257 6.582 5.220 1.00 0.00 C ATOM 54 NH1 ARG A 4 1.289 6.393 3.899 1.00 0.00 N ATOM 55 NH2 ARG A 4 1.376 7.818 5.654 1.00 0.00 N ATOM 0 HA ARG A 4 1.541 1.549 8.919 1.00 0.00 H new ATOM 0 HB2 ARG A 4 -0.261 2.422 6.592 1.00 0.00 H new ATOM 0 HB3 ARG A 4 -0.156 3.234 8.141 1.00 0.00 H new ATOM 0 HG2 ARG A 4 1.938 3.994 7.782 1.00 0.00 H new ATOM 0 HG3 ARG A 4 2.357 2.670 6.714 1.00 0.00 H new ATOM 0 HD2 ARG A 4 2.341 4.244 5.227 1.00 0.00 H new ATOM 0 HD3 ARG A 4 0.632 3.863 5.169 1.00 0.00 H new ATOM 0 HE ARG A 4 0.764 5.846 7.053 1.00 0.00 H new ATOM 0 HH11 ARG A 4 1.196 5.452 3.516 1.00 0.00 H new ATOM 0 HH12 ARG A 4 1.407 7.189 3.273 1.00 0.00 H new ATOM 0 HH21 ARG A 4 1.353 8.011 6.655 1.00 0.00 H new ATOM 0 HH22 ARG A 4 1.492 8.583 4.989 1.00 0.00 H new HETATM 69 C1 1ZN A 5 -8.227 0.328 3.671 1.00 0.00 C HETATM 70 O1 1ZN A 5 -8.185 -0.418 4.832 1.00 0.00 O HETATM 71 C2 1ZN A 5 -7.620 -1.650 4.748 1.00 0.00 C HETATM 72 C3 1ZN A 5 -8.235 -2.562 3.696 1.00 0.00 C HETATM 73 C4 1ZN A 5 -9.721 -2.642 3.543 1.00 0.00 C HETATM 74 C5 1ZN A 5 -10.268 -2.589 2.249 1.00 0.00 C HETATM 75 C6 1ZN A 5 -11.629 -2.780 2.044 1.00 0.00 C HETATM 76 C7 1ZN A 5 -12.463 -3.034 3.126 1.00 0.00 C HETATM 77 C8 1ZN A 5 -11.938 -3.096 4.415 1.00 0.00 C HETATM 78 C9 1ZN A 5 -10.572 -2.909 4.623 1.00 0.00 C HETATM 79 C10 1ZN A 5 -6.180 -1.516 4.474 1.00 0.00 C HETATM 80 C11 1ZN A 5 -5.678 -0.886 3.213 1.00 0.00 C HETATM 81 C12 1ZN A 5 -5.413 -1.030 5.680 1.00 0.00 C HETATM 82 C13 1ZN A 5 -4.314 -1.662 6.073 1.00 0.00 C HETATM 83 C14 1ZN A 5 -4.003 -2.887 5.274 1.00 0.00 C HETATM 84 C15 1ZN A 5 -3.604 -1.220 7.099 1.00 0.00 C HETATM 85 C16 1ZN A 5 -2.443 -1.801 7.387 1.00 0.00 C HETATM 86 C17 1ZN A 5 -1.686 -1.492 8.575 1.00 0.00 C HETATM 87 N1 1ZN A 5 -0.545 -0.652 8.207 1.00 0.00 N HETATM 88 C18 1ZN A 5 -1.286 -2.678 9.420 1.00 0.00 C HETATM 89 C19 1ZN A 5 -2.361 -3.729 9.581 1.00 0.00 C HETATM 90 C20 1ZN A 5 -0.688 -2.282 10.737 1.00 0.00 C HETATM 91 O3 1ZN A 5 -1.375 -1.968 11.674 1.00 0.00 O HETATM 0 H9 1ZN A 5 -13.531 -3.185 2.966 1.00 0.00 H new HETATM 0 H8 1ZN A 5 -12.042 -2.731 1.036 1.00 0.00 H new HETATM 0 H7 1ZN A 5 -9.617 -2.396 1.397 1.00 0.00 H new HETATM 0 H6 1ZN A 5 -7.827 -2.263 2.731 1.00 0.00 H new HETATM 0 H5 1ZN A 5 -7.876 -3.572 3.895 1.00 0.00 H new HETATM 0 H4 1ZN A 5 -7.807 -2.122 5.713 1.00 0.00 H new HETATM 0 H3 1ZN A 5 -7.213 0.493 3.308 1.00 0.00 H new HETATM 0 H28 1ZN A 5 -3.236 -3.285 10.055 1.00 0.00 H new HETATM 0 H27 1ZN A 5 -2.638 -4.119 8.602 1.00 0.00 H new HETATM 0 H26 1ZN A 5 -1.985 -4.542 10.202 1.00 0.00 H new HETATM 0 H25 1ZN A 5 -0.499 -3.161 8.840 1.00 0.00 H new HETATM 0 H22 1ZN A 5 -2.355 -0.944 9.239 1.00 0.00 H new HETATM 0 H21 1ZN A 5 -2.046 -2.543 6.695 1.00 0.00 H new HETATM 0 H20 1ZN A 5 -3.967 -0.388 7.702 1.00 0.00 H new HETATM 0 H2 1ZN A 5 -8.800 -0.208 2.915 1.00 0.00 H new HETATM 0 H19 1ZN A 5 -4.829 -3.594 5.356 1.00 0.00 H new HETATM 0 H18 1ZN A 5 -3.862 -2.613 4.228 1.00 0.00 H new HETATM 0 H17 1ZN A 5 -3.092 -3.348 5.655 1.00 0.00 H new HETATM 0 H16 1ZN A 5 -5.763 -0.157 6.230 1.00 0.00 H new HETATM 0 H15 1ZN A 5 -6.042 -1.451 2.354 1.00 0.00 H new HETATM 0 H14 1ZN A 5 -6.038 0.141 3.151 1.00 0.00 H new HETATM 0 H13 1ZN A 5 -4.588 -0.889 3.214 1.00 0.00 H new HETATM 0 H12 1ZN A 5 -5.964 -2.560 4.246 1.00 0.00 H new HETATM 0 H11 1ZN A 5 -10.164 -2.971 5.632 1.00 0.00 H new HETATM 0 H10 1ZN A 5 -12.596 -3.291 5.262 1.00 0.00 H new HETATM 0 H1 1ZN A 5 -8.701 1.288 3.873 1.00 0.00 H new HETATM 119 N FGA A 6 0.630 -2.300 10.810 1.00 0.00 N HETATM 120 CA FGA A 6 1.396 -1.957 12.005 1.00 0.00 C HETATM 121 C FGA A 6 1.081 -2.956 13.154 1.00 0.00 C HETATM 122 O FGA A 6 1.220 -4.169 12.983 1.00 0.00 O HETATM 123 CB FGA A 6 2.898 -1.804 11.830 1.00 0.00 C HETATM 124 CG FGA A 6 3.146 -0.983 13.061 1.00 0.00 C HETATM 125 CD FGA A 6 4.383 -0.161 12.741 1.00 0.00 C HETATM 126 OE1 FGA A 6 3.772 0.502 11.948 1.00 0.00 O HETATM 0 HG3 FGA A 6 2.294 -0.342 13.287 1.00 0.00 H new HETATM 0 HG2 FGA A 6 3.308 -1.617 13.933 1.00 0.00 H new HETATM 0 HB3 FGA A 6 3.430 -2.756 11.835 1.00 0.00 H new HETATM 0 HB2 FGA A 6 3.173 -1.290 10.909 1.00 0.00 H new HETATM 0 HA FGA A 6 1.058 -0.952 12.257 1.00 0.00 H new HETATM 133 N DAM A 7 5.660 0.088 12.963 1.00 0.00 N HETATM 134 CM DAM A 7 5.803 -0.944 13.971 1.00 0.00 C HETATM 135 CA DAM A 7 6.832 0.901 12.649 1.00 0.00 C HETATM 136 CB DAM A 7 7.130 1.741 13.420 1.00 0.00 C HETATM 137 C DAM A 7 7.662 0.668 11.397 1.00 0.00 C HETATM 138 O DAM A 7 8.531 1.185 12.043 1.00 0.00 O HETATM 0 HM3 DAM A 7 6.567 -1.655 13.658 1.00 0.00 H new HETATM 0 HM2 DAM A 7 6.096 -0.490 14.918 1.00 0.00 H new HETATM 0 HM1 DAM A 7 4.853 -1.464 14.097 1.00 0.00 H new HETATM 0 HB2 DAM A 7 7.997 2.373 13.229 1.00 0.00 H new HETATM 0 HB1 DAM A 7 6.539 1.886 14.324 1.00 0.00 H new TER 144 DAM A 7 CONECT 1 2 137 CONECT 2 1 3 4 7 CONECT 3 2 8 9 10 CONECT 4 2 5 11 CONECT 5 4 CONECT 7 2 CONECT 8 3 CONECT 9 3 CONECT 10 3 CONECT 11 4 CONECT 30 31 32 33 45 CONECT 31 30 CONECT 32 30 CONECT 33 30 34 35 39 CONECT 34 33 40 CONECT 35 33 36 37 41 CONECT 36 35 38 CONECT 37 35 42 43 44 CONECT 38 36 CONECT 39 33 CONECT 40 34 CONECT 41 35 CONECT 42 37 CONECT 43 37 CONECT 44 37 CONECT 45 30 CONECT 47 87 CONECT 69 70 92 93 94 CONECT 70 69 71 CONECT 71 70 72 79 95 CONECT 72 71 73 96 97 CONECT 73 72 74 78 CONECT 74 73 75 98 CONECT 75 74 76 99 CONECT 76 75 77 100 CONECT 77 76 78 101 CONECT 78 73 77 102 CONECT 79 71 80 81 103 CONECT 80 79 104 105 106 CONECT 81 79 82 107 CONECT 82 81 83 84 CONECT 83 82 108 109 110 CONECT 84 82 85 111 CONECT 85 84 86 112 CONECT 86 85 87 88 113 CONECT 87 47 86 114 CONECT 88 86 89 90 115 CONECT 89 88 116 117 118 CONECT 90 88 91 119 CONECT 91 90 CONECT 92 69 CONECT 93 69 CONECT 94 69 CONECT 95 71 CONECT 96 72 CONECT 97 72 CONECT 98 74 CONECT 99 75 CONECT 100 76 CONECT 101 77 CONECT 102 78 CONECT 103 79 CONECT 104 80 CONECT 105 80 CONECT 106 80 CONECT 107 81 CONECT 108 83 CONECT 109 83 CONECT 110 83 CONECT 111 84 CONECT 112 85 CONECT 113 86 CONECT 114 87 CONECT 115 88 CONECT 116 89 CONECT 117 89 CONECT 118 89 CONECT 119 90 120 127 CONECT 120 119 121 123 128 CONECT 121 120 122 CONECT 122 121 CONECT 123 120 124 129 130 CONECT 124 123 125 131 132 CONECT 125 124 126 133 CONECT 126 125 CONECT 127 119 CONECT 128 120 CONECT 129 123 CONECT 130 123 CONECT 131 124 CONECT 132 124 CONECT 133 125 134 135 CONECT 134 133 139 140 141 CONECT 135 133 136 137 CONECT 136 135 142 143 CONECT 137 1 135 138 CONECT 138 137 CONECT 139 134 CONECT 140 134 CONECT 141 134 CONECT 142 136 CONECT 143 136 END