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Structure of a transiently phosphorylated switch in bacterial signal transduction.

NTRC is a transcriptional enhancer binding protein whose N-terminal domain is a
member of the family of receiver domains of two-component regulatory systems.
Using 3D and 4D NMR spectroscopy, we have completed the 1H, 15N, and 13C
assignments and determined the solution structure of the N-terminal receiver
domain of the NTRC protein. Determination of the three-dimensional structure
was carried out with the program X-PLOR (Briinger, 1992) using a total of 915
NMR-derived distance and dihedral angle restraints. The resultant family of
structures has an average root mean square deviation of 0.81 A from the average
structure for the backbone atoms involved in well-defined secondary structure.
The structure is comprised of five alpha-helices and a five-stranded parallel
beta-sheet, in a (beta/alpha)5 topology. Comparison of the solution structure
of the NTRC receiver domain with the crystal structures of the homologous
protein CheY in both the Mg(2+)-free and Mg(2+)-bound forms [Stock, A.M.,
Mottonen, J. M., Stock, J. B., & Schutt, C. E. (1989) Nature 337, 745-749;
Volz, K., & Matsumura, P. (1991) J. Biol. Chem. 296, 15511-15519; Stock, A. M.,
Martinez-Hackert, E., Rasmussen, B. F., West, A. H., Stock, J. B., Ringe, D., &
Petsko, G. A. (1993) Biochemistry 32, 13375-13380; Bellsolell, L., Prieto, J.,
Serrano, L., & Coll, M. (1994) J. Mol. Biol. 238, 489-495] reveals a very
similar fold, with the only significant difference occurring in the positioning
of helix 4 relative to the rest of the protein. Examination of the conformation
of consensus residues of the receiver domain superfamily [Volz, K. (1993)
Biochemistry 32, 11741-11753] in the structures of the NTRC receiver domain and
CheY establishes the structural importance of residues whose side chains are
involved in hydrogen bonding or hydrophobic core interactions. The importance
of some nonconsensus residues which may be conserved for their ability to
fulfill helix capping roles is also discussed.

Three-dimensional solution structure of the N-terminal receiver domain of NTRC.

Nitrogen regulatory protein C N-terminal receiver domain

Structure Of A Transiently Phosphorylated "switch" In Bacterial Signal Transduction

Minimized Average Structure Of Beryllofluoride-Activated Ntrc Receiver Domain: Model Structure Incorporating Active Site Contac

Solution Structure And Backbone Dynamics Of Beryllofluoride- Activated Ntrc Receiver Domain

Solution Structure Of Beryllofluoride-Activated Ntrc Receiver Domain: Model Structures Incorporating Active Site Contacts

Solution Structure Of The N-Terminal Receiver Domain Of Ntrc

Solution Structure And Chemical Shift Assignments For Bef3 Activated Receiver Domain Of Nitrogen Regulatory Protein C (ntrc) At

Solution Structure And Chemical Shift Assignments For The Apo Form Of The Receiver Domain Of Nitrogen Regulatory Protein C (ntr

response regulator for gln GlnG [Escherichia coli O157:H7 str. Sakai]

fused DNA-binding response regulator in two-component regulatory system with GlnL, nitrogen regulator I (NRI) [Escherichia coli

two-component regulator protein [Escherichia coli SE11]

fused DNA-binding response regulator GlnG in two-component regulatory system with GlnL: response regulator/sigma 54 interaction

unnamed protein product [Escherichia coli K-12]

nitrogen regulatory protein C [Salmonella enterica subsp. enterica serovar Typhimurium]

Two-component system, response regulator [Salmonella enterica subsp. enterica serovar Typhi str. CT18]

Nitrogen regulation protein NR(I) [Escherichia coli LF82]

NtrC transcriptional dual regulator, subunit of NtrC-Phosphorylated transcriptional dual regulator [Escherichia coli BL21(DE3)]

CG Site No. 702 [Escherichia coli str. K-12 substr. MG1655]

fused DNA-binding response regulator in two-component regulatory system with GlnL: response regulator/sigma54 interaction prote

response regulator for gln (sensor glnL) (nitrogen regulator I, NRI) [Escherichia coli O157:H7 str. EDL933]

EBP family response regulator in two-component regulatory system with GlnL [Salmonella enterica subsp. enterica serovar Typhimu

sensor glnL response regulator (nitrogen regulator I, NRI) [Shigella flexneri 2a str. 301]

Two-component system, response regulator STY3876 [imported] - Salmonella enterica subsp. enterica serovar Typhi (strain CT18)

hypothetical protein glnG [imported] - Escherichia coli (strain O157:H7, substrain EDL933)

nitrogen regulation protein NR(I) [Escherichia coli O157:H7 str. Sakai]

two-component system response regulator [Salmonella enterica subsp. enterica serovar Typhi str. CT18]

nitrogen regulation protein NR(I) [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]

nitrogen regulation protein NR(I) [Shigella flexneri 2a str. 301]

RecName: Full=Nitrogen regulation protein NR(I)

Salmonella enterica subsp. enterica serovar Typhimurium

1H, 13C, and 15N Chemical Shift Assignments for the N-terminal receiver domain
of NtrC (phosphorylated)