The major subunit of widespread competence pili exhibits a novel and conserved type IV pilin fold.

Major subunit ComGC from S. sanguinis Com pseudopili

0.5 mM [U-100% 15N] ComGC, 25 mM NA Na2HPO4/NaH2PO4, 50 mM NA NaCl, 5 % NA D2O, 95% H2O/5% D2O

0.5 mM [U-100% 15N] ComGC, 25 mM NA Na2HPO4/NaH2PO4, 50 mM NA NaCl, 5 % NA D2O, 3 % NA PEG/hexanol, 95% H2O/5% D2O

type IV filaments type IV pilin competence pseudopili mainly alpha orthogonal bundle

Schwieters, Kuszewski, Tjandra and Clore

Delaglio, Grzesiek, Vuister, Zhu, Pfeifer and Bax