Role of backbone strain in de novo design of complex alpha/beta protein structures
Accurate de novo design of asymetric alpha/beta proteins with ten or more secondary structure elements requires consideration of backbone strain
Design principle proposed from designed larger alpha/beta-proteins not folded as designed: Consistency between local, non-local, and global structures

Solution NMR Structure of DE NOVO DESIGNED Rossmann 2x3 Fold Protein r2x3_168, Northeast Structural Genomics Consortium (NESG) Target OR386

Northeast Structural Genomics Consortium

Zimmerman, Moseley, Kulikowski and Montelione

Delaglio, Grzesiek, Vuister, Zhu, Pfeifer and Bax

Brunger, Adams, Clore, Gros, Nilges and Read