Proceedings of the National Academy of Sciences of the United States of America
Computational design of closely related proteins that adopt two well-defined but structurally divergent folds.

NMR ensemble of computationally designed protein XAA

440 uM U-[15N, 12C, 2H] 13Ce Met 13Cb Ala 13Cd1 Ile 13Cd2 Leu 13Cg2 Val XAA_MAI(LV)proS, 95% H2O/5% D2O

U-[15N, 12C, 2H] 13Ce Met 13Cb Ala 13Cd1 Ile 13Cd2 Leu 13Cg2 Val

Delaglio, Grzesiek, Vuister, Zhu, Pfeifer and Bax