Reproducibilty from repeated experiemnts

(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid

3D 12C-filtered-13C/15N-editedNOESY-HSQC

Aedes aegypti Odorant Binding Protein 22 selectively binds fatty acids through a conformational change in its C-terminal tail.

Structure of Aedes aegypti OBP22 in the complex with arachidonic acid

650 uM [U-13C; U-15N] OBP22, 650 uM ARACHIDONIC ACID, 20 mM sodium phosphate, 90% H2O/10% D2O
670 uM [U-95% 13C; U-98% 15N] Aedes aegypti odorant binding protein 22, 670 uM ARACHIDONIC ACID, 20 mM sodium phosphate, 99% D2O/1 % H2O
Aedes aegypti odorant binding protein 22
Odorant binding protein Chemo-sensory signaling Lipid binding
Brunger, Adams, Clore, Gros, Nilges and Read