Tyrosine-protein kinase ABL1 (E.C.2.7.10.2)

Atomic view of the energy landscape in the allosteric regulation of Abl kinase.

Abelson murine leukemia viral oncogene homolog 1

Abl 1b Regulatory Module 'inhibiting state'

Abl1b Regulatory Module 'Activating' conformation
0.3 mM [U-99% 13C; U-99% 15N] Abl1b, 20 mM potassium phosphate, 5 mM beta-mercaptoethanol, 100 mM potassium chloride, 0.05 % sodium azide, 90% H2O/10% D2O
Brunger, Adams, Clore, Gros, Nilges and Read