Driving Drug Discovery with Biophysical Information Application to Staphylococcus aureus Dihydrofolate Reductase (DHFR)

Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

Backbone resonance assignments for apo S. aureus DHFR

Delaglio, Grzesiek, Vuister, Zhu, Pfeifer and Bax