Proceedings of the National Academy of Sciences of the United States of America
Structural basis for recognition of phosphodiester-containing lysosomal enzymes by the cation-independent mannose 6-phosphate receptor.

Mannose 6-phosphate Receptor Homology domain
Residues 578-583 are a cloning artifact.

Solution Structure Of Ci-Mpr Ligand-Free Domain 5

Solution Structure Of Ci-mpr Domain 5 Bound To N-acetylglucosaminyl 6- Phosphomethylmannoside

SOLUTION STRUCTURE OF CI-MPR domain 5 bound to N-acetylglucosaminyl 6-phosphomethylmannoside

AUTOMATED METHODS WERE USED FOR BACKBONE CHEMICAL SHIFT ASSIGNMENT AND ITERATIVE NOE REFINEMENT. FINAL STRUCTURES WERE OBTAINED BY MOLECULAR DYNAMICS IN EXPLICIT SOLVENT
1.25 mM domain-5 U-15N/13C, 8 mM N-acetylglucosaminyl 6-phosphomethylmannoside, 10 mM bis-Tris, 150 mM sodium chloride
N-acetylglucosaminyl 6-phosphomethylmannoside
Schwieters, Kuszewski, Tjandra and Clore
Delaglio, Grzesiek, Vuister, Zhu, Pfeifer and Bax