Structure and dynamics of human apolipoprotein CIII.

inhibits lipoproteinlipase (LPL) and LDL receptor binding of lipoproteins

Structure And Dynamics Of Human Apolipoprotein C-Iii

apolipoprotein C-III precursor [Homo sapiens]

PREDICTED: apolipoprotein C-III isoform 1 [Gorilla gorilla gorilla]

PREDICTED: apolipoprotein C-III isoform 2 [Gorilla gorilla gorilla]

RecName: Full=Apolipoprotein C-III; Short=Apo-CIII; Short=ApoC-III; AltName: Full=Apolipoprotein C3; Flags: Precursor

S.Wijmenga group; Radboud University of Nijmegen

Equipped with triple resonance (1H/13C/15N) with XYZ gradient capabilities

simulated annealing, torsion angle dynamics

SDS-micelle "in 4 % stretched polyacrylamide gel 37.5:1 w/w acrlamide:bisacrylamide"

Derivation of torsion angles via CA,CB chemical shifts

backbone torsion angles from chemical shifts

Monte Carlo simulation to fit helical structures to experimental RDCs using dipolar waves formulation of RDCs

Caclulations of hydropobic moment directions

Inverse kinematic for junction of helices, RDC simulation

Program for positioning helices on the micelle

Schwieters, Kuszewski, Tjandra and Clore

Delaglio, Grzesiek, Vuister, Zhu, Pfeifer and Bax