data_4097 ####################### # Entry information # ####################### save_entry_information _Entry.Sf_category entry_information _Entry.Sf_framecode entry_information _Entry.ID 4097 _Entry.Title ; Backbone 1H, 13C and 15N Chemical Shift Assignment for the HIV-1 RNase H Domain ; _Entry.Type macromolecule _Entry.Version_type original _Entry.Submission_date 1998-01-16 _Entry.Accession_date 1998-01-16 _Entry.Last_release_date 1999-01-25 _Entry.Original_release_date 1999-01-25 _Entry.Origination author _Entry.NMR_STAR_version 3.1.1.61 _Entry.Original_NMR_STAR_version 2.1 _Entry.Experimental_method NMR _Entry.Experimental_method_subtype . _Entry.Details . _Entry.BMRB_internal_directory_name . loop_ _Entry_author.Ordinal _Entry_author.Given_name _Entry_author.Family_name _Entry_author.First_initial _Entry_author.Middle_initials _Entry_author.Family_title _Entry_author.Entry_ID 1 Kern Gunther . . . 4097 2 Tracy Handel . M. . 4097 3 Susan Marqusee . . . 4097 stop_ loop_ _Data_set.Type _Data_set.Count _Data_set.Entry_ID assigned_chemical_shifts 1 4097 stop_ loop_ _Datum.Type _Datum.Count _Datum.Entry_ID '13C chemical shifts' 217 4097 '15N chemical shifts' 111 4097 '1H chemical shifts' 111 4097 stop_ loop_ _Release.Release_number _Release.Format_type _Release.Format_version _Release.Date _Release.Submission_date _Release.Type _Release.Author _Release.Detail _Release.Entry_ID 1 . . 1999-01-25 1998-01-16 original author . 4097 stop_ save_ ############### # Citations # ############### save_entry_citation _Citation.Sf_category citations _Citation.Sf_framecode entry_citation _Citation.Entry_ID 4097 _Citation.ID 1 _Citation.Class 'entry citation' _Citation.CAS_abstract_code . _Citation.MEDLINE_UI_code 99006568 _Citation.DOI . _Citation.PubMed_ID . _Citation.Full_citation ; Kern, G., Handel, T., and Marqusee, S. "Characterization of a Folding Intermediate from HIV-1 Ribonuclease H," Protein Sci. 7, 2164-2174 (1998). ; _Citation.Title 'Characterization of a Folding Intermediate from HIV-1 Ribonuclease H' _Citation.Status published _Citation.Type journal _Citation.Journal_abbrev 'Protein Sci.' _Citation.Journal_name_full . _Citation.Journal_volume 7 _Citation.Journal_issue . _Citation.Journal_ASTM . _Citation.Journal_ISSN . _Citation.Journal_CSD . _Citation.Book_title . _Citation.Book_chapter_title . _Citation.Book_volume . _Citation.Book_series . _Citation.Book_publisher . _Citation.Book_publisher_city . _Citation.Book_ISBN . _Citation.Conference_title . _Citation.Conference_site . _Citation.Conference_state_province . _Citation.Conference_country . _Citation.Conference_start_date . _Citation.Conference_end_date . _Citation.Conference_abstract_number . _Citation.Thesis_institution . _Citation.Thesis_institution_city . _Citation.Thesis_institution_country . _Citation.WWW_URL . _Citation.Page_first 2164 _Citation.Page_last 2174 _Citation.Year 1998 _Citation.Details . loop_ _Citation_author.Ordinal _Citation_author.Given_name _Citation_author.Family_name _Citation_author.First_initial _Citation_author.Middle_initials _Citation_author.Family_title _Citation_author.Entry_ID _Citation_author.Citation_ID 1 Kern Gunther . . . 4097 1 2 Tracy Handel . M. . 4097 1 3 Susan Marqusee . . . 4097 1 stop_ loop_ _Citation_keyword.Keyword _Citation_keyword.Entry_ID _Citation_keyword.Citation_ID AIDS 4097 1 Folding 4097 1 'H/D exchange' 4097 1 HIV-1 4097 1 stop_ save_ save_citation_one _Citation.Sf_category citations _Citation.Sf_framecode citation_one _Citation.Entry_ID 4097 _Citation.ID 2 _Citation.Class 'reference citation' _Citation.CAS_abstract_code . _Citation.MEDLINE_UI_code . _Citation.DOI . _Citation.PubMed_ID 8589602 _Citation.Full_citation ; Wishart, D. S., Bigam, C. G., Yao, J., Abildgaard, F., Dyson, H. J., Oldfield, E., Markley, J. L., and Sykes, B. D. J. Biomol. NMR 6, 135-140 (1995). ; _Citation.Title '1H, 13C and 15N chemical shift referencing in biomolecular NMR.' _Citation.Status published _Citation.Type journal _Citation.Journal_abbrev 'J. Biomol. NMR' _Citation.Journal_name_full 'Journal of biomolecular NMR' _Citation.Journal_volume 6 _Citation.Journal_issue 2 _Citation.Journal_ASTM . _Citation.Journal_ISSN 0925-2738 _Citation.Journal_CSD . _Citation.Book_title . _Citation.Book_chapter_title . _Citation.Book_volume . _Citation.Book_series . _Citation.Book_publisher . _Citation.Book_publisher_city . _Citation.Book_ISBN . _Citation.Conference_title . _Citation.Conference_site . _Citation.Conference_state_province . _Citation.Conference_country . _Citation.Conference_start_date . _Citation.Conference_end_date . _Citation.Conference_abstract_number . _Citation.Thesis_institution . _Citation.Thesis_institution_city . _Citation.Thesis_institution_country . _Citation.WWW_URL . _Citation.Page_first 135 _Citation.Page_last 140 _Citation.Year 1995 _Citation.Details ; A considerable degree of variability exists in the way that 1H, 13C and 15N chemical shifts are reported and referenced for biomolecules. In this article we explore some of the reasons for this situation and propose guidelines for future chemical shift referencing and for conversion from many common 1H, 13C and 15N chemical shift standards, now used in biomolecular NMR, to those proposed here. ; loop_ _Citation_author.Ordinal _Citation_author.Given_name _Citation_author.Family_name _Citation_author.First_initial _Citation_author.Middle_initials _Citation_author.Family_title _Citation_author.Entry_ID _Citation_author.Citation_ID 1 'D S' Wishart D. S. . 4097 2 2 'C G' Bigam C. G. . 4097 2 3 J Yao J. . . 4097 2 4 F Abildgaard F. . . 4097 2 5 'H J' Dyson H. J. . 4097 2 6 E Oldfield E. . . 4097 2 7 'J L' Markley J. L. . 4097 2 8 'B D' Sykes B. D. . 4097 2 stop_ save_ save_citation_two _Citation.Sf_category citations _Citation.Sf_framecode citation_two _Citation.Entry_ID 4097 _Citation.ID 3 _Citation.Class 'reference citation' _Citation.CAS_abstract_code . _Citation.MEDLINE_UI_code . _Citation.DOI . _Citation.PubMed_ID 1719214 _Citation.Full_citation ; Assignment for a mutant RNase H from HIV-1 strain HXB2 is available Powers et al. 1991, J. Mol. Biol. 221 1081-90 ; _Citation.Title 'Secondary structure of the ribonuclease H domain of the human immunodeficiency virus reverse transcriptase in solution using three-dimensional double and triple resonance heteronuclear magnetic resonance spectroscopy.' _Citation.Status published _Citation.Type journal _Citation.Journal_abbrev 'J. Mol. Biol.' _Citation.Journal_name_full 'Journal of molecular biology' _Citation.Journal_volume 221 _Citation.Journal_issue 4 _Citation.Journal_ASTM . _Citation.Journal_ISSN 0022-2836 _Citation.Journal_CSD . _Citation.Book_title . _Citation.Book_chapter_title . _Citation.Book_volume . _Citation.Book_series . _Citation.Book_publisher . _Citation.Book_publisher_city . _Citation.Book_ISBN . _Citation.Conference_title . _Citation.Conference_site . _Citation.Conference_state_province . _Citation.Conference_country . _Citation.Conference_start_date . _Citation.Conference_end_date . _Citation.Conference_abstract_number . _Citation.Thesis_institution . _Citation.Thesis_institution_city . _Citation.Thesis_institution_country . _Citation.WWW_URL . _Citation.Page_first 1081 _Citation.Page_last 1090 _Citation.Year 1991 _Citation.Details ; The solution structure of the ribonuclease H domain of HIV-1 reverse transcriptase has been investigated by three-dimensional double and triple resonance heteronuclear magnetic resonance spectroscopy. The domain studied has 138 residues and comprises residues 427 to 560 of the 66 kDa reverse transcriptase with an additional four residues at the N terminus. Initial studies on the wild-type protein were hindered by severe differential line broadening, presumably due to conformational averaging. Mutation of the single tryptophan residue located in a loop at position 113 (position 535 in the reverse transcriptase sequence) to an alanine resulted in much improved spectral properties with no apparent change in structure. 1H, 15N and 13C backbone resonances were assigned sequentially using a range of three-dimensional double and triple resonance heteronuclear experiments on samples of uniformly (greater than 95%) 15N and 15N/13C-labeled protein, and the secondary structure was elucidated from a qualitative analysis of data derived from three-dimensional 15N- and 13C-edited nuclear Overhauser enhancement spectra. The secondary structure comprises three alpha-helices and five strands arranged in a mixed parallel/antiparallel beta-sheet with a +1, +1, -3x, -1x topology. The C-terminal region from residue 114 onwards appears to be conformationally disordered in solution as evidenced by an almost complete absence of sequential and medium range nuclear Overhauser effects. ; loop_ _Citation_author.Ordinal _Citation_author.Given_name _Citation_author.Family_name _Citation_author.First_initial _Citation_author.Middle_initials _Citation_author.Family_title _Citation_author.Entry_ID _Citation_author.Citation_ID 1 R Powers R. . . 4097 3 2 'G M' Clore G. M. . 4097 3 3 A Bax A. . . 4097 3 4 'D S' Garrett D. S. . 4097 3 5 'S J' Stahl S. J. . 4097 3 6 'P T' Wingfield P. T. . 4097 3 7 'A M' Gronenborn A. M. . 4097 3 stop_ save_ ############################################# # Molecular system (assembly) description # ############################################# save_system_RNase_H-HIV-1 _Assembly.Sf_category assembly _Assembly.Sf_framecode system_RNase_H-HIV-1 _Assembly.Entry_ID 4097 _Assembly.ID 1 _Assembly.Name 'RNase H domain of HIV-1 RVT strain BH10' _Assembly.BMRB_code . _Assembly.Number_of_components . _Assembly.Organic_ligands . _Assembly.Metal_ions . _Assembly.Non_standard_bonds . _Assembly.Ambiguous_conformational_states . _Assembly.Ambiguous_chem_comp_sites . _Assembly.Molecules_in_chemical_exchange . _Assembly.Paramagnetic no _Assembly.Thiol_state . _Assembly.Molecular_mass . _Assembly.Enzyme_commission_number 3.1.26.4 _Assembly.Details 'The assignment is done on the isolated RNase H domain' _Assembly.DB_query_date . _Assembly.DB_query_revised_last_date . loop_ _Assembly_type.Type _Assembly_type.Entry_ID _Assembly_type.Assembly_ID monomer 4097 1 stop_ loop_ _Entity_assembly.ID _Entity_assembly.Entity_assembly_name _Entity_assembly.Entity_ID _Entity_assembly.Entity_label _Entity_assembly.Asym_ID _Entity_assembly.PDB_chain_ID _Entity_assembly.Experimental_data_reported _Entity_assembly.Physical_state _Entity_assembly.Conformational_isomer _Entity_assembly.Chemical_exchange_state _Entity_assembly.Magnetic_equivalence_group_code _Entity_assembly.Role _Entity_assembly.Details _Entity_assembly.Entry_ID _Entity_assembly.Assembly_ID 1 RNase_H-HIV-1_(RVT) 1 $RNase_H-HIV-1_(RVT) . . . native . . . . . 4097 1 stop_ loop_ _Assembly_common_name.Name _Assembly_common_name.Type _Assembly_common_name.Entry_ID _Assembly_common_name.Assembly_ID 'RNase H domain of HIV-1 RVT strain BH10' system 4097 1 RNase_H-HIV-1 abbreviation 4097 1 stop_ loop_ _Assembly_bio_function.Biological_function _Assembly_bio_function.Entry_ID _Assembly_bio_function.Assembly_ID 'cleaves the RNA moiety of RNA:DNA hybrids' 4097 1 stop_ save_ #################################### # Biological polymers and ligands # #################################### save_RNase_H-HIV-1_(RVT) _Entity.Sf_category entity _Entity.Sf_framecode RNase_H-HIV-1_(RVT) _Entity.Entry_ID 4097 _Entity.ID 1 _Entity.BMRB_code . _Entity.Name 'Reverse Transcriptase of HIV-1' _Entity.Type polymer _Entity.Polymer_common_type . _Entity.Polymer_type polypeptide(L) _Entity.Polymer_type_details . _Entity.Polymer_strand_ID . _Entity.Polymer_seq_one_letter_code_can . _Entity.Polymer_seq_one_letter_code ; MYQLEKEPIVGAETFYVDGA ANRETKLGKAGYVTNKGRQK VVPLTNTTNQKTELQAIYLA LQDSGLEVNIVTDSQYALGI IQAQPDKSESELVNQIIEQL IKKEKVYLAWVPAHKGIGGN EQVDKLVSAGIRKIL ; _Entity.Target_identifier . _Entity.Polymer_author_defined_seq . _Entity.Polymer_author_seq_details . _Entity.Ambiguous_conformational_states . _Entity.Ambiguous_chem_comp_sites . _Entity.Nstd_monomer . _Entity.Nstd_chirality . _Entity.Nstd_linkage . _Entity.Nonpolymer_comp_ID . _Entity.Nonpolymer_comp_label . _Entity.Number_of_monomers 135 _Entity.Number_of_nonpolymer_components . _Entity.Paramagnetic . _Entity.Thiol_state . _Entity.Src_method . _Entity.Parent_entity_ID . _Entity.Fragment . _Entity.Mutation . _Entity.EC_number 3.1.26.4 _Entity.Calc_isoelectric_point . _Entity.Formula_weight 14885 _Entity.Formula_weight_exptl . _Entity.Formula_weight_exptl_meth . _Entity.Details 'RNase H, RVT heterodimer' _Entity.DB_query_date . _Entity.DB_query_revised_last_date 2015-11-25 loop_ _Entity_db_link.Ordinal _Entity_db_link.Author_supplied _Entity_db_link.Database_code _Entity_db_link.Accession_code _Entity_db_link.Entry_mol_code _Entity_db_link.Entry_mol_name _Entity_db_link.Entry_experimental_method _Entity_db_link.Entry_structure_resolution _Entity_db_link.Entry_relation_type _Entity_db_link.Entry_details _Entity_db_link.Chimera_segment_ID _Entity_db_link.Seq_query_to_submitted_percent _Entity_db_link.Seq_subject_length _Entity_db_link.Seq_identity _Entity_db_link.Seq_positive _Entity_db_link.Seq_homology_expectation_val _Entity_db_link.Seq_align_begin _Entity_db_link.Seq_align_end _Entity_db_link.Seq_difference_details _Entity_db_link.Seq_alignment_details _Entity_db_link.Entry_ID _Entity_db_link.Entity_ID 1 no PDB 1BQM . "Hiv-1 RtHBY 097" . . . . . 97.04 556 99.24 99.24 6.23e-81 . . . . 4097 1 2 no PDB 1BQN . "Tyr 188 Leu Hiv-1 RtHBY 097" . . . . . 98.52 558 98.50 99.25 4.25e-82 . . . . 4097 1 3 no PDB 1DLO . "Human Immunodeficiency Virus Type 1" . . . . . 97.04 556 99.24 99.24 6.23e-81 . . . . 4097 1 4 no PDB 1EET . "Hiv-1 Reverse Transcriptase In Complex With The Inhibitor Msc204" . . . . . 97.78 557 98.48 99.24 2.24e-81 . . . . 4097 1 5 no PDB 1HMV . "The Structure Of Unliganded Reverse Transcriptase From The Human Immunodeficiency Virus Type 1" . . . . . 100.00 560 99.26 99.26 8.46e-84 . . . . 4097 1 6 no PDB 1HNI . "Structure Of Hiv-1 Reverse Transcriptase In A Complex With The Nonnucleoside Inhibitor Alpha-Apa R 95845 At 2.8 Angstroms Resol" . . . . . 98.52 558 99.25 99.25 1.40e-82 . . . . 4097 1 7 no PDB 1HNV . "Structure Of Hiv-1 Rt(Slash)tibo R 86183 Complex Reveals Similarity In The Binding Of Diverse Nonnucleoside Inhibitors" . . . . . 98.52 558 99.25 99.25 1.40e-82 . . . . 4097 1 8 no PDB 1HPZ . "Human Immunodeficiency Virus Type 1" . . . . . 100.00 560 99.26 99.26 8.02e-84 . . . . 4097 1 9 no PDB 1HQE . "Human Immunodeficiency Virus Type 1" . . . . . 100.00 560 99.26 99.26 8.02e-84 . . . . 4097 1 10 no PDB 1HQU . "Human Immunodeficiency Virus Type 1" . . . . . 100.00 560 99.26 99.26 8.02e-84 . . . . 4097 1 11 no PDB 1HRH . "Crystal Structure Of The Ribonuclease H Domain Of Hiv-1 Reverse Transcriptase" . . . . . 99.26 136 100.00 100.00 5.33e-89 . . . . 4097 1 12 no PDB 1HVU . "Human Immunodeficiency Virus Type 1 Reverse Transcriptase Complexed With A 33-Base Nucleotide Rna Pseudoknot" . . . . . 95.56 554 99.22 99.22 2.17e-79 . . . . 4097 1 13 no PDB 1HYS . "Crystal Structure Of Hiv-1 Reverse Transcriptase In Complex With A Polypurine Tract Rna:dna" . . . . . 94.81 553 99.22 99.22 9.43e-79 . . . . 4097 1 14 no PDB 1IKV . "K103n Mutant Hiv-1 Reverse Transcriptase In Complex With Efivarenz" . . . . . 100.00 560 98.52 99.26 3.12e-83 . . . . 4097 1 15 no PDB 1IKW . "Wild Type Hiv-1 Reverse Transcriptase In Complex With Efavirenz" . . . . . 100.00 560 98.52 99.26 2.29e-83 . . . . 4097 1 16 no PDB 1IKX . "K103n Mutant Hiv-1 Reverse Transcriptase In Complex With The Inhibitor Pnu142721" . . . . . 100.00 560 98.52 99.26 3.12e-83 . . . . 4097 1 17 no PDB 1IKY . "Hiv-1 Reverse Transcriptase In Complex With The Inhibitor Msc194" . . . . . 100.00 560 98.52 99.26 3.12e-83 . . . . 4097 1 18 no PDB 1J5O . "Crystal Structure Of Met184ile Mutant Of Hiv-1 Reverse Transcriptase In Complex With Double Stranded Dna Template- Primer" . . . . . 98.52 558 99.25 99.25 1.56e-82 . . . . 4097 1 19 no PDB 1N5Y . "Hiv-1 Reverse Transcriptase Crosslinked To Post- Translocation Aztmp-Terminated Dna (Complex P)" . . . . . 98.52 558 99.25 99.25 1.54e-82 . . . . 4097 1 20 no PDB 1N6Q . "Hiv-1 Reverse Transcriptase Crosslinked To Pre- Translocation Aztmp-Terminated Dna (Complex N)" . . . . . 98.52 558 99.25 99.25 1.54e-82 . . . . 4097 1 21 no PDB 1QE1 . "Crystal Structure Of 3tc-Resistant M184i Mutant Of Hiv-1 Reverse Transcriptase" . . . . . 98.52 558 99.25 99.25 1.56e-82 . . . . 4097 1 22 no PDB 1R0A . "Crystal Structure Of Hiv-1 Reverse Transcriptase Covalently Tethered To Dna Template-primer Solved To 2.8 Angstroms" . . . . . 98.52 558 99.25 99.25 1.54e-82 . . . . 4097 1 23 no PDB 1RDH . "Crystallographic Analyses Of An Active Hiv-1 Ribonuclease H Domain Show Structural Features That Distinguish It From The Inacti" . . . . . 99.26 146 100.00 100.00 7.83e-89 . . . . 4097 1 24 no PDB 1RTD . "Structure Of A Catalytic Complex Of Hiv-1 Reverse Transcriptase: Implications For Nucleoside Analog Drug Resistance" . . . . . 95.56 554 96.90 99.22 1.41e-77 . . . . 4097 1 25 no PDB 1S6P . "Crystal Structure Of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Rt) In Complex With Janssen-R100943" . . . . . 100.00 560 99.26 99.26 6.98e-84 . . . . 4097 1 26 no PDB 1S6Q . "Crystal Structure Of Hiv-1 Reverse Transcriptase (Rt) In Complex With Janssen-R147681" . . . . . 100.00 560 99.26 99.26 6.98e-84 . . . . 4097 1 27 no PDB 1S9E . "Crystal Structure Of Hiv-1 Reverse Transcriptase (Rt) In Complex With Janssen-R129385" . . . . . 100.00 560 99.26 99.26 6.98e-84 . . . . 4097 1 28 no PDB 1S9G . "Crystal Structure Of Hiv-1 Reverse Transcriptase (Rt) In Complex With Janssen-R120394." . . . . . 100.00 560 99.26 99.26 6.98e-84 . . . . 4097 1 29 no PDB 1SUQ . "Crystal Structure Of Hiv-1 Reverse Transcriptase (Rt) In Complex With Janssen-R185545" . . . . . 100.00 560 99.26 99.26 6.98e-84 . . . . 4097 1 30 no PDB 1SV5 . "Crystal Structure Of K103n Mutant Hiv-1 Reverse Transcriptase (Rt) In Complex With Janssen-R165335" . . . . . 100.00 560 99.26 99.26 8.02e-84 . . . . 4097 1 31 no PDB 1T03 . "Hiv-1 Reverse Transcriptase Crosslinked To Tenofovir Terminated Template-Primer (Complex P)" . . . . . 98.52 558 99.25 99.25 1.54e-82 . . . . 4097 1 32 no PDB 1T05 . "Hiv-1 Reverse Transcriptase Crosslinked To Template-Primer With Tenofovir-Diphosphate Bound As The Incoming Nucleotide Substrat" . . . . . 98.52 558 99.25 99.25 1.54e-82 . . . . 4097 1 33 no PDB 1TV6 . "Hiv-1 Reverse Transcriptase Complexed With Cp-94,707" . . . . . 100.00 560 99.26 99.26 8.46e-84 . . . . 4097 1 34 no PDB 1TVR . "Hiv-1 Rt9-Cl Tibo" . . . . . 98.52 558 99.25 99.25 1.40e-82 . . . . 4097 1 35 no PDB 1UWB . "Tyr 181 Cys Hiv-1 Rt8-Cl Tibo" . . . . . 98.52 558 99.25 99.25 1.49e-82 . . . . 4097 1 36 no PDB 2B5J . "Crystal Structure Of Hiv-1 Reverse Transcriptase (Rt) In Complex With Janssen-R165481" . . . . . 100.00 560 99.26 99.26 6.98e-84 . . . . 4097 1 37 no PDB 2B6A . "Crystal Structure Of Hiv-1 Reverse Transcriptase (Rt) In Complex With Thr-50" . . . . . 100.00 560 99.26 99.26 6.98e-84 . . . . 4097 1 38 no PDB 2BAN . "Crystal Structure Of Hiv-1 Reverse Transcriptase (Rt) In Complex With Janssen-R157208" . . . . . 100.00 560 99.26 99.26 6.98e-84 . . . . 4097 1 39 no PDB 2BE2 . "Crystal Structure Of Hiv-1 Reverse Transcriptase (Rt) In Complex With R221239" . . . . . 100.00 560 99.26 99.26 6.98e-84 . . . . 4097 1 40 no PDB 2HMI . "Hiv-1 Reverse TranscriptaseFRAGMENT OF FAB 28DNA COMPLEX" . . . . . 98.52 558 99.25 99.25 1.40e-82 . . . . 4097 1 41 no PDB 2I5J . "Crystal Structure Of Hiv-1 Reverse Transcriptase (Rt) In Complex With Dhbnh, An Rnase H Inhibitor" . . . . . 94.07 552 99.21 99.21 4.56e-78 . . . . 4097 1 42 no PDB 2IAJ . "Crystal Structure Of K103nY181C MUTANT HIV-1 Reverse Transcriptase (Rt) In Complex With Atp" . . . . . 100.00 560 99.26 99.26 9.42e-84 . . . . 4097 1 43 no PDB 2IC3 . "Crystal Structure Of K103nY181C MUTANT HIV-1 Reverse Transcriptase (Rt) In Complex With Nonnucleoside Inhibitor Hby 097" . . . . . 100.00 560 99.26 99.26 9.42e-84 . . . . 4097 1 44 no PDB 2VG5 . "Crystal Structures Of Hiv-1 Reverse Transcriptase Complexes With Thiocarbamate Non-Nucleoside Inhibitors" . . . . . 97.78 557 99.24 99.24 6.64e-82 . . . . 4097 1 45 no PDB 2VG6 . "Crystal Structures Of Hiv-1 Reverse Transcriptase Complexes With Thiocarbamate Non-Nucleoside Inhibitors" . . . . . 97.78 557 99.24 99.24 6.64e-82 . . . . 4097 1 46 no PDB 2VG7 . "Crystal Structures Of Hiv-1 Reverse Transcriptase Complexes With Thiocarbamate Non-Nucleoside Inhibitors" . . . . . 97.78 557 99.24 99.24 6.64e-82 . . . . 4097 1 47 no PDB 2YKM . "Crystal Structure Of Hiv-1 Reverse Transcriptase (Rt) In Complex With A Difluoromethylbenzoxazole (Dfmb) Pyrimidine Thioether D" . . . . . 97.78 562 98.48 99.24 2.08e-81 . . . . 4097 1 48 no PDB 2YKN . "Crystal Structure Of Hiv-1 Reverse Transcriptase (Rt) In Complex With A Difluoromethylbenzoxazole (Dfmb) Pyrimidine Thioether D" . . . . . 97.78 562 98.48 99.24 1.85e-81 . . . . 4097 1 49 no PDB 2ZD1 . "Crystal Structure Of Hiv-1 Reverse Transcriptase (rt) In Complex With Tmc278 (rilpivirine), A Non-nucleoside Rt Inhibitor" . . . . . 96.30 557 99.23 99.23 2.47e-80 . . . . 4097 1 50 no PDB 2ZE2 . "Crystal Structure Of L100i/k103n Mutant Hiv-1 Reverse Transcriptase (rt) In Complex With Tmc278 (rilpivirine), A Non-nucleoside" . . . . . 96.30 557 99.23 99.23 2.37e-80 . . . . 4097 1 51 no PDB 3BGR . "Crystal Structure Of K103n/y181c Mutant Hiv-1 Reverse Transcriptase (rt) In Complex With Tmc278 (rilpivirine), A Non-nucleoside" . . . . . 96.30 557 99.23 99.23 2.47e-80 . . . . 4097 1 52 no PDB 3DLK . "Crystal Structure Of An Engineered Form Of The Hiv-1 Reverse Transcriptase, Rt69a" . . . . . 96.30 556 99.23 99.23 2.37e-80 . . . . 4097 1 53 no PDB 3HVT . "Structural Basis Of Asymmetry In The Human Immunodeficiency Virus Type 1 Reverse Transcriptase Heterodimer" . . . . . 97.04 556 99.24 99.24 6.72e-81 . . . . 4097 1 54 no PDB 3IG1 . "Hiv-1 Reverse Transcriptase With The Inhibitor Beta- Thujaplicinol Bound At The Rnase H Active Site" . . . . . 96.30 555 99.23 99.23 2.63e-80 . . . . 4097 1 55 no PDB 3IRX . "Crystal Structure Of Hiv-1 Reverse Transcriptase (Rt) In Complex With The Non-Nucleoside Rt Inhibitor (E)-S-Methyl 5-(1-(3,7-Di" . . . . . 96.30 558 99.23 99.23 2.81e-80 . . . . 4097 1 56 no PDB 3IS9 . "Crystal Structure Of The Hiv-1 Reverse Transcriptase (Rt) In Complex With The Alkenyldiarylmethane (Adam) Non-Nucleoside Rt Inh" . . . . . 96.30 558 99.23 99.23 2.81e-80 . . . . 4097 1 57 no PDB 3ISN . "Crystal Structure Of Hiv-1 Rt Bound To A 6-Vinylpyrimidine Inhibitor" . . . . . 100.00 560 98.52 99.26 2.29e-83 . . . . 4097 1 58 no PDB 3ITH . "Crystal Structure Of The Hiv-1 Reverse Transcriptase Bound To A 6-Vinylpyrimidine Inhibitor" . . . . . 100.00 560 98.52 99.26 2.29e-83 . . . . 4097 1 59 no PDB 3JSM . "K65r Mutant Hiv-1 Reverse Transcriptase Cross-Linked To Ds-Dna And Complexed With Tenofovir-Diphosphate As The Incoming Nucleot" . . . . . 98.52 558 99.25 99.25 1.61e-82 . . . . 4097 1 60 no PDB 3JYT . "K65r Mutant Hiv-1 Reverse Transcriptase Cross-Linked To Ds- Dna And Complexed With Datp As The Incoming Nucleotide Substrate" . . . . . 98.52 558 99.25 99.25 1.61e-82 . . . . 4097 1 61 no PDB 3K2P . "Hiv-1 Reverse Transcriptase Isolated Rnaseh Domain With The Inhibitor Beta-Thujaplicinol Bound At The Active Site" . . . . . 100.00 136 99.26 100.00 1.54e-89 . . . . 4097 1 62 no PDB 3KLE . "Crystal Structure Of Azt-Resistant Hiv-1 Reverse Transcriptase Crosslinked To A Dsdna With A Bound Excision Product, Aztppppa" . . . . . 100.00 562 98.52 99.26 1.85e-83 . . . . 4097 1 63 no PDB 3KLF . "Crystal Structure Of Wild-Type Hiv-1 Reverse Transcriptase Crosslinked To A Dsdna With A Bound Excision Product, Aztppppa" . . . . . 96.30 557 99.23 99.23 2.53e-80 . . . . 4097 1 64 no PDB 3KLG . "Crystal Structure Of Azt-Resistant Hiv-1 Reverse Transcriptase Crosslinked To Pre-Translocation Aztmp-Terminated Dna (Complex N" . . . . . 100.00 562 98.52 99.26 1.85e-83 . . . . 4097 1 65 no PDB 3KLH . "Crystal Structure Of Azt-resistant Hiv-1 Reverse Transcriptase Crosslinked To Post-translocation Aztmp-terminated Dna (complex " . . . . . 100.00 564 99.26 99.26 9.60e-84 . . . . 4097 1 66 no PDB 3KLI . "Crystal Structure Of Unliganded Azt-Resistant Hiv-1 Reverse Transcriptase" . . . . . 100.00 562 98.52 99.26 1.85e-83 . . . . 4097 1 67 no PDB 3LP3 . "P15 Hiv Rnaseh Domain With Inhibitor Mk3" . . . . . 99.26 138 100.00 100.00 3.72e-89 . . . . 4097 1 68 no PDB 3QLH . "Hiv-1 Reverse Transcriptase In Complex With Manicol At The Rnase H Active Site And Tmc278 (rilpivirine) At The Nnrti Binding Po" . . . . . 95.56 555 99.22 99.22 1.93e-79 . . . . 4097 1 69 no PDB 3QO9 . "Crystal Structure Of Hiv-1 Reverse Transcriptase (rt) In Complex With Tsao-t, A Non-nucleoside Rt Inhibitor (nnrti)" . . . . . 96.30 557 99.23 99.23 2.72e-80 . . . . 4097 1 70 no PDB 3V4I . "Crystal Structure Of Hiv-1 Reverse Transcriptase (Rt) With Dna And Azttp" . . . . . 95.56 556 98.45 99.22 1.13e-78 . . . . 4097 1 71 no PDB 3V6D . "Crystal Structure Of Hiv-1 Reverse Transcriptase (Rt) Cross-Linked With Azt-Terminated Dna" . . . . . 95.56 556 98.45 99.22 1.13e-78 . . . . 4097 1 72 no PDB 3V81 . "Crystal Structure Of Hiv-1 Reverse Transcriptase (Rt) With Dna And The Nonnucleoside Inhibitor Nevirapine" . . . . . 95.56 556 98.45 99.22 1.13e-78 . . . . 4097 1 73 no PDB 4DG1 . "Crystal Structure Of Hiv-1 Reverse Transcriptase (Rt) With Polymorphism Mutation K172a And K173a" . . . . . 91.85 549 99.19 99.19 2.80e-76 . . . . 4097 1 74 no PDB 4G1Q . "Crystal Structure Of Hiv-1 Reverse Transcriptase (rt) In Complex With Rilpivirine (tmc278, Edurant), A Non-nucleoside Rt-inhibi" . . . . . 96.30 557 99.23 99.23 2.47e-80 . . . . 4097 1 75 no PDB 4H4M . "Crystal Structure Of Hiv-1 Reverse Transcriptase In Complex With (E)- 3-(3-Chloro-5-(4-Chloro-2-(2-(2,4-Dioxo-3,4- Dihydropyrim" . . . . . 96.30 557 99.23 99.23 2.47e-80 . . . . 4097 1 76 no PDB 4H4O . "Crystal Structure Of Hiv-1 Reverse Transcriptase (Rt) In Complex With (E)-3-(3-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2h)-Yl)e" . . . . . 96.30 557 99.23 99.23 2.47e-80 . . . . 4097 1 77 no PDB 4I2P . "Crystal Structure Of Hiv-1 Reverse Transcriptase In Complex With Rilpivirine (tmc278) Based Analogue" . . . . . 96.30 557 99.23 99.23 2.47e-80 . . . . 4097 1 78 no PDB 4I2Q . "Crystal Structure Of K103n/y181c Mutant Of Hiv-1 Reverse Transcriptase In Complex With Rilpivirine (tmc278) Analogue" . . . . . 96.30 557 99.23 99.23 2.47e-80 . . . . 4097 1 79 no PDB 4ICL . "Hiv-1 Reverse Transcriptase With Bound Fragment At The Incoming Dntp Binding Site" . . . . . 96.30 557 99.23 99.23 2.47e-80 . . . . 4097 1 80 no PDB 4ID5 . "Hiv-1 Reverse Transcriptase With Bound Fragment At The Rnase H Primer Grip Site" . . . . . 96.30 557 99.23 99.23 2.47e-80 . . . . 4097 1 81 no PDB 4IDK . "Hiv-1 Reverse Transcriptase With Bound Fragment At The 428 Site" . . . . . 96.30 557 99.23 99.23 2.47e-80 . . . . 4097 1 82 no PDB 4IFV . "Detecting Allosteric Sites Of Hiv-1 Reverse Transcriptase By X-ray Crystallographic Fragment Screening" . . . . . 96.30 557 99.23 99.23 2.47e-80 . . . . 4097 1 83 no PDB 4IFY . "Hiv-1 Reverse Transcriptase With Bound Fragment At The Knuckles Site" . . . . . 96.30 557 99.23 99.23 2.47e-80 . . . . 4097 1 84 no PDB 4IG0 . "Hiv-1 Reverse Transcriptase With Bound Fragment At The 507 Site" . . . . . 96.30 557 99.23 99.23 2.47e-80 . . . . 4097 1 85 no PDB 4IG3 . "Hiv-1 Reverse Transcriptase With Bound Fragment Near Knuckles Site" . . . . . 96.30 557 99.23 99.23 2.47e-80 . . . . 4097 1 86 no PDB 4KFB . "Hiv-1 Reverse Transcriptase With Bound Fragment At Nnrti Adjacent Site" . . . . . 96.30 557 99.23 99.23 2.47e-80 . . . . 4097 1 87 no PDB 4KKO . "Crystal Structure Of Hiv-1 Reverse Transcriptase In Complex With 4- ((4-methoxy-6-(2-morpholinoethoxy)-1,3,5-triazin-2-yl)amino" . . . . . 96.30 557 99.23 99.23 2.47e-80 . . . . 4097 1 88 no PDB 4KO0 . "Crystal Structure Of Hiv-1 Reverse Transcriptase (rt) In Complex With An Anilinylpyrimidine Derivative (jlj-135)" . . . . . 96.30 557 99.23 99.23 2.47e-80 . . . . 4097 1 89 no PDB 4LSL . "Crystal Structure Of Hiv-1 Reverse Transcriptase In Complex With (e)- 3-(3-(4-chloro-2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)" . . . . . 96.30 557 99.23 99.23 2.47e-80 . . . . 4097 1 90 no PDB 4LSN . "Crystal Structure Of Hiv-1 Reverse Transcriptase In Complex With (e)- 3-(3-bromo-5-(4-chloro-2-(2-(2,4-dioxo-3,4-dihydropyrimid" . . . . . 96.30 557 99.23 99.23 2.47e-80 . . . . 4097 1 91 no PDB 4MFB . "Crystal Structure Of Hiv-1 Reverse Transcriptase In Complex With 8-(2- (2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)pheno" . . . . . 96.30 557 99.23 99.23 2.47e-80 . . . . 4097 1 92 no PDB 4O44 . "Crystal Structure Of Hiv-1 Reverse Transcriptase In Complex With 4- ((4-(mesitylamino)-6-(3-morpholinopropoxy)-1,3,5-triazin-2-" . . . . . 96.30 557 99.23 99.23 2.47e-80 . . . . 4097 1 93 no PDB 4O4G . "Crystal Structure Of Hiv-1 Reverse Transcriptase In Complex With 4- ((4-(mesitylamino)-1,3,5-triazin-2-yl)amino)benzonitrile (j" . . . . . 96.30 557 99.23 99.23 2.47e-80 . . . . 4097 1 94 no PDB 4PQU . "Crystal Structure Of Hiv-1 Reverse Transcriptase In Complex With Rna/dna And Datp" . . . . . 95.56 556 98.45 99.22 1.13e-78 . . . . 4097 1 95 no PDB 4PUO . "Crystal Structure Of Hiv-1 Reverse Transcriptase In Complex With Rna/dna And Nevirapine" . . . . . 95.56 556 98.45 99.22 1.13e-78 . . . . 4097 1 96 no PDB 4PWD . "Crystal Structure Of Hiv-1 Reverse Transcriptase In Complex With Bulge-rna/dna And Nevirapine" . . . . . 95.56 556 98.45 99.22 1.13e-78 . . . . 4097 1 97 no PDB 4Q0B . "Crystal Structure Of Hiv-1 Reverse Transcriptase In Complex With Gap- Rna/dna And Nevirapine" . . . . . 95.56 556 98.45 99.22 1.13e-78 . . . . 4097 1 98 no PDB 4QAG . "Structure Of A Dihydroxycoumarin Active-site Inhibitor In Complex With The Rnase H Domain Of Hiv-1 Reverse Transcriptase" . . . . . 97.04 133 100.00 100.00 5.40e-87 . . . . 4097 1 99 no PDB 4R5P . "Crystal Structure Of Hiv-1 Reverse Transcriptase (rt) With Dna And A Nucleoside Triphosphate Mimic Alpha-carboxy Nucleoside Pho" . . . . . 95.56 556 98.45 99.22 1.13e-78 . . . . 4097 1 100 no PDB 4RW4 . "Crystal Structure Of Hiv-1 Reverse Transcriptase (k103n,y181c) Variant In Complex With (e)-3-(3-chloro-5-(4-chloro-2-(2-(2,4-di" . . . . . 96.30 557 99.23 99.23 2.47e-80 . . . . 4097 1 101 no PDB 4RW6 . "Crystal Structure Of Hiv-1 Reverse Transcriptase (y181c) Variant In Complex With (e)-3-(3-chloro-5-(4-chloro-2-(2-(2,4-dioxo-3," . . . . . 96.30 557 99.23 99.23 2.61e-80 . . . . 4097 1 102 no PDB 4RW7 . "Crystal Structure Of Hiv-1 Reverse Transcriptase (k103n, Y181c) Variant In Complex With (e)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-" . . . . . 96.30 557 99.23 99.23 2.47e-80 . . . . 4097 1 103 no PDB 4RW8 . "Crystal Structure Of Hiv-1 Reverse Transcriptase In Complex With (e)- 3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)" . . . . . 96.30 557 99.23 99.23 2.47e-80 . . . . 4097 1 104 no PDB 4RW9 . "Crystal Structure Of Hiv-1 Reverse Transcriptase (y181c) Variant In Complex With (e)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydro" . . . . . 96.30 557 99.23 99.23 2.61e-80 . . . . 4097 1 105 no PDB 4WE1 . "Crystal Structure Of Hiv-1 Reverse Transcriptase In Complex With 5-(2- (2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)pheno" . . . . . 96.30 557 99.23 99.23 2.47e-80 . . . . 4097 1 106 no PDB 5C24 . "Crystal Structure Of Hiv-1 Reverse Transcriptase In Complex With 7- ((4-((4-cyanophenyl)amino)-1,3,5-triazin-2-yl)amino)-6,8- D" . . . . . 88.89 537 99.17 99.17 2.04e-73 . . . . 4097 1 107 no PDB 5C25 . "Crystal Structure Of Hiv-1 Reverse Transcriptase In Complex With 6- ((4-((4-cyanophenyl)amino)-1,3,5-triazin-2-yl)amino)-5,7-di" . . . . . 96.30 557 99.23 99.23 2.47e-80 . . . . 4097 1 108 no PDB 5C42 . "Crystal Structure Of Hiv-1 Reverse Transcriptase (k101p) Variant In Complex With 8-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-" . . . . . 96.30 557 99.23 99.23 2.13e-80 . . . . 4097 1 109 no PDB 5D3G . "Structure Of Hiv-1 Reverse Transcriptase Bound To A Novel 38-mer Hairpin Template-primer Dna Aptamer" . . . . . 96.30 555 99.23 99.23 2.89e-80 . . . . 4097 1 110 no DBJ BAA12989 . "Pol [Human immunodeficiency virus 1]" . . . . . 100.00 1015 97.78 99.26 5.57e-80 . . . . 4097 1 111 no GB AAA44198 . "pol polyprotein, partial [Human immunodeficiency virus 1]" . . . . . 100.00 1015 99.26 99.26 1.13e-80 . . . . 4097 1 112 no GB AAB24839 . "reverse transcriptase, RT [human immunodeficiency virus type 1 HIV-1, zidovudine (AZT)-sensitive, Peptide, 559 aa]" . . . . . 99.26 559 97.01 99.25 2.04e-81 . . . . 4097 1 113 no GB AAL28068 . "pol protein [synthetic construct]" . . . . . 100.00 739 98.52 99.26 1.67e-81 . . . . 4097 1 114 no GB AAL29457 . "pol protein [synthetic construct]" . . . . . 100.00 739 98.52 99.26 1.67e-81 . . . . 4097 1 115 no GB ADW78894 . "truncated pol protein [synthetic construct]" . . . . . 100.00 857 99.26 99.26 2.38e-81 . . . . 4097 1 116 no PRF 1102247C . "protein pol" . . . . . 100.00 1015 99.26 99.26 1.13e-80 . . . . 4097 1 117 no PRF 1103299E . "pol gene" . . . . . 100.00 1012 97.78 99.26 7.45e-80 . . . . 4097 1 118 no SP P03366 . "RecName: Full=Gag-Pol polyprotein; AltName: Full=Pr160Gag-Pol; Contains: RecName: Full=Matrix protein p17; Short=MA; Contains: " . . . . . 99.26 1447 100.00 100.00 4.80e-80 . . . . 4097 1 119 no SP P0C6F2 . "RecName: Full=Gag-Pol polyprotein; AltName: Full=Pr160Gag-Pol; Contains: RecName: Full=Matrix protein p17; Short=MA; Contains: " . . . . . 99.26 1435 100.00 100.00 4.81e-80 . . . . 4097 1 stop_ loop_ _Entity_common_name.Name _Entity_common_name.Type _Entity_common_name.Entry_ID _Entity_common_name.Entity_ID 'Reverse Transcriptase of HIV-1' common 4097 1 'RNase H domain of HIV-1 Reverse Transcriptase RVT' variant 4097 1 RNase_H-HIV-1_(RVT) abbreviation 4097 1 stop_ loop_ _Entity_comp_index.ID _Entity_comp_index.Auth_seq_ID _Entity_comp_index.Comp_ID _Entity_comp_index.Comp_label _Entity_comp_index.Entry_ID _Entity_comp_index.Entity_ID 1 . MET . 4097 1 2 . TYR . 4097 1 3 . GLN . 4097 1 4 . LEU . 4097 1 5 . GLU . 4097 1 6 . LYS . 4097 1 7 . GLU . 4097 1 8 . PRO . 4097 1 9 . ILE . 4097 1 10 . VAL . 4097 1 11 . GLY . 4097 1 12 . ALA . 4097 1 13 . GLU . 4097 1 14 . THR . 4097 1 15 . PHE . 4097 1 16 . TYR . 4097 1 17 . VAL . 4097 1 18 . ASP . 4097 1 19 . GLY . 4097 1 20 . ALA . 4097 1 21 . ALA . 4097 1 22 . ASN . 4097 1 23 . ARG . 4097 1 24 . GLU . 4097 1 25 . THR . 4097 1 26 . LYS . 4097 1 27 . LEU . 4097 1 28 . GLY . 4097 1 29 . LYS . 4097 1 30 . ALA . 4097 1 31 . GLY . 4097 1 32 . TYR . 4097 1 33 . VAL . 4097 1 34 . THR . 4097 1 35 . ASN . 4097 1 36 . LYS . 4097 1 37 . GLY . 4097 1 38 . ARG . 4097 1 39 . GLN . 4097 1 40 . LYS . 4097 1 41 . VAL . 4097 1 42 . VAL . 4097 1 43 . PRO . 4097 1 44 . LEU . 4097 1 45 . THR . 4097 1 46 . ASN . 4097 1 47 . THR . 4097 1 48 . THR . 4097 1 49 . ASN . 4097 1 50 . GLN . 4097 1 51 . LYS . 4097 1 52 . THR . 4097 1 53 . GLU . 4097 1 54 . LEU . 4097 1 55 . GLN . 4097 1 56 . ALA . 4097 1 57 . ILE . 4097 1 58 . TYR . 4097 1 59 . LEU . 4097 1 60 . ALA . 4097 1 61 . LEU . 4097 1 62 . GLN . 4097 1 63 . ASP . 4097 1 64 . SER . 4097 1 65 . GLY . 4097 1 66 . LEU . 4097 1 67 . GLU . 4097 1 68 . VAL . 4097 1 69 . ASN . 4097 1 70 . ILE . 4097 1 71 . VAL . 4097 1 72 . THR . 4097 1 73 . ASP . 4097 1 74 . SER . 4097 1 75 . GLN . 4097 1 76 . TYR . 4097 1 77 . ALA . 4097 1 78 . LEU . 4097 1 79 . GLY . 4097 1 80 . ILE . 4097 1 81 . ILE . 4097 1 82 . GLN . 4097 1 83 . ALA . 4097 1 84 . GLN . 4097 1 85 . PRO . 4097 1 86 . ASP . 4097 1 87 . LYS . 4097 1 88 . SER . 4097 1 89 . GLU . 4097 1 90 . SER . 4097 1 91 . GLU . 4097 1 92 . LEU . 4097 1 93 . VAL . 4097 1 94 . ASN . 4097 1 95 . GLN . 4097 1 96 . ILE . 4097 1 97 . ILE . 4097 1 98 . GLU . 4097 1 99 . GLN . 4097 1 100 . LEU . 4097 1 101 . ILE . 4097 1 102 . LYS . 4097 1 103 . LYS . 4097 1 104 . GLU . 4097 1 105 . LYS . 4097 1 106 . VAL . 4097 1 107 . TYR . 4097 1 108 . LEU . 4097 1 109 . ALA . 4097 1 110 . TRP . 4097 1 111 . VAL . 4097 1 112 . PRO . 4097 1 113 . ALA . 4097 1 114 . HIS . 4097 1 115 . LYS . 4097 1 116 . GLY . 4097 1 117 . ILE . 4097 1 118 . GLY . 4097 1 119 . GLY . 4097 1 120 . ASN . 4097 1 121 . GLU . 4097 1 122 . GLN . 4097 1 123 . VAL . 4097 1 124 . ASP . 4097 1 125 . LYS . 4097 1 126 . LEU . 4097 1 127 . VAL . 4097 1 128 . SER . 4097 1 129 . ALA . 4097 1 130 . GLY . 4097 1 131 . ILE . 4097 1 132 . ARG . 4097 1 133 . LYS . 4097 1 134 . ILE . 4097 1 135 . LEU . 4097 1 stop_ loop_ _Entity_poly_seq.Hetero _Entity_poly_seq.Mon_ID _Entity_poly_seq.Num _Entity_poly_seq.Comp_index_ID _Entity_poly_seq.Entry_ID _Entity_poly_seq.Entity_ID . MET 1 1 4097 1 . TYR 2 2 4097 1 . GLN 3 3 4097 1 . LEU 4 4 4097 1 . GLU 5 5 4097 1 . LYS 6 6 4097 1 . GLU 7 7 4097 1 . PRO 8 8 4097 1 . ILE 9 9 4097 1 . VAL 10 10 4097 1 . GLY 11 11 4097 1 . ALA 12 12 4097 1 . GLU 13 13 4097 1 . THR 14 14 4097 1 . PHE 15 15 4097 1 . TYR 16 16 4097 1 . VAL 17 17 4097 1 . ASP 18 18 4097 1 . GLY 19 19 4097 1 . ALA 20 20 4097 1 . ALA 21 21 4097 1 . ASN 22 22 4097 1 . ARG 23 23 4097 1 . GLU 24 24 4097 1 . THR 25 25 4097 1 . LYS 26 26 4097 1 . LEU 27 27 4097 1 . GLY 28 28 4097 1 . LYS 29 29 4097 1 . ALA 30 30 4097 1 . GLY 31 31 4097 1 . TYR 32 32 4097 1 . VAL 33 33 4097 1 . THR 34 34 4097 1 . ASN 35 35 4097 1 . LYS 36 36 4097 1 . GLY 37 37 4097 1 . ARG 38 38 4097 1 . GLN 39 39 4097 1 . LYS 40 40 4097 1 . VAL 41 41 4097 1 . VAL 42 42 4097 1 . PRO 43 43 4097 1 . LEU 44 44 4097 1 . THR 45 45 4097 1 . ASN 46 46 4097 1 . THR 47 47 4097 1 . THR 48 48 4097 1 . ASN 49 49 4097 1 . GLN 50 50 4097 1 . LYS 51 51 4097 1 . THR 52 52 4097 1 . GLU 53 53 4097 1 . LEU 54 54 4097 1 . GLN 55 55 4097 1 . ALA 56 56 4097 1 . ILE 57 57 4097 1 . TYR 58 58 4097 1 . LEU 59 59 4097 1 . ALA 60 60 4097 1 . LEU 61 61 4097 1 . GLN 62 62 4097 1 . ASP 63 63 4097 1 . SER 64 64 4097 1 . GLY 65 65 4097 1 . LEU 66 66 4097 1 . GLU 67 67 4097 1 . VAL 68 68 4097 1 . ASN 69 69 4097 1 . ILE 70 70 4097 1 . VAL 71 71 4097 1 . THR 72 72 4097 1 . ASP 73 73 4097 1 . SER 74 74 4097 1 . GLN 75 75 4097 1 . TYR 76 76 4097 1 . ALA 77 77 4097 1 . LEU 78 78 4097 1 . GLY 79 79 4097 1 . ILE 80 80 4097 1 . ILE 81 81 4097 1 . GLN 82 82 4097 1 . ALA 83 83 4097 1 . GLN 84 84 4097 1 . PRO 85 85 4097 1 . ASP 86 86 4097 1 . LYS 87 87 4097 1 . SER 88 88 4097 1 . GLU 89 89 4097 1 . SER 90 90 4097 1 . GLU 91 91 4097 1 . LEU 92 92 4097 1 . VAL 93 93 4097 1 . ASN 94 94 4097 1 . GLN 95 95 4097 1 . ILE 96 96 4097 1 . ILE 97 97 4097 1 . GLU 98 98 4097 1 . GLN 99 99 4097 1 . LEU 100 100 4097 1 . ILE 101 101 4097 1 . LYS 102 102 4097 1 . LYS 103 103 4097 1 . GLU 104 104 4097 1 . LYS 105 105 4097 1 . VAL 106 106 4097 1 . TYR 107 107 4097 1 . LEU 108 108 4097 1 . ALA 109 109 4097 1 . TRP 110 110 4097 1 . VAL 111 111 4097 1 . PRO 112 112 4097 1 . ALA 113 113 4097 1 . HIS 114 114 4097 1 . LYS 115 115 4097 1 . GLY 116 116 4097 1 . ILE 117 117 4097 1 . GLY 118 118 4097 1 . GLY 119 119 4097 1 . ASN 120 120 4097 1 . GLU 121 121 4097 1 . GLN 122 122 4097 1 . VAL 123 123 4097 1 . ASP 124 124 4097 1 . LYS 125 125 4097 1 . LEU 126 126 4097 1 . VAL 127 127 4097 1 . SER 128 128 4097 1 . ALA 129 129 4097 1 . GLY 130 130 4097 1 . ILE 131 131 4097 1 . ARG 132 132 4097 1 . LYS 133 133 4097 1 . ILE 134 134 4097 1 . LEU 135 135 4097 1 stop_ save_ #################### # Natural source # #################### save_natural_source _Entity_natural_src_list.Sf_category natural_source _Entity_natural_src_list.Sf_framecode natural_source _Entity_natural_src_list.Entry_ID 4097 _Entity_natural_src_list.ID 1 loop_ _Entity_natural_src.ID _Entity_natural_src.Entity_ID _Entity_natural_src.Entity_label _Entity_natural_src.Entity_chimera_segment_ID _Entity_natural_src.NCBI_taxonomy_ID _Entity_natural_src.Type _Entity_natural_src.Common _Entity_natural_src.Organism_name_scientific _Entity_natural_src.Organism_name_common _Entity_natural_src.Organism_acronym _Entity_natural_src.ICTVdb_decimal_code _Entity_natural_src.Superkingdom _Entity_natural_src.Kingdom _Entity_natural_src.Genus _Entity_natural_src.Species _Entity_natural_src.Strain _Entity_natural_src.Variant _Entity_natural_src.Subvariant _Entity_natural_src.Organ _Entity_natural_src.Tissue _Entity_natural_src.Tissue_fraction _Entity_natural_src.Cell_line _Entity_natural_src.Cell_type _Entity_natural_src.ATCC_number _Entity_natural_src.Organelle _Entity_natural_src.Cellular_location _Entity_natural_src.Fragment _Entity_natural_src.Fraction _Entity_natural_src.Secretion _Entity_natural_src.Plasmid _Entity_natural_src.Plasmid_details _Entity_natural_src.Gene_mnemonic _Entity_natural_src.Dev_stage _Entity_natural_src.Details _Entity_natural_src.Citation_ID _Entity_natural_src.Citation_label _Entity_natural_src.Entry_ID _Entity_natural_src.Entity_natural_src_list_ID 1 1 $RNase_H-HIV-1_(RVT) . 11678 . . 'Lentivirus HIV-1' HIV-1 HIV-1 61.0.6.5.001 . . Lentivirus HIV-1 BH10 pCC101 . . . . . . . . . . . . . . . . ; Family: Retroviridae, Genus: lentivirus, Type of species: HIV-1, Reference Strain: ICTVdb decimal code is 61.0.6.5.001 ; . . 4097 1 stop_ save_ ######################### # Experimental source # ######################### save_experimental_source _Entity_experimental_src_list.Sf_category experimental_source _Entity_experimental_src_list.Sf_framecode experimental_source _Entity_experimental_src_list.Entry_ID 4097 _Entity_experimental_src_list.ID 1 loop_ _Entity_experimental_src.ID _Entity_experimental_src.Entity_ID _Entity_experimental_src.Entity_label _Entity_experimental_src.Entity_chimera_segment_ID _Entity_experimental_src.Production_method _Entity_experimental_src.Host_org_scientific_name _Entity_experimental_src.Host_org_name_common _Entity_experimental_src.Host_org_details _Entity_experimental_src.Host_org_NCBI_taxonomy_ID _Entity_experimental_src.Host_org_genus _Entity_experimental_src.Host_org_species _Entity_experimental_src.Host_org_strain _Entity_experimental_src.Host_org_variant _Entity_experimental_src.Host_org_subvariant _Entity_experimental_src.Host_org_organ _Entity_experimental_src.Host_org_tissue _Entity_experimental_src.Host_org_tissue_fraction _Entity_experimental_src.Host_org_cell_line _Entity_experimental_src.Host_org_cell_type _Entity_experimental_src.Host_org_cellular_location _Entity_experimental_src.Host_org_organelle _Entity_experimental_src.Host_org_gene _Entity_experimental_src.Host_org_culture_collection _Entity_experimental_src.Host_org_ATCC_number _Entity_experimental_src.Vector_type _Entity_experimental_src.PDBview_host_org_vector_name _Entity_experimental_src.PDBview_plasmid_name _Entity_experimental_src.Vector_name _Entity_experimental_src.Vector_details _Entity_experimental_src.Vendor_name _Entity_experimental_src.Host_org_dev_stage _Entity_experimental_src.Details _Entity_experimental_src.Citation_ID _Entity_experimental_src.Citation_label _Entity_experimental_src.Entry_ID _Entity_experimental_src.Entity_experimental_src_list_ID 1 1 $RNase_H-HIV-1_(RVT) . 'chemical construct' . . . . . . HB10 . . . . . . . . . . . . plasmid . . pAED4 . . . ; native (The gene was synthesized and cloned into a pAED4 vector under the control of a T7 promotor) ; . . 4097 1 stop_ save_ ##################################### # Sample contents and methodology # ##################################### ######################## # Sample description # ######################## save_sample_one _Sample.Sf_category sample _Sample.Sf_framecode sample_one _Sample.Entry_ID 4097 _Sample.ID 1 _Sample.Type solution _Sample.Sub_type . _Sample.Details . _Sample.Aggregate_sample_number . _Sample.Solvent_system . _Sample.Preparation_date . _Sample.Preparation_expiration_date . _Sample.Polycrystallization_protocol . _Sample.Single_crystal_protocol . _Sample.Crystal_grow_apparatus . _Sample.Crystal_grow_atmosphere . _Sample.Crystal_grow_details . _Sample.Crystal_grow_method . _Sample.Crystal_grow_method_cit_ID . _Sample.Crystal_grow_pH . _Sample.Crystal_grow_pH_range . _Sample.Crystal_grow_pressure . _Sample.Crystal_grow_pressure_esd . _Sample.Crystal_grow_seeding . _Sample.Crystal_grow_seeding_cit_ID . _Sample.Crystal_grow_temp . _Sample.Crystal_grow_temp_details . _Sample.Crystal_grow_temp_esd . _Sample.Crystal_grow_time . _Sample.Oriented_sample_prep_protocol . _Sample.Lyophilization_cryo_protectant . _Sample.Storage_protocol . loop_ _Sample_component.ID _Sample_component.Mol_common_name _Sample_component.Isotopic_labeling _Sample_component.Assembly_ID _Sample_component.Assembly_label _Sample_component.Entity_ID _Sample_component.Entity_label _Sample_component.Product_ID _Sample_component.Type _Sample_component.Concentration_val _Sample_component.Concentration_val_min _Sample_component.Concentration_val_max _Sample_component.Concentration_val_units _Sample_component.Concentration_val_err _Sample_component.Vendor _Sample_component.Vendor_product_name _Sample_component.Vendor_product_code _Sample_component.Entry_ID _Sample_component.Sample_ID 1 'Reverse Transcriptase of HIV-1' '[U-99.8% 13C; U-99.9% 15N]' . . 1 $RNase_H-HIV-1_(RVT) . . 1.1 1.05 1.15 mM . . . . 4097 1 stop_ save_ ####################### # Sample conditions # ####################### save_sample_conditions_one _Sample_condition_list.Sf_category sample_conditions _Sample_condition_list.Sf_framecode sample_conditions_one _Sample_condition_list.Entry_ID 4097 _Sample_condition_list.ID 1 _Sample_condition_list.Details . loop_ _Sample_condition_variable.Type _Sample_condition_variable.Val _Sample_condition_variable.Val_err _Sample_condition_variable.Val_units _Sample_condition_variable.Entry_ID _Sample_condition_variable.Sample_condition_list_ID 'ionic strength' 0.1 .02 n/a 4097 1 pH 4.5 0.1 n/a 4097 1 temperature 298 .5 K 4097 1 stop_ save_ ######################### # Experimental detail # ######################### ################################## # NMR Spectrometer definitions # ################################## save_spectrometer_one _NMR_spectrometer.Sf_category NMR_spectrometer _NMR_spectrometer.Sf_framecode spectrometer_one _NMR_spectrometer.Entry_ID 4097 _NMR_spectrometer.ID 1 _NMR_spectrometer.Details . _NMR_spectrometer.Manufacturer Bruker _NMR_spectrometer.Model DMX600 _NMR_spectrometer.Serial_number . _NMR_spectrometer.Field_strength 600 save_ save_spectrometer_list _NMR_spectrometer_list.Sf_category NMR_spectrometer_list _NMR_spectrometer_list.Sf_framecode spectrometer_list _NMR_spectrometer_list.Entry_ID 4097 _NMR_spectrometer_list.ID 1 loop_ _NMR_spectrometer_view.ID _NMR_spectrometer_view.Name _NMR_spectrometer_view.Manufacturer _NMR_spectrometer_view.Model _NMR_spectrometer_view.Serial_number _NMR_spectrometer_view.Field_strength _NMR_spectrometer_view.Details _NMR_spectrometer_view.Citation_ID _NMR_spectrometer_view.Citation_label _NMR_spectrometer_view.Entry_ID _NMR_spectrometer_view.NMR_spectrometer_list_ID 1 spectrometer_one Bruker DMX600 . 600 . . . 4097 1 stop_ save_ ############################# # NMR applied experiments # ############################# save_experiment_list _Experiment_list.Sf_category experiment_list _Experiment_list.Sf_framecode experiment_list _Experiment_list.Entry_ID 4097 _Experiment_list.ID 1 _Experiment_list.Details . loop_ _Experiment.ID _Experiment.Name _Experiment.Raw_data_flag _Experiment.NMR_spec_expt_ID _Experiment.NMR_spec_expt_label _Experiment.MS_expt_ID _Experiment.MS_expt_label _Experiment.SAXS_expt_ID _Experiment.SAXS_expt_label _Experiment.FRET_expt_ID _Experiment.FRET_expt_label _Experiment.EMR_expt_ID _Experiment.EMR_expt_label _Experiment.Sample_ID _Experiment.Sample_label _Experiment.Sample_state _Experiment.Sample_volume _Experiment.Sample_volume_units _Experiment.Sample_condition_list_ID _Experiment.Sample_condition_list_label _Experiment.Sample_spinning_rate _Experiment.Sample_angle _Experiment.NMR_tube_type _Experiment.NMR_spectrometer_ID _Experiment.NMR_spectrometer_label _Experiment.NMR_spectrometer_probe_ID _Experiment.NMR_spectrometer_probe_label _Experiment.NMR_spectral_processing_ID _Experiment.NMR_spectral_processing_label _Experiment.Mass_spectrometer_ID _Experiment.Mass_spectrometer_label _Experiment.Xray_instrument_ID _Experiment.Xray_instrument_label _Experiment.Fluorescence_instrument_ID _Experiment.Fluorescence_instrument_label _Experiment.EMR_instrument_ID _Experiment.EMR_instrument_label _Experiment.Chromatographic_system_ID _Experiment.Chromatographic_system_label _Experiment.Chromatographic_column_ID _Experiment.Chromatographic_column_label _Experiment.Entry_ID _Experiment.Experiment_list_ID 1 '1H-15N HSQC' . . . . . . . . . . . 1 $sample_one . . . . . . . . . . . . . . . . . . . . . . . . . . 4097 1 2 HNCA . . . . . . . . . . . 1 $sample_one . . . . . . . . . . . . . . . . . . . . . . . . . . 4097 1 3 CBCA(CO)NH . . . . . . . . . . . 1 $sample_one . . . . . . . . . . . . . . . . . . . . . . . . . . 4097 1 stop_ save_ save_NMR_spec_expt__0_1 _NMR_spec_expt.Sf_category NMR_spectrometer_expt _NMR_spec_expt.Sf_framecode NMR_spec_expt__0_1 _NMR_spec_expt.Entry_ID 4097 _NMR_spec_expt.ID 1 _NMR_spec_expt.Name '1H-15N HSQC' _NMR_spec_expt.Type . _NMR_spec_expt.Sample_volume . _NMR_spec_expt.Sample_volume_units . _NMR_spec_expt.NMR_tube_type . _NMR_spec_expt.Sample_spinning_rate . _NMR_spec_expt.Sample_angle . _NMR_spec_expt.NMR_spectrometer_ID . _NMR_spec_expt.NMR_spectrometer_label . _NMR_spec_expt.NMR_spectrometer_probe_ID . _NMR_spec_expt.NMR_spectrometer_probe_label . _NMR_spec_expt.Carrier_freq_switch_time . _NMR_spec_expt.Software_ID . _NMR_spec_expt.Software_label . _NMR_spec_expt.Method_ID . _NMR_spec_expt.Method_label . _NMR_spec_expt.Pulse_seq_accession_BMRB_code . _NMR_spec_expt.Details . save_ save_NMR_spec_expt__0_2 _NMR_spec_expt.Sf_category NMR_spectrometer_expt _NMR_spec_expt.Sf_framecode NMR_spec_expt__0_2 _NMR_spec_expt.Entry_ID 4097 _NMR_spec_expt.ID 2 _NMR_spec_expt.Name HNCA _NMR_spec_expt.Type . _NMR_spec_expt.Sample_volume . _NMR_spec_expt.Sample_volume_units . _NMR_spec_expt.NMR_tube_type . _NMR_spec_expt.Sample_spinning_rate . _NMR_spec_expt.Sample_angle . _NMR_spec_expt.NMR_spectrometer_ID . _NMR_spec_expt.NMR_spectrometer_label . _NMR_spec_expt.NMR_spectrometer_probe_ID . _NMR_spec_expt.NMR_spectrometer_probe_label . _NMR_spec_expt.Carrier_freq_switch_time . _NMR_spec_expt.Software_ID . _NMR_spec_expt.Software_label . _NMR_spec_expt.Method_ID . _NMR_spec_expt.Method_label . _NMR_spec_expt.Pulse_seq_accession_BMRB_code . _NMR_spec_expt.Details . save_ save_NMR_spec_expt__0_3 _NMR_spec_expt.Sf_category NMR_spectrometer_expt _NMR_spec_expt.Sf_framecode NMR_spec_expt__0_3 _NMR_spec_expt.Entry_ID 4097 _NMR_spec_expt.ID 3 _NMR_spec_expt.Name CBCA(CO)NH _NMR_spec_expt.Type . _NMR_spec_expt.Sample_volume . _NMR_spec_expt.Sample_volume_units . _NMR_spec_expt.NMR_tube_type . _NMR_spec_expt.Sample_spinning_rate . _NMR_spec_expt.Sample_angle . _NMR_spec_expt.NMR_spectrometer_ID . _NMR_spec_expt.NMR_spectrometer_label . _NMR_spec_expt.NMR_spectrometer_probe_ID . _NMR_spec_expt.NMR_spectrometer_probe_label . _NMR_spec_expt.Carrier_freq_switch_time . _NMR_spec_expt.Software_ID . _NMR_spec_expt.Software_label . _NMR_spec_expt.Method_ID . _NMR_spec_expt.Method_label . _NMR_spec_expt.Pulse_seq_accession_BMRB_code . _NMR_spec_expt.Details . save_ #################### # NMR parameters # #################### ############################## # Assigned chemical shifts # ############################## ################################ # Chemical shift referencing # ################################ save_chemical_shift_reference_one _Chem_shift_reference.Sf_category chem_shift_reference _Chem_shift_reference.Sf_framecode chemical_shift_reference_one _Chem_shift_reference.Entry_ID 4097 _Chem_shift_reference.ID 1 _Chem_shift_reference.Details . loop_ _Chem_shift_ref.Atom_type _Chem_shift_ref.Atom_isotope_number _Chem_shift_ref.Mol_common_name _Chem_shift_ref.Atom_group _Chem_shift_ref.Concentration_val _Chem_shift_ref.Concentration_units _Chem_shift_ref.Solvent _Chem_shift_ref.Rank _Chem_shift_ref.Chem_shift_units _Chem_shift_ref.Chem_shift_val _Chem_shift_ref.Ref_method _Chem_shift_ref.Ref_type _Chem_shift_ref.Indirect_shift_ratio _Chem_shift_ref.External_ref_loc _Chem_shift_ref.External_ref_sample_geometry _Chem_shift_ref.External_ref_axis _Chem_shift_ref.Indirect_shift_ratio_cit_ID _Chem_shift_ref.Indirect_shift_ratio_cit_label _Chem_shift_ref.Ref_correction_type _Chem_shift_ref.Correction_val _Chem_shift_ref.Correction_val_cit_ID _Chem_shift_ref.Correction_val_cit_label _Chem_shift_ref.Entry_ID _Chem_shift_ref.Chem_shift_reference_ID C 13 DSS 'methyl protons' . . . . ppm 0.00 . indirect 0.251449530 . . . 2 $citation_one . . . . 4097 1 H 1 DSS 'methyl protons' . . . . ppm 0.00 . direct 1.0 . . . 2 $citation_one . . . . 4097 1 N 15 DSS 'methyl protons' . . . . ppm 0.00 . indirect 0.101329118 . . . 2 $citation_one . . . . 4097 1 stop_ save_ ################################### # Assigned chemical shift lists # ################################### ################################################################### # Chemical Shift Ambiguity Index Value Definitions # # # # The values other than 1 are used for those atoms with different # # chemical shifts that cannot be assigned to stereospecific atoms # # or to specific residues or chains. # # # # Index Value Definition # # # # 1 Unique (including isolated methyl protons, # # geminal atoms, and geminal methyl # # groups with identical chemical shifts) # # (e.g. ILE HD11, HD12, HD13 protons) # # 2 Ambiguity of geminal atoms or geminal methyl # # proton groups (e.g. ASP HB2 and HB3 # # protons, LEU CD1 and CD2 carbons, or # # LEU HD11, HD12, HD13 and HD21, HD22, # # HD23 methyl protons) # # 3 Aromatic atoms on opposite sides of # # symmetrical rings (e.g. TYR HE1 and HE2 # # protons) # # 4 Intraresidue ambiguities (e.g. LYS HG and # # HD protons or TRP HZ2 and HZ3 protons) # # 5 Interresidue ambiguities (LYS 12 vs. LYS 27) # # 6 Intermolecular ambiguities (e.g. ASP 31 CA # # in monomer 1 and ASP 31 CA in monomer 2 # # of an asymmetrical homodimer, duplex # # DNA assignments, or other assignments # # that may apply to atoms in one or more # # molecule in the molecular assembly) # # 9 Ambiguous, specific ambiguity not defined # # # ################################################################### save_assigned_chemical_shifts _Assigned_chem_shift_list.Sf_category assigned_chemical_shifts _Assigned_chem_shift_list.Sf_framecode assigned_chemical_shifts _Assigned_chem_shift_list.Entry_ID 4097 _Assigned_chem_shift_list.ID 1 _Assigned_chem_shift_list.Sample_condition_list_ID 1 _Assigned_chem_shift_list.Sample_condition_list_label $sample_conditions_one _Assigned_chem_shift_list.Chem_shift_reference_ID 1 _Assigned_chem_shift_list.Chem_shift_reference_label $chemical_shift_reference_one _Assigned_chem_shift_list.Chem_shift_1H_err . _Assigned_chem_shift_list.Chem_shift_13C_err . _Assigned_chem_shift_list.Chem_shift_15N_err . _Assigned_chem_shift_list.Chem_shift_31P_err . _Assigned_chem_shift_list.Chem_shift_2H_err . _Assigned_chem_shift_list.Chem_shift_19F_err . _Assigned_chem_shift_list.Error_derivation_method . _Assigned_chem_shift_list.Details . _Assigned_chem_shift_list.Text_data_format . _Assigned_chem_shift_list.Text_data . loop_ _Chem_shift_experiment.Experiment_ID _Chem_shift_experiment.Experiment_name _Chem_shift_experiment.Sample_ID _Chem_shift_experiment.Sample_label _Chem_shift_experiment.Sample_state _Chem_shift_experiment.Entry_ID _Chem_shift_experiment.Assigned_chem_shift_list_ID . . 1 $sample_one . 4097 1 stop_ loop_ _Atom_chem_shift.ID _Atom_chem_shift.Assembly_atom_ID _Atom_chem_shift.Entity_assembly_ID _Atom_chem_shift.Entity_ID _Atom_chem_shift.Comp_index_ID _Atom_chem_shift.Seq_ID _Atom_chem_shift.Comp_ID _Atom_chem_shift.Atom_ID _Atom_chem_shift.Atom_type _Atom_chem_shift.Atom_isotope_number _Atom_chem_shift.Val _Atom_chem_shift.Val_err _Atom_chem_shift.Assign_fig_of_merit _Atom_chem_shift.Ambiguity_code _Atom_chem_shift.Occupancy _Atom_chem_shift.Resonance_ID _Atom_chem_shift.Auth_entity_assembly_ID _Atom_chem_shift.Auth_asym_ID _Atom_chem_shift.Auth_seq_ID _Atom_chem_shift.Auth_comp_ID _Atom_chem_shift.Auth_atom_ID _Atom_chem_shift.Details _Atom_chem_shift.Entry_ID _Atom_chem_shift.Assigned_chem_shift_list_ID 1 . 1 1 2 2 TYR CA C 13 57.3 0.06 . 1 . . . . . . . . 4097 1 2 . 1 1 2 2 TYR CB C 13 39.4 0.06 . 1 . . . . . . . . 4097 1 3 . 1 1 3 3 GLN N N 15 121.1 0.06 . 1 . . . . . . . . 4097 1 4 . 1 1 3 3 GLN H H 1 8.21 0.02 . 1 . . . . . . . . 4097 1 5 . 1 1 3 3 GLN CA C 13 54.3 0.06 . 1 . . . . . . . . 4097 1 6 . 1 1 3 3 GLN CB C 13 30.9 0.06 . 1 . . . . . . . . 4097 1 7 . 1 1 4 4 LEU N N 15 125.8 0.06 . 1 . . . . . . . . 4097 1 8 . 1 1 4 4 LEU H H 1 8.54 0.02 . 1 . . . . . . . . 4097 1 9 . 1 1 4 4 LEU CA C 13 54.1 0.06 . 1 . . . . . . . . 4097 1 10 . 1 1 4 4 LEU CB C 13 42.1 0.06 . 1 . . . . . . . . 4097 1 11 . 1 1 5 5 GLU N N 15 122.6 0.06 . 1 . . . . . . . . 4097 1 12 . 1 1 5 5 GLU H H 1 9.09 0.02 . 1 . . . . . . . . 4097 1 13 . 1 1 5 5 GLU CA C 13 54.9 0.06 . 1 . . . . . . . . 4097 1 14 . 1 1 5 5 GLU CB C 13 30.6 0.06 . 1 . . . . . . . . 4097 1 15 . 1 1 6 6 LYS N N 15 119.5 0.06 . 1 . . . . . . . . 4097 1 16 . 1 1 6 6 LYS H H 1 8.89 0.02 . 1 . . . . . . . . 4097 1 17 . 1 1 6 6 LYS CA C 13 56.9 0.06 . 1 . . . . . . . . 4097 1 18 . 1 1 6 6 LYS CB C 13 33.3 0.06 . 1 . . . . . . . . 4097 1 19 . 1 1 7 7 GLU N N 15 117.2 0.06 . 1 . . . . . . . . 4097 1 20 . 1 1 7 7 GLU H H 1 7.56 0.02 . 1 . . . . . . . . 4097 1 21 . 1 1 7 7 GLU CA C 13 52.8 0.06 . 1 . . . . . . . . 4097 1 22 . 1 1 8 8 PRO CA C 13 62.1 0.06 . 1 . . . . . . . . 4097 1 23 . 1 1 8 8 PRO CB C 13 31.1 0.06 . 1 . . . . . . . . 4097 1 24 . 1 1 9 9 ILE N N 15 124.9 0.06 . 1 . . . . . . . . 4097 1 25 . 1 1 9 9 ILE H H 1 9.37 0.02 . 1 . . . . . . . . 4097 1 26 . 1 1 9 9 ILE CA C 13 60.9 0.06 . 1 . . . . . . . . 4097 1 27 . 1 1 9 9 ILE CB C 13 38.5 0.06 . 1 . . . . . . . . 4097 1 28 . 1 1 10 10 VAL N N 15 132.3 0.06 . 1 . . . . . . . . 4097 1 29 . 1 1 10 10 VAL H H 1 8.7 0.02 . 1 . . . . . . . . 4097 1 30 . 1 1 10 10 VAL CA C 13 64.9 0.06 . 1 . . . . . . . . 4097 1 31 . 1 1 10 10 VAL CB C 13 31.1 0.06 . 1 . . . . . . . . 4097 1 32 . 1 1 11 11 GLY N N 15 115.1 0.06 . 1 . . . . . . . . 4097 1 33 . 1 1 11 11 GLY H H 1 8.86 0.02 . 1 . . . . . . . . 4097 1 34 . 1 1 11 11 GLY CA C 13 45.1 0.06 . 1 . . . . . . . . 4097 1 35 . 1 1 12 12 ALA N N 15 122.1 0.06 . 1 . . . . . . . . 4097 1 36 . 1 1 12 12 ALA H H 1 7.07 0.02 . 1 . . . . . . . . 4097 1 37 . 1 1 12 12 ALA CA C 13 50.6 0.06 . 1 . . . . . . . . 4097 1 38 . 1 1 12 12 ALA CB C 13 19.1 0.06 . 1 . . . . . . . . 4097 1 39 . 1 1 13 13 GLU N N 15 125.6 0.06 . 1 . . . . . . . . 4097 1 40 . 1 1 13 13 GLU H H 1 8.92 0.02 . 1 . . . . . . . . 4097 1 41 . 1 1 13 13 GLU CA C 13 57.3 0.06 . 1 . . . . . . . . 4097 1 42 . 1 1 13 13 GLU CB C 13 31 0.06 . 1 . . . . . . . . 4097 1 43 . 1 1 14 14 THR N N 15 121.9 0.06 . 1 . . . . . . . . 4097 1 44 . 1 1 14 14 THR H H 1 8.59 0.02 . 1 . . . . . . . . 4097 1 45 . 1 1 14 14 THR CA C 13 61.4 0.06 . 1 . . . . . . . . 4097 1 46 . 1 1 14 14 THR CB C 13 70.1 0.06 . 1 . . . . . . . . 4097 1 47 . 1 1 15 15 PHE N N 15 127.2 0.06 . 1 . . . . . . . . 4097 1 48 . 1 1 15 15 PHE H H 1 9.4 0.02 . 1 . . . . . . . . 4097 1 49 . 1 1 15 15 PHE CA C 13 56 0.06 . 1 . . . . . . . . 4097 1 50 . 1 1 15 15 PHE CB C 13 41 0.06 . 1 . . . . . . . . 4097 1 51 . 1 1 16 16 TYR N N 15 125 0.06 . 1 . . . . . . . . 4097 1 52 . 1 1 16 16 TYR H H 1 9.25 0.02 . 1 . . . . . . . . 4097 1 53 . 1 1 16 16 TYR CA C 13 57.1 0.06 . 1 . . . . . . . . 4097 1 54 . 1 1 17 17 VAL N N 15 114.9 0.06 . 1 . . . . . . . . 4097 1 55 . 1 1 17 17 VAL H H 1 8.42 0.02 . 1 . . . . . . . . 4097 1 56 . 1 1 17 17 VAL CA C 13 58.6 0.06 . 1 . . . . . . . . 4097 1 57 . 1 1 17 17 VAL CB C 13 33.6 0.06 . 1 . . . . . . . . 4097 1 58 . 1 1 18 18 ASP N N 15 118.8 0.06 . 1 . . . . . . . . 4097 1 59 . 1 1 18 18 ASP H H 1 8.59 0.02 . 1 . . . . . . . . 4097 1 60 . 1 1 18 18 ASP CA C 13 52.9 0.06 . 1 . . . . . . . . 4097 1 61 . 1 1 18 18 ASP CB C 13 43.6 0.06 . 1 . . . . . . . . 4097 1 62 . 1 1 19 19 GLY N N 15 108.9 0.06 . 1 . . . . . . . . 4097 1 63 . 1 1 19 19 GLY H H 1 7.96 0.02 . 1 . . . . . . . . 4097 1 64 . 1 1 19 19 GLY CA C 13 45.9 0.06 . 1 . . . . . . . . 4097 1 65 . 1 1 20 20 ALA N N 15 122.8 0.06 . 1 . . . . . . . . 4097 1 66 . 1 1 20 20 ALA H H 1 8.51 0.02 . 1 . . . . . . . . 4097 1 67 . 1 1 20 20 ALA CA C 13 51.8 0.06 . 1 . . . . . . . . 4097 1 68 . 1 1 20 20 ALA CB C 13 22.8 0.06 . 1 . . . . . . . . 4097 1 69 . 1 1 21 21 ALA N N 15 119.9 0.06 . 1 . . . . . . . . 4097 1 70 . 1 1 21 21 ALA H H 1 8.31 0.02 . 1 . . . . . . . . 4097 1 71 . 1 1 21 21 ALA CA C 13 63.5 0.06 . 1 . . . . . . . . 4097 1 72 . 1 1 21 21 ALA CB C 13 22.6 0.06 . 1 . . . . . . . . 4097 1 73 . 1 1 22 22 ASN N N 15 121.2 0.06 . 1 . . . . . . . . 4097 1 74 . 1 1 22 22 ASN H H 1 8.67 0.02 . 1 . . . . . . . . 4097 1 75 . 1 1 22 22 ASN CA C 13 52.3 0.06 . 1 . . . . . . . . 4097 1 76 . 1 1 22 22 ASN CB C 13 40.6 0.06 . 1 . . . . . . . . 4097 1 77 . 1 1 23 23 ARG N N 15 127.9 0.06 . 1 . . . . . . . . 4097 1 78 . 1 1 23 23 ARG H H 1 9.16 0.02 . 1 . . . . . . . . 4097 1 79 . 1 1 23 23 ARG CA C 13 58.7 0.06 . 1 . . . . . . . . 4097 1 80 . 1 1 23 23 ARG CB C 13 30.3 0.06 . 1 . . . . . . . . 4097 1 81 . 1 1 24 24 GLU N N 15 117.5 0.06 . 1 . . . . . . . . 4097 1 82 . 1 1 24 24 GLU H H 1 8.43 0.02 . 1 . . . . . . . . 4097 1 83 . 1 1 24 24 GLU CA C 13 58.7 0.06 . 1 . . . . . . . . 4097 1 84 . 1 1 24 24 GLU CB C 13 29.7 0.06 . 1 . . . . . . . . 4097 1 85 . 1 1 25 25 THR N N 15 108.2 0.06 . 1 . . . . . . . . 4097 1 86 . 1 1 25 25 THR H H 1 8.21 0.02 . 1 . . . . . . . . 4097 1 87 . 1 1 25 25 THR CA C 13 61.9 0.06 . 1 . . . . . . . . 4097 1 88 . 1 1 25 25 THR CB C 13 70.3 0.06 . 1 . . . . . . . . 4097 1 89 . 1 1 26 26 LYS N N 15 115.5 0.06 . 1 . . . . . . . . 4097 1 90 . 1 1 26 26 LYS H H 1 8.12 0.02 . 1 . . . . . . . . 4097 1 91 . 1 1 26 26 LYS CA C 13 57.8 0.06 . 1 . . . . . . . . 4097 1 92 . 1 1 26 26 LYS CB C 13 29 0.06 . 1 . . . . . . . . 4097 1 93 . 1 1 27 27 LEU N N 15 117.6 0.06 . 1 . . . . . . . . 4097 1 94 . 1 1 27 27 LEU H H 1 7.5 0.02 . 1 . . . . . . . . 4097 1 95 . 1 1 27 27 LEU CA C 13 54.1 0.06 . 1 . . . . . . . . 4097 1 96 . 1 1 27 27 LEU CB C 13 45.9 0.06 . 1 . . . . . . . . 4097 1 97 . 1 1 28 28 GLY N N 15 108.7 0.06 . 1 . . . . . . . . 4097 1 98 . 1 1 28 28 GLY H H 1 7.92 0.02 . 1 . . . . . . . . 4097 1 99 . 1 1 28 28 GLY CA C 13 45.9 0.06 . 1 . . . . . . . . 4097 1 100 . 1 1 29 29 LYS N N 15 119.4 0.06 . 1 . . . . . . . . 4097 1 101 . 1 1 29 29 LYS H H 1 9.02 0.02 . 1 . . . . . . . . 4097 1 102 . 1 1 29 29 LYS CA C 13 55.7 0.06 . 1 . . . . . . . . 4097 1 103 . 1 1 30 30 ALA N N 15 121 0.06 . 1 . . . . . . . . 4097 1 104 . 1 1 30 30 ALA H H 1 8.4 0.02 . 1 . . . . . . . . 4097 1 105 . 1 1 30 30 ALA CA C 13 50.1 0.06 . 1 . . . . . . . . 4097 1 106 . 1 1 30 30 ALA CB C 13 21.4 0.06 . 1 . . . . . . . . 4097 1 107 . 1 1 31 31 GLY N N 15 106.2 0.06 . 1 . . . . . . . . 4097 1 108 . 1 1 31 31 GLY H H 1 8.66 0.02 . 1 . . . . . . . . 4097 1 109 . 1 1 31 31 GLY CA C 13 46.8 0.06 . 1 . . . . . . . . 4097 1 110 . 1 1 32 32 TYR N N 15 111.2 0.06 . 1 . . . . . . . . 4097 1 111 . 1 1 32 32 TYR H H 1 8.54 0.02 . 1 . . . . . . . . 4097 1 112 . 1 1 32 32 TYR CA C 13 55.4 0.06 . 1 . . . . . . . . 4097 1 113 . 1 1 32 32 TYR CB C 13 43.3 0.06 . 1 . . . . . . . . 4097 1 114 . 1 1 33 33 VAL N N 15 115.3 0.06 . 1 . . . . . . . . 4097 1 115 . 1 1 33 33 VAL H H 1 8.77 0.02 . 1 . . . . . . . . 4097 1 116 . 1 1 33 33 VAL CA C 13 61 0.06 . 1 . . . . . . . . 4097 1 117 . 1 1 33 33 VAL CB C 13 36.1 0.06 . 1 . . . . . . . . 4097 1 118 . 1 1 34 34 THR N N 15 114.8 0.06 . 1 . . . . . . . . 4097 1 119 . 1 1 34 34 THR H H 1 9.06 0.02 . 1 . . . . . . . . 4097 1 120 . 1 1 34 34 THR CA C 13 57.5 0.06 . 1 . . . . . . . . 4097 1 121 . 1 1 34 34 THR CB C 13 72.8 0.06 . 1 . . . . . . . . 4097 1 122 . 1 1 35 35 ASN N N 15 119 0.06 . 1 . . . . . . . . 4097 1 123 . 1 1 35 35 ASN H H 1 9.14 0.02 . 1 . . . . . . . . 4097 1 124 . 1 1 35 35 ASN CA C 13 54.3 0.06 . 1 . . . . . . . . 4097 1 125 . 1 1 35 35 ASN CB C 13 37.5 0.06 . 1 . . . . . . . . 4097 1 126 . 1 1 36 36 LYS N N 15 118.1 0.06 . 1 . . . . . . . . 4097 1 127 . 1 1 36 36 LYS H H 1 8.04 0.02 . 1 . . . . . . . . 4097 1 128 . 1 1 36 36 LYS CA C 13 55 0.06 . 1 . . . . . . . . 4097 1 129 . 1 1 36 36 LYS CB C 13 32 0.06 . 1 . . . . . . . . 4097 1 130 . 1 1 37 37 GLY N N 15 107.6 0.06 . 1 . . . . . . . . 4097 1 131 . 1 1 37 37 GLY H H 1 7.88 0.02 . 1 . . . . . . . . 4097 1 132 . 1 1 37 37 GLY CA C 13 45.6 0.06 . 1 . . . . . . . . 4097 1 133 . 1 1 38 38 ARG N N 15 118.2 0.06 . 1 . . . . . . . . 4097 1 134 . 1 1 38 38 ARG H H 1 7.24 0.02 . 1 . . . . . . . . 4097 1 135 . 1 1 38 38 ARG CA C 13 56.3 0.06 . 1 . . . . . . . . 4097 1 136 . 1 1 38 38 ARG CB C 13 31.9 0.06 . 1 . . . . . . . . 4097 1 137 . 1 1 39 39 GLN N N 15 117.7 0.06 . 1 . . . . . . . . 4097 1 138 . 1 1 39 39 GLN H H 1 8.56 0.02 . 1 . . . . . . . . 4097 1 139 . 1 1 39 39 GLN CA C 13 54.7 0.06 . 1 . . . . . . . . 4097 1 140 . 1 1 39 39 GLN CB C 13 32.9 0.06 . 1 . . . . . . . . 4097 1 141 . 1 1 40 40 LYS N N 15 123.2 0.06 . 1 . . . . . . . . 4097 1 142 . 1 1 40 40 LYS H H 1 7.91 0.02 . 1 . . . . . . . . 4097 1 143 . 1 1 40 40 LYS CA C 13 56.5 0.06 . 1 . . . . . . . . 4097 1 144 . 1 1 40 40 LYS CB C 13 33.1 0.06 . 1 . . . . . . . . 4097 1 145 . 1 1 41 41 VAL N N 15 123.3 0.06 . 1 . . . . . . . . 4097 1 146 . 1 1 41 41 VAL H H 1 8.24 0.02 . 1 . . . . . . . . 4097 1 147 . 1 1 41 41 VAL CA C 13 60.5 0.06 . 1 . . . . . . . . 4097 1 148 . 1 1 41 41 VAL CB C 13 34.9 0.06 . 1 . . . . . . . . 4097 1 149 . 1 1 42 42 VAL N N 15 124.9 0.06 . 1 . . . . . . . . 4097 1 150 . 1 1 42 42 VAL H H 1 9.35 0.02 . 1 . . . . . . . . 4097 1 151 . 1 1 42 42 VAL CA C 13 57.6 0.06 . 1 . . . . . . . . 4097 1 152 . 1 1 43 43 PRO CA C 13 61.6 0.06 . 1 . . . . . . . . 4097 1 153 . 1 1 43 43 PRO CB C 13 32.3 0.06 . 1 . . . . . . . . 4097 1 154 . 1 1 44 44 LEU N N 15 122.1 0.06 . 1 . . . . . . . . 4097 1 155 . 1 1 44 44 LEU H H 1 8.56 0.02 . 1 . . . . . . . . 4097 1 156 . 1 1 44 44 LEU CA C 13 53.9 0.06 . 1 . . . . . . . . 4097 1 157 . 1 1 44 44 LEU CB C 13 46.9 0.06 . 1 . . . . . . . . 4097 1 158 . 1 1 45 45 THR N N 15 112.1 0.06 . 1 . . . . . . . . 4097 1 159 . 1 1 45 45 THR H H 1 8.23 0.02 . 1 . . . . . . . . 4097 1 160 . 1 1 45 45 THR CA C 13 59.8 0.06 . 1 . . . . . . . . 4097 1 161 . 1 1 45 45 THR CB C 13 71.4 0.06 . 1 . . . . . . . . 4097 1 162 . 1 1 46 46 ASN N N 15 120.7 0.06 . 1 . . . . . . . . 4097 1 163 . 1 1 46 46 ASN H H 1 8.71 0.02 . 1 . . . . . . . . 4097 1 164 . 1 1 46 46 ASN CA C 13 53.9 0.06 . 1 . . . . . . . . 4097 1 165 . 1 1 46 46 ASN CB C 13 37.3 0.06 . 1 . . . . . . . . 4097 1 166 . 1 1 47 47 THR N N 15 114.7 0.06 . 1 . . . . . . . . 4097 1 167 . 1 1 47 47 THR H H 1 9.09 0.02 . 1 . . . . . . . . 4097 1 168 . 1 1 47 47 THR CA C 13 59.8 0.06 . 1 . . . . . . . . 4097 1 169 . 1 1 47 47 THR CB C 13 70.2 0.06 . 1 . . . . . . . . 4097 1 170 . 1 1 48 48 THR N N 15 109.1 0.06 . 1 . . . . . . . . 4097 1 171 . 1 1 48 48 THR H H 1 8.15 0.02 . 1 . . . . . . . . 4097 1 172 . 1 1 48 48 THR CA C 13 58.5 0.06 . 1 . . . . . . . . 4097 1 173 . 1 1 48 48 THR CB C 13 73.1 0.06 . 1 . . . . . . . . 4097 1 174 . 1 1 49 49 ASN N N 15 121.7 0.06 . 1 . . . . . . . . 4097 1 175 . 1 1 49 49 ASN H H 1 9.2 0.02 . 1 . . . . . . . . 4097 1 176 . 1 1 49 49 ASN CA C 13 57.3 0.06 . 1 . . . . . . . . 4097 1 177 . 1 1 49 49 ASN CB C 13 38.2 0.06 . 1 . . . . . . . . 4097 1 178 . 1 1 50 50 GLN N N 15 118.7 0.06 . 1 . . . . . . . . 4097 1 179 . 1 1 50 50 GLN H H 1 8.65 0.02 . 1 . . . . . . . . 4097 1 180 . 1 1 50 50 GLN CA C 13 59.8 0.06 . 1 . . . . . . . . 4097 1 181 . 1 1 50 50 GLN CB C 13 28.4 0.06 . 1 . . . . . . . . 4097 1 182 . 1 1 51 51 LYS N N 15 117.5 0.06 . 1 . . . . . . . . 4097 1 183 . 1 1 51 51 LYS H H 1 7.5 0.02 . 1 . . . . . . . . 4097 1 184 . 1 1 51 51 LYS CA C 13 60.6 0.06 . 1 . . . . . . . . 4097 1 185 . 1 1 51 51 LYS CB C 13 32.4 0.06 . 1 . . . . . . . . 4097 1 186 . 1 1 52 52 THR N N 15 110.7 0.06 . 1 . . . . . . . . 4097 1 187 . 1 1 52 52 THR H H 1 8.33 0.02 . 1 . . . . . . . . 4097 1 188 . 1 1 52 52 THR CA C 13 52.9 0.06 . 1 . . . . . . . . 4097 1 189 . 1 1 52 52 THR CB C 13 68.4 0.06 . 1 . . . . . . . . 4097 1 190 . 1 1 53 53 GLU N N 15 121.4 0.06 . 1 . . . . . . . . 4097 1 191 . 1 1 53 53 GLU H H 1 7.56 0.02 . 1 . . . . . . . . 4097 1 192 . 1 1 53 53 GLU CA C 13 58.8 0.06 . 1 . . . . . . . . 4097 1 193 . 1 1 54 54 LEU N N 15 118.5 0.06 . 1 . . . . . . . . 4097 1 194 . 1 1 54 54 LEU H H 1 7.64 0.02 . 1 . . . . . . . . 4097 1 195 . 1 1 54 54 LEU CA C 13 57.6 0.06 . 1 . . . . . . . . 4097 1 196 . 1 1 54 54 LEU CB C 13 41.8 0.06 . 1 . . . . . . . . 4097 1 197 . 1 1 55 55 GLN N N 15 120.1 0.06 . 1 . . . . . . . . 4097 1 198 . 1 1 55 55 GLN H H 1 8.87 0.02 . 1 . . . . . . . . 4097 1 199 . 1 1 55 55 GLN CA C 13 58.6 0.06 . 1 . . . . . . . . 4097 1 200 . 1 1 55 55 GLN CB C 13 27.4 0.06 . 1 . . . . . . . . 4097 1 201 . 1 1 56 56 ALA N N 15 121.1 0.06 . 1 . . . . . . . . 4097 1 202 . 1 1 56 56 ALA H H 1 8.01 0.02 . 1 . . . . . . . . 4097 1 203 . 1 1 56 56 ALA CA C 13 55.7 0.06 . 1 . . . . . . . . 4097 1 204 . 1 1 56 56 ALA CB C 13 19.1 0.06 . 1 . . . . . . . . 4097 1 205 . 1 1 57 57 ILE N N 15 115.9 0.06 . 1 . . . . . . . . 4097 1 206 . 1 1 57 57 ILE H H 1 7.16 0.02 . 1 . . . . . . . . 4097 1 207 . 1 1 57 57 ILE CA C 13 65.6 0.06 . 1 . . . . . . . . 4097 1 208 . 1 1 57 57 ILE CB C 13 38 0.06 . 1 . . . . . . . . 4097 1 209 . 1 1 58 58 TYR N N 15 119.6 0.06 . 1 . . . . . . . . 4097 1 210 . 1 1 58 58 TYR H H 1 8.22 0.02 . 1 . . . . . . . . 4097 1 211 . 1 1 58 58 TYR CA C 13 61.2 0.06 . 1 . . . . . . . . 4097 1 212 . 1 1 58 58 TYR CB C 13 37.5 0.06 . 1 . . . . . . . . 4097 1 213 . 1 1 59 59 LEU N N 15 118.6 0.06 . 1 . . . . . . . . 4097 1 214 . 1 1 59 59 LEU H H 1 8.43 0.02 . 1 . . . . . . . . 4097 1 215 . 1 1 59 59 LEU CA C 13 57.5 0.06 . 1 . . . . . . . . 4097 1 216 . 1 1 59 59 LEU CB C 13 42.6 0.06 . 1 . . . . . . . . 4097 1 217 . 1 1 60 60 ALA N N 15 118.1 0.06 . 1 . . . . . . . . 4097 1 218 . 1 1 60 60 ALA H H 1 7.43 0.02 . 1 . . . . . . . . 4097 1 219 . 1 1 60 60 ALA CA C 13 53.8 0.06 . 1 . . . . . . . . 4097 1 220 . 1 1 60 60 ALA CB C 13 19.2 0.06 . 1 . . . . . . . . 4097 1 221 . 1 1 61 61 LEU N N 15 116.8 0.06 . 1 . . . . . . . . 4097 1 222 . 1 1 61 61 LEU H H 1 7.84 0.02 . 1 . . . . . . . . 4097 1 223 . 1 1 61 61 LEU CA C 13 57.5 0.06 . 1 . . . . . . . . 4097 1 224 . 1 1 61 61 LEU CB C 13 41.5 0.06 . 1 . . . . . . . . 4097 1 225 . 1 1 62 62 GLN N N 15 118 0.06 . 1 . . . . . . . . 4097 1 226 . 1 1 62 62 GLN H H 1 8.23 0.02 . 1 . . . . . . . . 4097 1 227 . 1 1 62 62 GLN CA C 13 58.9 0.06 . 1 . . . . . . . . 4097 1 228 . 1 1 62 62 GLN CB C 13 30 0.06 . 1 . . . . . . . . 4097 1 229 . 1 1 63 63 ASP N N 15 115.7 0.06 . 1 . . . . . . . . 4097 1 230 . 1 1 63 63 ASP H H 1 7.49 0.02 . 1 . . . . . . . . 4097 1 231 . 1 1 63 63 ASP CA C 13 54.3 0.06 . 1 . . . . . . . . 4097 1 232 . 1 1 63 63 ASP CB C 13 39.3 0.06 . 1 . . . . . . . . 4097 1 233 . 1 1 64 64 SER N N 15 113.2 0.06 . 1 . . . . . . . . 4097 1 234 . 1 1 64 64 SER H H 1 7.06 0.02 . 1 . . . . . . . . 4097 1 235 . 1 1 64 64 SER CA C 13 55.9 0.06 . 1 . . . . . . . . 4097 1 236 . 1 1 64 64 SER CB C 13 67.6 0.06 . 1 . . . . . . . . 4097 1 237 . 1 1 65 65 GLY N N 15 105.3 0.06 . 1 . . . . . . . . 4097 1 238 . 1 1 65 65 GLY H H 1 8.33 0.02 . 1 . . . . . . . . 4097 1 239 . 1 1 65 65 GLY CA C 13 43.8 0.06 . 1 . . . . . . . . 4097 1 240 . 1 1 66 66 LEU N N 15 117.9 0.06 . 1 . . . . . . . . 4097 1 241 . 1 1 66 66 LEU H H 1 8.42 0.02 . 1 . . . . . . . . 4097 1 242 . 1 1 66 66 LEU CA C 13 57.6 0.06 . 1 . . . . . . . . 4097 1 243 . 1 1 66 66 LEU CB C 13 42.9 0.06 . 1 . . . . . . . . 4097 1 244 . 1 1 67 67 GLU N N 15 115.2 0.06 . 1 . . . . . . . . 4097 1 245 . 1 1 67 67 GLU H H 1 7.67 0.02 . 1 . . . . . . . . 4097 1 246 . 1 1 67 67 GLU CA C 13 53.6 0.06 . 1 . . . . . . . . 4097 1 247 . 1 1 67 67 GLU CB C 13 31.3 0.06 . 1 . . . . . . . . 4097 1 248 . 1 1 68 68 VAL N N 15 119.6 0.06 . 1 . . . . . . . . 4097 1 249 . 1 1 68 68 VAL H H 1 8.04 0.02 . 1 . . . . . . . . 4097 1 250 . 1 1 68 68 VAL CA C 13 61 0.06 . 1 . . . . . . . . 4097 1 251 . 1 1 68 68 VAL CB C 13 34.9 0.06 . 1 . . . . . . . . 4097 1 252 . 1 1 69 69 ASN N N 15 123.2 0.06 . 1 . . . . . . . . 4097 1 253 . 1 1 69 69 ASN H H 1 7.79 0.02 . 1 . . . . . . . . 4097 1 254 . 1 1 69 69 ASN CA C 13 51.8 0.06 . 1 . . . . . . . . 4097 1 255 . 1 1 69 69 ASN CB C 13 41.5 0.06 . 1 . . . . . . . . 4097 1 256 . 1 1 70 70 ILE N N 15 125.2 0.06 . 1 . . . . . . . . 4097 1 257 . 1 1 70 70 ILE H H 1 9.76 0.02 . 1 . . . . . . . . 4097 1 258 . 1 1 70 70 ILE CA C 13 60.7 0.06 . 1 . . . . . . . . 4097 1 259 . 1 1 70 70 ILE CB C 13 40.6 0.06 . 1 . . . . . . . . 4097 1 260 . 1 1 71 71 VAL N N 15 126.5 0.06 . 1 . . . . . . . . 4097 1 261 . 1 1 71 71 VAL H H 1 8.91 0.02 . 1 . . . . . . . . 4097 1 262 . 1 1 71 71 VAL CA C 13 60.7 0.06 . 1 . . . . . . . . 4097 1 263 . 1 1 71 71 VAL CB C 13 33.7 0.06 . 1 . . . . . . . . 4097 1 264 . 1 1 75 75 GLN CA C 13 58.3 0.06 . 1 . . . . . . . . 4097 1 265 . 1 1 75 75 GLN CB C 13 27.8 0.06 . 1 . . . . . . . . 4097 1 266 . 1 1 76 76 TYR N N 15 120 0.06 . 1 . . . . . . . . 4097 1 267 . 1 1 76 76 TYR H H 1 8.23 0.02 . 1 . . . . . . . . 4097 1 268 . 1 1 76 76 TYR CA C 13 60 0.06 . 1 . . . . . . . . 4097 1 269 . 1 1 76 76 TYR CB C 13 38.7 0.06 . 1 . . . . . . . . 4097 1 270 . 1 1 77 77 ALA N N 15 121 0.06 . 1 . . . . . . . . 4097 1 271 . 1 1 77 77 ALA H H 1 8.15 0.02 . 1 . . . . . . . . 4097 1 272 . 1 1 77 77 ALA CA C 13 54.2 0.06 . 1 . . . . . . . . 4097 1 273 . 1 1 77 77 ALA CB C 13 18.6 0.06 . 1 . . . . . . . . 4097 1 274 . 1 1 78 78 LEU N N 15 115.5 0.06 . 1 . . . . . . . . 4097 1 275 . 1 1 78 78 LEU H H 1 7.39 0.02 . 1 . . . . . . . . 4097 1 276 . 1 1 78 78 LEU CA C 13 57.6 0.06 . 1 . . . . . . . . 4097 1 277 . 1 1 78 78 LEU CB C 13 41.8 0.06 . 1 . . . . . . . . 4097 1 278 . 1 1 79 79 GLY N N 15 105.1 0.06 . 1 . . . . . . . . 4097 1 279 . 1 1 79 79 GLY H H 1 7.88 0.02 . 1 . . . . . . . . 4097 1 280 . 1 1 79 79 GLY CA C 13 46.6 0.06 . 1 . . . . . . . . 4097 1 281 . 1 1 80 80 ILE N N 15 120.1 0.06 . 1 . . . . . . . . 4097 1 282 . 1 1 80 80 ILE H H 1 7.37 0.02 . 1 . . . . . . . . 4097 1 283 . 1 1 80 80 ILE CA C 13 62.3 0.06 . 1 . . . . . . . . 4097 1 284 . 1 1 80 80 ILE CB C 13 37.5 0.06 . 1 . . . . . . . . 4097 1 285 . 1 1 81 81 ILE N N 15 117.3 0.06 . 1 . . . . . . . . 4097 1 286 . 1 1 81 81 ILE H H 1 7.39 0.02 . 1 . . . . . . . . 4097 1 287 . 1 1 81 81 ILE CA C 13 63.5 0.06 . 1 . . . . . . . . 4097 1 288 . 1 1 82 82 GLN CA C 13 57 0.06 . 1 . . . . . . . . 4097 1 289 . 1 1 82 82 GLN CB C 13 29 0.06 . 1 . . . . . . . . 4097 1 290 . 1 1 83 83 ALA N N 15 121.1 0.06 . 1 . . . . . . . . 4097 1 291 . 1 1 83 83 ALA H H 1 7.44 0.02 . 1 . . . . . . . . 4097 1 292 . 1 1 83 83 ALA CA C 13 52.6 0.06 . 1 . . . . . . . . 4097 1 293 . 1 1 83 83 ALA CB C 13 19 0.06 . 1 . . . . . . . . 4097 1 294 . 1 1 84 84 GLN N N 15 116.4 0.06 . 1 . . . . . . . . 4097 1 295 . 1 1 84 84 GLN H H 1 8.06 0.02 . 1 . . . . . . . . 4097 1 296 . 1 1 84 84 GLN CA C 13 54.7 0.06 . 1 . . . . . . . . 4097 1 297 . 1 1 85 85 PRO CA C 13 63.1 0.06 . 1 . . . . . . . . 4097 1 298 . 1 1 85 85 PRO CB C 13 31.9 0.06 . 1 . . . . . . . . 4097 1 299 . 1 1 86 86 ASP N N 15 119.1 0.06 . 1 . . . . . . . . 4097 1 300 . 1 1 86 86 ASP H H 1 8.3 0.02 . 1 . . . . . . . . 4097 1 301 . 1 1 86 86 ASP CA C 13 53.7 0.06 . 1 . . . . . . . . 4097 1 302 . 1 1 86 86 ASP CB C 13 41.3 0.06 . 1 . . . . . . . . 4097 1 303 . 1 1 87 87 LYS N N 15 120.2 0.06 . 1 . . . . . . . . 4097 1 304 . 1 1 87 87 LYS H H 1 8.21 0.02 . 1 . . . . . . . . 4097 1 305 . 1 1 87 87 LYS CA C 13 56.8 0.06 . 1 . . . . . . . . 4097 1 306 . 1 1 87 87 LYS CB C 13 32.8 0.06 . 1 . . . . . . . . 4097 1 307 . 1 1 88 88 SER N N 15 115.9 0.06 . 1 . . . . . . . . 4097 1 308 . 1 1 88 88 SER H H 1 8.53 0.02 . 1 . . . . . . . . 4097 1 309 . 1 1 88 88 SER CA C 13 58.6 0.06 . 1 . . . . . . . . 4097 1 310 . 1 1 88 88 SER CB C 13 63.8 0.06 . 1 . . . . . . . . 4097 1 311 . 1 1 89 89 GLU N N 15 122.7 0.06 . 1 . . . . . . . . 4097 1 312 . 1 1 89 89 GLU H H 1 8.34 0.02 . 1 . . . . . . . . 4097 1 313 . 1 1 89 89 GLU CA C 13 56.2 0.06 . 1 . . . . . . . . 4097 1 314 . 1 1 89 89 GLU CB C 13 29 0.06 . 1 . . . . . . . . 4097 1 315 . 1 1 90 90 SER N N 15 114.8 0.06 . 1 . . . . . . . . 4097 1 316 . 1 1 90 90 SER H H 1 8.1 0.02 . 1 . . . . . . . . 4097 1 317 . 1 1 90 90 SER CA C 13 57.9 0.06 . 1 . . . . . . . . 4097 1 318 . 1 1 90 90 SER CB C 13 63.3 0.06 . 1 . . . . . . . . 4097 1 319 . 1 1 91 91 GLU N N 15 126.7 0.06 . 1 . . . . . . . . 4097 1 320 . 1 1 91 91 GLU H H 1 8.8 0.02 . 1 . . . . . . . . 4097 1 321 . 1 1 91 91 GLU CA C 13 59.1 0.06 . 1 . . . . . . . . 4097 1 322 . 1 1 91 91 GLU CB C 13 28.6 0.06 . 1 . . . . . . . . 4097 1 323 . 1 1 92 92 LEU N N 15 120 0.06 . 1 . . . . . . . . 4097 1 324 . 1 1 92 92 LEU H H 1 7.88 0.02 . 1 . . . . . . . . 4097 1 325 . 1 1 92 92 LEU CA C 13 57.3 0.06 . 1 . . . . . . . . 4097 1 326 . 1 1 92 92 LEU CB C 13 42.1 0.06 . 1 . . . . . . . . 4097 1 327 . 1 1 93 93 VAL N N 15 118.2 0.06 . 1 . . . . . . . . 4097 1 328 . 1 1 93 93 VAL H H 1 7.57 0.02 . 1 . . . . . . . . 4097 1 329 . 1 1 93 93 VAL CA C 13 67.3 0.06 . 1 . . . . . . . . 4097 1 330 . 1 1 93 93 VAL CB C 13 31.2 0.06 . 1 . . . . . . . . 4097 1 331 . 1 1 94 94 ASN N N 15 117.4 0.06 . 1 . . . . . . . . 4097 1 332 . 1 1 94 94 ASN H H 1 8.01 0.02 . 1 . . . . . . . . 4097 1 333 . 1 1 94 94 ASN CA C 13 56.7 0.06 . 1 . . . . . . . . 4097 1 334 . 1 1 94 94 ASN CB C 13 37.8 0.06 . 1 . . . . . . . . 4097 1 335 . 1 1 95 95 GLN N N 15 119.6 0.06 . 1 . . . . . . . . 4097 1 336 . 1 1 95 95 GLN H H 1 8.16 0.02 . 1 . . . . . . . . 4097 1 337 . 1 1 95 95 GLN CA C 13 59 0.06 . 1 . . . . . . . . 4097 1 338 . 1 1 95 95 GLN CB C 13 27.9 0.06 . 1 . . . . . . . . 4097 1 339 . 1 1 96 96 ILE N N 15 121.5 0.06 . 1 . . . . . . . . 4097 1 340 . 1 1 96 96 ILE H H 1 8.05 0.02 . 1 . . . . . . . . 4097 1 341 . 1 1 96 96 ILE CA C 13 66.2 0.06 . 1 . . . . . . . . 4097 1 342 . 1 1 96 96 ILE CB C 13 37.8 0.06 . 1 . . . . . . . . 4097 1 343 . 1 1 97 97 ILE N N 15 121.4 0.06 . 1 . . . . . . . . 4097 1 344 . 1 1 97 97 ILE H H 1 8.54 0.02 . 1 . . . . . . . . 4097 1 345 . 1 1 97 97 ILE CA C 13 65.5 0.06 . 1 . . . . . . . . 4097 1 346 . 1 1 97 97 ILE CB C 13 37.2 0.06 . 1 . . . . . . . . 4097 1 347 . 1 1 98 98 GLU N N 15 116.4 0.06 . 1 . . . . . . . . 4097 1 348 . 1 1 98 98 GLU H H 1 7.99 0.02 . 1 . . . . . . . . 4097 1 349 . 1 1 98 98 GLU CA C 13 59.1 0.06 . 1 . . . . . . . . 4097 1 350 . 1 1 98 98 GLU CB C 13 28.6 0.06 . 1 . . . . . . . . 4097 1 351 . 1 1 99 99 GLN N N 15 114.9 0.06 . 1 . . . . . . . . 4097 1 352 . 1 1 99 99 GLN H H 1 7.47 0.02 . 1 . . . . . . . . 4097 1 353 . 1 1 99 99 GLN CA C 13 57.4 0.06 . 1 . . . . . . . . 4097 1 354 . 1 1 99 99 GLN CB C 13 29.5 0.06 . 1 . . . . . . . . 4097 1 355 . 1 1 100 100 LEU N N 15 121.5 0.06 . 1 . . . . . . . . 4097 1 356 . 1 1 100 100 LEU H H 1 8.55 0.02 . 1 . . . . . . . . 4097 1 357 . 1 1 100 100 LEU CA C 13 58.5 0.06 . 1 . . . . . . . . 4097 1 358 . 1 1 100 100 LEU CB C 13 41.8 0.06 . 1 . . . . . . . . 4097 1 359 . 1 1 101 101 ILE N N 15 112.4 0.06 . 1 . . . . . . . . 4097 1 360 . 1 1 101 101 ILE H H 1 7.88 0.02 . 1 . . . . . . . . 4097 1 361 . 1 1 101 101 ILE CA C 13 64.1 0.06 . 1 . . . . . . . . 4097 1 362 . 1 1 101 101 ILE CB C 13 38.1 0.06 . 1 . . . . . . . . 4097 1 363 . 1 1 102 102 LYS N N 15 117.2 0.06 . 1 . . . . . . . . 4097 1 364 . 1 1 102 102 LYS H H 1 6.98 0.02 . 1 . . . . . . . . 4097 1 365 . 1 1 102 102 LYS CA C 13 56.7 0.06 . 1 . . . . . . . . 4097 1 366 . 1 1 102 102 LYS CB C 13 33.1 0.06 . 1 . . . . . . . . 4097 1 367 . 1 1 103 103 LYS N N 15 117 0.06 . 1 . . . . . . . . 4097 1 368 . 1 1 103 103 LYS H H 1 7.44 0.02 . 1 . . . . . . . . 4097 1 369 . 1 1 103 103 LYS CA C 13 54.1 0.06 . 1 . . . . . . . . 4097 1 370 . 1 1 103 103 LYS CB C 13 32.7 0.06 . 1 . . . . . . . . 4097 1 371 . 1 1 104 104 GLU N N 15 120.1 0.06 . 1 . . . . . . . . 4097 1 372 . 1 1 104 104 GLU H H 1 9.17 0.02 . 1 . . . . . . . . 4097 1 373 . 1 1 104 104 GLU CA C 13 58 0.06 . 1 . . . . . . . . 4097 1 374 . 1 1 104 104 GLU CB C 13 30.5 0.06 . 1 . . . . . . . . 4097 1 375 . 1 1 105 105 LYS N N 15 115.3 0.06 . 1 . . . . . . . . 4097 1 376 . 1 1 105 105 LYS H H 1 7.72 0.02 . 1 . . . . . . . . 4097 1 377 . 1 1 105 105 LYS CA C 13 56.1 0.06 . 1 . . . . . . . . 4097 1 378 . 1 1 105 105 LYS CB C 13 33.7 0.06 . 1 . . . . . . . . 4097 1 379 . 1 1 106 106 VAL N N 15 120.9 0.06 . 1 . . . . . . . . 4097 1 380 . 1 1 106 106 VAL H H 1 8.86 0.02 . 1 . . . . . . . . 4097 1 381 . 1 1 106 106 VAL CA C 13 60.5 0.06 . 1 . . . . . . . . 4097 1 382 . 1 1 106 106 VAL CB C 13 35.6 0.06 . 1 . . . . . . . . 4097 1 383 . 1 1 107 107 TYR N N 15 129.4 0.06 . 1 . . . . . . . . 4097 1 384 . 1 1 107 107 TYR H H 1 8.5 0.02 . 1 . . . . . . . . 4097 1 385 . 1 1 107 107 TYR CA C 13 56.3 0.06 . 1 . . . . . . . . 4097 1 386 . 1 1 107 107 TYR CB C 13 40.5 0.06 . 1 . . . . . . . . 4097 1 387 . 1 1 108 108 LEU N N 15 128.9 0.06 . 1 . . . . . . . . 4097 1 388 . 1 1 108 108 LEU H H 1 7.94 0.02 . 1 . . . . . . . . 4097 1 389 . 1 1 108 108 LEU CA C 13 52.6 0.06 . 1 . . . . . . . . 4097 1 390 . 1 1 108 108 LEU CB C 13 45.4 0.06 . 1 . . . . . . . . 4097 1 391 . 1 1 109 109 ALA N N 15 124.9 0.06 . 1 . . . . . . . . 4097 1 392 . 1 1 109 109 ALA H H 1 8.53 0.02 . 1 . . . . . . . . 4097 1 393 . 1 1 109 109 ALA CA C 13 50.8 0.06 . 1 . . . . . . . . 4097 1 394 . 1 1 112 112 PRO CA C 13 62.1 0.06 . 1 . . . . . . . . 4097 1 395 . 1 1 112 112 PRO CB C 13 31.9 0.06 . 1 . . . . . . . . 4097 1 396 . 1 1 113 113 ALA N N 15 122.2 0.06 . 1 . . . . . . . . 4097 1 397 . 1 1 113 113 ALA H H 1 8.19 0.02 . 1 . . . . . . . . 4097 1 398 . 1 1 113 113 ALA CA C 13 52.1 0.06 . 1 . . . . . . . . 4097 1 399 . 1 1 113 113 ALA CB C 13 19.5 0.06 . 1 . . . . . . . . 4097 1 400 . 1 1 114 114 HIS N N 15 115.5 0.06 . 1 . . . . . . . . 4097 1 401 . 1 1 114 114 HIS H H 1 8.58 0.02 . 1 . . . . . . . . 4097 1 402 . 1 1 114 114 HIS CA C 13 55.4 0.06 . 1 . . . . . . . . 4097 1 403 . 1 1 114 114 HIS CB C 13 28 0.06 . 1 . . . . . . . . 4097 1 404 . 1 1 115 115 LYS N N 15 120.1 0.06 . 1 . . . . . . . . 4097 1 405 . 1 1 115 115 LYS H H 1 8.19 0.02 . 1 . . . . . . . . 4097 1 406 . 1 1 115 115 LYS CA C 13 55.6 0.06 . 1 . . . . . . . . 4097 1 407 . 1 1 115 115 LYS CB C 13 33.1 0.06 . 1 . . . . . . . . 4097 1 408 . 1 1 116 116 GLY N N 15 110.1 0.06 . 1 . . . . . . . . 4097 1 409 . 1 1 116 116 GLY H H 1 8.58 0.02 . 1 . . . . . . . . 4097 1 410 . 1 1 116 116 GLY CA C 13 45.3 0.06 . 1 . . . . . . . . 4097 1 411 . 1 1 117 117 ILE N N 15 119.7 0.06 . 1 . . . . . . . . 4097 1 412 . 1 1 117 117 ILE H H 1 7.93 0.02 . 1 . . . . . . . . 4097 1 413 . 1 1 117 117 ILE CA C 13 60.8 0.06 . 1 . . . . . . . . 4097 1 414 . 1 1 117 117 ILE CB C 13 42.1 0.06 . 1 . . . . . . . . 4097 1 415 . 1 1 118 118 GLY N N 15 114.3 0.06 . 1 . . . . . . . . 4097 1 416 . 1 1 118 118 GLY H H 1 8.63 0.02 . 1 . . . . . . . . 4097 1 417 . 1 1 118 118 GLY CA C 13 45.9 0.06 . 1 . . . . . . . . 4097 1 418 . 1 1 128 128 SER N N 15 116.2 0.06 . 1 . . . . . . . . 4097 1 419 . 1 1 128 128 SER H H 1 8.37 0.02 . 1 . . . . . . . . 4097 1 420 . 1 1 128 128 SER CA C 13 58.6 0.06 . 1 . . . . . . . . 4097 1 421 . 1 1 128 128 SER CB C 13 63.6 0.06 . 1 . . . . . . . . 4097 1 422 . 1 1 129 129 ALA N N 15 122.4 0.06 . 1 . . . . . . . . 4097 1 423 . 1 1 129 129 ALA H H 1 8.33 0.02 . 1 . . . . . . . . 4097 1 424 . 1 1 129 129 ALA CA C 13 56.3 0.06 . 1 . . . . . . . . 4097 1 425 . 1 1 130 130 GLY N N 15 110.7 0.06 . 1 . . . . . . . . 4097 1 426 . 1 1 130 130 GLY H H 1 8.42 0.02 . 1 . . . . . . . . 4097 1 427 . 1 1 130 130 GLY CA C 13 45.5 0.06 . 1 . . . . . . . . 4097 1 428 . 1 1 131 131 ILE N N 15 120.3 0.06 . 1 . . . . . . . . 4097 1 429 . 1 1 131 131 ILE H H 1 8.06 0.02 . 1 . . . . . . . . 4097 1 430 . 1 1 131 131 ILE CA C 13 60.5 0.06 . 1 . . . . . . . . 4097 1 431 . 1 1 133 133 LYS CA C 13 56.2 0.06 . 1 . . . . . . . . 4097 1 432 . 1 1 133 133 LYS CB C 13 33.2 0.06 . 1 . . . . . . . . 4097 1 433 . 1 1 134 134 ILE N N 15 123.6 0.06 . 1 . . . . . . . . 4097 1 434 . 1 1 134 134 ILE H H 1 8.24 0.02 . 1 . . . . . . . . 4097 1 435 . 1 1 134 134 ILE CA C 13 61 0.06 . 1 . . . . . . . . 4097 1 436 . 1 1 134 134 ILE CB C 13 38.7 0.06 . 1 . . . . . . . . 4097 1 437 . 1 1 135 135 LEU N N 15 131.3 0.06 . 1 . . . . . . . . 4097 1 438 . 1 1 135 135 LEU H H 1 7.93 0.02 . 1 . . . . . . . . 4097 1 439 . 1 1 135 135 LEU CA C 13 56.4 0.06 . 1 . . . . . . . . 4097 1 stop_ save_