data_27729 ####################### # Entry information # ####################### save_entry_information _Saveframe_category entry_information _Entry_title ; IL37 53-206 dimer ; _BMRB_accession_number 27729 _BMRB_flat_file_name bmr27729.str _Entry_type original _Submission_date 2018-12-15 _Accession_date 2018-12-15 _Entry_origination author _NMR_STAR_version 2.1.1 _Experimental_method NMR _Details 'Asymmetrical dimer of IL37 residues 53-206 (no floppy termini)' loop_ _Author_ordinal _Author_family_name _Author_given_name _Author_middle_initials _Author_family_title 1 Eisenmesser Elan . . stop_ loop_ _Saveframe_category_type _Saveframe_category_type_count assigned_chemical_shifts 1 stop_ loop_ _Data_type _Data_type_count "1H chemical shifts" 239 "13C chemical shifts" 444 "15N chemical shifts" 145 stop_ loop_ _Revision_date _Revision_keyword _Revision_author _Revision_detail 2019-04-17 update BMRB 'update entry citation' 2019-01-15 original author 'original release' stop_ _Original_release_date 2018-12-17 save_ ############################# # Citation for this entry # ############################# save_entry_citation _Saveframe_category entry_citation _Citation_full . _Citation_title ; Interleukin-37 monomer is the active form for reducing innate immunity. ; _Citation_status published _Citation_type journal _CAS_abstract_code . _MEDLINE_UI_code . _PubMed_ID 30819901 loop_ _Author_ordinal _Author_family_name _Author_given_name _Author_middle_initials _Author_family_title 1 Eisenmesser Elan Z. . 2 Gottschlich Adrian . . 3 Redzic Jasmina S. . 4 Paukovich Natasia . . 5 Nix Jay C. . 6 Azam Tania . . 7 Zhang Lingdi . . 8 Zhao Rui . . 9 Kieft Jeffrey S. . 10 The Erlinda . . 11 Meng Xianzhong . . 12 Dinarello Charles A. . stop_ _Journal_abbreviation 'Proc. Natl. Acad. Sci. U.S.A.' _Journal_name_full 'Proceedings of the National Academy of Sciences of the United States of America' _Journal_volume 116 _Journal_issue 12 _Journal_ISSN 1091-6490 _Journal_CSD . _Book_chapter_title . _Book_volume . _Book_series . _Book_ISBN . _Conference_state_province . _Conference_abstract_number . _Page_first 5514 _Page_last 5522 _Year 2019 _Details . loop_ _Keyword cytokine 'immune system' inflammation interleukin stop_ save_ ################################## # Molecular system description # ################################## save_assembly _Saveframe_category molecular_system _Mol_system_name 'Il37 dimer' _Enzyme_commission_number . loop_ _Mol_system_component_name _Mol_label 'Il37 chain A' $IL37_dimer 'Il37 chain B' $IL37_dimer stop_ _System_molecular_weight 19300 _System_physical_state native _System_oligomer_state ? _System_paramagnetic no _System_thiol_state . _Database_query_date . _Details . save_ ######################## # Monomeric polymers # ######################## save_IL37_dimer _Saveframe_category monomeric_polymer _Mol_type polymer _Mol_polymer_class protein _Name_common IL37_dimer _Molecular_mass . _Mol_thiol_state 'all free' loop_ _Biological_function 'anti-inflammatory cytokine' stop_ _Details . ############################## # Polymer residue sequence # ############################## _Residue_count 218 _Mol_residue_sequence ; MSFVGENSGVKMGSEDWEKD EPQCCLEDPAGSPLEPGPSL PTMNFVHTSPKVKNLNPKKF SIHDQDHKVLVLDSGNLIAV PDKNYIRPEIFFALASSLSS ASAEKGSPILLGVSKGEFCL YCDKDKGQSHPSLQLKKEKL MKLAAQKESARRPFIFYRAQ VGSWNMLESAAHPGWFICTS CNCNEPVGVTDKFENRKHIE FSFQPVCKAEMSPSEVSD ; loop_ _Residue_seq_code _Residue_label 1 MET 2 SER 3 PHE 4 VAL 5 GLY 6 GLU 7 ASN 8 SER 9 GLY 10 VAL 11 LYS 12 MET 13 GLY 14 SER 15 GLU 16 ASP 17 TRP 18 GLU 19 LYS 20 ASP 21 GLU 22 PRO 23 GLN 24 CYS 25 CYS 26 LEU 27 GLU 28 ASP 29 PRO 30 ALA 31 GLY 32 SER 33 PRO 34 LEU 35 GLU 36 PRO 37 GLY 38 PRO 39 SER 40 LEU 41 PRO 42 THR 43 MET 44 ASN 45 PHE 46 VAL 47 HIS 48 THR 49 SER 50 PRO 51 LYS 52 VAL 53 LYS 54 ASN 55 LEU 56 ASN 57 PRO 58 LYS 59 LYS 60 PHE 61 SER 62 ILE 63 HIS 64 ASP 65 GLN 66 ASP 67 HIS 68 LYS 69 VAL 70 LEU 71 VAL 72 LEU 73 ASP 74 SER 75 GLY 76 ASN 77 LEU 78 ILE 79 ALA 80 VAL 81 PRO 82 ASP 83 LYS 84 ASN 85 TYR 86 ILE 87 ARG 88 PRO 89 GLU 90 ILE 91 PHE 92 PHE 93 ALA 94 LEU 95 ALA 96 SER 97 SER 98 LEU 99 SER 100 SER 101 ALA 102 SER 103 ALA 104 GLU 105 LYS 106 GLY 107 SER 108 PRO 109 ILE 110 LEU 111 LEU 112 GLY 113 VAL 114 SER 115 LYS 116 GLY 117 GLU 118 PHE 119 CYS 120 LEU 121 TYR 122 CYS 123 ASP 124 LYS 125 ASP 126 LYS 127 GLY 128 GLN 129 SER 130 HIS 131 PRO 132 SER 133 LEU 134 GLN 135 LEU 136 LYS 137 LYS 138 GLU 139 LYS 140 LEU 141 MET 142 LYS 143 LEU 144 ALA 145 ALA 146 GLN 147 LYS 148 GLU 149 SER 150 ALA 151 ARG 152 ARG 153 PRO 154 PHE 155 ILE 156 PHE 157 TYR 158 ARG 159 ALA 160 GLN 161 VAL 162 GLY 163 SER 164 TRP 165 ASN 166 MET 167 LEU 168 GLU 169 SER 170 ALA 171 ALA 172 HIS 173 PRO 174 GLY 175 TRP 176 PHE 177 ILE 178 CYS 179 THR 180 SER 181 CYS 182 ASN 183 CYS 184 ASN 185 GLU 186 PRO 187 VAL 188 GLY 189 VAL 190 THR 191 ASP 192 LYS 193 PHE 194 GLU 195 ASN 196 ARG 197 LYS 198 HIS 199 ILE 200 GLU 201 PHE 202 SER 203 PHE 204 GLN 205 PRO 206 VAL 207 CYS 208 LYS 209 ALA 210 GLU 211 MET 212 SER 213 PRO 214 SER 215 GLU 216 VAL 217 SER 218 ASP stop_ _Sequence_homology_query_date . _Sequence_homology_query_revised_last_date . save_ #################### # Natural source # #################### save_natural_source _Saveframe_category natural_source loop_ _Mol_label _Organism_name_common _NCBI_taxonomy_ID _Superkingdom _Kingdom _Genus _Species $IL37_dimer 'E. coli' 562 Bacteria . Escherichia coli stop_ save_ ######################### # Experimental source # ######################### save_experimental_source _Saveframe_category experimental_source loop_ _Mol_label _Production_method _Host_organism_name_common _Genus _Species _Strain _Vector_name $IL37_dimer 'recombinant technology' . Escherichia coli . pET21 stop_ save_ ##################################### # Sample contents and methodology # ##################################### ######################## # Sample description # ######################## save_sample_1 _Saveframe_category sample _Sample_type solution _Details . loop_ _Mol_label _Concentration_value _Concentration_value_units _Isotopic_labeling $IL37_dimer 1 mM '[U-100% 15N]' Phosphate 50 mM 'natural abundance' NaCl 150 mM 'natural abundance' EDTA 1 mM 'natural abundance' stop_ save_ save_sample_2 _Saveframe_category sample _Sample_type solution _Details . loop_ _Mol_label _Concentration_value _Concentration_value_units _Isotopic_labeling $IL37_dimer 1 mM '[U-13C; U-15N; U-2H]' Phosphate 50 mM 'natural abundance' NaCl 150 mM 'natural abundance' EDTA 1 mM 'natural abundance' stop_ save_ ############################ # Computer software used # ############################ save_VNMRJ _Saveframe_category software _Name VNMRJ _Version . loop_ _Vendor _Address _Electronic_address Varian . . stop_ loop_ _Task collection stop_ _Details . save_ ######################### # Experimental detail # ######################### ################################## # NMR Spectrometer definitions # ################################## save_900 _Saveframe_category NMR_spectrometer _Manufacturer Varian _Model INOVA _Field_strength 900 _Details . save_ save_600 _Saveframe_category NMR_spectrometer _Manufacturer Varian _Model INOVA _Field_strength 600 _Details . save_ ############################# # NMR applied experiments # ############################# save_3D_HNCA_1 _Saveframe_category NMR_applied_experiment _Experiment_name '3D HNCA' _Sample_label $sample_2 save_ save_3D_HNCACB_2 _Saveframe_category NMR_applied_experiment _Experiment_name '3D HNCACB' _Sample_label $sample_2 save_ save_3D_HN(CO)CA_3 _Saveframe_category NMR_applied_experiment _Experiment_name '3D HN(CO)CA' _Sample_label $sample_2 save_ save_3D_HN(COCA)CB_4 _Saveframe_category NMR_applied_experiment _Experiment_name '3D HN(COCA)CB' _Sample_label $sample_2 save_ save_2D_1H-15N_HSQC_5 _Saveframe_category NMR_applied_experiment _Experiment_name '2D 1H-15N HSQC' _Sample_label $sample_2 save_ save_3D_HNCO_6 _Saveframe_category NMR_applied_experiment _Experiment_name '3D HNCO' _Sample_label $sample_2 save_ save_2D_1H-13C_HSQC_7 _Saveframe_category NMR_applied_experiment _Experiment_name '2D 1H-13C HSQC' _Sample_label $sample_1 save_ save_3D_HCACO_8 _Saveframe_category NMR_applied_experiment _Experiment_name '3D HCACO' _Sample_label $sample_2 save_ ####################### # Sample conditions # ####################### save_sample_conditions_1 _Saveframe_category sample_conditions _Details . loop_ _Variable_type _Variable_value _Variable_value_error _Variable_value_units 'ionic strength' 0.15 . M pH 6.5 . pH pressure 1 . atm temperature 298 . K stop_ save_ #################### # NMR parameters # #################### ############################## # Assigned chemical shifts # ############################## ################################ # Chemical shift referencing # ################################ save_chemical_shift_reference_1 _Saveframe_category chemical_shift_reference _Details . loop_ _Mol_common_name _Atom_type _Atom_isotope_number _Atom_group _Chem_shift_units _Chem_shift_value _Reference_method _Reference_type _External_reference_sample_geometry _External_reference_location _External_reference_axis _Indirect_shift_ratio DSS C 13 'methyl protons' ppm 0.00 na indirect . . . 0.251449530 DSS H 1 'methyl protons' ppm 0.00 internal direct . . . 1.000000000 DSS N 15 'methyl protons' ppm 0.00 na indirect . . . 0.101329118 DSS P 31 'methyl protons' ppm 0.00 na indirect . . . 0.404808636 stop_ save_ ################################### # Assigned chemical shift lists # ################################### ################################################################### # Chemical Shift Ambiguity Index Value Definitions # # # # The values other than 1 are used for those atoms with different # # chemical shifts that cannot be assigned to stereospecific atoms # # or to specific residues or chains. # # # # Index Value Definition # # # # 1 Unique (including isolated methyl protons, # # geminal atoms, and geminal methyl # # groups with identical chemical shifts) # # (e.g. ILE HD11, HD12, HD13 protons) # # 2 Ambiguity of geminal atoms or geminal methyl # # proton groups (e.g. ASP HB2 and HB3 # # protons, LEU CD1 and CD2 carbons, or # # LEU HD11, HD12, HD13 and HD21, HD22, # # HD23 methyl protons) # # 3 Aromatic atoms on opposite sides of # # symmetrical rings (e.g. TYR HE1 and HE2 # # protons) # # 4 Intraresidue ambiguities (e.g. LYS HG and # # HD protons or TRP HZ2 and HZ3 protons) # # 5 Interresidue ambiguities (LYS 12 vs. LYS 27) # # 6 Intermolecular ambiguities (e.g. ASP 31 CA # # in monomer 1 and ASP 31 CA in monomer 2 # # of an asymmetrical homodimer, duplex # # DNA assignments, or other assignments # # that may apply to atoms in one or more # # molecule in the molecular assembly) # # 9 Ambiguous, specific ambiguity not defined # # # ################################################################### save_assigned_chem_shift_list_1 _Saveframe_category assigned_chemical_shifts _Details . loop_ _Experiment_label '3D HNCA' '3D HNCACB' '3D HN(CO)CA' '3D HN(COCA)CB' '2D 1H-15N HSQC' '3D HNCO' '2D 1H-13C HSQC' '3D HCACO' stop_ loop_ _Sample_label $sample_2 $sample_1 stop_ _Sample_conditions_label $sample_conditions_1 _Chem_shift_reference_set_label $chemical_shift_reference_1 _Mol_system_component_name 'Il37 chain A' _Text_data_format . _Text_data . loop_ _Atom_shift_assign_ID _Residue_author_seq_code _Residue_seq_code _Residue_label _Atom_name _Atom_type _Chem_shift_value _Chem_shift_value_error _Chem_shift_ambiguity_code 1 53 53 LYS H H 8.519 . . 2 53 53 LYS C C 176.261 . . 3 53 53 LYS CA C 56.155 . . 4 53 53 LYS CB C 32.256 . . 5 53 53 LYS N N 123.027 . . 6 54 54 ASN H H 8.413 . . 7 54 54 ASN C C 174.730 . . 8 54 54 ASN CA C 53.108 . . 9 54 54 ASN CB C 38.514 . . 10 54 54 ASN N N 119.318 . . 11 55 55 LEU H H 8.192 . . 12 55 55 LEU C C 175.944 . . 13 55 55 LEU CA C 54.410 . . 14 55 55 LEU CB C 41.738 . . 15 55 55 LEU N N 122.557 . . 16 56 56 ASN H H 8.290 . . 17 56 56 ASN C C 172.875 . . 18 56 56 ASN CA C 50.658 . . 19 56 56 ASN CB C 39.095 . . 20 56 56 ASN N N 119.246 . . 21 57 57 PRO C C 176.387 . . 22 57 57 PRO CA C 62.291 . . 23 57 57 PRO CB C 31.676 . . 24 58 58 LYS H H 8.629 . . 25 58 58 LYS C C 175.610 . . 26 58 58 LYS CA C 55.378 . . 27 58 58 LYS CB C 33.457 . . 28 58 58 LYS N N 122.357 . . 29 59 59 LYS H H 8.125 . . 30 59 59 LYS HB2 H 1.539 . . 31 59 59 LYS HB3 H 1.539 . . 32 59 59 LYS C C 177.151 . . 33 59 59 LYS CA C 54.560 . . 34 59 59 LYS CB C 34.275 . . 35 59 59 LYS N N 120.508 . . 36 60 60 PHE H H 8.312 . . 37 60 60 PHE C C 173.603 . . 38 60 60 PHE CA C 56.044 . . 39 60 60 PHE CB C 39.970 . . 40 60 60 PHE N N 118.850 . . 41 61 61 SER H H 9.325 . . 42 61 61 SER C C 174.625 . . 43 61 61 SER CA C 56.330 . . 44 61 61 SER CB C 65.827 . . 45 61 61 SER N N 114.044 . . 46 62 62 ILE H H 9.525 . . 47 62 62 ILE C C 173.959 . . 48 62 62 ILE CA C 62.640 . . 49 62 62 ILE CB C 38.334 . . 50 62 62 ILE N N 121.176 . . 51 63 63 HIS H H 8.778 . . 52 63 63 HIS C C 175.834 . . 53 63 63 HIS CA C 53.232 . . 54 63 63 HIS CB C 31.449 . . 55 63 63 HIS N N 124.986 . . 56 64 64 ASP H H 8.897 . . 57 64 64 ASP C C 177.255 . . 58 64 64 ASP CA C 52.497 . . 59 64 64 ASP CB C 41.278 . . 60 64 64 ASP N N 123.260 . . 61 65 65 GLN H H 8.008 . . 62 65 65 GLN C C 175.506 . . 63 65 65 GLN CA C 55.723 . . 64 65 65 GLN CB C 27.670 . . 65 65 65 GLN N N 115.396 . . 66 66 66 ASP H H 8.463 . . 67 66 66 ASP C C 174.929 . . 68 66 66 ASP CA C 52.670 . . 69 66 66 ASP CB C 42.062 . . 70 66 66 ASP N N 121.727 . . 71 67 67 HIS H H 8.109 . . 72 67 67 HIS HA H 4.291 . . 73 67 67 HIS HB2 H 3.584 . . 74 67 67 HIS HB3 H 3.584 . . 75 67 67 HIS C C 174.711 . . 76 67 67 HIS CA C 57.208 . . 77 67 67 HIS CB C 25.862 . . 78 67 67 HIS N N 110.826 . . 79 68 68 LYS H H 8.550 . . 80 68 68 LYS C C 175.227 . . 81 68 68 LYS CA C 55.568 . . 82 68 68 LYS CB C 33.189 . . 83 68 68 LYS N N 117.882 . . 84 69 69 VAL H H 9.377 . . 85 69 69 VAL C C 173.308 . . 86 69 69 VAL CA C 58.022 . . 87 69 69 VAL CB C 35.346 . . 88 69 69 VAL N N 119.748 . . 89 70 70 LEU H H 7.587 . . 90 70 70 LEU C C 177.222 . . 91 70 70 LEU CA C 55.787 . . 92 70 70 LEU CB C 40.470 . . 93 70 70 LEU N N 125.152 . . 94 71 71 VAL H H 8.773 . . 95 71 71 VAL C C 172.559 . . 96 71 71 VAL CA C 59.196 . . 97 71 71 VAL CB C 36.172 . . 98 71 71 VAL N N 115.180 . . 99 72 72 LEU H H 8.603 . . 100 72 72 LEU HB2 H 1.140 . . 101 72 72 LEU HB3 H 1.453 . . 102 72 72 LEU C C 176.004 . . 103 72 72 LEU CA C 53.121 . . 104 72 72 LEU CB C 43.602 . . 105 72 72 LEU N N 121.105 . . 106 73 73 ASP H H 9.040 . . 107 73 73 ASP HB2 H 2.432 . . 108 73 73 ASP HB3 H 2.763 . . 109 73 73 ASP C C 176.074 . . 110 73 73 ASP CA C 53.097 . . 111 73 73 ASP CB C 44.731 . . 112 73 73 ASP N N 122.545 . . 113 74 74 SER H H 9.148 . . 114 74 74 SER HB2 H 4.041 . . 115 74 74 SER HB3 H 3.911 . . 116 74 74 SER C C 174.839 . . 117 74 74 SER CA C 58.047 . . 118 74 74 SER CB C 61.595 . . 119 74 74 SER N N 121.344 . . 120 75 75 GLY H H 8.232 . . 121 75 75 GLY HA2 H 4.005 . . 122 75 75 GLY HA3 H 3.243 . . 123 75 75 GLY C C 172.483 . . 124 75 75 GLY CA C 44.600 . . 125 75 75 GLY N N 103.781 . . 126 76 76 ASN H H 7.737 . . 127 76 76 ASN HD21 H 6.912 . . 128 76 76 ASN HD22 H 7.547 . . 129 76 76 ASN C C 173.338 . . 130 76 76 ASN CA C 51.309 . . 131 76 76 ASN CB C 40.956 . . 132 76 76 ASN N N 116.547 . . 133 76 76 ASN ND2 N 114.425 . . 134 77 77 LEU H H 9.035 . . 135 77 77 LEU C C 175.588 . . 136 77 77 LEU CA C 53.980 . . 137 77 77 LEU CB C 41.931 . . 138 77 77 LEU N N 124.050 . . 139 78 78 ILE H H 8.941 . . 140 78 78 ILE C C 173.277 . . 141 78 78 ILE CA C 59.297 . . 142 78 78 ILE CB C 41.899 . . 143 78 78 ILE N N 120.518 . . 144 79 79 ALA H H 7.554 . . 145 79 79 ALA C C 177.159 . . 146 79 79 ALA CA C 49.931 . . 147 79 79 ALA CB C 20.675 . . 148 79 79 ALA N N 120.760 . . 149 80 80 VAL H H 8.923 . . 150 80 80 VAL C C 172.025 . . 151 80 80 VAL CA C 57.683 . . 152 80 80 VAL CB C 31.860 . . 153 80 80 VAL N N 118.828 . . 154 81 81 PRO C C 175.946 . . 155 81 81 PRO CA C 63.615 . . 156 82 82 ASP H H 8.321 . . 157 82 82 ASP C C 176.012 . . 158 82 82 ASP CA C 53.988 . . 159 82 82 ASP CB C 39.859 . . 160 82 82 ASP N N 122.129 . . 161 83 83 LYS H H 7.168 . . 162 83 83 LYS C C 178.027 . . 163 83 83 LYS CA C 52.805 . . 164 83 83 LYS CB C 36.144 . . 165 83 83 LYS N N 123.156 . . 166 84 84 ASN C C 175.156 . . 167 84 84 ASN CA C 55.696 . . 168 84 84 ASN CB C 38.145 . . 169 85 85 TYR H H 6.414 . . 170 85 85 TYR C C 173.140 . . 171 85 85 TYR CA C 55.582 . . 172 85 85 TYR CB C 36.379 . . 173 85 85 TYR N N 110.159 . . 174 86 86 ILE H H 7.331 . . 175 86 86 ILE C C 175.820 . . 176 86 86 ILE CA C 57.922 . . 177 86 86 ILE CB C 36.474 . . 178 86 86 ILE N N 123.489 . . 179 87 87 ARG H H 9.309 . . 180 87 87 ARG HB2 H 1.837 . . 181 87 87 ARG HB3 H 1.604 . . 182 87 87 ARG HD2 H 3.234 . . 183 87 87 ARG HD3 H 3.233 . . 184 87 87 ARG C C 173.074 . . 185 87 87 ARG CA C 52.016 . . 186 87 87 ARG CB C 30.256 . . 187 87 87 ARG CD C 43.512 . . 188 87 87 ARG N N 129.407 . . 189 88 88 PRO C C 176.331 . . 190 88 88 PRO CA C 62.036 . . 191 88 88 PRO CB C 32.785 . . 192 89 89 GLU H H 7.911 . . 193 89 89 GLU C C 175.421 . . 194 89 89 GLU CA C 56.030 . . 195 89 89 GLU CB C 28.949 . . 196 89 89 GLU N N 121.174 . . 197 90 90 ILE H H 7.732 . . 198 90 90 ILE C C 175.350 . . 199 90 90 ILE CA C 59.476 . . 200 90 90 ILE CB C 35.473 . . 201 90 90 ILE N N 126.509 . . 202 91 91 PHE H H 9.139 . . 203 91 91 PHE C C 174.626 . . 204 91 91 PHE CA C 56.964 . . 205 91 91 PHE CB C 39.422 . . 206 91 91 PHE N N 128.618 . . 207 92 92 PHE H H 8.903 . . 208 92 92 PHE C C 174.550 . . 209 92 92 PHE CA C 53.374 . . 210 92 92 PHE CB C 40.401 . . 211 92 92 PHE N N 118.932 . . 212 93 93 ALA H H 9.201 . . 213 93 93 ALA C C 177.038 . . 214 93 93 ALA CA C 49.902 . . 215 93 93 ALA CB C 22.184 . . 216 93 93 ALA N N 123.067 . . 217 94 94 LEU H H 8.711 . . 218 94 94 LEU HB2 H 1.720 . . 219 94 94 LEU HB3 H 1.190 . . 220 94 94 LEU C C 175.038 . . 221 94 94 LEU CA C 52.579 . . 222 94 94 LEU CB C 46.898 . . 223 94 94 LEU N N 124.048 . . 224 95 95 ALA H H 8.460 . . 225 95 95 ALA C C 176.994 . . 226 95 95 ALA CA C 53.124 . . 227 95 95 ALA CB C 18.592 . . 228 95 95 ALA N N 127.083 . . 229 96 96 SER H H 7.964 . . 230 96 96 SER C C 172.984 . . 231 96 96 SER CA C 56.221 . . 232 96 96 SER N N 116.677 . . 233 97 97 SER H H 8.266 . . 234 97 97 SER C C 173.263 . . 235 97 97 SER CA C 57.953 . . 236 97 97 SER CB C 64.768 . . 237 97 97 SER N N 115.930 . . 238 98 98 LEU H H 8.184 . . 239 98 98 LEU HB2 H 1.431 . . 240 98 98 LEU HB3 H 1.548 . . 241 98 98 LEU C C 177.080 . . 242 98 98 LEU CA C 53.717 . . 243 98 98 LEU CB C 44.741 . . 244 98 98 LEU N N 121.227 . . 245 99 99 SER H H 9.787 . . 246 99 99 SER HB2 H 3.952 . . 247 99 99 SER HB3 H 3.998 . . 248 99 99 SER C C 175.071 . . 249 99 99 SER CA C 60.623 . . 250 99 99 SER CB C 62.594 . . 251 99 99 SER N N 121.941 . . 252 100 100 SER H H 7.901 . . 253 100 100 SER C C 173.982 . . 254 100 100 SER CA C 57.087 . . 255 100 100 SER CB C 62.893 . . 256 100 100 SER N N 114.396 . . 257 101 101 ALA H H 7.794 . . 258 101 101 ALA HA H 4.374 . . 259 101 101 ALA HB H 1.520 . . 260 101 101 ALA C C 177.643 . . 261 101 101 ALA CA C 52.334 . . 262 101 101 ALA CB C 19.230 . . 263 101 101 ALA N N 124.419 . . 264 102 102 SER H H 7.987 . . 265 102 102 SER HB2 H 3.734 . . 266 102 102 SER HB3 H 3.755 . . 267 102 102 SER C C 175.764 . . 268 102 102 SER CA C 56.909 . . 269 102 102 SER CB C 63.579 . . 270 102 102 SER N N 115.956 . . 271 103 103 ALA H H 8.848 . . 272 103 103 ALA HA H 4.259 . . 273 103 103 ALA HB H 1.430 . . 274 103 103 ALA C C 178.961 . . 275 103 103 ALA CA C 54.322 . . 276 103 103 ALA CB C 18.125 . . 277 103 103 ALA N N 129.135 . . 278 104 104 GLU H H 8.843 . . 279 104 104 GLU HA H 4.165 . . 280 104 104 GLU C C 177.308 . . 281 104 104 GLU CA C 57.468 . . 282 104 104 GLU CB C 28.285 . . 283 104 104 GLU N N 116.481 . . 284 105 105 LYS H H 7.348 . . 285 105 105 LYS C C 175.218 . . 286 105 105 LYS CA C 56.221 . . 287 105 105 LYS CB C 31.641 . . 288 105 105 LYS N N 118.255 . . 289 106 106 GLY H H 7.294 . . 290 106 106 GLY C C 173.416 . . 291 106 106 GLY CA C 43.237 . . 292 106 106 GLY N N 102.674 . . 293 107 107 SER H H 8.442 . . 294 107 107 SER HB2 H 3.903 . . 295 107 107 SER HB3 H 4.170 . . 296 107 107 SER CA C 55.710 . . 297 107 107 SER CB C 64.383 . . 298 107 107 SER N N 117.016 . . 299 108 108 PRO C C 177.257 . . 300 108 108 PRO CA C 62.356 . . 301 108 108 PRO CB C 31.050 . . 302 109 109 ILE H H 9.739 . . 303 109 109 ILE C C 174.084 . . 304 109 109 ILE CA C 59.622 . . 305 109 109 ILE CB C 43.029 . . 306 109 109 ILE N N 121.711 . . 307 110 110 LEU H H 8.703 . . 308 110 110 LEU C C 176.610 . . 309 110 110 LEU CA C 53.379 . . 310 110 110 LEU CB C 44.824 . . 311 110 110 LEU N N 119.628 . . 312 111 111 LEU H H 10.596 . . 313 111 111 LEU C C 174.943 . . 314 111 111 LEU CA C 53.723 . . 315 111 111 LEU CB C 46.570 . . 316 111 111 LEU N N 122.817 . . 317 112 112 GLY H H 9.544 . . 318 112 112 GLY HA2 H 3.431 . . 319 112 112 GLY HA3 H 3.431 . . 320 112 112 GLY C C 172.372 . . 321 112 112 GLY CA C 44.125 . . 322 112 112 GLY N N 109.425 . . 323 113 113 VAL H H 8.838 . . 324 113 113 VAL C C 176.621 . . 325 113 113 VAL CA C 58.981 . . 326 113 113 VAL CB C 33.924 . . 327 113 113 VAL N N 111.876 . . 328 114 114 SER H H 9.565 . . 329 114 114 SER HB2 H 3.485 . . 330 114 114 SER HB3 H 4.323 . . 331 114 114 SER C C 176.532 . . 332 114 114 SER CA C 57.653 . . 333 114 114 SER CB C 62.092 . . 334 114 114 SER N N 119.647 . . 335 115 115 LYS H H 8.986 . . 336 115 115 LYS C C 176.498 . . 337 115 115 LYS CA C 56.793 . . 338 115 115 LYS CB C 29.050 . . 339 115 115 LYS N N 114.989 . . 340 116 116 GLY H H 7.248 . . 341 116 116 GLY C C 173.059 . . 342 116 116 GLY CA C 45.095 . . 343 116 116 GLY N N 104.121 . . 344 117 117 GLU H H 7.449 . . 345 117 117 GLU C C 174.964 . . 346 117 117 GLU CA C 56.596 . . 347 117 117 GLU CB C 29.897 . . 348 117 117 GLU N N 117.527 . . 349 118 118 PHE H H 7.649 . . 350 118 118 PHE C C 175.363 . . 351 118 118 PHE CA C 55.707 . . 352 118 118 PHE CB C 43.129 . . 353 118 118 PHE N N 113.436 . . 354 119 119 CYS H H 9.154 . . 355 119 119 CYS C C 174.485 . . 356 119 119 CYS CA C 57.948 . . 357 119 119 CYS CB C 32.401 . . 358 119 119 CYS N N 116.026 . . 359 120 120 LEU H H 8.664 . . 360 120 120 LEU C C 175.493 . . 361 120 120 LEU CA C 56.978 . . 362 120 120 LEU CB C 42.852 . . 363 120 120 LEU N N 124.894 . . 364 121 121 TYR H H 8.759 . . 365 121 121 TYR C C 173.073 . . 366 121 121 TYR CA C 56.307 . . 367 121 121 TYR CB C 41.871 . . 368 121 121 TYR N N 119.175 . . 369 122 122 CYS H H 8.176 . . 370 122 122 CYS C C 171.525 . . 371 122 122 CYS CA C 56.312 . . 372 122 122 CYS CB C 28.419 . . 373 122 122 CYS N N 125.901 . . 374 123 123 ASP H H 7.768 . . 375 123 123 ASP HB2 H 2.564 . . 376 123 123 ASP HB3 H 2.221 . . 377 123 123 ASP C C 174.295 . . 378 123 123 ASP CA C 51.688 . . 379 123 123 ASP CB C 44.073 . . 380 123 123 ASP N N 121.191 . . 381 124 124 LYS H H 8.378 . . 382 124 124 LYS C C 174.983 . . 383 124 124 LYS CA C 54.920 . . 384 124 124 LYS CB C 33.744 . . 385 124 124 LYS N N 120.172 . . 386 125 125 ASP H H 8.600 . . 387 125 125 ASP HB2 H 2.575 . . 388 125 125 ASP HB3 H 2.422 . . 389 125 125 ASP C C 176.185 . . 390 125 125 ASP CA C 53.074 . . 391 125 125 ASP CB C 41.695 . . 392 125 125 ASP N N 126.174 . . 393 126 126 LYS H H 8.536 . . 394 126 126 LYS C C 177.772 . . 395 126 126 LYS CA C 57.702 . . 396 126 126 LYS CB C 31.203 . . 397 126 126 LYS N N 120.837 . . 398 127 127 GLY H H 8.711 . . 399 127 127 GLY HA2 H 3.738 . . 400 127 127 GLY HA3 H 4.032 . . 401 127 127 GLY C C 174.383 . . 402 127 127 GLY CA C 45.128 . . 403 127 127 GLY N N 111.304 . . 404 128 128 GLN H H 7.806 . . 405 128 128 GLN HB2 H 1.946 . . 406 128 128 GLN HB3 H 1.946 . . 407 128 128 GLN HG2 H 2.325 . . 408 128 128 GLN HG3 H 2.204 . . 409 128 128 GLN HE21 H 6.813 . . 410 128 128 GLN HE22 H 7.566 . . 411 128 128 GLN C C 176.270 . . 412 128 128 GLN CA C 54.475 . . 413 128 128 GLN CB C 29.243 . . 414 128 128 GLN CG C 33.456 . . 415 128 128 GLN N N 118.845 . . 416 128 128 GLN NE2 N 112.938 . . 417 129 129 SER CA C 59.208 . . 418 129 129 SER CB C 63.910 . . 419 130 130 HIS H H 7.483 . . 420 130 130 HIS HB2 H 2.760 . . 421 130 130 HIS HB3 H 2.991 . . 422 130 130 HIS CA C 51.854 . . 423 130 130 HIS CB C 29.778 . . 424 130 130 HIS N N 117.329 . . 425 131 131 PRO C C 173.248 . . 426 131 131 PRO CA C 61.516 . . 427 131 131 PRO CB C 31.334 . . 428 132 132 SER H H 8.073 . . 429 132 132 SER HB2 H 3.777 . . 430 132 132 SER HB3 H 3.811 . . 431 132 132 SER C C 172.209 . . 432 132 132 SER CA C 56.417 . . 433 132 132 SER CB C 65.977 . . 434 132 132 SER N N 112.649 . . 435 133 133 LEU H H 8.947 . . 436 133 133 LEU C C 176.159 . . 437 133 133 LEU CA C 53.453 . . 438 133 133 LEU CB C 43.275 . . 439 133 133 LEU N N 124.385 . . 440 134 134 GLN H H 9.430 . . 441 134 134 GLN HE21 H 6.945 . . 442 134 134 GLN HE22 H 7.278 . . 443 134 134 GLN C C 173.279 . . 444 134 134 GLN CA C 53.722 . . 445 134 134 GLN CB C 33.370 . . 446 134 134 GLN N N 125.858 . . 447 134 134 GLN NE2 N 112.194 . . 448 135 135 LEU H H 8.579 . . 449 135 135 LEU C C 177.007 . . 450 135 135 LEU CA C 53.499 . . 451 135 135 LEU CB C 42.963 . . 452 135 135 LEU N N 119.209 . . 453 136 136 LYS H H 8.929 . . 454 136 136 LYS C C 175.804 . . 455 136 136 LYS CA C 53.505 . . 456 136 136 LYS CB C 35.136 . . 457 136 136 LYS N N 122.328 . . 458 137 137 LYS H H 8.999 . . 459 137 137 LYS HB2 H 1.796 . . 460 137 137 LYS HB3 H 1.328 . . 461 137 137 LYS C C 173.695 . . 462 137 137 LYS CA C 56.182 . . 463 137 137 LYS CB C 30.116 . . 464 137 137 LYS N N 127.217 . . 465 138 138 GLU H H 7.642 . . 466 138 138 GLU C C 172.931 . . 467 138 138 GLU CA C 54.409 . . 468 138 138 GLU CB C 31.989 . . 469 138 138 GLU N N 131.298 . . 470 139 139 LYS H H 8.357 . . 471 139 139 LYS HB2 H 1.533 . . 472 139 139 LYS HB3 H 1.533 . . 473 139 139 LYS C C 178.138 . . 474 139 139 LYS CA C 55.573 . . 475 139 139 LYS CB C 32.436 . . 476 139 139 LYS N N 122.093 . . 477 140 140 LEU H H 8.476 . . 478 140 140 LEU HA H 3.921 . . 479 140 140 LEU C C 177.260 . . 480 140 140 LEU CA C 58.456 . . 481 140 140 LEU CB C 42.611 . . 482 140 140 LEU N N 128.082 . . 483 141 141 MET H H 8.455 . . 484 141 141 MET HA H 4.123 . . 485 141 141 MET C C 178.745 . . 486 141 141 MET CA C 56.779 . . 487 141 141 MET CB C 30.201 . . 488 141 141 MET N N 110.731 . . 489 142 142 LYS H H 6.940 . . 490 142 142 LYS HA H 4.129 . . 491 142 142 LYS C C 179.397 . . 492 142 142 LYS CA C 57.588 . . 493 142 142 LYS CB C 31.947 . . 494 142 142 LYS N N 118.101 . . 495 143 143 LEU H H 8.228 . . 496 143 143 LEU C C 178.984 . . 497 143 143 LEU CA C 57.164 . . 498 143 143 LEU CB C 41.211 . . 499 143 143 LEU N N 123.620 . . 500 144 144 ALA H H 7.704 . . 501 144 144 ALA C C 177.987 . . 502 144 144 ALA CA C 54.034 . . 503 144 144 ALA CB C 18.174 . . 504 144 144 ALA N N 116.052 . . 505 145 145 ALA H H 6.944 . . 506 145 145 ALA HA H 4.384 . . 507 145 145 ALA HB H 1.408 . . 508 145 145 ALA C C 177.940 . . 509 145 145 ALA CA C 51.449 . . 510 145 145 ALA CB C 18.927 . . 511 145 145 ALA N N 116.237 . . 512 146 146 GLN H H 7.515 . . 513 146 146 GLN HB2 H 2.025 . . 514 146 146 GLN HB3 H 2.025 . . 515 146 146 GLN HG2 H 2.505 . . 516 146 146 GLN HG3 H 2.502 . . 517 146 146 GLN HE21 H 6.782 . . 518 146 146 GLN HE22 H 6.929 . . 519 146 146 GLN C C 175.991 . . 520 146 146 GLN CA C 55.295 . . 521 146 146 GLN CB C 28.981 . . 522 146 146 GLN CG C 33.833 . . 523 146 146 GLN N N 117.990 . . 524 146 146 GLN NE2 N 111.705 . . 525 147 147 LYS H H 8.554 . . 526 147 147 LYS C C 177.375 . . 527 147 147 LYS CA C 56.091 . . 528 147 147 LYS CB C 32.403 . . 529 147 147 LYS N N 119.750 . . 530 148 148 GLU C C 177.710 . . 531 148 148 GLU CA C 60.933 . . 532 148 148 GLU CB C 29.355 . . 533 149 149 SER H H 8.632 . . 534 149 149 SER C C 175.989 . . 535 149 149 SER CA C 60.814 . . 536 149 149 SER CB C 61.835 . . 537 149 149 SER N N 111.378 . . 538 150 150 ALA H H 7.013 . . 539 150 150 ALA C C 178.964 . . 540 150 150 ALA CA C 53.027 . . 541 150 150 ALA CB C 18.928 . . 542 150 150 ALA N N 123.000 . . 543 151 151 ARG H H 7.677 . . 544 151 151 ARG C C 177.667 . . 545 151 151 ARG CA C 57.950 . . 546 151 151 ARG CB C 32.003 . . 547 151 151 ARG N N 113.723 . . 548 152 152 ARG H H 7.932 . . 549 152 152 ARG CA C 62.484 . . 550 152 152 ARG CB C 27.363 . . 551 152 152 ARG N N 118.347 . . 552 153 153 PRO CA C 65.139 . . 553 153 153 PRO CB C 30.135 . . 554 154 154 PHE H H 8.279 . . 555 154 154 PHE C C 174.458 . . 556 154 154 PHE CA C 57.052 . . 557 154 154 PHE CB C 39.468 . . 558 154 154 PHE N N 116.694 . . 559 155 155 ILE H H 7.506 . . 560 155 155 ILE C C 175.742 . . 561 155 155 ILE CA C 60.102 . . 562 155 155 ILE CB C 36.556 . . 563 155 155 ILE N N 118.282 . . 564 156 156 PHE H H 9.311 . . 565 156 156 PHE C C 174.721 . . 566 156 156 PHE CA C 55.607 . . 567 156 156 PHE CB C 42.196 . . 568 156 156 PHE N N 127.085 . . 569 157 157 TYR H H 10.228 . . 570 157 157 TYR C C 175.721 . . 571 157 157 TYR CA C 57.540 . . 572 157 157 TYR CB C 38.988 . . 573 157 157 TYR N N 120.950 . . 574 158 158 ARG H H 9.226 . . 575 158 158 ARG C C 175.002 . . 576 158 158 ARG CA C 54.577 . . 577 158 158 ARG CB C 30.186 . . 578 158 158 ARG N N 124.200 . . 579 159 159 ALA H H 9.209 . . 580 159 159 ALA C C 176.219 . . 581 159 159 ALA CA C 50.676 . . 582 159 159 ALA CB C 20.333 . . 583 159 159 ALA N N 135.109 . . 584 160 160 GLN H H 8.739 . . 585 160 160 GLN HB2 H 1.866 . . 586 160 160 GLN HB3 H 1.990 . . 587 160 160 GLN HE21 H 6.719 . . 588 160 160 GLN HE22 H 7.390 . . 589 160 160 GLN C C 175.653 . . 590 160 160 GLN CA C 55.404 . . 591 160 160 GLN CB C 30.023 . . 592 160 160 GLN N N 122.481 . . 593 160 160 GLN NE2 N 111.281 . . 594 161 161 VAL H H 8.338 . . 595 161 161 VAL C C 175.888 . . 596 161 161 VAL CA C 60.016 . . 597 161 161 VAL CB C 32.367 . . 598 161 161 VAL N N 126.017 . . 599 162 162 GLY H H 8.780 . . 600 162 162 GLY C C 175.554 . . 601 162 162 GLY CA C 46.505 . . 602 162 162 GLY N N 116.423 . . 603 163 163 SER H H 8.313 . . 604 163 163 SER HB2 H 3.396 . . 605 163 163 SER HB3 H 3.017 . . 606 163 163 SER C C 172.843 . . 607 163 163 SER CA C 58.416 . . 608 163 163 SER CB C 62.774 . . 609 163 163 SER N N 123.000 . . 610 164 164 TRP H H 8.028 . . 611 164 164 TRP HE1 H 9.911 . . 612 164 164 TRP C C 175.124 . . 613 164 164 TRP CA C 55.438 . . 614 164 164 TRP CB C 31.841 . . 615 164 164 TRP N N 121.651 . . 616 164 164 TRP NE1 N 129.006 . . 617 165 165 ASN H H 9.232 . . 618 165 165 ASN C C 173.829 . . 619 165 165 ASN CA C 52.579 . . 620 165 165 ASN CB C 43.805 . . 621 165 165 ASN N N 118.200 . . 622 166 166 MET H H 9.160 . . 623 166 166 MET C C 175.162 . . 624 166 166 MET CA C 54.299 . . 625 166 166 MET CB C 36.559 . . 626 166 166 MET N N 120.090 . . 627 167 167 LEU H H 10.097 . . 628 167 167 LEU C C 173.895 . . 629 167 167 LEU CA C 52.992 . . 630 167 167 LEU CB C 45.189 . . 631 167 167 LEU N N 122.655 . . 632 168 168 GLU H H 9.050 . . 633 168 168 GLU HB2 H 2.071 . . 634 168 168 GLU HB3 H 2.153 . . 635 168 168 GLU HG2 H 1.133 . . 636 168 168 GLU HG3 H 2.182 . . 637 168 168 GLU C C 177.030 . . 638 168 168 GLU CA C 53.216 . . 639 168 168 GLU CB C 32.821 . . 640 168 168 GLU CG C 34.538 . . 641 168 168 GLU N N 125.369 . . 642 169 169 SER H H 9.035 . . 643 169 169 SER C C 175.043 . . 644 169 169 SER CA C 58.763 . . 645 169 169 SER CB C 63.212 . . 646 169 169 SER N N 120.492 . . 647 170 170 ALA H H 7.915 . . 648 170 170 ALA C C 179.430 . . 649 170 170 ALA CA C 52.994 . . 650 170 170 ALA CB C 17.944 . . 651 170 170 ALA N N 126.629 . . 652 171 171 ALA H H 7.218 . . 653 171 171 ALA C C 176.591 . . 654 171 171 ALA CA C 53.062 . . 655 171 171 ALA CB C 18.850 . . 656 171 171 ALA N N 118.318 . . 657 172 172 HIS H H 7.493 . . 658 172 172 HIS C C 169.769 . . 659 172 172 HIS CA C 53.117 . . 660 172 172 HIS CB C 30.619 . . 661 172 172 HIS N N 116.735 . . 662 173 173 PRO C C 178.761 . . 663 173 173 PRO CA C 63.013 . . 664 173 173 PRO CB C 31.203 . . 665 174 174 GLY H H 10.463 . . 666 174 174 GLY HA2 H 3.418 . . 667 174 174 GLY HA3 H 3.418 . . 668 174 174 GLY C C 172.639 . . 669 174 174 GLY CA C 44.050 . . 670 174 174 GLY N N 112.825 . . 671 175 175 TRP H H 7.770 . . 672 175 175 TRP HE1 H 10.035 . . 673 175 175 TRP C C 174.464 . . 674 175 175 TRP CA C 56.396 . . 675 175 175 TRP CB C 27.730 . . 676 175 175 TRP N N 119.518 . . 677 175 175 TRP NE1 N 128.551 . . 678 176 176 PHE H H 9.394 . . 679 176 176 PHE C C 177.311 . . 680 176 176 PHE CA C 55.930 . . 681 176 176 PHE CB C 41.546 . . 682 176 176 PHE N N 121.923 . . 683 177 177 ILE H H 8.884 . . 684 177 177 ILE C C 175.320 . . 685 177 177 ILE CA C 63.168 . . 686 177 177 ILE CB C 36.518 . . 687 177 177 ILE N N 122.085 . . 688 178 178 CYS H H 8.917 . . 689 178 178 CYS HB2 H 2.916 . . 690 178 178 CYS HB3 H 2.634 . . 691 178 178 CYS C C 174.485 . . 692 178 178 CYS CA C 54.728 . . 693 178 178 CYS CB C 33.338 . . 694 178 178 CYS N N 121.484 . . 695 179 179 THR H H 9.058 . . 696 179 179 THR C C 174.383 . . 697 179 179 THR CA C 59.363 . . 698 179 179 THR CB C 70.308 . . 699 179 179 THR N N 112.383 . . 700 180 180 SER H H 8.970 . . 701 180 180 SER C C 174.877 . . 702 180 180 SER CA C 56.331 . . 703 180 180 SER CB C 63.674 . . 704 180 180 SER N N 113.451 . . 705 181 181 CYS H H 8.272 . . 706 181 181 CYS C C 175.041 . . 707 181 181 CYS CA C 59.589 . . 708 181 181 CYS CB C 27.447 . . 709 181 181 CYS N N 119.844 . . 710 182 182 ASN H H 8.494 . . 711 182 182 ASN HD21 H 7.741 . . 712 182 182 ASN HD22 H 6.935 . . 713 182 182 ASN C C 175.465 . . 714 182 182 ASN CA C 51.656 . . 715 182 182 ASN CB C 39.361 . . 716 182 182 ASN N N 119.345 . . 717 182 182 ASN ND2 N 114.345 . . 718 183 183 CYS C C 173.567 . . 719 183 183 CYS CA C 59.982 . . 720 183 183 CYS CB C 28.189 . . 721 184 184 ASN H H 8.367 . . 722 184 184 ASN C C 173.413 . . 723 184 184 ASN CA C 54.517 . . 724 184 184 ASN CB C 36.502 . . 725 184 184 ASN N N 114.721 . . 726 185 185 GLU H H 8.161 . . 727 185 185 GLU C C 173.784 . . 728 185 185 GLU CA C 53.859 . . 729 185 185 GLU CB C 30.222 . . 730 185 185 GLU N N 119.456 . . 731 186 186 PRO C C 177.961 . . 732 186 186 PRO CA C 62.356 . . 733 186 186 PRO CB C 32.167 . . 734 187 187 VAL H H 8.316 . . 735 187 187 VAL C C 175.566 . . 736 187 187 VAL CA C 62.909 . . 737 187 187 VAL CB C 31.594 . . 738 187 187 VAL N N 124.486 . . 739 188 188 GLY H H 8.389 . . 740 188 188 GLY C C 172.921 . . 741 188 188 GLY CA C 45.029 . . 742 188 188 GLY N N 116.545 . . 743 189 189 VAL H H 8.078 . . 744 189 189 VAL C C 176.274 . . 745 189 189 VAL CA C 58.867 . . 746 189 189 VAL CB C 36.485 . . 747 189 189 VAL N N 110.751 . . 748 190 190 THR H H 9.489 . . 749 190 190 THR C C 170.133 . . 750 190 190 THR CA C 60.183 . . 751 190 190 THR CB C 70.085 . . 752 190 190 THR N N 115.468 . . 753 191 191 ASP H H 7.503 . . 754 191 191 ASP HA H 4.368 . . 755 191 191 ASP C C 176.889 . . 756 191 191 ASP CA C 51.526 . . 757 191 191 ASP CB C 38.525 . . 758 191 191 ASP N N 124.608 . . 759 192 192 LYS H H 8.083 . . 760 192 192 LYS C C 175.616 . . 761 192 192 LYS CA C 54.306 . . 762 192 192 LYS CB C 32.109 . . 763 192 192 LYS N N 122.569 . . 764 193 193 PHE H H 7.828 . . 765 193 193 PHE C C 175.275 . . 766 193 193 PHE CA C 56.235 . . 767 193 193 PHE CB C 38.049 . . 768 193 193 PHE N N 121.485 . . 769 194 194 GLU H H 8.261 . . 770 194 194 GLU C C 176.969 . . 771 194 194 GLU CA C 57.443 . . 772 194 194 GLU CB C 28.902 . . 773 194 194 GLU N N 119.015 . . 774 195 195 ASN H H 7.967 . . 775 195 195 ASN C C 176.015 . . 776 195 195 ASN CA C 51.826 . . 777 195 195 ASN CB C 37.443 . . 778 195 195 ASN N N 118.269 . . 779 199 199 ILE C C 173.250 . . 780 199 199 ILE CA C 59.755 . . 781 199 199 ILE CB C 39.568 . . 782 200 200 GLU H H 6.333 . . 783 200 200 GLU C C 175.288 . . 784 200 200 GLU CA C 54.464 . . 785 200 200 GLU CB C 30.037 . . 786 200 200 GLU N N 118.997 . . 787 201 201 PHE H H 9.246 . . 788 201 201 PHE HB2 H 3.134 . . 789 201 201 PHE HB3 H 3.134 . . 790 201 201 PHE C C 177.714 . . 791 201 201 PHE CA C 56.477 . . 792 201 201 PHE CB C 43.310 . . 793 201 201 PHE N N 118.299 . . 794 202 202 SER H H 9.916 . . 795 202 202 SER HB2 H 3.591 . . 796 202 202 SER HB3 H 3.666 . . 797 202 202 SER C C 174.023 . . 798 202 202 SER CA C 56.536 . . 799 202 202 SER CB C 63.958 . . 800 202 202 SER N N 118.566 . . 801 203 203 PHE H H 8.635 . . 802 203 203 PHE C C 175.753 . . 803 203 203 PHE CA C 51.817 . . 804 203 203 PHE CB C 37.261 . . 805 203 203 PHE N N 127.214 . . 806 204 204 GLN H H 9.040 . . 807 204 204 GLN HB2 H 1.983 . . 808 204 204 GLN HB3 H 2.188 . . 809 204 204 GLN HG2 H 2.163 . . 810 204 204 GLN HG3 H 2.073 . . 811 204 204 GLN CA C 52.464 . . 812 204 204 GLN CB C 28.524 . . 813 204 204 GLN CG C 32.976 . . 814 204 204 GLN N N 125.645 . . 815 205 205 PRO C C 176.577 . . 816 205 205 PRO CA C 62.763 . . 817 205 205 PRO CB C 32.394 . . 818 206 206 VAL H H 7.638 . . 819 206 206 VAL HA H 4.132 . . 820 206 206 VAL HB H 2.003 . . 821 206 206 VAL HG1 H 0.818 . . 822 206 206 VAL HG2 H 0.826 . . 823 206 206 VAL C C 180.789 . . 824 206 206 VAL CA C 63.000 . . 825 206 206 VAL CB C 32.876 . . 826 206 206 VAL CG1 C 20.556 . . 827 206 206 VAL CG2 C 20.367 . . 828 206 206 VAL N N 124.037 . . stop_ save_