BMRB Entry 7420

Name: STRUCTURE OF CCP MODULE 7 OF COMPLEMENT FACTOR H- THE AMD AT RISK VARIENT (402H)
Published: 2008-08-08

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PDB ID: 2jgw
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR7420
MolProbity Validation Chart

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Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

STRUCTURE OF CCP MODULE 7 OF COMPLEMENT FACTOR H- THE AMD AT RISK VARIENT (402H)

Deposition date:

2008-03-06

Original release date:

2008-08-08

Authors:

Herbert, A.; Deakin, J.; Schmidt, C.; Blaum, B.; Egan, C.; Ferreira, V.; Pangburn, M.; Lyon, M.; Uhrin, D.; Barlow, P.

Citation:

Citation: Herbert, A.; Deakin, J.; Schmidt, C.; Blaum, B.; Egan, C.; Ferreira, V.; Pangburn, M.; Lyon, M.; Uhrin, D.; Barlow, P.. "Structure Shows Glycosaminoglycan- and Protein-Recognition Site in Factor H is Perturbed by Age-Related Macular Degeneration-Linked single nucleotide polymorphism" J. Biol. Chem. 282, 18960-18968 (2007).
PubMed: 17360715

Assembly members:

Assembly members:
COMPLEMENT_FACTOR_H, polymer, 65 residues, Formula weight is not available

Natural source:

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology Host organism: PICHIA PASTORIS Vector: PPICZALPHAB

Entity Sequences (FASTA):

Entity Sequences (FASTA):
COMPLEMENT_FACTOR_H: EAAGLRKCYFPYLENGYNQN HGRKFVQGKSIDVACHPGYA LPKAQTTVTCMENGWSPTPR CIRVK

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list_1

Data type	Count
13C chemical shifts	275
15N chemical shifts	68
1H chemical shifts	439

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	COMPLEMENT FACTOR H	1

Entities:

Entity 1, COMPLEMENT FACTOR H 65 residues - Formula weight is not available

1

GLU

ALA

GLY

LEU

ARG

LYS

CYS

TYR

PHE

2

PRO

TYR

LEU

GLU

ASN

GLY

TYR

ASN

GLN

ASN

3

HIS

GLY

ARG

LYS

PHE

VAL

GLN

GLY

LYS

SER

4

ILE

ASP

VAL

ALA

CYS

HIS

PRO

GLY

TYR

ALA

5

LEU

PRO

LYS

ALA

GLN

THR

VAL

THR

CYS

6

MET

GLU

ASN

GLY

TRP

SER

PRO

THR

PRO

ARG

7

CYS

ILE

ARG

VAL

LYS

Samples:

sample: COMPLEMENT FACTOR H mM

sample_conditions_1: ionic strength: 20 mM; pH: 5.2; pressure: 1.0 atm; temperature: 298.0 K

Experiments:

Name	Sample	Sample state	Sample conditions
CBCACONH	sample	isotropic	sample_conditions_1
CBCANH	sample	isotropic	sample_conditions_1
H_CCONH TOCSY	sample	isotropic	sample_conditions_1
HCCH TOCSY	sample	isotropic	sample_conditions_1
HNCO	sample	isotropic	sample_conditions_1
15N EDITED TOCSY HSQC	sample	isotropic	sample_conditions_1
HBHACONH	sample	isotropic	sample_conditions_1
HBHANH	sample	isotropic	sample_conditions_1
C_CCONH TOCSY	sample	isotropic	sample_conditions_1
HBCBCGCDCEHE	sample	isotropic	sample_conditions_1
HBCBCGCDHD	sample	isotropic	sample_conditions_1

Software:

CNS v1.1, BRUNGER,ADAMS,CLORE,DELANO,GROS, GROSSE-KUNSTLEVE,JIANG,KUSZEWSKI,NILGES, PANNU,READ,RICE,SIMONSON,WARREN - refinement

ANALYSIS vANALYSIS - structure solution

NMR spectrometers:

BRUKER OTHER 600 MHz

BMRB	7421
PDB	2IC4 2JGW 2JGX 2UWN 2V8E 2W80 2W81 4AYD 4AYE 4AYI 4AYM
EMBL	CAA30403 CAB41739
GB	AAA52013 AAH37285 AAI10644 ADZ15369 AHH32464
REF	NP_001014975 XP_004028137