BMRB Entry 7419

Name: SOLUTION STRUCTURE OF AMINO TERMINAL DOMAIN OF HUMAN DNA POLYMERASE EPSILON SUBUNIT B REVEALS ITS HOMOLOGY TO C-DOMAINS OF AAA PROTEINS.
Published: 2008-08-22

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PDB ID: 2v6z
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS, SPARTA
BMRB Entry DOI: doi:10.13018/BMR7419
MolProbity Validation Chart

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Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

SOLUTION STRUCTURE OF AMINO TERMINAL DOMAIN OF HUMAN DNA POLYMERASE EPSILON SUBUNIT B REVEALS ITS HOMOLOGY TO C-DOMAINS OF AAA PROTEINS.

Deposition date:

2008-03-06

Original release date:

2008-08-22

Authors:

Nuutinen, T.; Fredriksson, K.; Tossavainen, H.; Pospiech, H.; Pirila, P.; Permi, P.; Annila, A.; Syvaoja, J.

Citation:

Citation: Nuutinen, Tarmo; Tossavainen, Helena; Fredriksson, Kai; Pirila, Paivi; Permi, Perttu; Pospiech, Helmut; Syvaoja, Juhani. "The solution structure of the amino-terminal domain of human DNA polymerase epsilon subunit B is homologous to C-domains of AAA+ proteins" Nucleic Acids Res. 36, 5102-5110 (2008).
PubMed: 18676977

Assembly members:

Assembly members:
AAA_protein, polymer, 99 residues, Formula weight is not available

Natural source:

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology

Entity Sequences (FASTA):

Entity Sequences (FASTA):
AAA_protein: MGSSHHHHHHSQDPNSSSAR LQVDMAPERLRSRALSAFKL RGLLLRGEAIKYLTEALQSI SELELEDKLEKIINAVEKQP LSSNMIERSVVEAAVQESS

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list_1

Data type	Count
13C chemical shifts	386
15N chemical shifts	90
1H chemical shifts	646

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	AAA_protein	1

Entities:

Entity 1, AAA_protein 99 residues - Formula weight is not available

1

MET

GLY

SER

HIS

2

SER

GLN

ASP

PRO

ASN

SER

ALA

ARG

3

LEU

GLN

VAL

ASP

MET

ALA

PRO

GLU

ARG

LEU

4

ARG

SER

ARG

ALA

LEU

SER

ALA

PHE

LYS

LEU

5

ARG

GLY

LEU

ARG

GLY

GLU

ALA

ILE

6

LYS

TYR

LEU

THR

GLU

ALA

LEU

GLN

SER

ILE

7

SER

GLU

LEU

GLU

LEU

GLU

ASP

LYS

LEU

GLU

8

LYS

ILE

ASN

ALA

VAL

GLU

LYS

GLN

PRO

9

LEU

SER

ASN

MET

ILE

GLU

ARG

SER

VAL

10

VAL

GLU

ALA

VAL

GLN

GLU

SER

Samples:

sample: entity_1 mM

sample_conditions_1: pH: 6.62; pressure: 1.0 atm; temperature: 298.0 K

Experiments:

Name	Sample	Sample state	Sample conditions
HNCA	sample	isotropic	sample_conditions_1
HNCACB	sample	isotropic	sample_conditions_1
HNCOCACB	sample	isotropic	sample_conditions_1
HNCO	sample	isotropic	sample_conditions_1
HCCONH	sample	isotropic	sample_conditions_1
CCCONH	sample	isotropic	sample_conditions_1
HCCH-COSY	sample	isotropic	sample_conditions_1
NOESY-HSQC	sample	isotropic	sample_conditions_1

Software:

CYANA - structure solution

AMBER v8 - structure solution

ProcheckNMR vNMR - structure solution

NMR spectrometers:

VARIAN UNITYINOVA 800 MHz

PDB	2V6Z
DBJ	BAG56707 BAJ21084
GB	AAC39610 AAC51920 AAI12963 AAI26219 AAI26221
REF	NP_001184259 NP_001184260 NP_002683 XP_003267698 XP_003267699
SP	P56282
AlphaFold	P56282