BMRB Entry 6570

Name: NMR Assignments of the F-actin binding domain of human Bcr-Abl/c-Abl
Published: 2005-10-24

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PDB ID: 1zzp
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR6570
MolProbity Validation Chart

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Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

NMR Assignments of the F-actin binding domain of human Bcr-Abl/c-Abl

Deposition date:

2005-03-24

Original release date:

2005-10-24

Authors:

Wiesner, Silke; Hantschel, Oliver; Mackereth, Cameron; Superti-Furga, Giulio; Sattler, Michael

Citation:

Citation: Wiesner, Silke; Hantschel, Oliver; Mackereth, Cameron; Superti-Furga, Giulio; Sattler, Michael. "NMR Assignment Reveals an alpha-Helical Fold for the F-Actin Binding Domain of Human Bcr-Abl/c-Abl" J. Biomol. NMR 32, 335-335 (2005).
PubMed: 16211486

Assembly members:

Assembly members:
F-actin binding domain of cellular Abelson tyrosine kinase, polymer, 130 residues, 10251 Da.

Natural source:

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pETM30 (modified pET24d)

Entity Sequences (FASTA):

Entity Sequences (FASTA):
F-actin binding domain of cellular Abelson tyrosine kinase: GAMASTRVSLRKTRQPPERI ASGAITKGVVLDSTEALCLA ISRNSEQMASHSAVLEAGKN LYSFCVSYVDSIQQMRNKFA FREAINKLENNLRELQICPA TAGSGPAATQDFSKLLSSVK EISDIVQRLE

Data sets:

assigned_chemical_shifts
- ChemShifts

Data type	Count
1H chemical shifts	763
13C chemical shifts	499
15N chemical shifts	137

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	c-Abl, FABD	1

Entities:

Entity 1, c-Abl, FABD 130 residues - 10251 Da.

1	GLY	ALA	MET	ALA	SER	THR	ARG	VAL	SER	LEU
2	ARG	LYS	THR	ARG	GLN	PRO	PRO	GLU	ARG	ILE
3	ALA	SER	GLY	ALA	ILE	THR	LYS	GLY	VAL	VAL
4	LEU	ASP	SER	THR	GLU	ALA	LEU	CYS	LEU	ALA
5	ILE	SER	ARG	ASN	SER	GLU	GLN	MET	ALA	SER
6	HIS	SER	ALA	VAL	LEU	GLU	ALA	GLY	LYS	ASN
7	LEU	TYR	SER	PHE	CYS	VAL	SER	TYR	VAL	ASP
8	SER	ILE	GLN	GLN	MET	ARG	ASN	LYS	PHE	ALA
9	PHE	ARG	GLU	ALA	ILE	ASN	LYS	LEU	GLU	ASN
10	ASN	LEU	ARG	GLU	LEU	GLN	ILE	CYS	PRO	ALA
11	THR	ALA	GLY	SER	GLY	PRO	ALA	ALA	THR	GLN
12	ASP	PHE	SER	LYS	LEU	LEU	SER	SER	VAL	LYS
13	GLU	ILE	SER	ASP	ILE	VAL	GLN	ARG	LEU	GLU

Name	Sample	Sample state	Sample conditions
HN-HSQC	not available	not available	not available
HNCA	not available	not available	not available
CBCANH	not available	not available	not available
CBCA(CO)NH	not available	not available	not available
HNHA-J	not available	not available	not available
HNCO	not available	not available	not available
CBCACO(N)H	not available	not available	not available
HN-HSQC-NOESY-(H)C-HMQC	not available	not available	not available
HC-HSQC	not available	not available	not available
H(CCO)NH	not available	not available	not available
(H)C(CO)NH	not available	not available	not available
HC(C)H-TOCSY	not available	not available	not available
13C-HMQC-NOESY	not available	not available	not available
15N-HSQC-NOESY	not available	not available	not available

PDB	1ZZP
DBJ	BAD92693 BAD92879 BAG10808 BAG58052
EMBL	CAA34438
GB	AAB60393 AAB60394 AAI07070 AAI07071 AAI17452
REF	NP_005148 NP_009297 XP_001118598 XP_001166213 XP_003276793
SP	P00519
AlphaFold	P00519

BMRB Entry 6570

Additional metadata:

Assembly:

Entities:

Samples:

Experiments:

Software:

NMR spectrometers:

Related Database Links:

1	GLY	ALA	MET	ALA	SER	THR	ARG	VAL	SER	LEU
2	ARG	LYS	THR	ARG	GLN	PRO	PRO	GLU	ARG	ILE
3	ALA	SER	GLY	ALA	ILE	THR	LYS	GLY	VAL	VAL
4	LEU	ASP	SER	THR	GLU	ALA	LEU	CYS	LEU	ALA
5	ILE	SER	ARG	ASN	SER	GLU	GLN	MET	ALA	SER
6	HIS	SER	ALA	VAL	LEU	GLU	ALA	GLY	LYS	ASN
7	LEU	TYR	SER	PHE	CYS	VAL	SER	TYR	VAL	ASP
8	SER	ILE	GLN	GLN	MET	ARG	ASN	LYS	PHE	ALA
9	PHE	ARG	GLU	ALA	ILE	ASN	LYS	LEU	GLU	ASN
10	ASN	LEU	ARG	GLU	LEU	GLN	ILE	CYS	PRO	ALA
11	THR	ALA	GLY	SER	GLY	PRO	ALA	ALA	THR	GLN
12	ASP	PHE	SER	LYS	LEU	LEU	SER	SER	VAL	LYS
13	GLU	ILE	SER	ASP	ILE	VAL	GLN	ARG	LEU	GLU

1	GLY	ALA	MET	ALA	SER	THR	ARG	VAL	SER	LEU
2	ARG	LYS	THR	ARG	GLN	PRO	PRO	GLU	ARG	ILE
3	ALA	SER	GLY	ALA	ILE	THR	LYS	GLY	VAL	VAL
4	LEU	ASP	SER	THR	GLU	ALA	LEU	CYS	LEU	ALA
5	ILE	SER	ARG	ASN	SER	GLU	GLN	MET	ALA	SER
6	HIS	SER	ALA	VAL	LEU	GLU	ALA	GLY	LYS	ASN
7	LEU	TYR	SER	PHE	CYS	VAL	SER	TYR	VAL	ASP
8	SER	ILE	GLN	GLN	MET	ARG	ASN	LYS	PHE	ALA
9	PHE	ARG	GLU	ALA	ILE	ASN	LYS	LEU	GLU	ASN
10	ASN	LEU	ARG	GLU	LEU	GLN	ILE	CYS	PRO	ALA
11	THR	ALA	GLY	SER	GLY	PRO	ALA	ALA	THR	GLN
12	ASP	PHE	SER	LYS	LEU	LEU	SER	SER	VAL	LYS
13	GLU	ILE	SER	ASP	ILE	VAL	GLN	ARG	LEU	GLU

1	GLY	ALA	MET	ALA	SER	THR	ARG	VAL	SER	LEU
2	ARG	LYS	THR	ARG	GLN	PRO	PRO	GLU	ARG	ILE
3	ALA	SER	GLY	ALA	ILE	THR	LYS	GLY	VAL	VAL
4	LEU	ASP	SER	THR	GLU	ALA	LEU	CYS	LEU	ALA
5	ILE	SER	ARG	ASN	SER	GLU	GLN	MET	ALA	SER
6	HIS	SER	ALA	VAL	LEU	GLU	ALA	GLY	LYS	ASN
7	LEU	TYR	SER	PHE	CYS	VAL	SER	TYR	VAL	ASP
8	SER	ILE	GLN	GLN	MET	ARG	ASN	LYS	PHE	ALA
9	PHE	ARG	GLU	ALA	ILE	ASN	LYS	LEU	GLU	ASN
10	ASN	LEU	ARG	GLU	LEU	GLN	ILE	CYS	PRO	ALA
11	THR	ALA	GLY	SER	GLY	PRO	ALA	ALA	THR	GLN
12	ASP	PHE	SER	LYS	LEU	LEU	SER	SER	VAL	LYS
13	GLU	ILE	SER	ASP	ILE	VAL	GLN	ARG	LEU	GLU