BMRB Entry 5837

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR5837

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Title:
Structure of a peptide derived from the voltage gated Na+ channel and its selective interaction with local anesthetic as determined by NMR spectroscopy
Deposition date:
2003-06-18
Original release date:
2008-06-27
Authors:
Fraceto, Leonardo; Nakaie, Clovis; Spisni, Alberto; de Paula, Eneida; Pertinhez, Thelma
Citation:

Citation: Fraceto, Leonardo; Oyama, Sergio; Nakaie, Clovis; Spisni, Alberto; de Paula, Eneida; Pertinhez, Thelma. "Interaction of local anesthetics with a peptide encompassing the IV/S4-S5 linker of the Na+ channel."  Biophys. Chem. 123, 29-39 (2006).
PubMed: 16687202

Assembly members:

Assembly members:
Sodium Channel, polymer, 21 residues, Formula weight is not available

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: chemical synthesis

Entity Sequences (FASTA):

Entity Sequences (FASTA):
Sodium Channel: KGIRTLLFALMMSLPALFNI G

Data sets:
Data typeCount
1H chemical shifts163

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
  • Hide all

Assembly:

Entity Assembly IDEntity NameEntity ID
1Sodium channel subunit 41

Entities:

Entity 1, Sodium channel subunit 4 21 residues - Formula weight is not available

1   LYSGLYILEARGTHRLEULEUPHEALALEU
2   METMETSERLEUPROALALEUPHEASNILE
3   GLY

Samples:

sample_1: Sodium Channel 1.0 mM; trifluethanol 30%

condition_1: pH: 4.1; temperature: 293 K

Experiments:

NameSampleSample stateSample conditions
COSYnot availablenot availablenot available
TOCSYnot availablenot availablenot available
NOESYnot availablenot availablenot available
ROESYnot availablenot availablenot available
15N-HSQCnot availablenot availablenot available
DOSYnot availablenot availablenot available

Software:

Felix v2000 -

NMR spectrometers:

  • Varian INOVA 600 MHz
  • Varian INOVA 500 MHz

Related Database Links:

DBJ BAA07195 BAA78033 BAA90445 BAA90446 BAA90447
EMBL CAA25587 CAA27286 CAA27287 CAA46439 CAA58042
GB AAA18895 AAA41682 AAA42114 AAA58644 AAA60554
PRF 1012288A 1204264A 1204264B 2117364A 2203417A
REF NP_000325 NP_000326 NP_001002994 NP_001003203 NP_001034914
SP O08562 O46669 O88420 P02719 P04774
TPG DAA17127 DAA17236 DAA30006 DAA32687 DAA32692
AlphaFold O08562 O46669 O88420 P02719 P04774