BMRB Entry 5509
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR5509
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Citation: Liu, Kai; Kelly, Jeffery; Wemmer, David. "Native State Hydrogen Exchange Study of Suppressor and Pathogenic Variants of
Transthyretin" J. Mol. Biol. 320, 821-832 (2002).
PubMed: 12095258
Assembly members:
Transthyretin, polymer, 128 residues, Formula weight is not available
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: recombinant technology
Entity Sequences (FASTA):
Transthyretin: MGPTGTGESKCPLMVKVLDA
VRGSPAINVAMHVFRKAADD
TWEPFASGKTSESGELHGLT
TEEEFVEGIYKVEIDTKSYW
KALGISPFHEHAEVVFTAND
SGPRRYTIAALLSPYSYSTT
AVVTNPKE
- assigned_chemical_shifts
| Data type | Count |
| 1H chemical shifts | 121 |
| 13C chemical shifts | 128 |
| 15N chemical shifts | 121 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | TTR subunit 1 | 1 |
| 2 | TTR subunit 2 | 1 |
| 3 | TTR subunit 3 | 1 |
| 4 | TTR subunit 4 | 1 |
Entities:
Entity 1, TTR subunit 1 128 residues - Formula weight is not available
| 1 | MET | GLY | PRO | THR | GLY | THR | GLY | GLU | SER | LYS | ||||
| 2 | CYS | PRO | LEU | MET | VAL | LYS | VAL | LEU | ASP | ALA | ||||
| 3 | VAL | ARG | GLY | SER | PRO | ALA | ILE | ASN | VAL | ALA | ||||
| 4 | MET | HIS | VAL | PHE | ARG | LYS | ALA | ALA | ASP | ASP | ||||
| 5 | THR | TRP | GLU | PRO | PHE | ALA | SER | GLY | LYS | THR | ||||
| 6 | SER | GLU | SER | GLY | GLU | LEU | HIS | GLY | LEU | THR | ||||
| 7 | THR | GLU | GLU | GLU | PHE | VAL | GLU | GLY | ILE | TYR | ||||
| 8 | LYS | VAL | GLU | ILE | ASP | THR | LYS | SER | TYR | TRP | ||||
| 9 | LYS | ALA | LEU | GLY | ILE | SER | PRO | PHE | HIS | GLU | ||||
| 10 | HIS | ALA | GLU | VAL | VAL | PHE | THR | ALA | ASN | ASP | ||||
| 11 | SER | GLY | PRO | ARG | ARG | TYR | THR | ILE | ALA | ALA | ||||
| 12 | LEU | LEU | SER | PRO | TYR | SER | TYR | SER | THR | THR | ||||
| 13 | ALA | VAL | VAL | THR | ASN | PRO | LYS | GLU |
Samples:
sample_1: Transthyretin, [U-C13; U-N15], 0.3 – 1.5 mM; D2O 100%
Native_State: pH: 7; temperature: 298 K
Experiments:
| Name | Sample | Sample state | Sample conditions |
|---|---|---|---|
| HSQC | not available | not available | not available |
| HNCA | not available | not available | not available |
| HNCACB | not available | not available | not available |
| 1H-15N NOESY | not available | not available | not available |
Software:
No software information available
NMR spectrometers:
- Bruker DRX 600 MHz
Related Database Links:
| BMRB | 2476 5507 5508 5510 |
| PDB | |
| DBJ | BAA00059 BAG34987 |
| EMBL | CAA42087 CAG33189 |
| GB | AAA60011 AAA60012 AAA60013 AAA60018 AAA61181 |
| PRF | 0908191A 1008142A 1101213A 1709210A |
| REF | NP_000362 |
| SP | P02766 |
| AlphaFold | P02766 |
Download HSQC peak lists in one of the following formats:
CSV: Backbone
or all simulated peaks
SPARKY: Backbone
or all simulated peaks