BMRB Entry 53449

Name: 7SK Sites1,4 SL1-d RNA
Published: 2025-12-16

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR53449

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Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

7SK Sites1,4 SL1-d RNA

Deposition date:

2025-11-24

Original release date:

2025-12-16

Authors:

Yang, Yuan; Feigon, Juli

Citation:

Citation: Yang, Yuan; Murrali, Maria; Galvan, Sabrina; Wang, Yaqiang; Stephen, Christine; Ajjampore, Neha; Wang, Xiaoyu; Feigon, Juli. "HEXIM1 inter-monomer autoinhibition governs 7SK RNA binding specificity and P-TEFb inactivation" Nat. Comm. ., .-. (2025).

Assembly members:

Assembly members:
entity_1, polymer, 57 residues, Formula weight is not available

Natural source:

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: enzymatic semisynthesis

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: GGGAUCUGUCACCCCAUUGA UCGCCUUCGGGCUGAUCUGG CUGGCUAGGCGGGUCCC

Data sets:

assigned_chemical_shifts
- assigned_chemical_shifts_1

Data type	Count
1H chemical shifts	61

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	7SK SL1-d RNA	1

Entities:

Entity 1, 7SK SL1-d RNA 57 residues - Formula weight is not available

1

G

A

U

C

U

G

U

C

2

A

C

A

U

G

A

3

U

C

G

C

U

C

G

4

G

C

U

G

A

U

C

U

G

5

C

U

G

C

U

A

G

C

6

G

U

C

Samples:

sample_1: sodium phosphate 50 mM; sodium azide 0.02 % w/v; D2O 5 % v/v; 7SK SL1-dII RNA 0.39 mM

sample_conditions_1: ionic strength: 50 mM; pH: 6.2; pressure: 1 atm; temperature: 288.15 K

Experiments:

Name	Sample	Sample state	Sample conditions
2D 1H-1H NOESY	sample_1	isotropic	sample_conditions_1
2D 1H-1H TOCSY	sample_1	isotropic	sample_conditions_1

Software:

TOPSPIN - collection

NMRPipe - processing

NMRFAM-SPARKY - chemical shift assignment

NMR spectrometers:

Bruker AVANCE NEO 800 MHz