BMRB Entry 53417

Name: MCM6 NTD1
Published: 2026-01-05

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR53417

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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

MCM6 NTD1

Deposition date:

2025-11-05

Original release date:

2026-01-05

Authors:

Yang, Min June; Park, Chin-Ju

Citation:

Citation: Yang, Min June; Park, Chin-Ju. "Solution NMR Assignment of the MCM6 NTD1 Domain Reveals No Detectable Binding to BLM MBD-N and MBD-D Regions" .

Assembly members:

Assembly members:
entity_1, polymer, 104 residues, Formula weight is not available

Natural source:

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pET His6 LIC

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: SNAHLEVRDEVAEKCQKLFL DFLEEFQSSDGEIKYLQLAE ELIRPERNTLVVSFVDLEQF NQQLSTTIQEEFYRVYPYLC RALKTFVKDRKEIPLAKDFY VAFQ

Data sets:

assigned_chemical_shifts
- assigned_chemical_shifts_1

Data type	Count
13C chemical shifts	274
15N chemical shifts	81
1H chemical shifts	81

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	MCM6 NTD1	1

Entities:

Entity 1, MCM6 NTD1 104 residues - Formula weight is not available

1

SER

ASN

ALA

HIS

LEU

GLU

VAL

ARG

ASP

GLU

2

VAL

ALA

GLU

LYS

CYS

GLN

LYS

LEU

PHE

LEU

3

ASP

PHE

LEU

GLU

PHE

GLN

SER

ASP

4

GLY

GLU

ILE

LYS

TYR

LEU

GLN

LEU

ALA

GLU

5

GLU

LEU

ILE

ARG

PRO

GLU

ARG

ASN

THR

LEU

6

VAL

SER

PHE

VAL

ASP

LEU

GLU

GLN

PHE

7

ASN

GLN

LEU

SER

THR

ILE

GLN

GLU

8

GLU

PHE

TYR

ARG

VAL

TYR

PRO

TYR

LEU

CYS

9

ARG

ALA

LEU

LYS

THR

PHE

VAL

LYS

ASP

ARG

10

LYS

GLU

ILE

PRO

LEU

ALA

LYS

ASP

PHE

TYR

11

VAL

ALA

PHE

GLN

Samples:

sample_1: MCM6 NTD1, [U-99% 13C; U-99% 15N], 500 uM; HEPES 20 mM; NaCl 50 mM; DTT 2 mM

sample_conditions_1: ionic strength: 50 mM; pH: 7.0; pressure: 1 atm; temperature: 298 K

Experiments:

Name	Sample	Sample state	Sample conditions
2D 1H-15N HSQC	sample_1	isotropic	sample_conditions_1
2D 1H-13C HSQC	sample_1	isotropic	sample_conditions_1
3D CC(CO)NH	sample_1	isotropic	sample_conditions_1
3D HNCACB	sample_1	isotropic	sample_conditions_1
3D HNCACO	sample_1	isotropic	sample_conditions_1
3D HNCO	sample_1	isotropic	sample_conditions_1
3D HN(CO)CA	sample_1	isotropic	sample_conditions_1
3D HN(CO)CACB	sample_1	isotropic	sample_conditions_1

Software:

NMRFAM-POKY - chemical shift assignment

NMR spectrometers:

Bruker Avance 800 MHz

Download HSQC peak lists in one of the following formats:
CSV: Backbone or all simulated peaks
SPARKY: Backbone or all simulated peaks