BMRB Entry 52664

Name: Human TOPBP1 region 1055-1177
Published: 2024-11-21

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR52664

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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

Human TOPBP1 region 1055-1177

Deposition date:

2024-10-25

Original release date:

2024-11-21

Authors:

Zheng, Haoyang; Bartkevihi Di Piero, Leonardo

Citation:

Citation: Zheng, Haoyang; Bartkevihi Di Piero, Leonardo; Miron, Simona; Basbous, Jihane. "Structural analysis of TOPBP1 condensation" .

Assembly members:

Assembly members:
entity_1, polymer, 123 residues, Formula weight is not available

Natural source:

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pGEX

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: NDSKGVLTQTLEMRENFQKQ LQEIMSATSIVKPQGQRTSL SRSGCNSASSTPDSTRSARS GRSRVLEALRQSRQTVPDVN TEPSQNEQIIWDDPTAREER ARLASNLQWPSCPTQYSELQ VDI

Data sets:

assigned_chemical_shifts
- assigned_chemical_shifts_1

Data type	Count
13C chemical shifts	309
15N chemical shifts	114
1H chemical shifts	114

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	TOPBP1	1

Entities:

Entity 1, TOPBP1 123 residues - Formula weight is not available

1

ASN

ASP

SER

LYS

GLY

VAL

LEU

THR

GLN

THR

2

LEU

GLU

MET

ARG

GLU

ASN

PHE

GLN

LYS

GLN

3

LEU

GLN

GLU

ILE

MET

SER

ALA

THR

SER

ILE

4

VAL

LYS

PRO

GLN

GLY

GLN

ARG

THR

SER

LEU

5

SER

ARG

SER

GLY

CYS

ASN

SER

ALA

SER

6

THR

PRO

ASP

SER

THR

ARG

SER

ALA

ARG

SER

7

GLY

ARG

SER

ARG

VAL

LEU

GLU

ALA

LEU

ARG

8

GLN

SER

ARG

GLN

THR

VAL

PRO

ASP

VAL

ASN

9

THR

GLU

PRO

SER

GLN

ASN

GLU

GLN

ILE

10

TRP

ASP

PRO

THR

ALA

ARG

GLU

ARG

11

ALA

ARG

LEU

ALA

SER

ASN

LEU

GLN

TRP

PRO

12

SER

CYS

PRO

THR

GLN

TYR

SER

GLU

LEU

GLN

13

VAL

ASP

ILE

Samples:

sample_1: Human TOPBP1 residues 1055-1177, [U-95% 13C; U-95% 15N], 200 uM

sample_conditions_1: ionic strength: 150 mM; pH: 7; pressure: 1 atm; temperature: 283 K

Experiments:

Name	Sample	Sample state	Sample conditions
2D 1H-15N HSQC	sample_1	isotropic	sample_conditions_1

Software:

CcpNMR - chemical shift assignment

NMR spectrometers:

Bruker AVANCE NEO 950 MHz

Download HSQC peak lists in one of the following formats:
CSV: Backbone or all simulated peaks
SPARKY: Backbone or all simulated peaks