BMRB Entry 52577
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR52577
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Citation: Berardi, Andrea; Leonie Kaestner, Charlotte; Ghitti, Michela; Quilici, Giacomo; Cocomazzi, Paolo; Li, Jianping; Ballabio, Federico; Zucchelli, Chiara; Knapp, Stefan; Licht, Jonathan; Musco, Giovanna. "The C-terminal PHDVC5HCH tandem domain of NSD2 is a combinatorial reader of unmodified H3K4 and tri-methylated H3K27 that regulates transcription of cell adhesion genes in multiple myeloma" Nucleic Acids Res. 53, gkae1121-gkae1121 (2025).
PubMed: 39656918
Assembly members:
entity_1, polymer, 94 residues, Formula weight is not available
entity_ZN, non-polymer, 65.409 Da.
Natural source: Common Name: Mouse Taxonomy ID: 10090 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Mus musculus
Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pet-M11
Entity Sequences (FASTA):
entity_1: GAMEREDECFSCGDAGQLVS
CKKPGCPKVYHADCLNLTKR
PAGKWECPWHQCDVCGKEAA
SFCEMCPSSFCKQHREGMLF
ISKLDGRLSCTEHD
- heteronucl_NOEs
- heteronucl_T1_relaxation
- heteronucl_T2_relaxation
| Data type | Count |
| T1 relaxation values | 79 |
| T2 relaxation values | 79 |
| heteronuclear NOE values | 80 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | PHDCv5HCH domain of NSD1 | 1 |
| 2 | ZINC ION, 1 | 2 |
| 3 | ZINC ION, 2 | 2 |
| 4 | ZINC ION, 3 | 2 |
| 5 | ZINC ION, 4 | 2 |
Entities:
Entity 1, PHDCv5HCH domain of NSD1 94 residues - Formula weight is not available
The first three residues do not belong to the natural sequence
| 1 | GLY | ALA | MET | GLU | ARG | GLU | ASP | GLU | CYS | PHE | ||||
| 2 | SER | CYS | GLY | ASP | ALA | GLY | GLN | LEU | VAL | SER | ||||
| 3 | CYS | LYS | LYS | PRO | GLY | CYS | PRO | LYS | VAL | TYR | ||||
| 4 | HIS | ALA | ASP | CYS | LEU | ASN | LEU | THR | LYS | ARG | ||||
| 5 | PRO | ALA | GLY | LYS | TRP | GLU | CYS | PRO | TRP | HIS | ||||
| 6 | GLN | CYS | ASP | VAL | CYS | GLY | LYS | GLU | ALA | ALA | ||||
| 7 | SER | PHE | CYS | GLU | MET | CYS | PRO | SER | SER | PHE | ||||
| 8 | CYS | LYS | GLN | HIS | ARG | GLU | GLY | MET | LEU | PHE | ||||
| 9 | ILE | SER | LYS | LEU | ASP | GLY | ARG | LEU | SER | CYS | ||||
| 10 | THR | GLU | HIS | ASP |
Entity 2, ZINC ION, 1 - Zn - 65.409 Da.
| 1 | ZN |
Related Database Links:
| NCBI | NM 008739.3 |