BMRB Entry 5238

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PDB ID: 1kmx
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR5238
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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

1H and 15N chemical shift assignments for the heparin-binding domain of vascular endothelial growth factor

Deposition date:

2001-12-18

Original release date:

2002-02-08

Authors:

Fairbrother, Wayne; Champe, Mark; Christinger, Hans; Keyt, Bruce; Starovasnik, Melissa

Citation:

Citation: Fairbrother, Wayne; Champe, Mark; Christinger, Hans; Keyt, Bruce; Starovasnik, Melissa. "Solution structure of the heparin-binding domain of vascular endothelial growth factor" Structure 6, 637-649 (1998).
PubMed: 9634701

Assembly members:

Assembly members:
vascular endothelial growth factor, polymer, 55 residues, 6477 Da.

Natural source:

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli

Entity Sequences (FASTA):

Entity Sequences (FASTA):
vascular endothelial growth factor: ARQENPCGPCSERRKHLFVQ DPQTCKCSCKNTDSRCKARQ LELNERTCRCDKPRR

Data sets:

assigned_chemical_shifts
- shift_set_1

Data type	Count
15N chemical shifts	55
1H chemical shifts	359

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	VEGF heparin-binding domain	1

Entities:

Entity 1, VEGF heparin-binding domain 55 residues - 6477 Da.

1

ALA

ARG

GLN

GLU

ASN

PRO

CYS

GLY

PRO

CYS

2

SER

GLU

ARG

LYS

HIS

LEU

PHE

VAL

GLN

3

ASP

PRO

GLN

THR

CYS

LYS

CYS

SER

CYS

LYS

4

ASN

THR

ASP

SER

ARG

CYS

LYS

ALA

ARG

GLN

5

LEU

GLU

LEU

ASN

GLU

ARG

THR

CYS

ARG

CYS

6

ASP

LYS

PRO

ARG

Samples:

sample_1: vascular endothelial growth factor 1.0 mM

sample_2: vascular endothelial growth factor, [U-15N], 2.0 mM

condition_1: pH: 5.5; temperature: 300 K

Experiments:

Name	Sample	Sample state	Sample conditions
2QF-COSY	not available	not available	not available
2Q	not available	not available	not available
TOCSY	not available	not available	not available
NOESY	not available	not available	not available
1H-15N HSQC	not available	not available	not available
1H-15N TOCSY-HSQC	not available	not available	not available
1H-15N NOESY-HSQC	not available	not available	not available
1H-15N ROESY-HSQC	not available	not available	not available
HNHA	not available	not available	not available
HNHB	not available	not available	not available

Software:

FELIX - analysis, processing

NMR spectrometers:

Bruker AMX 500 MHz

PDB	1KMX 1VGH 2VGH
DBJ	BAA78418 BAB20890 BAB68520
EMBL	CAA09179 CAA44447 CAA57143 CAB82426 CAC19512
GenBank	AAA30502 AAA30804 AAA35789 AAA36804 AAA36807
PRF	2105202A
REF	NP_001003175 NP_001009854 NP_001020537 NP_001020538 NP_001020539
SWISS-PROT	P15691 P15692 P26617 P49151 Q9GKR0