BMRB Entry 52379

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR52379

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Title:
HIF-1alpha oxygen-dependent degradation domain
Deposition date:
2024-03-29
Original release date:
2024-08-20
Authors:
He, Wenguang; Gasmi-Seabrook, Genevieve; Ikura, Mitsuhiko; Lee, Jeffrey; Ohh, Michael
Citation:

Citation: He, Wenguang; Gasmi-Seabrook, Genevieve; Ikura, Mitsuhiko; Lee, Jeffrey; Ohh, Michael. "Time-resolved NMR detection of prolyl-hydroxylation in intrinsically disordered region of HIF-1a"  Proc. Natl. Acad. Sci. U. S. A. 121, e2408104121-e2408104121 (2024).
PubMed: 39231207

Assembly members:

Assembly members:
entity_1, polymer, 181 residues, 19997.06 Da.

Natural source:

Natural source:   Common Name: E. coli   Taxonomy ID: 562   Superkingdom: Bacteria   Kingdom: not available   Genus/species: Escherichia coli

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: pCDF Ek/LIC

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: PDALTLLAPAAGDTIISLDF GSNDTETDDQQLEEVPLYND VMLPSPNEKLQNINLAMSPL PTAETPKPLRSSADPALNQE VALKLEPNPESLELSFTMPQ IQDQTPSPSDGSTRQSSPEP NSPSEYCFYVDSDMVNEFKL ELVEKLFAEDTEAKNPFSTQ DTDLDLEMLAPYIPMDDDFQ L

Data sets:
Data typeCount
13C chemical shifts531
15N chemical shifts173
1H chemical shifts155

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
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Assembly:

Entity Assembly IDEntity NameEntity ID
1HIF-1alpha ODD1

Entities:

Entity 1, HIF-1alpha ODD 181 residues - 19997.06 Da.

1   PROASPALALEUTHRLEULEUALAPROALA
2   ALAGLYASPTHRILEILESERLEUASPPHE
3   GLYSERASNASPTHRGLUTHRASPASPGLN
4   GLNLEUGLUGLUVALPROLEUTYRASNASP
5   VALMETLEUPROSERPROASNGLULYSLEU
6   GLNASNILEASNLEUALAMETSERPROLEU
7   PROTHRALAGLUTHRPROLYSPROLEUARG
8   SERSERALAASPPROALALEUASNGLNGLU
9   VALALALEULYSLEUGLUPROASNPROGLU
10   SERLEUGLULEUSERPHETHRMETPROGLN
11   ILEGLNASPGLNTHRPROSERPROSERASP
12   GLYSERTHRARGGLNSERSERPROGLUPRO
13   ASNSERPROSERGLUTYRCYSPHETYRVAL
14   ASPSERASPMETVALASNGLUPHELYSLEU
15   GLULEUVALGLULYSLEUPHEALAGLUASP
16   THRGLUALALYSASNPROPHESERTHRGLN
17   ASPTHRASPLEUASPLEUGLUMETLEUALA
18   PROTYRILEPROMETASPASPASPPHEGLN
19   LEU

Related Database Links:

UNP Q16665

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