BMRB Entry 52175

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR52175

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Title:
Ligand-induced transition state stabilization of protein conformational change switches the binding pathway from conformational selection to induced fit - LACTOSE
Deposition date:
2023-10-15
Original release date:
2024-02-22
Authors:
Stenstrom, Olof; Diehl, Carl; Modig, Kristofer; Akke, Mikael
Citation:

Citation: Stenstrom, Olof; Diehl, Carl; Modig, Kristofer; Akke, Mikael. "Ligand-induced transition state stabilization of protein conformational change switches the binding pathway from conformational selection to induced fit"  Proc. Natl. Acad. Sci. U.S.A. 121, e2317747121-e2317747121 (2024).
PubMed: 38527204

Assembly members:

Assembly members:
entity_1, polymer, 138 residues, Formula weight is not available
entity_2, polymer, 2 residues, Formula weight is not available

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: PET9a

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: ALIVPYNLPLPGGVVPRMLI TILGTVKPNANRIALDFQRG NDVAFHFNPRFNENNRRVIV CNTKLDNNWGREERQSVFPF ESGKPFKIQVLVEPDHFKVA VNDAHLLQYNHRVKKLNEIS KLGISGDIDLTSASYTMI
entity_2: XX

Data typeCount

Additional metadata:

  • Assembly
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Assembly:

Entity Assembly IDEntity NameEntity ID
1Galectin-3C1
2Lactose2

Entities:

Entity 1, Galectin-3C 138 residues - Formula weight is not available

1   ALALEUILEVALPROTYRASNLEUPROLEU
2   PROGLYGLYVALVALPROARGMETLEUILE
3   THRILELEUGLYTHRVALLYSPROASNALA
4   ASNARGILEALALEUASPPHEGLNARGGLY
5   ASNASPVALALAPHEHISPHEASNPROARG
6   PHEASNGLUASNASNARGARGVALILEVAL
7   CYSASNTHRLYSLEUASPASNASNTRPGLY
8   ARGGLUGLUARGGLNSERVALPHEPROPHE
9   GLUSERGLYLYSPROPHELYSILEGLNVAL
10   LEUVALGLUPROASPHISPHELYSVALALA
11   VALASNASPALAHISLEULEUGLNTYRASN
12   HISARGVALLYSLYSLEUASNGLUILESER
13   LYSLEUGLYILESERGLYASPILEASPLEU
14   THRSERALASERTYRTHRMETILE

Entity 2, Lactose 2 residues - Formula weight is not available

1   GALBGC