BMRB Entry 51476

Name: Androgen Receptor C-terminal NTD
Published: 2023-11-17

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR51476

NMR-STAR file interactive viewer.
NMR-STAR v3 text file.
XML gzip file.
RDF gzip file.
All files associated with the entry

Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

Select model:

I am color blind

Download raw data. Direct link to this display. Help

Title:

Androgen Receptor C-terminal NTD

Deposition date:

2022-05-27

Original release date:

2023-11-17

Authors:

Garcia, Jesus; Buzon, Victor; Salvatella, Xavier

Citation:

Citation: Basu, Shaon; Martinez-Cristobal, Paula; Frigole-Vivas, Marta; Pesarrodona, Mireia; Lewis, Michael; Szulc, Elzbieta; Banuelos, C Adriana; Sanchez-Zarzalejo, Carolina; Bielskute, Stase; Zhu, Jiaqi; Pombo-Garcia, Karina; Garcia-Cabau, Carla; Zodi, Levente; Dockx, Hannes; Smak, Jordann; Kaur, Harpreet; Batlle, Cristina; Mateos, Borja; Biesaga, Mateusz; Escobedo, Albert; Bardia, Lidia; Verdaguer, Xavier; Ruffoni, Alessandro; Mawji, Nasrin; Wang, Jun; Obst, Jon; Tam, Teresa; Brun-Heath, Isabelle; Ventura, Salvador; Meierhofer, David; Garcia, Jesus; Robustelli, Paul; Stracker, Travis; Sadar, Marianne; Riera, Antoni; Hnisz, Denes; Salvatella, Xavier. "Rational optimization of a transcription factor activation domain inhibitor" Nat. Struct. Mol. Biol. 30, 1958-1969 (2023).
PubMed: 38049566

Assembly members:

Assembly members:
entity_1, polymer, 98 residues, Formula weight is not available

Natural source:

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pDEST17

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: EGQLYGPCGGGGEAGAVAPY GYTRPPQGLAGQESDFTAPD VWYPGGMVSRVPYPSPTCVK SEMGPWMDSYSGPYGDMRLE TARDHVLPIDYYFPPQKT

Data sets:

assigned_chemical_shifts
- assigned_chemical_shifts_1

Data type	Count
13C chemical shifts	267
15N chemical shifts	82
1H chemical shifts	82

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
Hide all

Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	AR	1

Entities:

Entity 1, AR 98 residues - Formula weight is not available

1

GLU

GLY

GLN

LEU

TYR

GLY

PRO

CYS

GLY

2

GLY

GLU

ALA

GLY

ALA

VAL

ALA

PRO

TYR

3

GLY

TYR

THR

ARG

PRO

GLN

GLY

LEU

ALA

4

GLY

GLN

GLU

SER

ASP

PHE

THR

ALA

PRO

ASP

5

VAL

TRP

TYR

PRO

GLY

MET

VAL

SER

ARG

6

VAL

PRO

TYR

PRO

SER

PRO

THR

CYS

VAL

LYS

7

SER

GLU

MET

GLY

PRO

TRP

MET

ASP

SER

TYR

8

SER

GLY

PRO

TYR

GLY

ASP

MET

ARG

LEU

GLU

9

THR

ALA

ARG

ASP

HIS

VAL

LEU

PRO

ILE

ASP

10

TYR

PHE

PRO

GLN

LYS

THR

Samples:

sample_1: Androgen Receptor 441-558, [U-100% 13C; U-100% 15N], 300 uM; D2O 10%; sodium phosphate 20 mM; sodium azide 0.05%; TCEP 1 mM

sample_conditions_1: ionic strength: 0 M; pH: 7.4; pressure: 1 atm; temperature: 278 K

Experiments:

Name	Sample	Sample state	Sample conditions
2D 1H-15N HSQC	sample_1	isotropic	sample_conditions_1
3D HNCO	sample_1	isotropic	sample_conditions_1
3D HN(CA)CO	sample_1	isotropic	sample_conditions_1
3D HNCA	sample_1	isotropic	sample_conditions_1
3D HN(CO)CA	sample_1	isotropic	sample_conditions_1
3D CBCA(CO)NH	sample_1	isotropic	sample_conditions_1
3D CBCANH	sample_1	isotropic	sample_conditions_1

Software:

NMRPipe - processing

qMDD - processing

CcpNMR - chemical shift assignment

NMR spectrometers:

Bruker AVANCE NEO 18.8 T MHz

Download HSQC peak lists in one of the following formats:
CSV: Backbone or all simulated peaks
SPARKY: Backbone or all simulated peaks