BMRB Entry 51332

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR51332

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Title:
Structural insights into the mechanism of p53 regulation by MDM2 acidic domain
Deposition date:
2022-02-19
Original release date:
2022-10-11
Authors:
Song, Qinyan; Rainey, Jan; Liu, Paul
Citation:

Citation: Song, Qinyan; Liu, Xiang-Qin; Rainey, Jan. "The MDMX acidic domain competes with the p53 transactivation domain for MDM2 N-terminal domain binding"  Biochim. Biophys. Acta Mol. Cell Res. 1869, 119319-119319 (2022).
PubMed: 35780910

Assembly members:

Assembly members:
entity_1, polymer, 221 residues, Formula weight is not available

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: pET-32

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: HMSSSVPSQKTYQGSYGFRL GFLHSGTAKSVTCTYSPALN KMFCQLAKTCPVQLWVDSTP PPGTRVRAMAIYKQSQHMTE VVRRCPHHERCSDSDGLAPP QHLIRVEGNLRVEYLDDRNT FRHSVVVPYEPPEVGSDCTT IHYNYMCNSSCMGGMNRRPI LTIITLEDSSGNLLGRNSFE VRVCACPGRDRRTEEENLRK KGEPHHELPPGSTKRALPNN T

Data sets:
Data typeCount
13C chemical shifts569
15N chemical shifts199
1H chemical shifts198

Additional metadata:

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Assembly:

Entity Assembly IDEntity NameEntity ID
1p53 DNA-binding domain1

Entities:

Entity 1, p53 DNA-binding domain 221 residues - Formula weight is not available

1   HISMETSERSERSERVALPROSERGLNLYS
2   THRTYRGLNGLYSERTYRGLYPHEARGLEU
3   GLYPHELEUHISSERGLYTHRALALYSSER
4   VALTHRCYSTHRTYRSERPROALALEUASN
5   LYSMETPHECYSGLNLEUALALYSTHRCYS
6   PROVALGLNLEUTRPVALASPSERTHRPRO
7   PROPROGLYTHRARGVALARGALAMETALA
8   ILETYRLYSGLNSERGLNHISMETTHRGLU
9   VALVALARGARGCYSPROHISHISGLUARG
10   CYSSERASPSERASPGLYLEUALAPROPRO
11   GLNHISLEUILEARGVALGLUGLYASNLEU
12   ARGVALGLUTYRLEUASPASPARGASNTHR
13   PHEARGHISSERVALVALVALPROTYRGLU
14   PROPROGLUVALGLYSERASPCYSTHRTHR
15   ILEHISTYRASNTYRMETCYSASNSERSER
16   CYSMETGLYGLYMETASNARGARGPROILE
17   LEUTHRILEILETHRLEUGLUASPSERSER
18   GLYASNLEULEUGLYARGASNSERPHEGLU
19   VALARGVALCYSALACYSPROGLYARGASP
20   ARGARGTHRGLUGLUGLUASNLEUARGLYS
21   LYSGLYGLUPROHISHISGLULEUPROPRO
22   GLYSERTHRLYSARGALALEUPROASNASN
23   THR

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