BMRB Entry 51081

Name: FOXO4 (aa 14-217)
Published: 2022-05-06

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR51081

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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

FOXO4 (aa 14-217)

Deposition date:

2021-09-08

Original release date:

2022-05-06

Authors:

Kohoutova, Klara

Citation:

Citation: Mandal, Raju; Kohoutova, Klara; Petrvalska, Olivia; Horvath, Matej; Srb, Pavel; Veverka, Vaclav; Obsilova, Veronika; Obsil, Tomas. "FOXO4 interacts with p53 TAD and CRD and inhibits its binding to DNA" Protein Sci. 31, e4287-e4287 (2022).
PubMed: 35481640

Assembly members:

Assembly members:
entity_1, polymer, 204 residues, Formula weight is not available

Natural source:

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pET

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: GIIDLDPDFEPQSRPRSCTW PLPRPEIANQPSEPPEVEPD LGEKVHTEGRSEPILLPSRL PEPAGGPQPGILGAVTGPRK GGSRRNAWGNQSYAELISQA IESAPEKRLTLAQIYEWMVR TVPYFKDKGDSNSSAGWKNS IRHNLSLHSKFIKVHNEATG KSSWWMLNPEGGKSGKAPRR RAASMDSSSKLLRGRSKAPK KKPS

Data sets:

assigned_chemical_shifts
- assigned_chemical_shifts_1

Data type	Count
13C chemical shifts	503
15N chemical shifts	143
1H chemical shifts	144

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
Hide all

Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	FOXO4	1

Entities:

Entity 1, FOXO4 204 residues - Formula weight is not available

1

GLY

ILE

ASP

LEU

ASP

PRO

ASP

PHE

GLU

2

PRO

GLN

SER

ARG

PRO

ARG

SER

CYS

THR

TRP

3

PRO

LEU

PRO

ARG

PRO

GLU

ILE

ALA

ASN

GLN

4

PRO

SER

GLU

PRO

GLU

VAL

GLU

PRO

ASP

5

LEU

GLY

GLU

LYS

VAL

HIS

THR

GLU

GLY

ARG

6

SER

GLU

PRO

ILE

LEU

PRO

SER

ARG

LEU

7

PRO

GLU

PRO

ALA

GLY

PRO

GLN

PRO

GLY

8

ILE

LEU

GLY

ALA

VAL

THR

GLY

PRO

ARG

LYS

9

GLY

SER

ARG

ASN

ALA

TRP

GLY

ASN

10

GLN

SER

TYR

ALA

GLU

LEU

ILE

SER

GLN

ALA

11

ILE

GLU

SER

ALA

PRO

GLU

LYS

ARG

LEU

THR

12

LEU

ALA

GLN

ILE

TYR

GLU

TRP

MET

VAL

ARG

13

THR

VAL

PRO

TYR

PHE

LYS

ASP

LYS

GLY

ASP

14

SER

ASN

SER

ALA

GLY

TRP

LYS

ASN

SER

15

ILE

ARG

HIS

ASN

LEU

SER

LEU

HIS

SER

LYS

16

PHE

ILE

LYS

VAL

HIS

ASN

GLU

ALA

THR

GLY

17

LYS

SER

TRP

MET

LEU

ASN

PRO

GLU

18

GLY

LYS

SER

GLY

LYS

ALA

PRO

ARG

19

ARG

ALA

SER

MET

ASP

SER

LYS

20

LEU

ARG

GLY

ARG

SER

LYS

ALA

PRO

LYS

21

LYS

PRO

SER

Samples:

sample_1: FOXO4, [U-13C; U-15N], 250 uM; TRIS 25 mM; sodium chloride 150 mM

sample_conditions_1: ionic strength: 175 mM; pH: 7.5; pressure: 1 atm; temperature: 298 K

Experiments:

Name	Sample	Sample state	Sample conditions
2D 1H-15N TROSY	sample_1	isotropic	sample_conditions_1
3D HNCA	sample_1	isotropic	sample_conditions_1
3D HNCO	sample_1	isotropic	sample_conditions_1

Software:

TOPSPIN - collection

TOPSPIN - processing

NMRFAM-SPARKY - chemical shift assignment

NMR spectrometers:

Bruker AVANCE III 850 MHz

Download HSQC peak lists in one of the following formats:
CSV: Backbone or all simulated peaks
SPARKY: Backbone or all simulated peaks