BMRB Entry 50867

Name: Complex of the CBP TAZ1 domain and a CITED2-HIF-1alpha fusion peptide (L63A)
Published: 2021-07-24

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR50867

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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

Complex of the CBP TAZ1 domain and a CITED2-HIF-1alpha fusion peptide (L63A)

Deposition date:

2021-03-31

Original release date:

2021-07-24

Authors:

Appling, Francis; Berlow, Rebecca; Stanfield, Robyn; Dyson, H Jane; Wright, Peter

Citation:

Citation: Appling, Francis; Berlow, Rebecca; Stanfield, Robyn; Dyson, H Jane; Wright, Peter. "The molecular basis of allostery in a facilitated dissociation process" Structure 29, 1327-1338 (2021).
PubMed: 34520739

Assembly members:

Assembly members:
entity_1, polymer, 100 residues, Formula weight is not available
entity_2, polymer, 67 residues, Formula weight is not available
entity_ZN, non-polymer, 65.409 Da.

Natural source:

Natural source: Common Name: Mouse Taxonomy ID: 10090 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Mus musculus

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pET21d

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: ATGPTADPEKRKLIQQQLVL LLHAHKCQRREQANGEVRAC SLPHCRTMKNVLNHMTHCQA GKACQVAHCASSRQIISHWK NCTRHDCPVCLPLKNASDKR
entity_2: GSHMSNVIDTDFIDEEVLMS LVIEMGLDRIKELPELTSYD CEVNAPIQGSRNLLQGEELL RAADQVN

Data sets:

assigned_chemical_shifts
- assigned_chemical_shifts_1
- assigned_chemical_shifts_2

Data type	Count
13C chemical shifts	412
15N chemical shifts	140
1H chemical shifts	205

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
Hide all

Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	TAZ1	1
2	CITED2-HIF1alpha fusion peptide (L63A)	2
3	zinc1	3
4	zinc2	3
5	zinc3	3

Entities:

Entity 1, TAZ1 100 residues - Formula weight is not available

1	ALA	THR	GLY	PRO	THR	ALA	ASP	PRO	GLU	LYS
2	ARG	LYS	LEU	ILE	GLN	GLN	GLN	LEU	VAL	LEU
3	LEU	LEU	HIS	ALA	HIS	LYS	CYS	GLN	ARG	ARG
4	GLU	GLN	ALA	ASN	GLY	GLU	VAL	ARG	ALA	CYS
5	SER	LEU	PRO	HIS	CYS	ARG	THR	MET	LYS	ASN
6	VAL	LEU	ASN	HIS	MET	THR	HIS	CYS	GLN	ALA
7	GLY	LYS	ALA	CYS	GLN	VAL	ALA	HIS	CYS	ALA
8	SER	SER	ARG	GLN	ILE	ILE	SER	HIS	TRP	LYS
9	ASN	CYS	THR	ARG	HIS	ASP	CYS	PRO	VAL	CYS
10	LEU	PRO	LEU	LYS	ASN	ALA	SER	ASP	LYS	ARG

Entity 2, CITED2-HIF1alpha fusion peptide (L63A) 67 residues - Formula weight is not available

1

GLY

SER

HIS

MET

SER

ASN

VAL

ILE

ASP

THR

2

ASP

PHE

ILE

ASP

GLU

VAL

LEU

MET

SER

3

LEU

VAL

ILE

GLU

MET

GLY

LEU

ASP

ARG

ILE

4

LYS

GLU

LEU

PRO

GLU

LEU

THR

SER

TYR

ASP

5

CYS

GLU

VAL

ASN

ALA

PRO

ILE

GLN

GLY

SER

6

ARG

ASN

LEU

GLN

GLY

GLU

LEU

7

ARG

ALA

ASP

GLN

VAL

ASN

Entity 3, zinc1 - Zn - 65.409 Da.

1

ZN

Name	Sample	Sample state	Sample conditions
2D 1H-15N HSQC	sample_1	isotropic	sample_conditions_1
3D HNCO	sample_1	isotropic	sample_conditions_1
3D HN(CA)CO	sample_1	isotropic	sample_conditions_1
3D HNCA	sample_1	isotropic	sample_conditions_1
3D HN(CO)CA	sample_1	isotropic	sample_conditions_1
3D HNCACB	sample_1	isotropic	sample_conditions_1
3D HN(CO)CACB	sample_1	isotropic	sample_conditions_1
2D 1H-15N HSQC	sample_2	isotropic	sample_conditions_1
3D HNCO	sample_2	isotropic	sample_conditions_1
3D HN(CA)CO	sample_2	isotropic	sample_conditions_1
3D HNCA	sample_2	isotropic	sample_conditions_1
3D HN(CO)CA	sample_2	isotropic	sample_conditions_1
3D HNCACB	sample_2	isotropic	sample_conditions_1
3D HN(CO)CACB	sample_2	isotropic	sample_conditions_1

Download HSQC peak lists in one of the following formats:
CSV: Backbone or all simulated peaks
SPARKY: Backbone or all simulated peaks

BMRB Entry 50867

Additional metadata:

Assembly:

Entities:

Samples:

Experiments:

Software:

NMR spectrometers:

1	ALA	THR	GLY	PRO	THR	ALA	ASP	PRO	GLU	LYS
2	ARG	LYS	LEU	ILE	GLN	GLN	GLN	LEU	VAL	LEU
3	LEU	LEU	HIS	ALA	HIS	LYS	CYS	GLN	ARG	ARG
4	GLU	GLN	ALA	ASN	GLY	GLU	VAL	ARG	ALA	CYS
5	SER	LEU	PRO	HIS	CYS	ARG	THR	MET	LYS	ASN
6	VAL	LEU	ASN	HIS	MET	THR	HIS	CYS	GLN	ALA
7	GLY	LYS	ALA	CYS	GLN	VAL	ALA	HIS	CYS	ALA
8	SER	SER	ARG	GLN	ILE	ILE	SER	HIS	TRP	LYS
9	ASN	CYS	THR	ARG	HIS	ASP	CYS	PRO	VAL	CYS
10	LEU	PRO	LEU	LYS	ASN	ALA	SER	ASP	LYS	ARG

1	ALA	THR	GLY	PRO	THR	ALA	ASP	PRO	GLU	LYS
2	ARG	LYS	LEU	ILE	GLN	GLN	GLN	LEU	VAL	LEU
3	LEU	LEU	HIS	ALA	HIS	LYS	CYS	GLN	ARG	ARG
4	GLU	GLN	ALA	ASN	GLY	GLU	VAL	ARG	ALA	CYS
5	SER	LEU	PRO	HIS	CYS	ARG	THR	MET	LYS	ASN
6	VAL	LEU	ASN	HIS	MET	THR	HIS	CYS	GLN	ALA
7	GLY	LYS	ALA	CYS	GLN	VAL	ALA	HIS	CYS	ALA
8	SER	SER	ARG	GLN	ILE	ILE	SER	HIS	TRP	LYS
9	ASN	CYS	THR	ARG	HIS	ASP	CYS	PRO	VAL	CYS
10	LEU	PRO	LEU	LYS	ASN	ALA	SER	ASP	LYS	ARG

1	ALA	THR	GLY	PRO	THR	ALA	ASP	PRO	GLU	LYS
2	ARG	LYS	LEU	ILE	GLN	GLN	GLN	LEU	VAL	LEU
3	LEU	LEU	HIS	ALA	HIS	LYS	CYS	GLN	ARG	ARG
4	GLU	GLN	ALA	ASN	GLY	GLU	VAL	ARG	ALA	CYS
5	SER	LEU	PRO	HIS	CYS	ARG	THR	MET	LYS	ASN
6	VAL	LEU	ASN	HIS	MET	THR	HIS	CYS	GLN	ALA
7	GLY	LYS	ALA	CYS	GLN	VAL	ALA	HIS	CYS	ALA
8	SER	SER	ARG	GLN	ILE	ILE	SER	HIS	TRP	LYS
9	ASN	CYS	THR	ARG	HIS	ASP	CYS	PRO	VAL	CYS
10	LEU	PRO	LEU	LYS	ASN	ALA	SER	ASP	LYS	ARG