BMRB Entry 5082

Title:
Solution Structure of a K(+)-Channel Blocker from the Scorpion Tityus cambridgei
Deposition date:
2001-07-17
Original release date:
2001-11-13
Authors:
Wang, Iren; Wu, Shih-Hsiung; Chang, Hsueh-Kai; Shieh, Ru-Chi; Yu, Hui-Ming; Chen, Chinpan
Citation:

Citation: Wang, Iren; Wu, Shih-Hsiung; Chang, Hsueh-Kai; Shieh, Ru-Chi; Yu, Hui-Ming; Chen, Chinpan. "Solution Structure of a K(+)-Channel Blocker from the Scorpion Tityus cambridgei"  Protein Sci. 11, 390-400 (2002).
PubMed: 11790849

Assembly members:

Assembly members:
Tityustoxin alpha-KTx, polymer, 23 residues, 2448 Da.

Natural source:

Natural source:   Common Name: Tityustoxin alpha-KTx   Taxonomy ID: not available   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Tityus cambridgei

Experimental source:

Experimental source:   Production method: chemical synthesis

Entity Sequences (FASTA):

Entity Sequences (FASTA):
Tityustoxin alpha-KTx: ACGSCRKKCKGSGKCINGRC KCY

Data sets:
Data typeCount
1H chemical shifts155

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
  • Hide all

Assembly:

Entity Assembly IDEntity NameEntity ID
1Tc11

Entities:

Entity 1, Tc1 23 residues - 2448 Da.

1   ALACYSGLYSERCYSARGLYSLYSCYSLYS
2   GLYSERGLYLYSCYSILEASNGLYARGCYS
3   LYSCYSTYR

Samples:

sample_1: Tityustoxin alpha-KTx1.5 – 2.0 mM

Ex-cond_1: pH: 3.0; temperature: 275 K

Experiments:

NameSampleSample stateSample conditions
1H-1H NOESYnot availablenot availablenot available
1H-1H TOCSYnot availablenot availablenot available
1H-1H COSYnot availablenot availablenot available

Software:

xwinnmr v2.5 - data processing

NMR spectrometers:

  • Bruker AMX 500 MHz
  • Bruker Avance 600 MHz

Related Database Links:

PDB
SWISS-PROT P83243