BMRB Entry 50529

Title:
Resonance assignment of the designed MASP2 inhibitor SFMI2
Deposition date:
2020-10-27
Original release date:
2022-10-14
Authors:
Angyan, Annamaria; Mezo, Gabor; Perczel, Andras; Gaspari, Zoltan; Pal, Gabor
Citation:

Citation: Durvanger, Zsolt; Boros, Eszter; Nagy, Zoltan Attila; Hegedus, Rozsa; Megyeri, Marton; Dobo, Jozsef; Gal, Peter; Schlosser, Gitta; angyan, Annamaria; Gaspari, Zoltan; Perczel, Andras; Harmat, Veronika; Mezo, Gabor; Menyhard, Dora; Pal, Gabor. "Directed Evolution-Driven Increase of Structural Plasticity Is a Prerequisite for Binding the Complement Lectin Pathway Blocking MASP-Inhibitor Peptides"  ACS Chem. Biol. 17, 969-986 (2022).
PubMed: 35378038

Assembly members:

Assembly members:
entity_1, polymer, 14 residues, Formula weight is not available

Natural source:

Natural source:   Common Name: not available   Taxonomy ID: not available   Superkingdom: not available   Kingdom: not available   Genus/species: not available not available

Experimental source:

Experimental source:   Production method: chemical synthesis

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: GYCSRSYPPVCIPD

Data sets:
Data typeCount
1H chemical shifts86

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
  • Hide all

Assembly:

Entity Assembly IDEntity NameEntity ID
1SFMI21

Entities:

Entity 1, SFMI2 14 residues - Formula weight is not available

1   GLYTYRCYSSERARGSERTYRPROPROVAL
2   CYSILEPROASP

Samples:

sample_1: SFMI2 2.5 mM

sample_conditions_1: pH: 3.04; pressure: 1 atm; temperature: 300 K

Experiments:

NameSampleSample stateSample conditions
2D 1H-1H TOCSYsample_1isotropicsample_conditions_1
2D 1H-1H NOESYsample_1isotropicsample_conditions_1

Software:

SPARKY v3.1 - chemical shift assignment

NMR spectrometers:

  • Bruker Avance 500 MHz