BMRB Entry 50427

Name: FOXP2_247-341
Published: 2021-06-30

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR50427

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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

FOXP2_247-341

Deposition date:

2020-08-06

Original release date:

2021-06-30

Authors:

Richter, Gesa; Madl, Tobias

Citation:

Citation: Richter, Gesa; Gui, Tianshu; Bourgeois, Benjamin; Koyani, Chintan; Ulz, Peter; Heitzer, Ellen; von Lewinski, Dirk; Burgering, Boudewijn; Malle, Ernst; Madl, Tobias. "b-catenin regulates FOXP2 transcriptional activity via multiple binding sites" FEBS J. 288, 3261-3284 (2021).
PubMed: 33284517

Assembly members:

Assembly members:
entity_1, polymer, 95 residues, Formula weight is not available

Natural source:

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: petZ2_1a

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: GQAALPVQSLPQAGLSPAEI QQLWKEVTGVHSMEDNGIKH GGLDLTTNNSSSTTSSNTSK ASPPITHHSIVNGQSSVLSA RRDSSSHEETGASHT

Data sets:

assigned_chemical_shifts
- assigned_chemical_shifts_1

Data type	Count
13C chemical shifts	180
15N chemical shifts	69
1H chemical shifts	69

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	FOXP2_247-341	1

Entities:

Entity 1, FOXP2_247-341 95 residues - Formula weight is not available

1

GLY

GLN

ALA

LEU

PRO

VAL

GLN

SER

LEU

2

PRO

GLN

ALA

GLY

LEU

SER

PRO

ALA

GLU

ILE

3

GLN

LEU

TRP

LYS

GLU

VAL

THR

GLY

VAL

4

HIS

SER

MET

GLU

ASP

ASN

GLY

ILE

LYS

HIS

5

GLY

LEU

ASP

LEU

THR

ASN

SER

6

SER

THR

SER

ASN

THR

SER

LYS

7

ALA

SER

PRO

ILE

THR

HIS

SER

ILE

8

VAL

ASN

GLY

GLN

SER

VAL

LEU

SER

ALA

9

ARG

ASP

SER

HIS

GLU

THR

10

GLY

ALA

SER

HIS

THR

Samples:

sample_1: FOXP2_247-341, [U-99% 13C; U-99% 15N], 500 uM; sodium chloride 150 mM; sodium phosphate 50 mM; beta-mercaptoethanol 2 mM

sample_conditions_1: ionic strength: 0.15 M; pH: 6.5; pressure: 1 atm; temperature: 298 K

Experiments:

Name	Sample	Sample state	Sample conditions
2D 1H-15N HSQC	sample_1	isotropic	sample_conditions_1
3D CBCA(CO)NH	sample_1	isotropic	sample_conditions_1
3D HNCACB	sample_1	isotropic	sample_conditions_1
3D HN(CA)NNH	sample_1	isotropic	sample_conditions_1

Software:

CcpNMR - chemical shift assignment

TOPSPIN - collection, processing

NMR spectrometers:

Bruker AVANCE III 700 MHz

Download HSQC peak lists in one of the following formats:
CSV: Backbone or all simulated peaks
SPARKY: Backbone or all simulated peaks