BMRB Entry 50426

Name: FOXP2_FH_504-594
Published: 2021-06-30

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR50426

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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

FOXP2_FH_504-594

Deposition date:

2020-08-06

Original release date:

2021-06-30

Authors:

Richter, Gesa; Madl, Tobias

Citation:

Citation: Richter, Gesa; Gui, Tianshu; Bourgeois, Benjamin; Koyani, Chintan; Ulz, Peter; Heitzer, Ellen; von Lewinski, Dirk; Burgering, Boudewijn; Malle, Ernst; Madl, Tobias. "b-catenin regulates FOXP2 transcriptional activity via multiple binding sites" FEBS J. 288, 3261-3284 (2021).
PubMed: 33284517

Assembly members:

Assembly members:
entity_1, polymer, 91 residues, Formula weight is not available

Natural source:

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: petZ2_1a

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: RPPFTYATLIRQAIMESSDR QLTLNEIYSWFTRTFAYFRR NAATWKNAVRHNLSLHKCFV RVENVKGAVWTVDEVEYQKR RSQKITGSPTL

Data sets:

assigned_chemical_shifts
- assigned_chemical_shifts_1

Data type	Count
15N chemical shifts	80
1H chemical shifts	79

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	FOXP2_FH_504-594	1

Entities:

Entity 1, FOXP2_FH_504-594 91 residues - Formula weight is not available

1

ARG

PRO

PHE

THR

TYR

ALA

THR

LEU

ILE

2

ARG

GLN

ALA

ILE

MET

GLU

SER

ASP

ARG

3

GLN

LEU

THR

LEU

ASN

GLU

ILE

TYR

SER

TRP

4

PHE

THR

ARG

THR

PHE

ALA

TYR

PHE

ARG

5

ASN

ALA

THR

TRP

LYS

ASN

ALA

VAL

ARG

6

HIS

ASN

LEU

SER

LEU

HIS

LYS

CYS

PHE

VAL

7

ARG

VAL

GLU

ASN

VAL

LYS

GLY

ALA

VAL

TRP

8

THR

VAL

ASP

GLU

VAL

GLU

TYR

GLN

LYS

ARG

9

ARG

SER

GLN

LYS

ILE

THR

GLY

SER

PRO

THR

10

LEU

Samples:

sample_1: FOXP2_FH_504-594, [U-99% 13C; U-99% 15N], 500 uM; sodium phosphate 50 mM; sodium chloride 150 mM; beta-mercaptoethanol 2 mM

sample_conditions_1: ionic strength: 0.15 M; pH: 6.5; pressure: 1 atm; temperature: 298 K

Experiments:

Name	Sample	Sample state	Sample conditions
2D 1H-15N HSQC	sample_1	isotropic	sample_conditions_1
3D CBCACONH	sample_1	isotropic	sample_conditions_1
3D HNCACB	sample_1	isotropic	sample_conditions_1
3D HNCO	sample_1	isotropic	sample_conditions_1
3D HN(CA)CO	sample_1	isotropic	sample_conditions_1

Software:

CcpNMR - data analysis

TOPSPIN - collection, processing

NMR spectrometers:

Bruker AVANCE III 700 MHz

Download HSQC peak lists in one of the following formats:
CSV: Backbone or all simulated peaks
SPARKY: Backbone or all simulated peaks