BMRB Entry 50264

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PDB ID: 6z0h
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR50264
MolProbity Validation Chart

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Title:
NMR Backbone Resonance Assignment of TREM2 transmembrane helix K186A variant
Deposition date:
2020-05-08
Original release date:
2020-06-08
Authors:
Steiner, Andrea; Hagn, Franz
Citation:

Citation: Steiner, Andrea; Schlepckow, Kai; Brunner, Bettina; Steiner, Harald; Haass, Christian; Hagn, Franz. "gamma-Secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics"  EMBO J. 39, e104247-e104247 (2020).
PubMed: 32830336

Assembly members:

Assembly members:
entity_1, polymer, 49 residues, Formula weight is not available

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: pET15b

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: GSGRSLLEGEIPFPPTSILL LLACIFLIAILAASALWAAA WHGQKPGTH

Data sets:
Data typeCount
13C chemical shifts93
15N chemical shifts36
1H chemical shifts36

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
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Assembly:

Entity Assembly IDEntity NameEntity ID
1TREM21

Entities:

Entity 1, TREM2 49 residues - Formula weight is not available

1   GLYSERGLYARGSERLEULEUGLUGLYGLU
2   ILEPROPHEPROPROTHRSERILELEULEU
3   LEULEUALACYSILEPHELEUILEALAILE
4   LEUALAALASERALALEUTRPALAALAALA
5   TRPHISGLYGLNLYSPROGLYTHRHIS

Related Database Links:

UNP Q9NZC2
AlphaFold Q8WYN6

Download HSQC peak lists in one of the following formats:
CSV: Backbone or all simulated peaks
SPARKY: Backbone or all simulated peaks