BMRB Entry 4590

Name: Solution structure of the human chemokine Eotaxin-2
Published: 2001-03-08

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PDB ID: 1eig
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR4590
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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

Solution structure of the human chemokine Eotaxin-2

Deposition date:

2000-05-05

Original release date:

2001-03-08

Authors:

Mayer, K.; Stone, M.

Citation:

Citation: Mayer, K.; Stone, M.. "NMR Solution Structure and Receptor Peptide Binding of the CC-CHemokine Eotaxin-2 " Biochemistry 39, 8382-8395 (2000).

Assembly members:

Assembly members:
EOTAXIN-2, polymer, 73 residues, Formula weight is not available

Natural source:

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: PET28A

Entity Sequences (FASTA):

Entity Sequences (FASTA):
EOTAXIN-2: VVIPSPCCMFFVSKRIPENR VVSYQLSSRSTCLKAGVIFT TKKGQQSCGDPKQEWVQRYM KNLDAKQKKASPR

Data sets:

assigned_chemical_shifts
- chemical_shift_set_EOTAXIN-2
coupling_constants
- coupling_constants

Data type	Count
1H chemical shifts	461
13C chemical shifts	252
15N chemical shifts	76
coupling constants	51

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	EOTAXIN-2	1

Entities:

Entity 1, EOTAXIN-2 73 residues - Formula weight is not available

1

VAL

ILE

PRO

SER

PRO

CYS

MET

PHE

2

PHE

VAL

SER

LYS

ARG

ILE

PRO

GLU

ASN

ARG

3

VAL

SER

TYR

GLN

LEU

SER

ARG

SER

4

THR

CYS

LEU

LYS

ALA

GLY

VAL

ILE

PHE

THR

5

THR

LYS

GLY

GLN

SER

CYS

GLY

ASP

6

PRO

LYS

GLN

GLU

TRP

VAL

GLN

ARG

TYR

MET

7

LYS

ASN

LEU

ASP

ALA

LYS

GLN

LYS

ALA

8

SER

PRO

ARG

Samples:

sample_1: EOTAXIN-2, [U-15N; U-13C], 1 mM; NaAc 20 mM; H2O 90%; D2O 10%

sample_2: EOTAXIN-2, [U-13C], 1 mM; NaAc 20 mM; H2O 90%; D2O 10%

sample_3: EOTAXIN-2, [U-15N; U-13C], 1 mM; NaAc 20 mM; D2O 100%

sample_4: EOTAXIN-2, [U-10% 13C], 1 mM; NaAc 20 mM; D2O 100%

sample_cond_1: pH: 4.1; temperature: 298 K; ionic strength: 20 mM; pressure: 1 atm

Experiments:

Name	Sample	Sample state	Sample conditions

Software:

VNMR - collection

FELIX v98 - processing

X-PLOR v98 - structure solution

NMR spectrometers:

Varian Unity INOVA 500 MHz

PDB	1EIG 1EIH
DBJ	BAG35149 BAJ21120
EMBL	CAA11383
GB	AAB51135 AAD15410 AAH69072 AAH69391 ADQ32923
REF	NP_002982 XP_001155246 XP_003808972 XP_004045658 XP_009451649
SP	O00175
AlphaFold	O00175 O00175