BMRB Entry 36280

Name: Structure of single disulfide peptide Czon1107-P7A(major conformer)
Published: 2025-10-22

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PDB ID: 6knp
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR36280
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Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

Structure of single disulfide peptide Czon1107-P7A(major conformer)

Deposition date:

2019-08-06

Original release date:

2025-10-22

Authors:

Sarma, S.; Madhan Kumar, M.

Citation:

Citation: Mohan, Madhan Kumar; Abraham, Nikita; R, Rajesh; Jayaseelan, Benajamin Franklin; Ragnarsson, Lotten; Lewis, Richard; Sarma, Siddhartha. "Structure and allosteric activity of a single-disulfide conopeptide from Conus zonatus at human a3b4 and a7 nicotinic acetylcholine receptors." J. Biol. Chem. 295, 7096-7112 (2020).
PubMed: 32234761

Assembly members:

Assembly members:
Czon1107-P7A(major), polymer, 11 residues, 1083.287 Da.

Natural source:

Natural source: Common Name: not available Taxonomy ID: 754466 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Conus zonatus

Experimental source:

Experimental source: Production method: chemical synthesis Host organism: unidentified

Entity Sequences (FASTA):

Entity Sequences (FASTA):
Czon1107-P7A(major): GFRSPCAPFCX

Data sets:

assigned_chemical_shifts
- assigned_chemical_shifts_1

Data type	Count
13C chemical shifts	33
1H chemical shifts	55

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	entity_1	1

Entities:

Entity 1, entity_1 11 residues - 1083.287 Da.

1

GLY

PHE

ARG

SER

PRO

CYS

ALA

PRO

PHE

CYS

2

NH2

Samples:

sample_1: Czon1107-P7A(major) 3.0 ± 0.3 mM; H2O 90%; D2O, [U-2H], 10%

sample_conditions_1: ionic strength: 0 Not defined; pH: 7.0; pressure: 1 atm; temperature: 298 K

Experiments:

Name	Sample	Sample state	Sample conditions
2D DQF-COSY	sample_1	isotropic	sample_conditions_1
2D 1H-1H TOCSY	sample_1	isotropic	sample_conditions_1
2D 1H-1H NOESY	sample_1	isotropic	sample_conditions_1
2D 1H-13C HSQC	sample_1	isotropic	sample_conditions_1

Software:

CYANA, Guntert P. - structure calculation

CcpNmr Analysis, CCPN - chemical shift assignment

NMRPipe, Delaglio, Grzesiek, Vuister, Zhu, Pfeifer and Bax - data analysis

CcpNmr Analysis, CCPN - peak picking

NMR spectrometers:

Varian INOVA 600 MHz